Catalytic effects of mutations of distant protein residues in human DNA polymerase β: Theory and experiment

Biochemistry

Volumn 51, Issue 44, 2012, Pages 8829-8843

  Klvaňa, Martin ^a   Murphy, Drew L ^b   Jeřábek, Petr ^a   Goodman, Myron F ^c   Warshel, Arieh ^c   Sweasy, Joann B ^b   Florián, Jan ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA SEQUENCES; KINETICS; STATISTICS; VAN DER WAALS FORCES; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHIC STUDIES; EXPERIMENTAL CONDITIONS; FREE ENERGY PERTURBATION; FREE-ENERGY CALCULATIONS; HUMAN DNA POLYMERASE; LINEAR INTERACTION ENERGIES (LIE); SURROUNDING ENVIRONMENT; TRANSITION STATE STRUCTURE;

FREE ENERGY;

DEOXYRIBONUCLEOTIDE; DEOXYRIBONUCLEOTIDE 5' TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE BETA; MUTANT PROTEIN; PHOSPHORANE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA SEQUENCE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; GENE INSERTION; HUMAN; PHASE TRANSITION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS; WILD TYPE; X RAY CRYSTALLOGRAPHY;

EID: 84868595539     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300783t     Document Type: Article

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