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Volumn 89, Issue 1, 2011, Pages 22-28

The case for blood-brain barrier dysfunction in the pathogenesis of Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid; Blood brain barrier

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCOPROTEIN P; LIPOPROTEIN RECEPTOR; MEMBRANE PROTEIN; TAU PROTEIN; VASCULOTROPIN;

EID: 78649518938     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22527     Document Type: Review
Times cited : (43)

References (71)
  • 3
    • 78650595532 scopus 로고    scopus 로고
    • Report. Rising tide: the impact of dementia on Canadian society
    • Alzheimer Society of Canada., Toronto, Alzheimer Society of Canada
    • Alzheimer Society of Canada. 2010. Report. Rising tide: the impact of dementia on Canadian society. Toronto: Alzheimer Society of Canada
    • (2010)
  • 4
    • 84880065255 scopus 로고    scopus 로고
    • Alzheimer's disease facts and figures
    • American Alzheimer's Association.
    • American Alzheimer's Association. 2010. Alzheimer's disease facts and figures. Alzheimer's Dement 6: 1-194.
    • (2010) Alzheimer's Dement , vol.6 , pp. 1-194
  • 6
    • 67349142021 scopus 로고    scopus 로고
    • Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    • Bell RD, Zlokovic BV. 2009. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol 118: 103-113.
    • (2009) Acta Neuropathol , vol.118 , pp. 103-113
    • Bell, R.D.1    Zlokovic, B.V.2
  • 8
    • 78649506845 scopus 로고    scopus 로고
    • Gene reviews [internet]
    • In, Pagon RA,Bird TC,Dolan CR,Stephens K, editors., Seattle (WA), University of Washington, Seattle; 23 Oct 1993-1998 [updated 30 Mar 2010].
    • Bird TD. 2010. In: Pagon RA, Bird TC, Dolan CR, Stephens K, editors. Gene reviews [internet]. Seattle (WA): University of Washington, Seattle; 23 Oct 1993-1998 [updated 30 Mar 2010].
    • (2010)
    • Bird, T.D.1
  • 9
    • 33749150163 scopus 로고    scopus 로고
    • Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
    • Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K. 2006. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112: 389-404.
    • (2006) Acta Neuropathol , vol.112 , pp. 389-404
    • Braak, H.1    Alafuzoff, I.2    Arzberger, T.3    Kretzschmar, H.4    Del Tredici, K.5
  • 12
    • 57449084208 scopus 로고    scopus 로고
    • ApoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain
    • Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB. 2008. ApoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest 118: 4002-4013.
    • (2008) J Clin Invest , vol.118 , pp. 4002-4013
    • Deane, R.1    Sagare, A.2    Hamm, K.3    Parisi, M.4    Lane, S.5    Finn, M.B.6
  • 13
    • 65649105035 scopus 로고    scopus 로고
    • Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease
    • Deane R, Bell RD, Sagare A, Zlokovic BV. 2009. Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Targets 8: 16-30.
    • (2009) CNS Neurol Disord Targets , vol.8 , pp. 16-30
    • Deane, R.1    Bell, R.D.2    Sagare, A.3    Zlokovic, B.V.4
  • 15
    • 41949101345 scopus 로고    scopus 로고
    • Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease [review]
    • erratum in 67:634.
    • Donahue JE, Johanson CE. 2008. Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease [review]. J Neuropathol Exp Neurol 67: 261-270; erratum in 67:634.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 261-270
    • Donahue, J.E.1    Johanson, C.E.2
  • 17
    • 33344463349 scopus 로고    scopus 로고
    • Discovery of vascular permeability factor (VPF)
    • Dvorak HF. 2006 Discovery of vascular permeability factor (VPF). Exp Cell Res 312: 522-526.
    • (2006) Exp Cell Res , vol.312 , pp. 522-526
    • Dvorak, H.F.1
  • 19
    • 0030780381 scopus 로고    scopus 로고
    • Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts
    • Giannakopoulos P, Hof PR, Michel JP, Guimon J, Bouras C. 1997. Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts. Brain Res Brain Res Rev 25: 217-245.
    • (1997) Brain Res Brain Res Rev , vol.25 , pp. 217-245
    • Giannakopoulos, P.1    Hof, P.R.2    Michel, J.P.3    Guimon, J.4    Bouras, C.5
  • 20
    • 77952117808 scopus 로고    scopus 로고
    • Targeting tau protein in Alzheimer's disease
    • Gong CX, Grundke-Iqbal I, Iqbal K. 2010. Targeting tau protein in Alzheimer's disease. Drugs Aging 27: 351-365.
    • (2010) Drugs Aging , vol.27 , pp. 351-365
    • Gong, C.X.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 21
    • 30744477950 scopus 로고    scopus 로고
    • From angiogenesis to neuropathology
    • Greenberg DA, Jin K. 2005. From angiogenesis to neuropathology. Nature 438: 954-959.
    • (2005) Nature , vol.438 , pp. 954-959
    • Greenberg, D.A.1    Jin, K.2
  • 22
    • 0031913355 scopus 로고    scopus 로고
    • Cytoarchitectonic alterations in the supramarginal gyrus of late-onsheimer's disease
    • Grignon Y, Duyckaerts C, Bennecib M, Hauw JJ. 1998. Cytoarchitectonic alterations in the supramarginal gyrus of late-onset Alzheimer's disease. Acta Neuropathol 95: 395-406.
    • (1998) Acta Neuropathol , vol.95 , pp. 395-406
    • Grignon, Y.1    Duyckaerts, C.2    Bennecib, M.3    Hauw, J.J.4
  • 24
    • 84899547370 scopus 로고    scopus 로고
    • Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors
    • doi: 10.3389/neuro.24.003.2010.
    • Guglielmotto M, Giliberto L, Tamagno E, Tabaton M. 2010. Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors. Front Aging Neurosci 2: 3 doi: 10.3389/neuro.24.003.2010.
    • (2010) Front Aging Neurosci , vol.2 , pp. 3
    • Guglielmotto, M.1    Giliberto, L.2    Tamagno, E.3    Tabaton, M.4
  • 25
    • 0038326624 scopus 로고    scopus 로고
    • Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment
    • Guillozet AL, Weintraub S, Mash D, Mesulam MM. 2003. Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. Arch Neurol 60: 729-736.
    • (2003) Arch Neurol , vol.60 , pp. 729-736
    • Guillozet, A.L.1    Weintraub, S.2    Mash, D.3    Mesulam, M.M.4
  • 26
    • 24144494527 scopus 로고    scopus 로고
    • The physiology and pathophysiology of nitric oxide in the brain
    • Guix FX, Uribesalgo I, Coma M, Munoz FJ. 2005. The physiology and pathophysiology of nitric oxide in the brain. Prog Neurobiol 76: 126-152.
    • (2005) Prog Neurobiol , vol.76 , pp. 126-152
    • Guix, F.X.1    Uribesalgo, I.2    Coma, M.3    Munoz, F.J.4
  • 27
    • 67651180986 scopus 로고    scopus 로고
    • The amyloid hypothesis for Alzheimer's disease: a critical reappraisal
    • Hardy J. 2009. The amyloid hypothesis for Alzheimer's disease: a critical reappraisal. J Neurochem 110: 1129-1134.
    • (2009) J Neurochem , vol.110 , pp. 1129-1134
    • Hardy, J.1
  • 28
    • 3042707731 scopus 로고    scopus 로고
    • Role of LRP in TGF2-mediated neuronal uptake of Abeta and effects on memory
    • Harris-White ME, Balverde Z, Lim GP, Kim P. 2004. Role of LRP in TGF2-mediated neuronal uptake of Abeta and effects on memory. J Neurosci Res 77: 217-228.
    • (2004) J Neurosci Res , vol.77 , pp. 217-228
    • Harris-White, M.E.1    Balverde, Z.2    Lim, G.P.3    Kim, P.4
  • 29
    • 0030938688 scopus 로고    scopus 로고
    • Automated identification and quantitative morphometry of the senile plaques of Alzheimer's disease
    • Hibbard LS, McKeel DWJr. 1997. Automated identification and quantitative morphometry of the senile plaques of Alzheimer's disease. Anal Quant Cytol Histol 19: 123-138.
    • (1997) Anal Quant Cytol Histol , vol.19 , pp. 123-138
    • Hibbard, L.S.1    McKeel Jr, D.W.2
  • 30
    • 73249144348 scopus 로고    scopus 로고
    • Alzheimer's disease and infection: do infectious agents contribute to progression of Alzheimer's disease?
    • Itzhaki RF, Wozniak MA. 2010. Alzheimer's disease and infection: do infectious agents contribute to progression of Alzheimer's disease? Alzheimers Dement 6: 83-84.
    • (2010) Alzheimers Dement , vol.6 , pp. 83-84
    • Itzhaki, R.F.1    Wozniak, M.A.2
  • 32
    • 33749143872 scopus 로고    scopus 로고
    • The possible role of capillary cerebral amyloid angiopathy in Alzheimer lesion development: a regional comparison
    • Jeynes B, Provias 2006. The possible role of capillary cerebral amyloid angiopathy in Alzheimer lesion development: a regional comparison. Acta Neuropathol 112: 417-427.
    • (2006) Acta Neuropathol , vol.112 , pp. 417-427
    • Jeynes, B.1    Provias2
  • 33
    • 53549086409 scopus 로고    scopus 로고
    • Evidence for altered LRP/RAGE in Alzheimer lesion pathogenesis
    • Jeynes B, Provias J. 2008. Evidence for altered LRP/RAGE in Alzheimer lesion pathogenesis. Curr Alzheimers Res 5: 432-437.
    • (2008) Curr Alzheimers Res , vol.5 , pp. 432-437
    • Jeynes, B.1    Provias, J.2
  • 34
    • 68949202838 scopus 로고    scopus 로고
    • Correlations between capillary expressed NOS isoforms presence and AD lesions in Alzheimer and normative brains
    • Jeynes B, Provias J. 2009. Correlations between capillary expressed NOS isoforms presence and AD lesions in Alzheimer and normative brains. Neurosci Lett 463: 244-248.
    • (2009) Neurosci Lett , vol.463 , pp. 244-248
    • Jeynes, B.1    Provias, J.2
  • 36
    • 77953039025 scopus 로고    scopus 로고
    • Can size alone explain some of the differences in toxicity between beta-amyloid oligomers and fibrils
    • Keshet B, Yang IH, Good TA. 2010. Can size alone explain some of the differences in toxicity between beta-amyloid oligomers and fibrils. Biotechnol Bioeng 106: 333-337.
    • (2010) Biotechnol Bioeng , vol.106 , pp. 333-337
    • Keshet, B.1    Yang, I.H.2    Good, T.A.3
  • 37
    • 43649096040 scopus 로고    scopus 로고
    • The amyloid cascade hypothesis
    • Korczyn AD. 2008. The amyloid cascade hypothesis. Alzheimers Dement 4: 176-178.
    • (2008) Alzheimers Dement , vol.4 , pp. 176-178
    • Korczyn, A.D.1
  • 40
    • 28344453429 scopus 로고    scopus 로고
    • Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability
    • Lillis AP, Mikhailenko I, Strickland DK. 2005. Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability. J Thromb Haemost 3: 1884-1893.
    • (2005) J Thromb Haemost , vol.3 , pp. 1884-1893
    • Lillis, A.P.1    Mikhailenko, I.2    Strickland, D.K.3
  • 41
    • 19944424142 scopus 로고    scopus 로고
    • Preventing activation of receptor for advanced glycation end products in Alzheimer's disease
    • Lue LF, Yan SD, Stern DM, Walker DG. 2005. Preventing activation of receptor for advanced glycation end products in Alzheimer's disease. Curr Drug Targets CNS Neurol Disord 4: 249-266.
    • (2005) Curr Drug Targets CNS Neurol Disord , vol.4 , pp. 249-266
    • Lue, L.F.1    Yan, S.D.2    Stern, D.M.3    Walker, D.G.4
  • 43
    • 67649534694 scopus 로고    scopus 로고
    • Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity
    • McCarthy JV, Twomey C, Wujek P. 2009. Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity. Cell Mol Life Sci 66: 1534-1555.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 1534-1555
    • McCarthy, J.V.1    Twomey, C.2    Wujek, P.3
  • 44
    • 67651056378 scopus 로고    scopus 로고
    • JEM spotlight: metal speciation related to neurotoxicity in humans
    • Michalke B, Halbach S, Nischwitz V. 2009. JEM spotlight: metal speciation related to neurotoxicity in humans. J Environ Monit 11: 939-954.
    • (2009) J Environ Monit , vol.11 , pp. 939-954
    • Michalke, B.1    Halbach, S.2    Nischwitz, V.3
  • 45
    • 46949098349 scopus 로고    scopus 로고
    • Modulation of p-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy
    • Miller DS, Bauer B, Hartz AMS. 2008. Modulation of p-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy. Pharmacol Rev 60: 196-209.
    • (2008) Pharmacol Rev , vol.60 , pp. 196-209
    • Miller, D.S.1    Bauer, B.2    Hartz, A.M.S.3
  • 46
    • 0023881281 scopus 로고
    • Bilateral symmetry of morphologic lesions in Alzheimer's disease
    • Moosy J, Zubenko GS, Martinez AJ, Rao GR. 1988. Bilateral symmetry of morphologic lesions in Alzheimer's disease. Arch Neurol 45: 251-254.
    • (1988) Arch Neurol , vol.45 , pp. 251-254
    • Moosy, J.1    Zubenko, G.S.2    Martinez, A.J.3    Rao, G.R.4
  • 48
    • 40849102300 scopus 로고    scopus 로고
    • LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-β peptide in a blood-brain barrier in vitro model
    • Nazer B, Hong S, Selkoe DJ. 2008. LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-β peptide in a blood-brain barrier in vitro model. Neurobiol Dis 30: 94-102.
    • (2008) Neurobiol Dis , vol.30 , pp. 94-102
    • Nazer, B.1    Hong, S.2    Selkoe, D.J.3
  • 49
    • 37349096335 scopus 로고    scopus 로고
    • Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity
    • Nelson PT, Jicha GA, Schmitt FA, Liu H, Davis DG, Mendiondo MS, Abner EL, Markesbery WR. 2007. Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity. J Neuropathol Exp Neurol 66: 1136-1146.
    • (2007) J Neuropathol Exp Neurol , vol.66 , pp. 1136-1146
    • Nelson, P.T.1    Jicha, G.A.2    Schmitt, F.A.3    Liu, H.4    Davis, D.G.5    Mendiondo, M.S.6    Abner, E.L.7    Markesbery, W.R.8
  • 50
    • 2442498577 scopus 로고    scopus 로고
    • FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein
    • Pietrzik CU, Yoon IS, Jaeger S, Busse T, Weggen S, Koo EH. 2004. FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J Neurosci 24: 4259-4265.
    • (2004) J Neurosci , vol.24 , pp. 4259-4265
    • Pietrzik, C.U.1    Yoon, I.S.2    Jaeger, S.3    Busse, T.4    Weggen, S.5    Koo, E.H.6
  • 51
    • 60349125886 scopus 로고    scopus 로고
    • Reassessing the amyloid cascade hypothesis of Alzheimer's disease
    • Pimplikar SW. 2009. Reassessing the amyloid cascade hypothesis of Alzheimer's disease. Int J Biochem Cell Biol 41: 1261-1268.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1261-1268
    • Pimplikar, S.W.1
  • 52
    • 49949084427 scopus 로고    scopus 로고
    • Neurofibrillary tangles and senile plaques in Alzheimer's brains are associated with reduced capillary expression of vascular endothelial growth factor and endothelial nitric oxide synthase
    • Provias J, Jeynes B. 2008. Neurofibrillary tangles and senile plaques in Alzheimer's brains are associated with reduced capillary expression of vascular endothelial growth factor and endothelial nitric oxide synthase. Curr Neurovasc Res 5: 199-205.
    • (2008) Curr Neurovasc Res , vol.5 , pp. 199-205
    • Provias, J.1    Jeynes, B.2
  • 53
    • 72049104784 scopus 로고    scopus 로고
    • Beta-amyloid deposition and the aging brain [review]
    • Rodrigue KM, Kennedy KM, Park DC. 2009. Beta-amyloid deposition and the aging brain [review]. Neuropsychol Rev 19: 436-450.
    • (2009) Neuropsychol Rev , vol.19 , pp. 436-450
    • Rodrigue, K.M.1    Kennedy, K.M.2    Park, D.C.3
  • 54
    • 70349419559 scopus 로고    scopus 로고
    • Contribution of neural networks to Alzheimer disease's progression
    • Savioz A, Leuba G, Vallet PG, Walzer C. 2009. Contribution of neural networks to Alzheimer disease's progression. Brain Res Bull 80: 309-314.
    • (2009) Brain Res Bull , vol.80 , pp. 309-314
    • Savioz, A.1    Leuba, G.2    Vallet, P.G.3    Walzer, C.4
  • 55
    • 0025878832 scopus 로고
    • Senile dementia of the Alzheimer type: is there a correlation between entorhinal cortex and dentate gyrus lesions?
    • Senut MC, Roudier M, Davous P, Fallet-Bianco C, Lamour Y. 1991. Senile dementia of the Alzheimer type: is there a correlation between entorhinal cortex and dentate gyrus lesions? Acta Neuropathol 82: 306-315.
    • (1991) Acta Neuropathol , vol.82 , pp. 306-315
    • Senut, M.C.1    Roudier, M.2    Davous, P.3    Fallet-Bianco, C.4    Lamour, Y.5
  • 56
    • 77953141219 scopus 로고    scopus 로고
    • ABC transporters and drug efflux at the blood-brain barrier
    • Shen S, Zhang W. 2010. ABC transporters and drug efflux at the blood-brain barrier. Rev Neurosci 21: 29-53.
    • (2010) Rev Neurosci , vol.21 , pp. 29-53
    • Shen, S.1    Zhang, W.2
  • 57
    • 53049093702 scopus 로고    scopus 로고
    • Multitracer PET imaging of amyloid plaques and neurofibrillary tangles in Alzheimer's disease
    • Shin J, Lee S-Y, Kim S-H, Kim Y-B, Cho S-J. 2008. Multitracer PET imaging of amyloid plaques and neurofibrillary tangles in Alzheimer's disease. Neuroimage 43: 236-244.
    • (2008) Neuroimage , vol.43 , pp. 236-244
    • Shin, J.1    Lee, S.2    Kim, S.3    Kim, Y.4    Cho, S.5
  • 58
    • 56349119351 scopus 로고    scopus 로고
    • Linking Aβ and tau in late-onsheimer's disease: a dual pathway hypothesis
    • Small SA, Duff K. 2008. Linking Aβ and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron 60: 534-542.
    • (2008) Neuron , vol.60 , pp. 534-542
    • Small, S.A.1    Duff, K.2
  • 59
    • 34247578755 scopus 로고    scopus 로고
    • Neurodegeneration and Alzheimer's disease: the lesson from tauopathies
    • Sorrentino G, Bonavita V. 2007. Neurodegeneration and Alzheimer's disease: the lesson from tauopathies. Neurol Sci 28: 63-71.
    • (2007) Neurol Sci , vol.28 , pp. 63-71
    • Sorrentino, G.1    Bonavita, V.2
  • 60
    • 58149220667 scopus 로고    scopus 로고
    • Cholesterol in Alzheimer's disease: unresolved questions
    • Stefani M, Liguri G. 2009. Cholesterol in Alzheimer's disease: unresolved questions. Curr Alzheimers Res 6: 15-29.
    • (2009) Curr Alzheimers Res , vol.6 , pp. 15-29
    • Stefani, M.1    Liguri, G.2
  • 62
    • 77955367175 scopus 로고    scopus 로고
    • The involvement of beta-amyloid in the etiology of Alzheimer disease
    • Tomiyama T. 2010. The involvement of beta-amyloid in the etiology of Alzheimer disease. Brain Nerve 62: 691-699.
    • (2010) Brain Nerve , vol.62 , pp. 691-699
    • Tomiyama, T.1
  • 64
    • 52649157170 scopus 로고    scopus 로고
    • Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid β-protein in perivascular astrocytes
    • Utter S, Tamboli IY, Walter J, Upadhaya AR, Birkenmeier G, Pietrzik CU. 2008. Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid β-protein in perivascular astrocytes. J Neuropathol Exp Neurol 67: 842-856.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 842-856
    • Utter, S.1    Tamboli, I.Y.2    Walter, J.3    Upadhaya, A.R.4    Birkenmeier, G.5    Pietrzik, C.U.6
  • 65
    • 33748753481 scopus 로고    scopus 로고
    • Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives
    • Wang Y-J, Zhou H-D, Zhou X-F. 2006. Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives. Drug Discov Today 11: 931-938.
    • (2006) Drug Discov Today , vol.11 , pp. 931-938
    • Wang, Y.1    Zhou, H.2    Zhou, X.3
  • 66
    • 63249115678 scopus 로고    scopus 로고
    • The blood-brain barrier in brain homeostasis and neurological diseases
    • Weiss N, Miller F, Cazaubon S, Couraud P-O. 2009. The blood-brain barrier in brain homeostasis and neurological diseases. Biochim Biophys Acta 1788: 842-857.
    • (2009) Biochim Biophys Acta , vol.1788 , pp. 842-857
    • Weiss, N.1    Miller, F.2    Cazaubon, S.3    Couraud, P.4
  • 67
    • 67349118757 scopus 로고    scopus 로고
    • Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy
    • Weller RO, Boche D, Nicoll JAR. 2009. Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy. Acta Neuropathol 118: 87-102.
    • (2009) Acta Neuropathol , vol.118 , pp. 87-102
    • Weller, R.O.1    Boche, D.2    Nicoll, J.A.R.3
  • 68
    • 0033014539 scopus 로고    scopus 로고
    • Progression of Alzheimer-related neuritic plaque pathology in the enthorinal region, perihinal cortex and hippocampal formation
    • Yilmazer-Hanke DM, Hanke J. 1999. Progression of Alzheimer-related neuritic plaque pathology in the enthorinal region, perihinal cortex and hippocampal formation. Dement Geriatr Cogn Disord 10: 70-76.
    • (1999) Dement Geriatr Cogn Disord , vol.10 , pp. 70-76
    • Yilmazer-Hanke, D.M.1    Hanke, J.2
  • 69
    • 71849099881 scopus 로고    scopus 로고
    • Amyloid β and APP as biomarkers for Alzheimer's disease
    • Zetterberg H, Blennow K, Hanse E. 2010. Amyloid β and APP as biomarkers for Alzheimer's disease. Exp Gerontol 45: 23-29.
    • (2010) Exp Gerontol , vol.45 , pp. 23-29
    • Zetterberg, H.1    Blennow, K.2    Hanse, E.3
  • 70
    • 46749099351 scopus 로고    scopus 로고
    • New therapeutic targets in the neurovascular pathway in Alzheimer's disease
    • Zlokovic BV. 2008. New therapeutic targets in the neurovascular pathway in Alzheimer's disease. Neurotherapeutics 5: 409-414.
    • (2008) Neurotherapeutics , vol.5 , pp. 409-414
    • Zlokovic, B.V.1


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