Mismatch-induced conformational distortions in polymerase β support an induced-fit mechanism for fidelity

Biochemistry

Volumn 44, Issue 40, 2005, Pages 13328-13341

  Arora, Karunesh ^a   Beard, William A ^b   Wilson, Samuel H ^b   Schlick, Tamar ^a  

^a NEW YORK UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CATALYSTS; COMPUTER SIMULATION; DNA; MAGNESIUM PRINTING PLATES; MOLECULAR DYNAMICS;

DELINEATE STRUCTURE-FUNCTIONS; MISMTCH-INDUCED CONFORMATIONAL DISTORTION; TEMPLATE-PRIMER TERMINUS;

ENZYMES;

DNA DIRECTED DNA POLYMERASE BETA; GUANINE; NUCLEOTIDE; NUCLEOTIDYLTRANSFERASE; PRIMER DNA; THYMINE;

ARTICLE; BASE MISPAIRING; BASE PAIRING; CHEMICAL REACTION; DNA BINDING; DNA TEMPLATE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SIMULATION; STRUCTURE ACTIVITY RELATION;

BASE PAIR MISMATCH; BASE PAIRING; BINDING SITES; CARBON; CATALYSIS; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; DNA; DNA POLYMERASE BETA; DNA PRIMERS; DNA-DIRECTED DNA POLYMERASE; HUMANS; IONS; KINETICS; LIGANDS; MAGNESIUM; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEIC ACID CONFORMATION; NUCLEOTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 26444470895     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0507682     Document Type: Article

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