The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator

Biochemistry

Volumn 51, Issue 26, 2012, Pages 5269-5275

  Murphy, Drew L ^a   Donigan, Katherine A ^a   Jaeger, Joachim ^b   Sweasy, Joann B ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASE EXCISION REPAIRS; BASE PAIRS; CODING REGION; DNA LESIONS; DNA POLYMERASE; GENOMIC INSTABILITY; IN-VITRO; KINETIC DATA; MALIGNANT TUMORS; NUCLEOTIDE BINDING; OPEN CONFORMATION; WILD TYPES; WILD-TYPE ENZYMES;

DNA; GENES; NUCLEOTIDES; TUMORS;

POLYMERS;

DNA DIRECTED DNA POLYMERASE BETA; GLUTAMIC ACID; LYSINE; PROTEIN E288K; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; COLON TUMOR; CONFORMATION; GENE MUTATION; GENETIC VARIABILITY; NUCLEOTIDE BINDING SITE; PHENOTYPE; PRIORITY JOURNAL;

CELL LINE; CIRCULAR DICHROISM; COLONIC NEOPLASMS; DNA POLYMERASE BETA; GENOMIC INSTABILITY; HUMANS; MUTAGENESIS; MUTATION;

EID: 84863533866     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi3003583     Document Type: Article

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