An abridged transition state model to derive structure, dynamics, and energy components of DNA polymerase β fidelity

Biochemistry

Volumn 50, Issue 32, 2011, Pages 7023-7032

  Klvaňa, Martin ^a   Jeřábek, Petr ^a,c   Goodman, Myron F ^b   Florián, Jan ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BASE PAIRS; BOND FORMATION; CLASSICAL MOLECULAR DYNAMICS; DNA POLYMERASE; DNA STRANDS; ELECTROSTATIC CONTRIBUTIONS; ENERGY COMPONENTS; H-BONDS; HUMAN DNA POLYMERASE; LINEAR FREE ENERGY; NUCLEOPHILIC ATTACK; P-O BONDS; PHOSPHORANES; REACTION FREE ENERGY; REACTION SURFACES; SHORT DISTANCES; STRUCTURAL WATER; SUBDOMAIN; TRANSITION STATE; TWO-POINT; WATER MOLECULE;

BOND STRENGTH (CHEMICAL); DYNAMICS; ELECTROSTATICS; FREE ENERGY; MOLECULAR DYNAMICS; POLYMERS; REACTION KINETICS; SURFACE REACTIONS;

DNA;

ARGININE; DEOXYCYTIDINE TRIPHOSPHATE; DNA; DNA DIRECTED DNA POLYMERASE BETA; NUCLEOPHILE; OXYGEN;

ARTICLE; BASE PAIRING; CALCULATION; CATALYSIS; CHEMICAL BOND; CONTROLLED STUDY; ENZYME STRUCTURE; GEOMETRY; HUMAN; HYDROGEN BOND; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SIMULATION; STATIC ELECTRICITY;

BASE PAIRING; DNA; DNA POLYMERASE BETA; HUMANS; MODELS, MOLECULAR; WATER;

EID: 80051481658     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200790s     Document Type: Article

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