-
1
-
-
57449096122
-
A prescription for human immunology
-
Davis, M.M. 2008. A prescription for human immunology. Immunity 29 : 835-838.
-
(2008)
Immunity
, vol.29
, pp. 835-838
-
-
Davis, M.M.1
-
3
-
-
79955750055
-
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum
-
Bendall, S.C. et al 2011. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science 332 : 687-696.
-
(2011)
Science
, vol.332
, pp. 687-696
-
-
Bendall, S.C.1
-
4
-
-
80051989398
-
Systems biology of vaccination for seasonal influenza in humans
-
Nakaya, H.I. et al 2011. Systems biology of vaccination for seasonal influenza in humans. Nat. Immunol. 12 : 786-795.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 786-795
-
-
Nakaya, H.I.1
-
5
-
-
58049095495
-
Thymectomy in early childhood: significant alterations of the CD4(+)CD45RA(+)CD62L(+) T cell compartment in later life
-
Prelog, M. et al 2009. Thymectomy in early childhood: significant alterations of the CD4(+)CD45RA(+)CD62L(+) T cell compartment in later life. Clin. Immunol. 130 : 123-132.
-
(2009)
Clin. Immunol.
, vol.130
, pp. 123-132
-
-
Prelog, M.1
-
6
-
-
70349664158
-
Evidence of premature immune aging in patients thymectomized during early childhood
-
Sauce, D. et al 2009. Evidence of premature immune aging in patients thymectomized during early childhood. J. Clin. Invest. 119 : 3070-3078.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3070-3078
-
-
Sauce, D.1
-
8
-
-
0033581935
-
Selecting and maintaining a diverse T-cell repertoire
-
Goldrath, A.W. & M.J. Bevan 1999. Selecting and maintaining a diverse T-cell repertoire. Nature 402 : 255-262.
-
(1999)
Nature
, vol.402
, pp. 255-262
-
-
Goldrath, A.W.1
Bevan, M.J.2
-
9
-
-
0029895686
-
Thymic involution with ageing: obsolescence or good housekeeping?
-
George, A.J. & M.A. Ritter 1996. Thymic involution with ageing: obsolescence or good housekeeping? Immunol. Today 17 : 267-272.
-
(1996)
Immunol. Today
, vol.17
, pp. 267-272
-
-
George, A.J.1
Ritter, M.A.2
-
11
-
-
20344396835
-
Human immunosenescence: is it infectious?
-
Pawelec, G. et al 2005. Human immunosenescence: is it infectious? Immunol. Rev. 205 : 257-268.
-
(2005)
Immunol. Rev.
, vol.205
, pp. 257-268
-
-
Pawelec, G.1
-
12
-
-
23944490475
-
Memory T cell homeostasis and senescence during aging
-
Akbar, A.N. & J.M. Fletcher 2005. Memory T cell homeostasis and senescence during aging. Curr. Opin. Immunol. 17 : 480-485.
-
(2005)
Curr. Opin. Immunol
, vol.17
, pp. 480-485
-
-
Akbar, A.N.1
Fletcher, J.M.2
-
13
-
-
77951258833
-
Features of responding T cells in cancer and chronic infection
-
Kim, P.S. & R. Ahmed 2010. Features of responding T cells in cancer and chronic infection. Curr. Opin. Immunol. 22 : 223-230.
-
(2010)
Curr. Opin. Immunol.
, vol.22
, pp. 223-230
-
-
Kim, P.S.1
Ahmed, R.2
-
14
-
-
19644385539
-
Aging, immunity, and the varicella-zoster virus
-
Arvin, A. 2005. Aging, immunity, and the varicella-zoster virus. N. Engl. J. Med. 352 : 2266-2267.
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 2266-2267
-
-
Arvin, A.1
-
15
-
-
79551614790
-
HIV infection, inflammation, immunosenescence, and aging
-
Deeks, S.G. 2011. HIV infection, inflammation, immunosenescence, and aging. Annu. Rev. Med. 62 : 141-155.
-
(2011)
Annu. Rev. Med.
, vol.62
, pp. 141-155
-
-
Deeks, S.G.1
-
17
-
-
4444320377
-
Stem cell aging and autoimmunity in rheumatoid arthritis
-
Weyand, C.M. & J.J. Goronzy 2004. Stem cell aging and autoimmunity in rheumatoid arthritis. Trends Mol. Med. 10 : 426-433.
-
(2004)
Trends Mol. Med
, vol.10
, pp. 426-433
-
-
Weyand, C.M.1
Goronzy, J.J.2
-
18
-
-
2342527293
-
Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity-catalysts of autoimmunity and chronic inflammation
-
Goronzy, J.J. & C.M. Weyand 2003. Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity-catalysts of autoimmunity and chronic inflammation. Arthritis Res. Ther. 5 : 225-234.
-
(2003)
Arthritis Res. Ther.
, vol.5
, pp. 225-234
-
-
Goronzy, J.J.1
Weyand, C.M.2
-
19
-
-
0022585737
-
Changes in the human thymus during aging
-
Steinmann, G.G. 1986. Changes in the human thymus during aging. Curr. Top. Pathol. 75 : 43-88.
-
(1986)
Curr. Top. Pathol.
, vol.75
, pp. 43-88
-
-
Steinmann, G.G.1
-
20
-
-
42649138855
-
Thymus organogenesis
-
Rodewald, H.R. 2008. Thymus organogenesis. Annu. Rev. Immunol. 26 : 355-388.
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 355-388
-
-
Rodewald, H.R.1
-
21
-
-
67649396090
-
Thymic involution and immune reconstitution
-
Lynch, H.E. et al 2009. Thymic involution and immune reconstitution. Trends Immunol. 30 : 366-373.
-
(2009)
Trends Immunol
, vol.30
, pp. 366-373
-
-
Lynch, H.E.1
-
22
-
-
0034124915
-
The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection
-
Haynes, B.F. et al 2000. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu. Rev. Immunol. 18 : 529-560.
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 529-560
-
-
Haynes, B.F.1
-
23
-
-
77955661045
-
Thymic fatness and approaches to enhance thymopoietic fitness in aging
-
Dixit, V.D. 2010. Thymic fatness and approaches to enhance thymopoietic fitness in aging. Curr. Opin. Immunol. 22 : 521-528.
-
(2010)
Curr. Opin. Immunol.
, vol.22
, pp. 521-528
-
-
Dixit, V.D.1
-
24
-
-
17444433046
-
Homeostatic control of T-cell generation in neonates
-
Schonland, S.O. et al 2003. Homeostatic control of T-cell generation in neonates. Blood 102 : 1428-1434.
-
(2003)
Blood
, vol.102
, pp. 1428-1434
-
-
Schonland, S.O.1
-
25
-
-
69049098827
-
Modelling naive T-cell homeostasis: consequences of heritable cellular lifespan during ageing
-
Dowling, M.R. & P.D. Hodgkin 2009. Modelling naive T-cell homeostasis: consequences of heritable cellular lifespan during ageing. Immunol. Cell. Biol. 87 : 445-456.
-
(2009)
Immunol. Cell. Biol.
, vol.87
, pp. 445-456
-
-
Dowling, M.R.1
Hodgkin, P.D.2
-
26
-
-
67650901972
-
The dynamics of T-cell receptor repertoire diversity following thymus transplantation for DiGeorge anomaly
-
Ciupe, S.M. et al 2009. The dynamics of T-cell receptor repertoire diversity following thymus transplantation for DiGeorge anomaly. PLoS Comput. Biol. 5 : e1000396.
-
(2009)
PLoS Comput. Biol.
, vol.5
-
-
Ciupe, S.M.1
-
27
-
-
0033615678
-
A direct estimate of the human alphabeta T cell receptor diversity
-
Arstila, T.P. et al 1999. A direct estimate of the human alphabeta T cell receptor diversity. Science 286 : 958-961.
-
(1999)
Science
, vol.286
, pp. 958-961
-
-
Arstila, T.P.1
-
28
-
-
0034084062
-
Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes
-
Casrouge, A. et al 2000. Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes. J. Immunol. 164 : 5782-5787.
-
(2000)
J. Immunol.
, vol.164
, pp. 5782-5787
-
-
Casrouge, A.1
-
29
-
-
41149170727
-
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
-
Yager, E.J. et al. 2008. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J. Exp. Med. 205 : 711-723.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 711-723
-
-
Yager, E.J.1
-
30
-
-
34548038390
-
Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and responsivle magnitude
-
Moon, J.J. et al. 2007. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and responsivle magnitude. Immunity 27 : 203-213.
-
(2007)
Immunity
, vol.27
, pp. 203-213
-
-
Moon, J.J.1
-
31
-
-
23944441502
-
T cell development and receptor diversity during aging
-
Goronzy, J.J. & C.M. Weyand 2005. T cell development and receptor diversity during aging. Curr. Opin. Immunol. 17 : 468-475.
-
(2005)
Curr. Opin. Immunol
, vol.17
, pp. 468-475
-
-
Goronzy, J.J.1
Weyand, C.M.2
-
32
-
-
21044451726
-
The influence of age on T cell generation and TCR diversity
-
Naylor, K. et al 2005. The influence of age on T cell generation and TCR diversity. J. Immunol. 174 : 7446-7452.
-
(2005)
J. Immunol.
, vol.174
, pp. 7446-7452
-
-
Naylor, K.1
-
33
-
-
77950541195
-
Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells
-
Robins, H.S. et al 2009. Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells. Blood 114 : 4099-4107.
-
(2009)
Blood
, vol.114
, pp. 4099-4107
-
-
Robins, H.S.1
-
34
-
-
33744927395
-
Estrogen induces thymic atrophy by eliminating early thymic progenitors and inhibiting proliferation of beta-selected thymocytes
-
Zoller, A.L. & G.J. Kersh 2006. Estrogen induces thymic atrophy by eliminating early thymic progenitors and inhibiting proliferation of beta-selected thymocytes. J. Immunol. 176 : 7371-7378.
-
(2006)
J. Immunol
, vol.176
, pp. 7371-7378
-
-
Zoller, A.L.1
Kersh, G.J.2
-
35
-
-
79959567594
-
Structure and function of the thymic microenvironment
-
Manley, N.R. et al 2011. Structure and function of the thymic microenvironment. Front. Biosci. 17 : 2461-2477.
-
(2011)
Front. Biosci.
, vol.17
, pp. 2461-2477
-
-
Manley, N.R.1
-
36
-
-
2942700206
-
Reduction in the developmental potential of intrathymic T cell progenitors with age
-
Min, H., E. Montecino-Rodriguez & K. Dorshkind 2004. Reduction in the developmental potential of intrathymic T cell progenitors with age. J. Immunol. 173: 245-250.
-
(2004)
J. Immunol.
, vol.173
, pp. 245-250
-
-
Min, H.1
Montecino-Rodriguez, E.2
Dorshkind, K.3
-
37
-
-
77950418688
-
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
-
Beerman, I. et al 2010. Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc. Natl. Acad. Sci. USA 107 : 5465-5470.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 5465-5470
-
-
Beerman, I.1
-
38
-
-
77949904634
-
Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice
-
Song, Z. et al 2010. Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice. Blood 115 : 1481-1489.
-
(2010)
Blood
, vol.115
, pp. 1481-1489
-
-
Song, Z.1
-
39
-
-
70349231092
-
Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution
-
Yang, H., Y.H. Youm & V.D. Dixit 2009. Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution. J. Immunol. 183 : 3040-3052.
-
(2009)
J. Immunol
, vol.183
, pp. 3040-3052
-
-
Yang, H.1
Youm, Y.H.2
Dixit, V.D.3
-
40
-
-
77955652947
-
Thiazolidinedione treatment and constitutive-PPARgamma activation induces ectopic adipogenesis and promotes age-related thymic involution
-
Youm, Y.H. et al 2010. Thiazolidinedione treatment and constitutive-PPARgamma activation induces ectopic adipogenesis and promotes age-related thymic involution. Aging Cell. 9 : 478-489.
-
(2010)
Aging Cell
, vol.9
, pp. 478-489
-
-
Youm, Y.H.1
-
41
-
-
68149148869
-
Biomarkers of human immunosenescence: impact of Cytomegalovirus infection
-
Derhovanessian, E., A. Larbi & G. Pawelec 2009. Biomarkers of human immunosenescence: impact of Cytomegalovirus infection. Curr. Opin. Immunol. 21 : 440-445.
-
(2009)
Curr. Opin. Immunol.
, vol.21
, pp. 440-445
-
-
Derhovanessian, E.1
Larbi, A.2
Pawelec, G.3
-
42
-
-
0037446775
-
Frequencies of circulating cytolytic, CD45RA+CD27-, CD8+ T lymphocytes depend on infection with CMV
-
Kuijpers, T.W. et al 2003. Frequencies of circulating cytolytic, CD45RA+CD27-, CD8+ T lymphocytes depend on infection with CMV. J. Immunol. 170 : 4342-4348.
-
(2003)
J. Immunol.
, vol.170
, pp. 4342-4348
-
-
Kuijpers, T.W.1
-
43
-
-
40849145398
-
T cell subset-specific susceptibility to aging
-
Czesnikiewicz-Guzik, M. et al 2008. T cell subset-specific susceptibility to aging. Clin. Immunol. 127 : 107-118.
-
(2008)
Clin. Immunol.
, vol.127
, pp. 107-118
-
-
Czesnikiewicz-Guzik, M.1
-
44
-
-
0032957642
-
Role of cytomegalovirus in the T cell changes seen in elderly individuals
-
Looney, R.J. et al 1999. Role of cytomegalovirus in the T cell changes seen in elderly individuals. Clin. Immunol. 90 : 213-219.
-
(1999)
Clin. Immunol.
, vol.90
, pp. 213-219
-
-
Looney, R.J.1
-
45
-
-
77955655332
-
Immune memory and aging: an infinite or finite resource?
-
Nikolich-Zugich, J. & B.D. Rudd 2010. Immune memory and aging: an infinite or finite resource? Curr. Opin. Immunol. 22 : 535-540.
-
(2010)
Curr. Opin. Immunol
, vol.22
, pp. 535-540
-
-
Nikolich-Zugich, J.1
Rudd, B.D.2
-
46
-
-
73349101903
-
Key role of T cell defects in age-related vulnerability to West Nile virus
-
Brien, J.D. et al 2009. Key role of T cell defects in age-related vulnerability to West Nile virus. J. Exp. Med. 206 : 2735-2745.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2735-2745
-
-
Brien, J.D.1
-
47
-
-
0035202615
-
Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals
-
Goronzy, J.J. et al 2001. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J. Virol. 75 : 12182-12187.
-
(2001)
J. Virol.
, vol.75
, pp. 12182-12187
-
-
Goronzy, J.J.1
-
48
-
-
0036604275
-
Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines
-
Saurwein-Teissl, M. et al 2002. Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J. Immunol. 168 : 5893-5899.
-
(2002)
J. Immunol.
, vol.168
, pp. 5893-5899
-
-
Saurwein-Teissl, M.1
-
49
-
-
0032524932
-
Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study
-
Wikby, A. et al 1998. Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech. Ageing Dev. 102 : 187-198.
-
(1998)
Mech. Ageing Dev.
, vol.102
, pp. 187-198
-
-
Wikby, A.1
-
50
-
-
0037103256
-
Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals
-
Khan, N. et al 2002. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J. Immunol. 169 : 1984-1992.
-
(2002)
J. Immunol.
, vol.169
, pp. 1984-1992
-
-
Khan, N.1
-
51
-
-
59249090000
-
Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals
-
Chidrawar, S. et al 2009. Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals. Clin. Exp. Immunol. 155 : 423-432.
-
(2009)
Clin. Exp. Immunol.
, vol.155
, pp. 423-432
-
-
Chidrawar, S.1
-
52
-
-
33745113482
-
Human virus-specific CD8+ T cells: diversity specialists
-
van Leeuwen, E.M. et al 2006. Human virus-specific CD8+ T cells: diversity specialists. Immunol. Rev. 211 : 225-235.
-
(2006)
Immunol. Rev.
, vol.211
, pp. 225-235
-
-
van Leeuwen, E.M.1
-
53
-
-
54049137681
-
Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow
-
Palendira, U. et al 2008. Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow. Blood 112 : 3293-3302.
-
(2008)
Blood
, vol.112
, pp. 3293-3302
-
-
Palendira, U.1
-
54
-
-
24344489044
-
Broadly targeted human cytomegalovirus-specific CD4 +and CD8+ T cells dominate the memory compartments of exposed subjects
-
Sylwester, A.W. et al 2005. Broadly targeted human cytomegalovirus-specific CD4 +and CD8+ T cells dominate the memory compartments of exposed subjects. J. Exp. Med. 202 : 673-685.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 673-685
-
-
Sylwester, A.W.1
-
55
-
-
29144435156
-
Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion
-
Fletcher, J.M. et al 2005. Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion. J. Immunol. 175 : 8218-8225.
-
(2005)
J. Immunol.
, vol.175
, pp. 8218-8225
-
-
Fletcher, J.M.1
-
56
-
-
78049414864
-
Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation
-
Hertoghs, K.M. et al 2010. Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation. J. Clin. Invest. 120 : 4077-4090.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 4077-4090
-
-
Hertoghs, K.M.1
-
57
-
-
77957723967
-
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients
-
Fourcade, J. et al 2010. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J. Exp. Med. 207 : 2175-2186.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2175-2186
-
-
Fourcade, J.1
-
58
-
-
77957744369
-
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
-
Sakuishi, K. et al 2010. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J. Exp. Med. 207 : 2187-2194.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2187-2194
-
-
Sakuishi, K.1
-
59
-
-
66649114758
-
High antigen levels are the cause of T cell exhaustion during chronic viral infection
-
Mueller, S.N. & R. Ahmed 2009. High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc. Natl. Acad. Sci. USA 106 : 8623-8628.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 8623-8628
-
-
Mueller, S.N.1
Ahmed, R.2
-
60
-
-
35349014587
-
Molecular signature of CD8+ T cell exhaustion during chronic viral infection
-
Wherry, E.J. et al 2007. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 27 : 670-684.
-
(2007)
Immunity
, vol.27
, pp. 670-684
-
-
Wherry, E.J.1
-
61
-
-
77957059176
-
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
-
Jin, H.T. et al 2010. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc. Natl. Acad. Sci. USA 107 : 14733-14738.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 14733-14738
-
-
Jin, H.T.1
-
62
-
-
67649407892
-
CD28(-) T cells: their role in the age-associated decline of immune function
-
Weng, N.P., A.N. Akbar & J. Goronzy 2009. CD28(-) T cells: their role in the age-associated decline of immune function. Trends Immunol. 30 : 306-312.
-
(2009)
Trends Immunol.
, vol.30
, pp. 306-312
-
-
Weng, N.P.1
Akbar, A.N.2
Goronzy, J.3
-
63
-
-
79953159005
-
Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
-
Akbar, A.N. & S.M. Henson 2011. Are senescence and exhaustion intertwined or unrelated processes that compromise immunity? Nat. Rev. Immunol. 11 : 289-295.
-
(2011)
Nat. Rev. Immunol
, vol.11
, pp. 289-295
-
-
Akbar, A.N.1
Henson, S.M.2
-
64
-
-
0242552003
-
Decline in varicella-zoster virus (VZV)-specific cell-mediated immunity with increasing age and boosting with a high-dose VZV vaccine
-
Levin, M.J. et al 2003. Decline in varicella-zoster virus (VZV)-specific cell-mediated immunity with increasing age and boosting with a high-dose VZV vaccine. J. Infect. Dis. 188 : 1336-1344.
-
(2003)
J. Infect. Dis.
, vol.188
, pp. 1336-1344
-
-
Levin, M.J.1
-
65
-
-
10344257508
-
Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection
-
Khan, N. et al 2004. Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection. J. Immunol. 173 : 7481-7489.
-
(2004)
J. Immunol.
, vol.173
, pp. 7481-7489
-
-
Khan, N.1
-
66
-
-
77952561045
-
Advances in the understanding of the pathogenesis and epidemiology of herpes zoster
-
Gershon, A.A. et al 2010. Advances in the understanding of the pathogenesis and epidemiology of herpes zoster. J. Clin. Virol. 48(Suppl 1): S2-S7.
-
(2010)
J. Clin. Virol.
, vol.48
, Issue.SUPPL. 1
-
-
Gershon, A.A.1
-
67
-
-
77649097739
-
Two kinetic patterns of epitope-specific CD8 T-cell responses following murine gammaherpesvirus 68 infection
-
Freeman, M.L. et al 2010. Two kinetic patterns of epitope-specific CD8 T-cell responses following murine gammaherpesvirus 68 infection. J. Virol. 84 : 2881-2892.
-
(2010)
J. Virol.
, vol.84
, pp. 2881-2892
-
-
Freeman, M.L.1
-
68
-
-
77951243991
-
Differential impact of ageing on cellular and humoral immunity to a persistent murine gamma-herpesvirus
-
Yager, E.J. et al 2010. Differential impact of ageing on cellular and humoral immunity to a persistent murine gamma-herpesvirus. Immun. Ageing 7 : 3.
-
(2010)
Immun. Ageing
, vol.7
, pp. 3
-
-
Yager, E.J.1
-
69
-
-
33750128821
-
Seroprevalence of cytomegalovirus infection in the United States, 1988-1994
-
Staras, S.A. et al 2006. Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. Clin. Infect. Dis. 43 : 1143-1151.
-
(2006)
Clin. Infect. Dis.
, vol.43
, pp. 1143-1151
-
-
Staras, S.A.1
-
70
-
-
78349299096
-
Seroprevalence of cytomegalovirus (CMV) and risk factors for infection in adolescent males
-
Stadler, L.P. et al 2010. Seroprevalence of cytomegalovirus (CMV) and risk factors for infection in adolescent males. Clin. Infect. Dis. 51 : e76-e81.
-
(2010)
Clin. Infect. Dis.
, vol.51
-
-
Stadler, L.P.1
-
71
-
-
79951821255
-
Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire
-
Rudd, B.D. et al 2011. Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire. J. Immunol. 186 : 2056-2064.
-
(2011)
J. Immunol.
, vol.186
, pp. 2056-2064
-
-
Rudd, B.D.1
-
72
-
-
78049489351
-
Hallmark features of immunosenescence are absent in familial longevity
-
Derhovanessian, E. et al 2010. Hallmark features of immunosenescence are absent in familial longevity. J. Immunol. 185 : 4618-4624.
-
(2010)
J. Immunol.
, vol.185
, pp. 4618-4624
-
-
Derhovanessian, E.1
-
73
-
-
77958167920
-
The number of cytomegalovirus-specific CD4+ T cells is markedly expanded in patients with B-cell chronic lymphocytic leukemia and determines the total CD4+ T-cell repertoire
-
Pourgheysari, B. et al 2010. The number of cytomegalovirus-specific CD4+ T cells is markedly expanded in patients with B-cell chronic lymphocytic leukemia and determines the total CD4+ T-cell repertoire. Blood 116 : 2968-2974.
-
(2010)
Blood
, vol.116
, pp. 2968-2974
-
-
Pourgheysari, B.1
-
74
-
-
76549107658
-
Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors
-
Pita-Lopez, M.L. et al 2009. Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors. Immun. Ageing 6 : 11.
-
(2009)
Immun. Ageing
, vol.6
, pp. 11
-
-
Pita-Lopez, M.L.1
-
75
-
-
77951889646
-
Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status
-
Vescovini, R. et al 2010. Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status. J. Immunol. 184 : 3242-3249.
-
(2010)
J. Immunol.
, vol.184
, pp. 3242-3249
-
-
Vescovini, R.1
-
76
-
-
77249105912
-
Early immune senescence in HIV disease
-
Desai, S. & A. Landay 2010. Early immune senescence in HIV disease. Curr. HIV/AIDS Rep. 7 : 4-10.
-
(2010)
Curr. HIV/AIDS Rep.
, vol.7
, pp. 4-10
-
-
Desai, S.1
Landay, A.2
-
77
-
-
77954621872
-
HIV and aging: time for a new paradigm
-
Justice, A.C. 2010. HIV and aging: time for a new paradigm. Curr. HIV/AIDS Rep. 7 : 69-76.
-
(2010)
Curr. HIV/AIDS Rep.
, vol.7
, pp. 69-76
-
-
Justice, A.C.1
-
78
-
-
34147110822
-
Accelerated immune senescence and HIV-1 infection
-
Appay, V. et al 2007. Accelerated immune senescence and HIV-1 infection. Exp. Gerontol. 42 : 432-437.
-
(2007)
Exp. Gerontol.
, vol.42
, pp. 432-437
-
-
Appay, V.1
-
79
-
-
0038577099
-
Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes
-
Kalayjian, R.C. et al 2003. Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes. J. Infect. Dis. 187 : 1924-1933.
-
(2003)
J. Infect. Dis.
, vol.187
, pp. 1924-1933
-
-
Kalayjian, R.C.1
-
80
-
-
10344246581
-
HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation
-
Dion, M.L. et al 2004. HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation. Immunity 21 : 757-768.
-
(2004)
Immunity
, vol.21
, pp. 757-768
-
-
Dion, M.L.1
-
81
-
-
78751680775
-
Telomere/telomerase dynamics within the human immune system: effect of chronic infection and stress
-
Effros, R.B. 2011. Telomere/telomerase dynamics within the human immune system: effect of chronic infection and stress. Exp. Gerontol. 46 : 135-140.
-
(2011)
Exp. Gerontol.
, vol.46
, pp. 135-140
-
-
Effros, R.B.1
-
82
-
-
20344373118
-
The role of CD8+ T-cell replicative senescence in human aging
-
Effros, R.B. et al 2005. The role of CD8+ T-cell replicative senescence in human aging. Immunol. Rev. 205 : 147-157.
-
(2005)
Immunol. Rev.
, vol.205
, pp. 147-157
-
-
Effros, R.B.1
-
83
-
-
79551549663
-
The dual impact of HIV-1 infection and aging on naive CD4 T-cells: additive and distinct patterns of impairment
-
Rickabaugh, T.M. et al 2011. The dual impact of HIV-1 infection and aging on naive CD4 T-cells: additive and distinct patterns of impairment. PLoS One 6 : e16459.
-
(2011)
PLoS One
, vol.6
-
-
Rickabaugh, T.M.1
-
84
-
-
17444372347
-
Changes in thymic function with age and during the treatment of HIV infection
-
Douek, D.C. et al 1998. Changes in thymic function with age and during the treatment of HIV infection. Nature 396 : 690-695.
-
(1998)
Nature
, vol.396
, pp. 690-695
-
-
Douek, D.C.1
-
85
-
-
33947606768
-
Slow disease progression and robust therapy-mediated CD4 +T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection
-
Dion, M.L. et al 2007. Slow disease progression and robust therapy-mediated CD4 +T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection. Blood 109 : 2912-2920.
-
(2007)
Blood
, vol.109
, pp. 2912-2920
-
-
Dion, M.L.1
-
86
-
-
79955962732
-
HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis
-
Sauce, D. et al 2011. HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis. Blood 117 : 5142-5151.
-
(2011)
Blood
, vol.117
, pp. 5142-5151
-
-
Sauce, D.1
-
87
-
-
0035964691
-
Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function
-
Teixeira, L. et al 2001. Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function. AIDS 15 : 1749-1756.
-
(2001)
AIDS
, vol.15
, pp. 1749-1756
-
-
Teixeira, L.1
-
88
-
-
80052918982
-
Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients
-
Appay, V. et al 2011. Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients. AIDS 25 : 1813-1822.
-
(2011)
AIDS
, vol.25
, pp. 1813-1822
-
-
Appay, V.1
-
90
-
-
77955277916
-
Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways
-
Taub, D.D., W.J. Murphy & D.L. Longo 2010. Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways. Curr. Opin. Pharmacol. 10 : 408-424.
-
(2010)
Curr. Opin. Pharmacol.
, vol.10
, pp. 408-424
-
-
Taub, D.D.1
Murphy, W.J.2
Longo, D.L.3
-
91
-
-
40549089870
-
Growth hormone enhances thymic function in HIV-1-infected adults
-
Napolitano, L.A. et al 2008. Growth hormone enhances thymic function in HIV-1-infected adults. J. Clin. Invest. 118 : 1085-1098.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 1085-1098
-
-
Napolitano, L.A.1
-
92
-
-
0034914252
-
Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis
-
Goronzy, J.J. & C.M. Weyand 2001. Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis. Trends Immunol. 22 : 251-255.
-
(2001)
Trends Immunol.
, vol.22
, pp. 251-255
-
-
Goronzy, J.J.1
Weyand, C.M.2
-
93
-
-
79959818390
-
CD4+CD28- T cell expansion in granulomatosis with polyangiitis (Wegener's) is driven by latent cytomegalovirus infection and is associated with an increased risk of infection and mortality
-
Morgan, M.D. et al 2011. CD4+CD28- T cell expansion in granulomatosis with polyangiitis (Wegener's) is driven by latent cytomegalovirus infection and is associated with an increased risk of infection and mortality. Arthritis Rheum. 63 : 2127-2137.
-
(2011)
Arthritis Rheum.
, vol.63
, pp. 2127-2137
-
-
Morgan, M.D.1
-
94
-
-
0034255127
-
T cell homeostasis in patients with rheumatoid arthritis
-
Koetz, K. et al 2000. T cell homeostasis in patients with rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 97 : 9203-9208.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9203-9208
-
-
Koetz, K.1
-
95
-
-
42449085252
-
Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis
-
Colmegna, I. et al 2008. Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis. Arthritis Rheum. 58 : 990-1000.
-
(2008)
Arthritis Rheum.
, vol.58
, pp. 990-1000
-
-
Colmegna, I.1
-
96
-
-
0344392248
-
Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages
-
Schonland, S.O. et al 2003. Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages. Proc. Natl. Acad. Sci. USA 100 : 13471-13476.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 13471-13476
-
-
Schonland, S.O.1
-
97
-
-
77953812233
-
Telomeres and immunological diseases of aging
-
Andrews, N.P. et al 2010. Telomeres and immunological diseases of aging. Gerontology 56 : 390-403.
-
(2010)
Gerontology
, vol.56
, pp. 390-403
-
-
Andrews, N.P.1
-
98
-
-
0032564450
-
Perturbation of the T cell repertoire in rheumatoid arthritis
-
Wagner, U.G. et al 1998. Perturbation of the T cell repertoire in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 95 : 14447-14452.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 14447-14452
-
-
Wagner, U.G.1
-
99
-
-
63149145433
-
Telomerase insufficiency in rheumatoid arthritis
-
Fujii, H. et al 2009. Telomerase insufficiency in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 106 : 4360-4365.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 4360-4365
-
-
Fujii, H.1
-
100
-
-
67449127107
-
Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis
-
Shao, L. et al 2009. Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis. J. Exp. Med. 206 : 1435-1449.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1435-1449
-
-
Shao, L.1
-
101
-
-
79952115866
-
DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis
-
Shao, L., J.J. Goronzy & C.M. Weyand 2010. DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis. EMBO Mol. Med. 2 : 415-427.
-
(2010)
EMBO Mol. Med.
, vol.2
, pp. 415-427
-
-
Shao, L.1
Goronzy, J.J.2
Weyand, C.M.3
-
102
-
-
33845699084
-
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A
-
Liu, Y. et al 2006. DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J. Cell Sci. 119 : 4644-4649.
-
(2006)
J. Cell Sci.
, vol.119
, pp. 4644-4649
-
-
Liu, Y.1
-
103
-
-
77957889331
-
A functional single nucleotide polymorphism in promoter of ATM is associated with longevity
-
Chen, T. et al 2010. A functional single nucleotide polymorphism in promoter of ATM is associated with longevity. Mech. Ageing Dev. 131 : 636-640.
-
(2010)
Mech. Ageing Dev.
, vol.131
, pp. 636-640
-
-
Chen, T.1
-
104
-
-
79958772323
-
Premature ageing of the immune system underlies immunodeficiency in ataxia telangiectasia
-
Exley, A.R. et al 2011. Premature ageing of the immune system underlies immunodeficiency in ataxia telangiectasia. Clin. Immunol. 140 : 26-36.
-
(2011)
Clin. Immunol.
, vol.140
, pp. 26-36
-
-
Exley, A.R.1
-
105
-
-
56849113103
-
Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates
-
Messaoudi, I. et al 2008. Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates. Aging Cell. 7 : 908-919.
-
(2008)
Aging Cell.
, vol.7
, pp. 908-919
-
-
Messaoudi, I.1
-
106
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison, D.E. et al 2009. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460 : 392-395.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
-
107
-
-
79951794971
-
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
-
Miller, R.A. et al 2011. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 66 : 191-201.
-
(2011)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.66
, pp. 191-201
-
-
Miller, R.A.1
-
108
-
-
79951912532
-
Four faces of cellular senescence
-
Rodier, F. & J. Campisi 2011. Four faces of cellular senescence. J. Cell Biol. 192 : 547-556.
-
(2011)
J. Cell Biol.
, vol.192
, pp. 547-556
-
-
Rodier, F.1
Campisi, J.2
|