Computer simulation studies of the fidelity of DNA polymerases

Biopolymers

Volumn 68, Issue 3, 2003, Pages 286-299

  Florián, Jan ^a   Goodman, Myron F ^a   Warshel, Arieh ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Computer simulations; DNA polymerases; Empirical valence bond; Free energy perturbation; Linear response approximation; Mismatched base pairs; Replication fidelity

Indexed keywords

APPROXIMATION THEORY; BINDING ENERGY; COMPUTER SIMULATION; FREE ENERGY; MOLECULAR STRUCTURE; PERTURBATION TECHNIQUES;

LINEAR RESPONSE APPROXIMATION (LRA);

ENZYMES;

DNA DIRECTED DNA POLYMERASE BETA; DNA POLYMERASE; DOUBLE STRANDED DNA;

AQUEOUS SOLUTION; BASE PAIRING; COMPUTER SIMULATION; CONFERENCE PAPER; ENERGY TRANSFER; ENZYME ANALYSIS; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; MISMATCH REPAIR; POLYMERIZATION; QUANTITATIVE ANALYSIS; TECHNIQUE;

COMPUTER SIMULATION; DNA POLYMERASE BETA; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0037343349     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.10244     Document Type: Conference Paper

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