Y265H mutator mutant of DNA polymerase β: Proper geometric alignment is critical for fidelity

Journal of Biological Chemistry

Volumn 276, Issue 14, 2001, Pages 10824-10831

  Shah, Amit M ^a   Li, Shu Xia ^a,b   Anderson, Karen S ^a   Sweasy, Joann B ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CURAGEN CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOSYNTHESIS; DATA REDUCTION; DNA; POLYMERIZATION;

GENETIC SCREENS;

ENZYMES;

DNA DIRECTED DNA POLYMERASE BETA; MUTANT PROTEIN; NUCLEOTIDYLTRANSFERASE; UNCLASSIFIED DRUG; Y265H PROTEIN; BACTERIAL PROTEIN;

ARTICLE; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE MUTATION; GENETIC SCREENING; NUCLEOTIDE TRANSPORT; POLYMERIZATION; PRIORITY JOURNAL; CHEMISTRY; GENETICS; MUTATION; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

BACTERIAL PROTEINS; DNA POLYMERASE BETA; MUTATION; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035815755     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008680200     Document Type: Article

References (30)

1. Loeb, L. A., and Christians, F. C. (1996) Mutat. Res. 350, 279-286
2. Loeb, L. A. (1998) Adv. Cancer Res. 72, 25-56
3. Sobol, R. W., Horton, J. K., Kuhn, R., Gu, H., Singhal, R. K., Prasad, R., Rajewsky, K., and Wilson, S. H. (1996) Nature 379, 183-186
4. Plug, A. W., Clairmont, C. A., Sapi, E., Ashley, T., and Sweasy, J. B. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 1327-1331
5. Sobol, R. W., Prasad, R., Evenski, A., Baker, A., Yang, X.-P., Horton, J. K., and Wilson, S. H. (2000) Nature 405, 807-810
6. Feng, J., Crasto, C. J., and Matsumoto, Y. (1998) Biochemistry 37, 9605-9611
7. Matsumoto, Y., and Kim, K. (1995) Science 269, 699-702
8. Chagovetz, A. M., Sweasy, J. B., and Preston, B. D. (1997) J. Biol. Chem. 272, 27501-27504
9. Sawaya, M. R., Prasad, R., Wilson, S. H., Kraut, J., and Pelletier, H. (1997) Biochemistry 36, 11205-11215
10. Joyce, C. M., and Steitz, T. A. (1995) J. Bacteriol. 177, 6321-6329
11. Steitz, T. A. (1999) J. Biol. Chem. 274, 17395-17398
12. Werneburg, B. G., Ahn, J., Zhong, X., Hondal, R. J., Kraynov, V. S., and Tsai, M. D. (1996) Biochemistry 35, 7041-7050
13. Washington, S. L., Yoon, M. S., Chagovetz, A. M., Li, S., Clairmont, C. A., Preston, B. D., Eckert, K. A., and Sweasy, J. B. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 1321-1326
14. Sweasy, J. B., and Loeb, L. A. (1992) J. Biol. Chem. 267, 1407-1410
15. Sweasy, J. B., Chen, M., and Loeb, L. A. (1995) J. Bacteriol. 177, 2923-2925
16. Li, S., Vaccaro, J., and Sweasy, J. B. (1999) Biochemistry 38, 4800-4808
17. Opresko, P. L., Sweasy, J. B., and Eckert, K. A. (1998) Biochemistry 37, 2111-2119
18. Pelletier, H., Sawaya, M. R., Wolfle, W., Wilson, S. H., and Kraut, J. (1996) Biochemistry 35, 12742-12761
19. Eckert, K. A., Hile, S. E., and Vargo, P. L. (1997) Nucleic Acids Res. 25, 1450-1457
20. Kosa, J. L., and Sweasy, J. B. (1999) J. Biol. Chem. 274, 3851-3858
21. Kosa, J. L., and Sweasy, J. B. (1999) J. Biol. Chem. 274, 35866-35872
22. Kati, W. M., Johnson, K. A., Jerva, L. F., and Anderson, K. S. (1992) J. Biol. Chem. 267, 25988-25997
23. Johnson, K. A. (1993) Annu. Rev. Biochem. 62, 685-713
24. Sowers, L. C., Fazackerly, G. V., Eritja, R., Kaplan, B. E., and Goodman, M. F. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 5434-5438
25. Zhong, X., Patel, S. S., Werneburg, B. G., and Tsai, M. D. (1997) Biochemistry 36, 11891-11900
26. Zhong, X. J., Patel, S. S., and Tsai, M. D. (1998) J. Am. Chem. Soc. 120, 235-236
27. Ahn, J. W., Kraynov, V. S., Zhong, X. J., Werneburg, B. G., and Tsai, M. D. (1998) Biochem. J. 331, 79-87
28. Opresko, P. L., Shiman, R., and Eckert, K. A. (2000) Biochemistry 39, 11399-11407
29. Patel, S. S., Wong, I., and Johnson, K. A. (1991) Biochemistry 30, 511-525
30. Carson, M. (1991) J. Appl. Crystallogr. 24, 958-961