Variants of DNA polymerase β extend mispaired DNA due to increased affinity for nucleotide substrate

Biochemistry

Volumn 42, Issue 36, 2003, Pages 10709-10717

  Shah, Amit M ^a,b   Maitra, Mausumi ^a   Sweasy, Joann B ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; POLYMERS; SUBSTRATES;

NUCLEOTIDE SUBSTRATES;

DNA;

DNA; DNA DIRECTED DNA POLYMERASE BETA;

ARTICLE; BINDING AFFINITY; DISSOCIATION CONSTANT; DNA SYNTHESIS; ENZYME ACTIVE SITE; GEL MOBILITY SHIFT ASSAY; MUTAGENESIS; NUCLEIC ACID BASE SUBSTITUTION; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DNA BINDING;

AMINO ACID SUBSTITUTION; ANIMALS; BASE PAIR MISMATCH; BASE SEQUENCE; DEOXYRIBONUCLEOTIDES; DNA; DNA POLYMERASE BETA; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; KINETICS; RATS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TEMPLATES, GENETIC;

EID: 0041817954     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034885d     Document Type: Article

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