Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

Genes and Development

Volumn 26, Issue 20, 2012, Pages 2311-2324

  Osorio, Fernando G ^a   Bárcena, Clea ^a   Soria Valles, Clara ^a   Ramsay, Andrew J ^a   de Carlos, Félix ^b   Cobo, Juan ^b   Fueyo, Antonio ^a   Freije, José M P ^a   López Otín, Carlos ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b UNIVERSITY OF OVIEDO   (Spain)

Author keywords

Longevity; Nuclear envelope; Progeroid laminopathies

Indexed keywords

ATM PROTEIN; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LAMIN; PRELAMIN A; UNCLASSIFIED DRUG;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; LAMINOPATHY; LONGEVITY; MOUSE; NONHUMAN; NORMAL HUMAN; NUCLEAR LAMINA; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

AGING; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL AGING; CELL CYCLE PROTEINS; CELL LINE; CELLS, CULTURED; DNA-BINDING PROTEINS; HUMANS; INFLAMMATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LONGEVITY; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MICE; NF-KAPPA B; NUCLEAR LAMINA; NUCLEAR PROTEINS; PROTEIN PRECURSORS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SODIUM SALICYLATE; TRANSCRIPTION FACTOR RELA; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEINS;

EID: 84867736667     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.197954.112     Document Type: Article

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