Regulation of DNA repair fidelity by molecular checkpoints: "Gates" in DNA polymerase β's substrate selection

Biochemistry

Volumn 45, Issue 51, 2006, Pages 15142-15156

  Radhakrishnan, Ravi ^a,c   Arora, Karunesh ^a,d   Wang, Yanli ^a   Beard, William A ^b   Wilson, Samuel H ^b   Schlick, Tamar ^a  

^a NEW YORK UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTATIONAL METHODS; CONFORMATIONS; ENZYME KINETICS; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; RANDOM PROCESSES;

ATOMIC MOTIONS; FIDELITY MECHANISMS; MOLECULAR CHECKPOINTS; POLYMERASES;

DNA;

DNA DIRECTED DNA POLYMERASE BETA; NUCLEOTIDE; WATER;

CONFORMATIONAL TRANSITION; DNA REPAIR; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON TRANSPORT; REGULATORY MECHANISM; REVIEW; STOCHASTIC MODEL; X RAY CRYSTALLOGRAPHY;

DNA POLYMERASE BETA; DNA REPAIR; HUMANS; MODELS, MOLECULAR; NUCLEOTIDES; SUBSTRATE SPECIFICITY;

EID: 33751206730     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061353z     Document Type: Review

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