-
1
-
-
0030099527
-
Transporting therapeutics across the blood-brain barrier
-
Abbott NJ, Romero IA 1996 Transporting therapeutics across the blood-brain barrier. Mol Med Today 2:106-113
-
(1996)
Mol Med Today
, vol.2
, pp. 106-113
-
-
Abbott, N.J.1
Romero, I.A.2
-
2
-
-
0030823912
-
P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain
-
Beaulieu E, Demeule M, Ghitescu L, Beliveau R 1997 P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain. Biochem J 326:539-544
-
(1997)
Biochem J
, vol.326
, pp. 539-544
-
-
Beaulieu, E.1
Demeule, M.2
Ghitescu, L.3
Beliveau, R.4
-
3
-
-
0029822580
-
Functional expression of P-glycoprotein in an immortalized cell line of rat brain endothelial cells, RBE4
-
Begley DJ, Lechardeur D, Chen ZD et al 1996 Functional expression of P-glycoprotein in an immortalized cell line of rat brain endothelial cells, RBE4. J Neurochem 67:988-995
-
(1996)
J Neurochem
, vol.67
, pp. 988-995
-
-
Begley, D.J.1
Lechardeur, D.2
Chen, Z.D.3
-
4
-
-
0003020725
-
The role of brain extracellular fluid production and efflux mechanisms in drug transport to the brain
-
Begley DJ, Bradbury MW, Kreuter J (eds) Marcel Dekker, New York
-
Begley DJ, Khan EU, Rollinson C, Abbott NJ, Regina A, Roux F 2000 The role of brain extracellular fluid production and efflux mechanisms in drug transport to the brain. In: Begley DJ, Bradbury MW, Kreuter J (eds) The blood-brain barrier and drug delivery to the CNS. Marcel Dekker, New York, p 93-108
-
(2000)
The Blood-brain Barrier and Drug Delivery to the CNS
, pp. 93-108
-
-
Begley, D.J.1
Khan, E.U.2
Rollinson, C.3
Abbott, N.J.4
Regina, A.5
Roux, F.6
-
5
-
-
0033526158
-
Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems
-
Bodor N, Buchwald P 1999 Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems. Adv Drug Deliv Rev 36:229-254
-
(1999)
Adv Drug Deliv Rev
, vol.36
, pp. 229-254
-
-
Bodor, N.1
Buchwald, P.2
-
6
-
-
0017761711
-
Acute hypertension causing blood-brain barrier breakdown during epileptic seizures
-
Bolwig TG, Hertz MM, Westergaard E 1977 Acute hypertension causing blood-brain barrier breakdown during epileptic seizures. Acta Neurol Scand 56:335-342
-
(1977)
Acta Neurol Scand
, vol.56
, pp. 335-342
-
-
Bolwig, T.G.1
Hertz, M.M.2
Westergaard, E.3
-
8
-
-
0034674901
-
A family of drug transporters: The multidrug resistance-associated proteins
-
Borst P, Evers R, Kool M, Wijnholds J 2000b A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 92:1295-1302
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 1295-1302
-
-
Borst, P.1
Evers, R.2
Kool, M.3
Wijnholds, J.4
-
9
-
-
41049113289
-
1- and adenosine receptor ligands in RBE4 cells, an in vitro model of the blood-brain barrier
-
1- and adenosine receptor ligands in RBE4 cells, an in vitro model of the blood-brain barrier. J Physiol 531:209-110P
-
(2001)
J Physiol
, vol.531
-
-
Chishty, M.1
Reichel, A.2
Abbott, N.J.3
Begley, D.J.4
-
10
-
-
0000712439
-
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
-
USA
-
Cordon-Cardo C, O'Brien JP, Casals D et al 1989 Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 86:695-698
-
(1989)
Proc Natl Acad Sci
, vol.86
, pp. 695-698
-
-
Cordon-Cardo, C.1
O'Brien, J.P.2
Casals, D.3
-
11
-
-
0033526185
-
Blood-brain barrier permeability to small and large molecules
-
Cornford EM, Hyman S 1999 Blood-brain barrier permeability to small and large molecules. Adv Drug Deliv Rev 36:145-163
-
(1999)
Adv Drug Deliv Rev
, vol.36
, pp. 145-163
-
-
Cornford, E.M.1
Hyman, S.2
-
13
-
-
0034214069
-
Functional expression of P-glycoprotein and multidrug resistance-associated protein (mrp1) in primary cultures of rat astrocytes
-
Declèves X, Regina A, Laplanche JL et al 2000a Functional expression of P-glycoprotein and multidrug resistance-associated protein (mrp1) in primary cultures of rat astrocytes. J Neurosci Res 60:594-610
-
(2000)
J Neurosci Res
, vol.60
, pp. 594-610
-
-
Declèves, X.1
Regina, A.2
Laplanche, J.L.3
-
14
-
-
0034181109
-
A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein
-
Declèves X, Chevillard S, Charpentier C, Vielh P, Laplanche JL 2000b A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein. Hum Mut 15:486
-
(2000)
Hum Mut
, vol.15
, pp. 486
-
-
Declèves, X.1
Chevillard, S.2
Charpentier, C.3
Vielh, P.4
Laplanche, J.L.5
-
16
-
-
0032956955
-
Mechanism of action of P-glycoprotein in relation to passive membrane permeation
-
Eytan GD, Kuchel PW 1999 Mechanism of action of P-glycoprotein in relation to passive membrane permeation. Int Rev Cytol 190:175-250
-
(1999)
Int Rev Cytol
, vol.190
, pp. 175-250
-
-
Eytan, G.D.1
Kuchel, P.W.2
-
17
-
-
0033932502
-
Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier
-
Gao B, Hagenbuch B, Kullak-Ublick GA, Benke D, Aguzzi A, Meier PJ 2000 Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J Pharmacol Exp Ther 294:73-79
-
(2000)
J Pharmacol Exp Ther
, vol.294
, pp. 73-79
-
-
Gao, B.1
Hagenbuch, B.2
Kullak-Ublick, G.A.3
Benke, D.4
Aguzzi, A.5
Meier, P.J.6
-
18
-
-
0033981738
-
Determinants of passive drug entry into the central nervous system
-
Habgood MD, Begley DJ, Abbott NJ 2000 Determinants of passive drug entry into the central nervous system. Cell Mol Neurobiol 20:231-253
-
(2000)
Cell Mol Neurobiol
, vol.20
, pp. 231-253
-
-
Habgood, M.D.1
Begley, D.J.2
Abbott, N.J.3
-
19
-
-
0034724324
-
Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
-
Hoffmeyer S, Burk O, von Richter O et al 2000 Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 97:3473-3478
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3473-3478
-
-
Hoffmeyer, S.1
Burk, O.2
Von Richter, O.3
-
20
-
-
0035253135
-
Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal barrier (Part 1)
-
Kusuhara H, Sugiyama Y 2001 Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal barrier (Part 1). Drug Discov Today 6:150-156
-
(2001)
Drug Discov Today
, vol.6
, pp. 150-156
-
-
Kusuhara, H.1
Sugiyama, Y.2
-
21
-
-
0016606548
-
Increased penetration of horseradish peroxidase across the blood-brain barrier induce by Metrazol seizures
-
Lorenzo AV, Hedley-Whyte ET, Eisenberg HM, Hsu DW 1975 Increased penetration of horseradish peroxidase across the blood-brain barrier induce by Metrazol seizures. Brain Res 88: 136-140
-
(1975)
Brain Res
, vol.88
, pp. 136-140
-
-
Lorenzo, A.V.1
Hedley-Whyte, E.T.2
Eisenberg, H.M.3
Hsu, D.W.4
-
22
-
-
0002883557
-
Drug metabolism in the brain: Benefits and risks
-
Begley DJ, Bradbury MW, Kreuter J (eds) Marcel Dekker, New York
-
Minn A, El-Bachá RS, Bayol-Denizot C, Lagrange P, Suleman FG, Gradinaru D 2000 Drug metabolism in the brain: benefits and risks. In: Begley DJ, Bradbury MW, Kreuter J (eds) The blood-brain barrier and drug delivery to the CNS. Marcel Dekker, New York, p 145-170
-
(2000)
The Blood-brain Barrier and Drug Delivery to the CNS
, pp. 145-170
-
-
Minn, A.1
El-Bachá, R.S.2
Bayol-Denizot, C.3
Lagrange, P.4
Suleman, F.G.5
Gradinaru, D.6
-
23
-
-
0034077338
-
Theoretical calculations and prediction of P-glycoprotein-interacting drugs using Molsurf parametrization and PLS statistics
-
Osterberg T, Norinder U 2000 Theoretical calculations and prediction of P-glycoprotein-interacting drugs using MolSurf parametrization and PLS statistics. Eur J Pharm Sci 10:295-303
-
(2000)
Eur J Pharm Sci
, vol.10
, pp. 295-303
-
-
Osterberg, T.1
Norinder, U.2
-
24
-
-
0031026780
-
Brain microvascular and astrocyte localization of P-glycoprotein
-
Pardridge WM, Golden PL, Kang YS, Bickel U 1997 Brain microvascular and astrocyte localization of P-glycoprotein. J Neurochem 68:1278-1285
-
(1997)
J Neurochem
, vol.68
, pp. 1278-1285
-
-
Pardridge, W.M.1
Golden, P.L.2
Kang, Y.S.3
Bickel, U.4
-
25
-
-
0034672607
-
Microdialysis in the study of drug transporters in the CNS
-
Sawchuk RJ, Elmquist WF 2000 Microdialysis in the study of drug transporters in the CNS. Adv Drug Deliv Rev 45:295-307
-
(2000)
Adv Drug Deliv Rev
, vol.45
, pp. 295-307
-
-
Sawchuk, R.J.1
Elmquist, W.F.2
-
26
-
-
0033739115
-
Structure-activity relationship of P-glycoprotein substrates and modifiers
-
Seelig A, Landwojtowicz E 2000 Structure-activity relationship of P-glycoprotein substrates and modifiers. Eur J Pharm Sci 12:31-40
-
(2000)
Eur J Pharm Sci
, vol.12
, pp. 31-40
-
-
Seelig, A.1
Landwojtowicz, E.2
-
27
-
-
0028229150
-
Disruption of the mouse mdr1a P-glycoprotein gene leads to deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
Schinkel AH, Smit LLM, van Tellingen O et al 1994 Disruption of the mouse mdr1a P-glycoprotein gene leads to deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
Smit, L.L.M.2
Van Tellingen, O.3
-
28
-
-
0033526176
-
P-glycoprotein, a gatekeeper in the blood-brain barrier
-
Schinkel AH 1999 P-glycoprotein, a gatekeeper in the blood-brain barrier. Adv Drug Deliv Rev 36:179-194
-
(1999)
Adv Drug Deliv Rev
, vol.36
, pp. 179-194
-
-
Schinkel, A.H.1
-
29
-
-
0031891475
-
Multidrug resistance-related transport proteins in isolated human brain microvessels and in cells cultured from these isolates
-
Seetharaman S, Barrand MA, Maskell L, Scheper RJ 1998 Multidrug resistance-related transport proteins in isolated human brain microvessels and in cells cultured from these isolates. J Neurochem 70:1151-1159
-
(1998)
J Neurochem
, vol.70
, pp. 1151-1159
-
-
Seetharaman, S.1
Barrand, M.A.2
Maskell, L.3
Scheper, R.J.4
-
30
-
-
0032693058
-
Over-expression of P-glycoprotein in malformations of cortical development
-
Sisodiya SM, Heffernan J, Squier MV 1999 Over-expression of P-glycoprotein in malformations of cortical development. Neuroreport 10:3437-3441
-
(1999)
Neuroreport
, vol.10
, pp. 3437-3441
-
-
Sisodiya, S.M.1
Heffernan, J.2
Squier, M.V.3
-
31
-
-
0035814649
-
Multidrug-resistance protein 1 in focal cortical dysplasia
-
Sisodiya SM, Kin W-R, Squier MV, Thom M 2001 Multidrug-resistance protein 1 in focal cortical dysplasia. Lancet 357:42-43
-
(2001)
Lancet
, vol.357
, pp. 42-43
-
-
Sisodiya, S.M.1
Kin, W.-R.2
Squier, M.V.3
Thom, M.4
-
32
-
-
0029900313
-
Cellular localization of P-glycoprotein in brain versus gonadal capillaries
-
Stewart PA, Béliveau R, Rogers KA 1996 Cellular localization of P-glycoprotein in brain versus gonadal capillaries. J Histochem Cytochem 44:679-685
-
(1996)
J Histochem Cytochem
, vol.44
, pp. 679-685
-
-
Stewart, P.A.1
Béliveau, R.2
Rogers, K.A.3
-
33
-
-
0025074116
-
Specialized localization of P-glycoprotein recognized by MRK16 monoclonal antibody in endothelial cells of the brain and spinal cord
-
Sugawara I, Hamada H, Tsuruo T, Mori S 1990 Specialized localization of P-glycoprotein recognized by MRK16 monoclonal antibody in endothelial cells of the brain and spinal cord. Jpn J Cancer Res 81:727-730
-
(1990)
Jpn J Cancer Res
, vol.81
, pp. 727-730
-
-
Sugawara, I.1
Hamada, H.2
Tsuruo, T.3
Mori, S.4
-
34
-
-
0026669192
-
Functional involvement of P-glycoprotein in blood-brain barrier
-
Tatsuta T, Naito M, Oh-hara T, Sugawara I, Tsuruo T 1992 Functional involvement of P-glycoprotein in blood-brain barrier. J Biol Chem 267:20383-20391
-
(1992)
J Biol Chem
, vol.267
, pp. 20383-20391
-
-
Tatsuta, T.1
Naito, M.2
Oh-Hara, T.3
Sugawara, I.4
Tsuruo, T.5
-
35
-
-
0028895740
-
MDR1 gene expression in brain of patients with medically intractable epilepsy
-
Tishler DM, Weinberg KI, Hinton DR, Barbara N, Annett GM, Raffel C 1995 MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 36:1-6
-
(1995)
Epilepsia
, vol.36
, pp. 1-6
-
-
Tishler, D.M.1
Weinberg, K.I.2
Hinton, D.R.3
Barbara, N.4
Annett, G.M.5
Raffel, C.6
-
36
-
-
0343247810
-
Blood-brain barrier function of P-glycoprotein
-
Tsuji A, Tamai I 1997 Blood-brain barrier function of P-glycoprotein. Adv Drug Deliv Rev 25:287-298
-
(1997)
Adv Drug Deliv Rev
, vol.25
, pp. 287-298
-
-
Tsuji, A.1
Tamai, I.2
-
37
-
-
0033526179
-
Carrier-mediated or specialized transport of drugs across the blood-brain barrier
-
Tsuji A, Tamai I 1999 Carrier-mediated or specialized transport of drugs across the blood-brain barrier. Adv Drug Deliv Rev 36:277-290
-
(1999)
Adv Drug Deliv Rev
, vol.36
, pp. 277-290
-
-
Tsuji, A.1
Tamai, I.2
-
39
-
-
0018123482
-
Increased permeability to horseradish peroxidase across cerebral vessels, evoked by electrically induced seizures in the rat
-
Westergaard E, Hertz MM, Bolwig TG 1978 Increased permeability to horseradish peroxidase across cerebral vessels, evoked by electrically induced seizures in the rat. Acta Neuropathol 41:73-80
-
(1978)
Acta Neuropathol
, vol.41
, pp. 73-80
-
-
Westergaard, E.1
Hertz, M.M.2
Bolwig, T.G.3
-
40
-
-
0032972644
-
Induction of P-glycoprotein expression in astrocytes following intracerebroventricular kainate injections
-
Zhang L, Ong WY, Lee T 1999 Induction of P-glycoprotein expression in astrocytes following intracerebroventricular kainate injections. Exp Brain Res 126:509-516
-
(1999)
Exp Brain Res
, vol.126
, pp. 509-516
-
-
Zhang, L.1
Ong, W.Y.2
Lee, T.3
-
41
-
-
0034623293
-
Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells
-
Zhang Y, Han H, Elmquist WF, Miller DW 2000 Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells. Brain Res 876:148-153
-
(2000)
Brain Res
, vol.876
, pp. 148-153
-
-
Zhang, Y.1
Han, H.2
Elmquist, W.F.3
Miller, D.W.4
|