Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood-brain barrier

Brain Research

Volumn 1018, Issue 1, 2004, Pages 1-9

  Berezowski, Vincent ^a   Landry, Christophe ^a   Dehouck, Marie Pierre ^a   Cecchelli, Roméo ^a   Fenart, Laurence ^b  

^a UNIVERSITÉ D'ARTOIS   (France)

^b Cellial Technologies   (France)

Author keywords

BBB; BCEC; Blood brain barrier; blood brain barrier; brain capillary endothelial cell; Cellular and molecular biology; Endothelial cell; Glial cell; MRP; Multidrug resistance associated protein; P glycoprotein; P gp; Pericyte

Indexed keywords

GLYCOPROTEIN P; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 7; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CATTLE; CELL CULTURE; CELL ISOLATION; CELL POPULATION; COCULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; ENDOTHELIUM CELL; EXPERIMENTAL MODEL; GENE AMPLIFICATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLIA CELL; GRAY MATTER; NONHUMAN; NUCLEOTIDE SEQUENCE; PERICYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; BLOOD-BRAIN BARRIER; CATTLE; CELL COMMUNICATION; CELLS, CULTURED; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; HUMANS; MODELS, BIOLOGICAL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEUROGLIA; P-GLYCOPROTEIN; PERICYTES; RATS; RNA, MESSENGER; UP-REGULATION;

EID: 3242682550     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.05.092     Document Type: Article

References (39)

1. Arthur F.E., Shivers R.R., Bowman P.D. Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model. Brain Res. 433:1987;155-159
2. Balabanov R., Dore-Duffy P. Role of the CNS microvascular pericyte in the blood-brain barrier. J. Neurosci. Res. 53:1998;637-644
3. Barrand M.A., Bagrij T., Neo S.Y. Multidrug resistance-associated protein: a protein distinct from P-glycoprotein involved in cytotoxic drug expulsion. Gen. Pharmacol. 28:1997;639-645
4. Batrakova E.V., Li S., Miller D.W., Kabanov A.V. Pluronic P85 increases permeability of a broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers. Pharm. Res. 16:1999;1366-1372
5. Beaulieu E., Demeule M., Ghitescu L., Beliveau R. P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain. Biochem. J. 326:1997;301-307
6. Betz A.L., Firth J.A., Goldstein G.W. Polarity of the blood-brain barrier: distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells. Brain Res. 192:1980;17-28
7. Cecchelli R., Dehouck B., Descamps L., Fenart L., Buee-Scherrer V., Duhem C., Lundquist S., Rentfel M., Torpier G., Dehouck M.P. In vitro model for evaluating drug transport across the blood-brain barrier. Adv. Drug Deliv. Rev. 36:1999;165-178
8. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159
9. Cordon-Cardo C., O'Brien J.P., Casals D., Rittman-Grauer L., Bielder J.L., Melamed M.R., Bertino J.R. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at the blood barrier sites. Proc. Natl. Acad. Sci. U. S. A. 816:1989;695-698
10. Decleves X., Regina A., Laplanche J.L., Roux F., Boval B., Launay J.M., Scherrmann J.M. Functional expression of P-glycoprotein and multidrug resistance-associated protein (Mrp1) in primary cultures of rat astrocytes. J. Neurosci. Res. 60:2000;594-601
11. Dehouck M.P., Méresse S., Delorme P., Fruchart J.C., Cecchelli R. An easier, reproducible and mass-production method to study the blood-brain barrier "in vitro" J. Neurochem. 54:1990;1798-1801
12. Dehouck M.P., Jolliet-Riant P., Brée F., Fruchart J.C., Cecchelli R., Tillement J.P. Drug transfer across the blood-brain barrier in vitro and in vivo models. J. Neurochem. 58:1992;1790-1797
13. Dehouck B., Dehouck M.P., Fruchart J.C., Cecchelli R. Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes. J. Cell Biol. 126:1994;465-473
14. Dehouck M.P., Vigne P., Torpier G., Breittmayer J.P., Cecchelli R., Frelin C. Endothelin-1 as a mediator of endothelial cell pericyte interactions in bovine brain capillaries. J. Cereb. Blood Flow Metab. 17:1997;464-469
15. Demeule M., Labelle M., Regina A., Berthelet F., Beliveau R. Isolation of endothelial cells from brain, lung, and kidney: expression of the multidrug resistance P-glycoprotein isoforms. Biochem. Biophys. Res. Commun. 281:2001;827-834
16. Descamps L., Coisne C., Dehouck B., Cecchelli R., Torpier G. Protective effect of glial cells against lipopolysaccharide-mediated blood-brain barrier injury. Glia. 42:2003;46-58
17. Fenart L., Buee-Scherrer V., Descamps L., Duhem C., Poullain M.G., Cecchelli R., Dehouck M.P. Inhibition of P-glycoprotein: rapid assessment of its implication in the blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier. Pharm. Res. 15:1998;993-1000
18. Hayashi Y., Nomura M.S., Yamagishi S., Harada S., Yamashita J., Yamamoto H. Induction of various blood-brain barrier properties in non-neuronal endothelial cells by close apposition to co-cultured astrocytes. Glia. 19:1997;13-26
19. Hirrlinger J., Konig J., Dringen R. Expression of mRNAs of multidrug resistance proteins (MRPs) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurones. J. Neurochem. 82:2002;716-724
20. Hopper E., Belinsky M.G., Zeng H., Tosolini A., Tesat J.R., Kruh G.D. Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily. Cancer Lett. 162:2001;181-191
21. Huai-Yun H., Secrest D.T., Mark K.S., Carney D., Brandquist C., Elmquist W.F., Miller D.W. Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells. Biochem. Biophys. Res. Commun. 243:1998;816-836
22. Janzer R.C., Raff M.C. Astrocytes induce blood-brain barrier properties in endothelial cells. Nature. 325:1987;523-533
23. Jedlitschky G., Leier I., Buchholz U., Barnouin K., Kurz G., Keppler D. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res. 56:1996;988-994
24. Kool M., de Haas M., Scheffer G.L., Scheper R.J., van Eijk M.J., Juijn J.A., Baas F., Borst P. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 57:1997;3537-3547
25. Kool M., van der Linden M., de Haas M., Baas F., Borst P. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells. Cancer Res. 59:1999;175-182
26. Lee G., Schlichter L., Bendayan M., Bendayan R. Functional expression of P-glycoprotein in rat brain microglia. J. Pharmacol. Exp. Ther. 299:2001;204-412
27. Marroni M., Marchi N., Cucullo L., Abbott N.J., Signorelli K., Janigro D. Vascular and parenchymal mechanisms in multiple drug resistance: a lesson from human epilepsy. Curr. Drug Targets. 4:2003;297-304
28. Megard I., Garrigues A., Orlowski S., Jorajuria S., Clayette P., Ezan E., Mabondzo A. A co-culture-based model of human blood-brain barrier: application to active transport of indinavir and in vivo-in vitro correlation. Brain Res. 927:2002;153-167
29. Meresse S., Dehouck M.P., Delorme P., Bensaid M., Tauber J.P., Delbart C., Fruchart J.C., Cecchelli R. Bovine brain endothelial cells express tight junctions and monoamine oxidase activity in long-term culture. J. Neurochem. 53:1989;1363-1371
30. Pardridge W.M., Golden P.L., Kang Y.S., Bickel U. Brain microvascular and astrocyte localization of P-glycoprotein. J. Neurochem. 68:1997;1278-1285
31. Ramsauer M., Kunz J., Krause D., Dermietzel R. Regulation of a blood-brain barrier-specific enzyme by cerebral pericytes (pericytic aminopeptidase N/pAPN) under cell culture conditions. J. Cereb. Blood Flow Metab. 18:1998;1270-1281
32. Rash J.E., Yasumura T., Hudson C.S., Agre P., Nielsen S. Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membrane in rat brain and spinal cord. Proc. Natl. Acad. Sci. U. S. A. 95:1998;11981-11986
33. Reese T.S., Karnovsky M.J. Fine structure localization of a blood-brain barrier to exogenous peroxidase. J. Cell Biol. 34:1967;207-217
34. Rubin L.L., Barbu K., Bard F., Cannon C., Hall D.E., Horner H., Janatpour M., Liaw C., Manning K., Morales J., et al. Differentiation of brain endothelial cells in cell culture. Ann. N. Y. Acad. Sci. 633:1991;420-425
35. Savettieri G., Di Liegro I., Catania C., Licata L., Pitarresi G.L., D'Agostino S., Schiera G., De Cavo V., Giandalia G., Giannola L.I., Cestelli A. Neurons and ECM regulate occludin localization in brain endothelial cells. NeuroReport. 11:2000;1081-1084
36. Schiera G., Bono E., Raffa M.P., Gallo A., Pitarresi G.L., Di Liegro I., Savettieri G. Synergistic effects of neurons and astrocytes on the differentiation of brain capillary endothelial cells in culture. J. Cell. Mol. Med. 7:2003;165-170
37. Schinkel A.H., Smit J.J., van Tellingen O., Beijnen J.H., Wagenaar E., van Deemter L., Mol C.A., van der Valk M.A., Robanus-Maandag E.C., te Riele H.P., et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell. 77:1994;491-502
38. Schlachetzki F., Pardridge W.M. P-glycoprotein and caveolin-1alpha in endothelium and astrocytes of primate brain. NeuroReport. 14:2003;2041-2046
39. Zhang Y., Huai-Yun H., Elmquist W.F., Miller D.W. Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells. Brain Res. 876:2000;148-153