Exploring the role of large conformational changes in the fidelity of DNA polymerase β

Proteins: Structure, Function and Genetics

Volumn 70, Issue 1, 2008, Pages 231-247

  Xiang, Yun ^a   Goodman, Myron F ^a   Beard, William A ^b   Wilson, Samuel H ^b   Warshel, Arieh ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Conformational change; Enzyme catalysis; Free energy landscape; Induced fit; Replication fidelity

Indexed keywords

DNA DIRECTED DNA POLYMERASE BETA;

ARTICLE; CALCULATION; CATALYSIS; CONFORMATIONAL TRANSITION; ENERGY; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; MOTION; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SIMULATION; STRUCTURE ANALYSIS;

CATALYSIS; DNA POLYMERASE BETA; PROTEIN CONFORMATION; QUANTUM THEORY;

EID: 37349079468     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21668     Document Type: Article

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