Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells

Journal of Cell Science

Volumn 115, Issue 24, 2002, Pages 4969-4976

  Amasheh, Salah ^a   Meiri, Noga ^a   Gitter, Alfred H ^a   Schöneberg, Torsten ^a   Mankertz, Joachim ^a   Schulzke, Jörg D ^a   Fromm, Michael ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Claudins; Impedance analysis; Occludin; Transepithelial resistance; Zonula occludens

Indexed keywords

BROMIDE; CATION CHANNEL; CHOLINE; CLAUDIN; CLAUDIN 1; COMPLEMENTARY DNA; DEXTRAN; LACTULOSE; MANNITOL; OCCLUDIN; POTASSIUM ION; RINGER SOLUTION; SODIUM ION;

ANIMAL CELL; ARTICLE; CELL MEMBRANE CONDUCTANCE; CELL MEMBRANE PERMEABILITY; CHLORIDE CONDUCTANCE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EPITHELIUM CELL; FLUORESCENCE ANALYSIS; GENE OVEREXPRESSION; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; ION PERMEABILITY; KIDNEY CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RADIOACTIVITY; SODIUM CONDUCTANCE; TIGHT JUNCTION;

ANIMALS; BASE SEQUENCE; CATIONS; CELL LINE; DNA PRIMERS; DOGS; FLUORESCENT ANTIBODY TECHNIQUE; ION CHANNELS; MEMBRANE PROTEINS; MICE; TRANSFECTION;

ANIMALIA; PHOCIDAE;

EID: 0037115724     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00165     Document Type: Article

References (33)

1. Anderson, J. M. (2001). Molecular structure of tight junctions and their role in epithelial transport. News Physiol. Sci. 16, 126-130.
2. Balda, M. S., Whitney, J. A., Flores, C., Gonzalez, S., Cereijido, M. and Matter, K. (1996). Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J. Cell Biol. 134, 1031-1049.
3. Balda, M. S., Flores-Maldonado, C., Cereijido, M. and Matter, K. (2000). Multiple domains of occludin are involved in the regulation of paracellular permeability. J. Cell Biochem. 78, 85-96.
4. Chen, Y., Merzdorf, C., Paul, D. L. and Goodenough, D. A. (1997). COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos. J. Cell Biol. 138, 891-899.
5. Colegio, O. R., van Itallie, C. M., McCrea, H. J., Rahner, C. and Anderson, J. M. (2002). Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Am. J. Physiol. Cell Physiol. 283, C142-C147
6. Contreras, R. G., Miller, J. H., Zamora, M., Gonzalez-Mariscal, L. and Cereijido, M. (1992). Interaction of calcium with plasma membrane of epithelial (MDCK) cells during junction formation. Am. J. Physiol. 263, C313-C318.
7. Fujita, K., Katahira, J., Horiguchi, Y., Sonoda, N., Furuse, M. and Tsukita, S. (2000). Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein. FEBS Lett. 476, 258-261.
8. Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S. and Tsukita, S. (1993). Occludin: a novel integral membrane protein localizing at tight junctions. J. Cell Biol. 123, 1777-1788.
9. Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K. and Tsukita, S. (1998). Claudin-1 and claudin-2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol. 141, 1539-1550.
10. Furuse, M., Furuse, K., Sasaki, H. and Tsukita, S. (2001). Conversion of Zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J. Cell Biol. 153, 263-272.
11. Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A. and Tsukita, S. (2002). Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J. Cell Biol. 156, 1099-1111.
12. Gekle, M., Wünsch, S., Oberleithner, H. and Silbernagl, S. (1994). Characterization of two MDCK-cell subtypes as a model system to study principal cell and intercalated cell properties. Pflügers Arch. 428, 157-162.
13. Gitter, A. H., Schulzke, J. D., Sorgenfrei, D. and Fromm, M. (1997a). Ussing chamber for high-frequency transmural impedance analysis of epithelial tissues. J. Biochem. Biophys. Methods 35, 81-88.
14. Gitter, A. H., Bertog, M., Schulzke, J. D. and Fromm, M. (1997b). Measurement of paracellular epithelial conductivity by conductance scanning. Pflügers. Arch. 434, 830-840.
15. Gow, A., Southwood, C. M., Li, J. S., Pariali, M., Riordan, G. P., Brodie, S. E., Danias, J., Bronstein, J. M., Kachar, B. and Lazzarini, R. A. (1999). CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Cell 99, 649-659.
16. Gregory, M., Dufresne, J., Hermo, L. and Cyr, D. G. (2001). Claudin-1 is not restricted to tight junctions in the rat epididymis. Endocrinology 142, 854-863.
17. Inai, T., Kobayashi, J. and Shibata, Y. (1999). Claudin-1 contributes to the epithelial barrier function in MDCK cells. Eur. J. Cell Biol. 78, 849-855.
18. Kottra, G. and Frömter, E. (1984). Rapid determination of intraepithelial resistance barriers by alternating current spectroscopy. I. Experimental procedures. Pflügers Arch. 402, 409-420.
19. - secretion in epithelial monolayers of mucus forming human colon cells (HT-29/B6). Am. J. Physiol. 261, C574-C582.
20. McCarthy, K. M., Skare, I. B., Stankewich, M. C., Furuse, M., Tsukita, S., Rogers, R. A., Lynch, R. D. and Schneeberger, E. E. (1996). Occludin is a functional component of the tight junction. J. Cell. Sci. 109, 2287-2298.
21. McCarthy, K. M., Francis, S. A., McCormack, J. M., Lai, J., Rogers, R. A., Skare, I. B., Lynch, R. D. and Schneeberger, E. E. (2000). Inducible expression of claudin-1-myc but not occludin-VSV-G results in aberrant tight junction strand formation in MDCK cells. J. Cell Sci. 113, 3387-3398.
22. Rahner, C., Mitic, L. L. and Anderson, J. M. (2001). Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. Gastroenterology 120, 411-422.
23. Richardson, J. C., Scalera, V. and Simmons, N. L. (1981). Identification of two strains of MDCK cells which resemble separate nephron tubule segments. Biochim. Biophys. Acta 673, 26-36.
24. Saitou, M., Fujimoto, K., Doi, Y., Itoh, M., Fujimoto, T., Furuse, M., Takano, H., Noda, T. and Tsukita, S. (1998). Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J. Cell Biol. 141, 397-408.
25. Saitou, M., Furuse, M., Sasaki, H., Schulzke, J. D., Fromm, M., Takano, H., Noda, T. and Tsukita, S. (2000). Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol. Biol. Cell 11, 4131-4142.
26. Schultz, S. G. and Zalusky, R. (1964). Ion transport in isolated rabbit ileum. I. Short-circuit current and Na fluxes. J. Gen. Physiol. 47, 567-584.
27. 2+ resorption. Science 285, 103-106.
28. Sonoda, N., Furuse, M., Sasaki, H., Yonemura, S., Katahira, J., Horiguchi, Y. and Tsukita, S. (1999). Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. J. Cell Biol. 147, 195-204.
29. Tsukita, S. and Furuse, M. (1998). Overcoming barriers in the study of tight junction functions: from occludin to claudin. Genes Cells 3, 569-573.
30. Tsukita, S., Furuse, M. and Itoh, M. (2001). Multifunctional strands in tight junctions. Nat. Rev. Mol. Cell. Biol. 2, 285-293.
31. Van Itallie, C., Rahner, C. and Anderson, J. M. (2001). Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J. Clin. Invest. 107, 1319-1327.
32. Weiske, J., Schöneberg, T., Schröder, W., Hatzfeld, M., Tauber, R. and Huber, O. (2001). The fate of desmosomal proteins in apoptotic cells. J. Biol. Chem. 276, 41175-41181.
33. Wilcox, E. R., Burton, Q. L., Naz, S., Riazuddin, S., Smith, T. N., Ploplis, B., Belyantseva, I., Ben-Yosef, T., Liburd, N. A., Morell, R. J. et al. (2001). Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29. Cell 104, 165-172.