Heterogeneity of multiple sclerosis pathogenesis: Implications for diagnosis and therapy

Trends in Molecular Medicine

Volumn 7, Issue 3, 2001, Pages 115-121

  Lassmann, Hans ^a   Brück, Wolfgang ^b   Lucchinetti, Claudia ^c  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CHEMOKINE; GLATIRAMER; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; MYELIN;

AXONAL INJURY; CLINICAL FEATURE; DEMYELINATION; DIAGNOSTIC IMAGING; ENCEPHALITIS; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNOMODULATION; MULTIPLE SCLEROSIS; MYELIN SHEATH; MYELINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOGENESIS; REVIEW; T LYMPHOCYTE; TH1 CELL;

GENETIC HETEROGENEITY; HUMANS; MULTIPLE SCLEROSIS; MYELIN SHEATH; RISK FACTORS; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; TH2 CELLS;

EID: 0035096330     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(00)01909-2     Document Type: Review

References (37)

1. Multiple sclerosis pathology
2. The neuropathology of multiple sclerosis
3. Axonal pathology in multiple sclerosis: A historical note
4. Immunology of multiple sclerosis
5. Proinflammatory and antiinflammatory cytokines in multiple sclerosis and central nervous system acquired immunodeficiency syndrome
6. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients
7. The genetics of multiple sclerosis. A review
8. Biotechnological agents for the immunotherapy of multiple sclerosis: Principles, problems and perspectives
9. Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis
10. Clonal expansion of CD8 T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
11. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
12. Bacterial vaccines for the treatment of multiple sclerosis and other autoimmune diseases
13. TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease
14. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein
15. Multiple sclerosis: Fas signaling in oligodendrocyte death
16. Oligodendroglial precursor cell susceptibility to hypoxia is related to poor ability to cope with reactive oxygen species
17. Evidence of a 'dying-back' gliopathy in demyelinating disease
18. Virus-induced demyelination in mice: 'Dying-back' of oligodendrocytes
19. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 117 cases
20. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
21. Selective degeneration of oligodendrocytes mediated by reactive oxygen species
22. Distribution of papovavirus, myelin-associated glycoprotein, and myelin basic protein in progressive multifocal leukoencephalopathy lesions
23. Humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica
24. Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive and remyelinated lesions
25. Axonal transsection in the lesions of multiple sclerosis
26. Axonal damage in acute multiple sclerosis
27. Temporary axonal conduction block and axonal loss in inflammatory neurological disease. A potential role for nitric oxide?
28. Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS
29. Mechanism of calcium entry during axon injury and degeneration
30. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
31. Macrophages in CNS remyelination: Friends or foe?
32. Activated human T cells, B cells and monocytes produce brain-derived neurotrophic factor (BDNF) in vitro and in brain lesions: A neuroprotective role of inflammation?
33. Magnetisation transfer imaging in multiple sclerosis
34. Multiple sclerosis: Serum gamma globulin and demyelination in culture
35. Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein
36. Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: A comparative study
37. Monocyte/macrophage differentiation in early multiple sclerosis