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Volumn 4, Issue 9, 2012, Pages 281-291

Therapeutic targeting of cancer cell metabolism: Role of metabolic enzymes, oncogenes and tumor suppressor genes

Author keywords

Cancer therapy; Glutaminolysis; Glycolysis; Hexokinase; Hypoxia; Oncogenes; Tumorigenesis

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 6 PHOSPHOFRUCTO 2 KINASE; ENOLASE; FRUCTOSE BISPHOSPHATE ALDOLASE; GLUTAMINASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEAT SHOCK PROTEIN 90; HEXOKINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOGLYCERATE KINASE; PICTILISIB; PROTEIN KINASE B; PROTEIN P53; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE KINASE; RAS PROTEIN; TRANSKETOLASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; XL 147; XL 418; XL 765;

EID: 84867567280     PISSN: None     EISSN: 19485956     Source Type: Journal    
DOI: 10.4172/1948-5956.1000156     Document Type: Review
Times cited : (24)

References (91)
  • 1
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: Oncogene and non-oncogene addiction
    • Luo J, Solimini NL, Elledge SJ (2009) Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 136: 823-837.
    • (2009) Cell , vol.136 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 2
    • 77955470822 scopus 로고    scopus 로고
    • Metabolism and proliferation share common regulatory pathways in cancer cells
    • Fritz V, Fajas L (2010) Metabolism and proliferation share common regulatory pathways in cancer cells. Oncogene 29: 4369-4377.
    • (2010) Oncogene , vol.29 , pp. 4369-4377
    • Fritz, V.1    Fajas, L.2
  • 3
    • 33646266734 scopus 로고    scopus 로고
    • Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over expressed but strongly product-inhibited hexokinase
    • Marín-Hernández A, Rodríguez-Enríquez S, Vital-González PA, Flores Rodríguez FL, Macías-Silva M, et al. (2006) Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over expressed but strongly product-inhibited hexokinase. FEBS J 273: 1975-1988.
    • (2006) FEBS J , vol.273 , pp. 1975-1988
    • Marín-Hernández, A.1    Rodríguez-Enríquez, S.2    Vital-González, P.A.3    Flores Rodríguez, F.L.4    Macías-Silva, M.5
  • 4
    • 33746924468 scopus 로고    scopus 로고
    • Hexokinase II: Cancer's double edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
    • Mathupala SP, Ko YH, Pedersen PL (2006) Hexokinase II: cancer's double edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 25: 4777-4786.
    • (2006) Oncogene , vol.25 , pp. 4777-4786
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3
  • 5
    • 60249083822 scopus 로고    scopus 로고
    • Hexokinase-2 bound to mitochondria: Cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy
    • Mathupala SP, Ko YH, Pedersen PL (2009) Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy. Semin Cancer Biol 19: 17-24.
    • (2009) Semin Cancer Biol , vol.19 , pp. 17-24
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3
  • 6
    • 35448982216 scopus 로고    scopus 로고
    • Hypoxia, glucose metabolism and the Warburg's effect
    • Bartrons R, Caro J (2007) Hypoxia, glucose metabolism and the Warburg's effect. J Bioenerg Biomembr 39: 223-229.
    • (2007) J Bioenerg Biomembr , vol.39 , pp. 223-229
    • Bartrons, R.1    Caro, J.2
  • 7
    • 0037108709 scopus 로고    scopus 로고
    • High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers
    • Atsumi T, Chesney J, Metz C, Leng L, Donnelly S, et al. (2002) High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers. Cancer Res 62: 5881-5887.
    • (2002) Cancer Res , vol.62 , pp. 5881-5887
    • Atsumi, T.1    Chesney, J.2    Metz, C.3    Leng, L.4    Donnelly, S.5
  • 8
    • 0242710750 scopus 로고    scopus 로고
    • Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2- 6-bisphosphatase gene family (PFKFB 1-4) expression in vivo
    • Minchenko O, Opentanova I, Caro J (2003) Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2- 6-bisphosphatase gene family (PFKFB 1-4) expression in vivo. FEBS Lett 554: 264-270.
    • (2003) FEBS Lett , vol.554 , pp. 264-270
    • Minchenko, O.1    Opentanova, I.2    Caro, J.3
  • 9
    • 79955777637 scopus 로고    scopus 로고
    • Posttranslational Modification of 6-phosphofructo-1-kinase as an Important Feature of Cancer Metabolism
    • Šmerc A, Sodja E, Legiša M (2011) Posttranslational Modification of 6-phosphofructo-1-kinase as an Important Feature of Cancer Metabolism. Plos One 6: 19645.
    • (2011) Plos One , vol.6 , pp. 19645
    • Šmerc, A.1    Sodja, E.2    Legiša, M.3
  • 10
    • 23044500915 scopus 로고    scopus 로고
    • Pyruvate kinase type M2 and its role in tumor growth and spreading
    • Mazurek S, Boschek CB, Hugo F, Eigenbrodt E (2005) Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol 15: 300-308.
    • (2005) Semin Cancer Biol , vol.15 , pp. 300-308
    • Mazurek, S.1    Boschek, C.B.2    Hugo, F.3    Eigenbrodt, E.4
  • 12
    • 0025855139 scopus 로고
    • Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance
    • Marshall S, Bacote V, Traxinger RR (1991) Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem 266: 4706-4712.
    • (1991) J Biol Chem , vol.266 , pp. 4706-4712
    • Marshall, S.1    Bacote, V.2    Traxinger, R.R.3
  • 13
    • 40749163248 scopus 로고    scopus 로고
    • The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    • Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, et al. (2008) The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452: 230-233.
    • (2008) Nature , vol.452 , pp. 230-233
    • Christofk, H.R.1    Vander, H.M.G.2    Harris, M.H.3    Ramanathan, A.4    Gerszten, R.E.5
  • 14
    • 75149150660 scopus 로고    scopus 로고
    • HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
    • David CJ, Chen M, Assanah M, Canoll P, Manley JL (2009) HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 463: 364-368.
    • (2009) Nature , vol.463 , pp. 364-368
    • David, C.J.1    Chen, M.2    Assanah, M.3    Canoll, P.4    Manley, J.L.5
  • 15
    • 0036249158 scopus 로고    scopus 로고
    • Tumor M2-pyruvate kinase in lung cancer patients: Immunohistochemical detection and disease monitoring
    • Schneider J, Neu K, Grimm H, Velcovsky HG, Weisse G, et al. (2002) Tumor M2-pyruvate kinase in lung cancer patients: immunohistochemical detection and disease monitoring. Anticancer Res 22: 311-318.
    • (2002) Anticancer Res , vol.22 , pp. 311-318
    • Schneider, J.1    Neu, K.2    Grimm, H.3    Velcovsky, H.G.4    Weisse, G.5
  • 16
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3: 177-185.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 17
    • 34547225129 scopus 로고    scopus 로고
    • Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy
    • Cairns RA, Papandreou I, Sutphin PD, Denko NC (2007) Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy. Proc Natl Acad Sci U S A 104: 9445-9450.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 9445-9450
    • Cairns, R.A.1    Papandreou, I.2    Sutphin, P.D.3    Denko, N.C.4
  • 18
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine AJ, Puzio-Kuter AM (2010) The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330: 1340-1344.
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 19
    • 79957991472 scopus 로고    scopus 로고
    • Glutaminase: A hot spot for regulation of cancer cell metabolism?
    • Erickson JW, Cerione RA (2011) Glutaminase: a hot spot for regulation of cancer cell metabolism? Oncotarget 1: 734-740.
    • (2011) Oncotarget , vol.1 , pp. 734-740
    • Erickson, J.W.1    Cerione, R.A.2
  • 20
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB (2008) The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7: 11-19.
    • (2008) Cell Metab , vol.7 , pp. 11-19
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 21
    • 80051709371 scopus 로고    scopus 로고
    • Metabolic alterations in cancer cells and therapeutic implications
    • Hammoudi N, Ahmed KB, Garcia-Prieto C, Huang P (2011) Metabolic alterations in cancer cells and therapeutic implications. Chin J Cancer 30: 508-525.
    • (2011) Chin J Cancer , vol.30 , pp. 508-525
    • Hammoudi, N.1    Ahmed, K.B.2    Garcia-Prieto, C.3    Huang, P.4
  • 23
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R, Bell DW, Haber DA, Settleman J (2004) Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305: 1163-1167.
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 24
    • 50049109789 scopus 로고    scopus 로고
    • AMP-activated protein kinase and human cancer: Cancer metabolism revisited
    • Kuhajda FP (2008) AMP-activated protein kinase and human cancer: cancer metabolism revisited. Int J Obes 32: 36-41.
    • (2008) Int J Obes , vol.32 , pp. 36-41
    • Kuhajda, F.P.1
  • 25
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
    • Shackelford DB, Shaw RJ (2009) The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nature Rev Cancer 9: 563-575.
    • (2009) Nature Rev Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 26
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell metabolism: Warburg and beyond
    • Hsu PP, Sabatini DM (2008) Cancer cell metabolism: Warburg and beyond. Cell 134: 703-707.
    • (2008) Cell , vol.134 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 27
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, et al. (1999) Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59: 5830-5835.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    de Marzo, A.M.2    Laughner, E.3    Lim, M.4    Hilton, D.A.5
  • 28
    • 0036077547 scopus 로고    scopus 로고
    • Glucose transporters: Expression, regulation and cancer
    • Medina RA, Owen GI (2002) Glucose transporters: expression, regulation and cancer. Biol Res 35: 9-26.
    • (2002) Biol Res , vol.35 , pp. 9-26
    • Medina, R.A.1    Owen, G.I.2
  • 29
    • 0037267005 scopus 로고    scopus 로고
    • Glucose transporters (GLUT and SGLT): Expanded families of sugar transport proteins
    • Wood IS, Trayhurn P (2003) Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr 89: 3-9.
    • (2003) Br J Nutr , vol.89 , pp. 3-9
    • Wood, I.S.1    Trayhurn, P.2
  • 30
    • 0034327416 scopus 로고    scopus 로고
    • Tumor induction by the c-Myc target genes rcl and lactate dehydrogenase A
    • Lewis BC, Prescott JE, Campbell SE, Shim H, Orlowski RZ, et al. (2000) Tumor induction by the c-Myc target genes rcl and lactate dehydrogenase A. Cancer Res 60: 6178-6183.
    • (2000) Cancer Res , vol.60 , pp. 6178-6183
    • Lewis, B.C.1    Prescott, J.E.2    Campbell, S.E.3    Shim, H.4    Orlowski, R.Z.5
  • 31
    • 35649014840 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase1
    • Kim JW, Gao P, Liu YC, Semenza GL, Dang CV (2007) Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase1. Mol Cell Biol 27: 7381-7393.
    • (2007) Mol Cell Biol , vol.27 , pp. 7381-7393
    • Kim, J.W.1    Gao, P.2    Liu, Y.C.3    Semenza, G.L.4    Dang, C.V.5
  • 32
    • 0034698178 scopus 로고    scopus 로고
    • Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc
    • Osthus RC, Shim H, Kim S, Li Q, Reddy R, et al. (2000) Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem 275: 21797-21800.
    • (2000) J Biol Chem , vol.275 , pp. 21797-21800
    • Osthus, R.C.1    Shim, H.2    Kim, S.3    Li, Q.4    Reddy, R.5
  • 33
    • 46349099384 scopus 로고    scopus 로고
    • Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo
    • Kim J, Lee JH, Iyer VR (2008) Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo. PLoS One 3: e1798.
    • (2008) PLoS One , vol.3
    • Kim, J.1    Lee, J.H.2    Iyer, V.R.3
  • 34
    • 43549098260 scopus 로고    scopus 로고
    • The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry
    • Morrish F, Neretti N, Sedivy JM, Hockenbery DM (2008) The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry. Cell Cycle 7: 1054-1066.
    • (2008) Cell Cycle , vol.7 , pp. 1054-1066
    • Morrish, F.1    Neretti, N.2    Sedivy, J.M.3    Hockenbery, D.M.4
  • 35
    • 11144309582 scopus 로고    scopus 로고
    • Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?
    • Menendez JA, Colomer R, Lupu R (2005) Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids? Med Hypotheses 64: 342-349.
    • (2005) Med Hypotheses , vol.64 , pp. 342-349
    • Menendez, J.A.1    Colomer, R.2    Lupu, R.3
  • 36
    • 0036385719 scopus 로고    scopus 로고
    • Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    • Yang YA, Han WF, Morin PJ, Chrest FJ, Pizer ES (2002) Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp Cell Res 279: 80-90.
    • (2002) Exp Cell Res , vol.279 , pp. 80-90
    • Yang, Y.A.1    Han, W.F.2    Morin, P.J.3    Chrest, F.J.4    Pizer, E.S.5
  • 38
    • 27844526600 scopus 로고    scopus 로고
    • Akt-dependent transformation: There is more to growth than just surviving
    • Plas DR, Thompson CB (2005) Akt-dependent transformation: there is more to growth than just surviving. Oncogene 24: 7435-7442.
    • (2005) Oncogene , vol.24 , pp. 7435-7442
    • Plas, D.R.1    Thompson, C.B.2
  • 39
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC (2007) AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 41
    • 0033575290 scopus 로고    scopus 로고
    • RRegulation of GLUT1 gene transcription by the serine/threonine kinase Akt1
    • Barthel A, Okino ST, Liao J, Nakatani K, Li J, et al. (1999) RRegulation of GLUT1 gene transcription by the serine/threonine kinase Akt1. J Biol Chem 274: 20281-20286.
    • (1999) J Biol Chem , vol.274 , pp. 20281-20286
    • Barthel, A.1    Okino, S.T.2    Liao, J.3    Nakatani, K.4    Li, J.5
  • 42
    • 0034983918 scopus 로고    scopus 로고
    • Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
    • Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, et al. (2001) Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 15: 1406-1418.
    • (2001) Genes Dev , vol.15 , pp. 1406-1418
    • Gottlob, K.1    Majewski, N.2    Kennedy, S.3    Kandel, E.4    Robey, R.B.5
  • 43
    • 0020377044 scopus 로고
    • Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography
    • Di Chiro G, DeLaPaz RL, Brooks RA, Sokoloff L, Kornblith PL, et al. (1982) Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography. Neurology 32: 1323-1329.
    • (1982) Neurology , vol.32 , pp. 1323-1329
    • Di Chiro, G.1    Delapaz, R.L.2    Brooks, R.A.3    Sokoloff, L.4    Kornblith, P.L.5
  • 44
    • 26244464326 scopus 로고    scopus 로고
    • PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
    • Porstmann T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, et al. (2005) PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24: 6465-6481.
    • (2005) Oncogene , vol.24 , pp. 6465-6481
    • Porstmann, T.1    Griffiths, B.2    Chung, Y.L.3    Delpuech, O.4    Griffiths, J.R.5
  • 45
    • 30544433533 scopus 로고    scopus 로고
    • ATP citrate lyase is an important component of cell growth and transformation
    • Bauer DE, Hatzivassiliou G, Zhao F, Andreadis C, Thompson CB (2005) ATP citrate lyase is an important component of cell growth and transformation. Oncogene 24: 6314-6322.
    • (2005) Oncogene , vol.24 , pp. 6314-6322
    • Bauer, D.E.1    Hatzivassiliou, G.2    Zhao, F.3    Andreadis, C.4    Thompson, C.B.5
  • 46
    • 78650885452 scopus 로고    scopus 로고
    • The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway
    • Fang M, Shen Z, Huang S, Zhao L, Chen S, et al. (2010) The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell 143: 711-724.
    • (2010) Cell , vol.143 , pp. 711-724
    • Fang, M.1    Shen, Z.2    Huang, S.3    Zhao, L.4    Chen, S.5
  • 47
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 48
    • 60549111398 scopus 로고    scopus 로고
    • Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis
    • Robey RB, Hay N (2009) Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis. Semin Cancer Biol 19: 25-31.
    • (2009) Semin Cancer Biol , vol.19 , pp. 25-31
    • Robey, R.B.1    Hay, N.2
  • 49
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM (2007) Defining the role of mTOR in cancer. Cancer Cell 12: 9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 50
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
    • Semenza GL (2000) HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88: 1474-1480.
    • (2000) J Appl Physiol , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 51
    • 18644366801 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors
    • Robey IF, Lien AD, Welsh SJ, Baggett BK, Gillies RJ (2005) Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia 7: 324-330.
    • (2005) Neoplasia , vol.7 , pp. 324-330
    • Robey, I.F.1    Lien, A.D.2    Welsh, S.J.3    Baggett, B.K.4    Gillies, R.J.5
  • 52
    • 0242710750 scopus 로고    scopus 로고
    • Hypoxic regulation of the 6-phos-phofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo
    • Minchenko O, Opentanova I, Caro J (2003) Hypoxic regulation of the 6-phos-phofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo. FEBS Lett 554: 264-270.
    • (2003) FEBS Lett , vol.554 , pp. 264-270
    • Minchenko, O.1    Opentanova, I.2    Caro, J.3
  • 53
    • 33644629183 scopus 로고    scopus 로고
    • Coming up for air: HIF-1 and mitochondrial oxygen consumption
    • Simon MC (2006) Coming up for air: HIF-1 and mitochondrial oxygen consumption. Cell Metab 3: 150-151.
    • (2006) Cell Metab , vol.3 , pp. 150-151
    • Simon, M.C.1
  • 54
    • 33745918951 scopus 로고    scopus 로고
    • TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    • Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, et al. (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126: 107-120.
    • (2006) Cell , vol.126 , pp. 107-120
    • Bensaad, K.1    Tsuruta, A.2    Selak, M.A.3    Vidal, M.N.4    Nakano, K.5
  • 56
    • 34248194200 scopus 로고    scopus 로고
    • The regulation of AMPK beta1, TSC2, and PTEN expression by p53: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
    • Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, et al. (2007) The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res 67: 3043-3053.
    • (2007) Cancer Res , vol.67 , pp. 3043-3053
    • Feng, Z.1    Hu, W.2    de Stanchina, E.3    Teresky, A.K.4    Jin, S.5
  • 57
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z, Zhang H, Levine AJ, Jin S (2005) The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A 102: 8204-8209.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 58
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, Podsypanina K, Bose S, et al. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3    Podsypanina, K.4    Bose, S.5
  • 59
    • 34547546177 scopus 로고    scopus 로고
    • Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure
    • Dali-Youcef N, Mataki C, Coste A, Messaddeq N, Giroud S, et al. (2007) Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure. Proc Natl Acad Sci U S A 104: 10703-10708.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10703-10708
    • Dali-Youcef, N.1    Mataki, C.2    Coste, A.3    Messaddeq, N.4    Giroud, S.5
  • 60
    • 77949967131 scopus 로고    scopus 로고
    • Targeting metabolic transformation for cancer therapy
    • Tennant DA, Durán RV, Gottlieb E (2010) Targeting metabolic transformation for cancer therapy. Nat Rev Cancer 10: 267-277.
    • (2010) Nat Rev Cancer , vol.10 , pp. 267-277
    • Tennant, D.A.1    Durán, R.V.2    Gottlieb, E.3
  • 62
    • 80051709371 scopus 로고    scopus 로고
    • Metabolic alterations in cancer cells and therapeutic implications
    • Hammoudi N, Ahmed KB, Garcia-Prieto C, Huang P (2011) Metabolic alterations in cancer cells and therapeutic implications. Chin J Cancer 30: 508-525.
    • (2011) Chin J Cancer , vol.30 , pp. 508-525
    • Hammoudi, N.1    Ahmed, K.B.2    Garcia-Prieto, C.3    Huang, P.4
  • 63
    • 38349183620 scopus 로고    scopus 로고
    • Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
    • Clem B, Telang S, Clem A, Yalcin A, Meier J, et al. (2008) Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther 7: 110-120.
    • (2008) Mol Cancer Ther , vol.7 , pp. 110-120
    • Clem, B.1    Telang, S.2    Clem, A.3    Yalcin, A.4    Meier, J.5
  • 66
    • 0030921103 scopus 로고    scopus 로고
    • c-Myc transactivation of LDHA: Implications for tumor metabolism and growth
    • Shim H, Dolde C, Lewis BC, Wu CS, Dang G, et al. (1997) c-Myc transactivation of LDHA: implications for tumor metabolism and growth. Proc Natl Acad Sci U S A 94: 6658-6663.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 6658-6663
    • Shim, H.1    Dolde, C.2    Lewis, B.C.3    Wu, C.S.4    Dang, G.5
  • 67
    • 78650403118 scopus 로고    scopus 로고
    • Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha
    • Qing G, Skuli N, Mayes PA, Pawel B, Martinez D, et al. (2010) Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha. Cancer Res 70: 10351-10361.
    • (2010) Cancer Res , vol.70 , pp. 10351-10361
    • Qing, G.1    Skuli, N.2    Mayes, P.A.3    Pawel, B.4    Martinez, D.5
  • 68
    • 76649126249 scopus 로고    scopus 로고
    • Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
    • Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, et al. (2010) Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A 107: 2037-2042.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 2037-2042
    • Le, A.1    Cooper, C.R.2    Gouw, A.M.3    Dinavahi, R.4    Maitra, A.5
  • 69
    • 40749095542 scopus 로고    scopus 로고
    • Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors
    • Thomas AA, Le Huerou Y, De Meese J, Gunawardana I, Kaplan T, et al. (2008) Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors. Bioorg Med Chem Lett 18: 2206-2210.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 2206-2210
    • Thomas, A.A.1    Le Huerou, Y.2    de Meese, J.3    Gunawardana, I.4    Kaplan, T.5
  • 70
    • 77956497712 scopus 로고    scopus 로고
    • Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
    • Wang JB, Erickson JW, Fuji R, Ramachandran S, Gao P, et al. (2010) Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 18: 207-219.
    • (2010) Cancer Cell , vol.18 , pp. 207-219
    • Wang, J.B.1    Erickson, J.W.2    Fuji, R.3    Ramachandran, S.4    Gao, P.5
  • 71
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, et al. (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321: 1807-1812.
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3    Lin, J.C.4    Leary, R.J.5
  • 72
    • 77954697566 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1 and 2 mutations in cancer: Alterations at a crossroads of cellular metabolism
    • Reitman ZJ, Yan H (2010) Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. J Natl Cancer Inst 102: 932-941.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 932-941
    • Reitman, Z.J.1    Yan, H.2
  • 73
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • Dang L, White DW, Gross S, Bennett BD, Bittinger MA, et al. (2009) Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462: 739-744.
    • (2009) Nature , vol.462 , pp. 739-744
    • Dang, L.1    White, D.W.2    Gross, S.3    Bennett, B.D.4    Bittinger, M.A.5
  • 74
    • 34247163550 scopus 로고    scopus 로고
    • Chemically targeting the PI3K family
    • Knight ZA, Shokat KM (2007) Chemically targeting the PI3K family. Biochem Soc Trans 35: 245-249.
    • (2007) Biochem Soc Trans , vol.35 , pp. 245-249
    • Knight, Z.A.1    Shokat, K.M.2
  • 76
    • 33646383684 scopus 로고    scopus 로고
    • A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
    • Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, et al. (2006) A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 125: 733-747.
    • (2006) Cell , vol.125 , pp. 733-747
    • Knight, Z.A.1    Gonzalez, B.2    Feldman, M.E.3    Zunder, E.R.4    Goldenberg, D.D.5
  • 77
    • 33646382364 scopus 로고    scopus 로고
    • A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
    • Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, et al. (2006) A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell 9: 341-349.
    • (2006) Cancer Cell , vol.9 , pp. 341-349
    • Fan, Q.W.1    Knight, Z.A.2    Goldenberg, D.D.3    Yu, W.4    Mostov, K.E.5
  • 78
    • 51049109033 scopus 로고    scopus 로고
    • Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
    • Maira SM, Stauffer F, Brueggen J, Furet P, Schnell C, et al. (2008) Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 7: 1851-1863.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1851-1863
    • Maira, S.M.1    Stauffer, F.2    Brueggen, J.3    Furet, P.4    Schnell, C.5
  • 79
    • 39149123820 scopus 로고    scopus 로고
    • A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity
    • Garlich JR, De P, Dey N, Su JD, Peng X, et al. (2008) A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res 68: 206-215.
    • (2008) Cancer Res , vol.68 , pp. 206-215
    • Garlich, J.R.1    De, P.2    Dey, N.3    Su, J.D.4    Peng, X.5
  • 80
    • 0031105972 scopus 로고    scopus 로고
    • D-21266, a new heterocyclic alkylphospholipid with antitumour activity
    • Hilgard P, Klenner T, Stekar J, Nössner G, Kutscher B, et al. (1997) D-21266, a new heterocyclic alkylphospholipid with antitumour activity. Eur J Cancer 33: 442-446.
    • (1997) Eur J Cancer , vol.33 , pp. 442-446
    • Hilgard, P.1    Klenner, T.2    Stekar, J.3    Nössner, G.4    Kutscher, B.5
  • 81
    • 9244224608 scopus 로고    scopus 로고
    • In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316
    • Meuillet EJ, Ihle N, Baker AF, Gard JM, Stamper C, et al. (2004) In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316. Oncol Res 14: 513-527.
    • (2004) Oncol Res , vol.14 , pp. 513-527
    • Meuillet, E.J.1    Ihle, N.2    Baker, A.F.3    Gard, J.M.4    Stamper, C.5
  • 82
    • 33645472274 scopus 로고    scopus 로고
    • Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt
    • Gills JJ, Holbeck S, Hollingshead M, Hewitt SM, Kozikowski AP, et al. (2006) Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt. Mol Cancer Ther 5: 713-722.
    • (2006) Mol Cancer Ther , vol.5 , pp. 713-722
    • Gills, J.J.1    Holbeck, S.2    Hollingshead, M.3    Hewitt, S.M.4    Kozikowski, A.P.5
  • 83
    • 42049115641 scopus 로고    scopus 로고
    • Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity
    • Rhodes N, Heerding DA, Duckett DR, Eberwein DJ, Knick VB, et al. (2008) Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res 68: 2366-2374.
    • (2008) Cancer Res , vol.68 , pp. 2366-2374
    • Rhodes, N.1    Heerding, D.A.2    Duckett, D.R.3    Eberwein, D.J.4    Knick, V.B.5
  • 84
    • 0016724057 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
    • Vézina C, Kudelski A, Sehgal SN (1975) Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 28: 721-726.
    • (1975) J Antibiot (Tokyo) , vol.28 , pp. 721-726
    • Vézina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 85
    • 0027430173 scopus 로고
    • Therapeutic monitoring of rapamycin: A new immunosuppressive drug
    • Yatscoff RW, LeGatt DF, Kneteman NM (1993) Therapeutic monitoring of rapamycin: a new immunosuppressive drug. Ther Drug Monit 15: 478-482.
    • (1993) Ther Drug Monit , vol.15 , pp. 478-482
    • Yatscoff, R.W.1    Legatt, D.F.2    Kneteman, N.M.3
  • 86
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S, Kroemer G, Raymond E (2006) Current development of mTOR inhibitors as anticancer agents. Nature Rev Drug Discov 5: 671-688.
    • (2006) Nature Rev Drug Discov , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 87
    • 58649114084 scopus 로고    scopus 로고
    • mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
    • Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, et al. (2009) mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell 15: 148-159.
    • (2009) Cancer Cell , vol.15 , pp. 148-159
    • Guertin, D.A.1    Stevens, D.M.2    Saitoh, M.3    Kinkel, S.4    Crosby, K.5
  • 88
    • 61349141302 scopus 로고    scopus 로고
    • Activesite inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
    • Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, et al. (2009) Activesite inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 7: e38.
    • (2009) PLoS Biol , vol.7
    • Feldman, M.E.1    Apsel, B.2    Uotila, A.3    Loewith, R.4    Knight, Z.A.5
  • 89
    • 65549145048 scopus 로고    scopus 로고
    • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    • Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, et al. (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 284: 8023-8032.
    • (2009) J Biol Chem , vol.284 , pp. 8023-8032
    • Thoreen, C.C.1    Kang, S.A.2    Chang, J.W.3    Liu, Q.4    Zhang, J.5
  • 90
    • 0037155901 scopus 로고    scopus 로고
    • Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1
    • Fujita N, Sato S, Ishida A, Tsuruo T (2002) Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1. J Biol Chem 277: 10346-10353.
    • (2002) J Biol Chem , vol.277 , pp. 10346-10353
    • Fujita, N.1    Sato, S.2    Ishida, A.3    Tsuruo, T.4
  • 91
    • 0038404927 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol
    • Solit DB, Basso AD, Olshen AB, Scher HI, Rosen N (2003) Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol. Cancer Res 63: 2139-2144.
    • (2003) Cancer Res , vol.63 , pp. 2139-2144
    • Solit, D.B.1    Basso, A.D.2    Olshen, A.B.3    Scher, H.I.4    Rosen, N.5


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