Tumor induction by the c-Myc target genes rcl and lactate dehydrogenase A

Cancer Research

Volumn 60, Issue 21, 2000, Pages 6178-6183

  Lewis, Brian C ^a,c   Prescott, Julia E ^a   Campbell, Susan E ^a   Shim, Hyunsuk ^a   Orlowski, Robert Z ^a,b,d   Dang, Chi V ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTATE DEHYDROGENASE ISOENZYME; LACTATE DEHYDROGENASE ISOENZYME 5; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; FIBROBLAST; GENE INDUCTION; MALE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; RAT;

ANIMALS; CELL ADHESION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; FIBROBLASTS; GENE EXPRESSION; GENES, MYC; ISOENZYMES; L-LACTATE DEHYDROGENASE; MALE; MICE; MICE, NUDE; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; RATS;

EID: 0034327416     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Identification of nucleotide sequences which may encode the oncogenic capacity of avian retrovirus MC29
2. In situ c-myc expression and genomic status of the c-myc locus in infiltrating ductal carcinomas of the breast
3. Amplification and expression of the c-myc oncogene in human lung cancer cell lines
4. Deregulation of c-myc gene expression in human colon carcinoma is not accompanied by amplification or rearrangement of the gene
5. Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas
6. Myc function and regulation
7. The myc oncogene: Its role in transformation and differentiation
8. Identification of c-Myc as a target of the APC pathway
9. Max: A helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc
10. Sequence-specific, DNA binding by the c-Myc protein
11. c-Myc target genes involved in cell growth, apoptosis, and metabolism
12. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
13. Induction of apoptosis in fibroblasts by c-myc protein
14. Identification of putative c-Myc responsive genes: Characterization of rcl, a novel growth related gene
15. c-Myc transactivation of LDH-A: Implications for tumor metabolism and growth
16. A unique glucose-dependent apoptotic pathway induced by c-Myc
17. Definition of regions in human c-myc that are involved in transformation and nuclear localization
18. Participation of cyclin A in Myc-induced apoptosis
19. Cyclin A links c-Myc to adhesion-independent cell proliferation
20. A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain
21. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays
22. The biology of vascular endothelial growth factor
23. Ornithine decarboxylase activity is critical for cell transformation
24. Human ornithine decarboxylase-overproducing NIH3T3 cells induce rapidly growing, highly vascularized tumors in nude mice
25. The MYC protein activates transcription of the α-prothymosin gene
26. An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence
27. CDC25 phosphatases as potential human oncogenes
28. Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo
29. Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap
30. The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts
31. Angiogenesis in cancer, vascular, rheumatoid and other disease
32. Tumor induction of VEGF promoter activity in stromal cells
33. Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
34. Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
35. Oncogenic ras fails to restore an in vivo tumorigenic phenotype in embryonic stem cells lacking vascular endothelial growth factor (VEGF)
36. Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype
37. Myc, and Max homologs in Drosophila