The mutator form of polymerase β with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors

Biochemistry

Volumn 37, Issue 8, 1998, Pages 2111-2119

  Opresko, Patricia L ^a   Sweasy, Joann B ^b   Eckert, Kristin A ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA DIRECTED DNA POLYMERASE BETA; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; DNA REPAIR; DNA SYNTHESIS; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; FRAMESHIFT MUTATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BASE SEQUENCE; BINDING SITES; DNA; DNA POLYMERASE BETA; DNA REPAIR; FRAMESHIFT MUTATION; LAC OPERON; MOLECULAR SEQUENCE DATA; PHENOTYPE; POINT MUTATION; RATS; SIMPLEXVIRUS; THYMIDINE KINASE; TYROSINE;

ANIMALIA;

EID: 0032562169     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9722711     Document Type: Article

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