Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase β

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 15, 2008, Pages 5670-5674

  Lin, Ping ^a   Batra, Vinod K ^b   Pedersen, Lars C ^b   Beard, William A ^b   Wilson, Samuel H ^b   Pedersen, Lee G ^a,b  

^a University of North Carolina at Chapel Hill   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Combined quantum mechanics and molecular mechanics; Incorrect nucleotide incorporation; Nucleotidyl transfer; Two stage mechanism

Indexed keywords

DNA DIRECTED DNA POLYMERASE BETA; NUCLEOTIDE; NUCLEOTIDYLTRANSFERASE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DNA SYNTHESIS; ELECTRICITY; HUMAN; MOLECULAR DYNAMICS; PRIORITY JOURNAL; QUANTUM MECHANICS; X RAY CRYSTALLOGRAPHY;

ADENINE; BASE PAIR MISMATCH; BINDING SITES; CATALYSIS; COMPUTER SIMULATION; DNA POLYMERASE BETA; ELECTROSTATICS; GUANINE; HUMANS; MODELS, MOLECULAR; MODELS, THEORETICAL; MOTION; THERMODYNAMICS;

EID: 44449088925     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801257105     Document Type: Article

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