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Volumn 5, Issue 1, 2012, Pages 73-87

Pharmacogenomic considerations in opioid analgesia

Author keywords

Genetic variation; Opioid analgesia; Pain perception; Pharmacogenetics

Indexed keywords

ALFENTANIL; CODEINE; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DIHYDROCODEINE; FENTANYL; HYDROCODONE; ITRACONAZOLE; METHADONE; MORPHINE; NARCOTIC ANALGESIC AGENT; OXYCODONE; OXYMORPHONE; PARACETAMOL; PLACEBO; QUINIDINE; REMIFENTANIL; TRAMADOL;

EID: 84866560648     PISSN: None     EISSN: 11787066     Source Type: Journal    
DOI: 10.2147/PGPM.S23422     Document Type: Review
Times cited : (47)

References (162)
  • 2
    • 48249123433 scopus 로고    scopus 로고
    • Pharmacogenomic biomarker information in drug labels approved by the United States food and drug administration: Prevalence of related drug use
    • Frueh FW, Amur S, Mummaneni P, et al. Pharmacogenomic biomarker information in drug labels approved by the United States food and drug administration: prevalence of related drug use. Pharmacotherapy. 2008;28:992-998.
    • (2008) Pharmacotherapy , vol.28 , pp. 992-998
    • Frueh, F.W.1    Amur, S.2    Mummaneni, P.3
  • 3
    • 79651470986 scopus 로고    scopus 로고
    • Pharmacogenomic biomarkers: New tools in current and future drug therapy
    • Sim SC, Ingelman-Sundberg M. Pharmacogenomic biomarkers: new tools in current and future drug therapy. Trends Pharmacol Sci. 2011;32:72-81.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 72-81
    • Sim, S.C.1    Ingelman-Sundberg, M.2
  • 4
    • 79951809825 scopus 로고    scopus 로고
    • CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network
    • Relling MV, Klein TE. CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network. Clin Pharmacol Ther. 2011;89:464-467.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 464-467
    • Relling, M.V.1    Klein, T.E.2
  • 5
    • 80052962391 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing
    • Johnson JA, Gong L, Whirl-Carrillo M, et al. Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing. Clin Pharmacol Ther. 2011;90:625-629.
    • (2011) Clin Pharmacol Ther , vol.90 , pp. 625-629
    • Johnson, J.A.1    Gong, L.2    Whirl-Carrillo, M.3
  • 6
    • 79960613122 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-452C19 (CYP2C19) genotype and clopidogrel therapy
    • Scott SA, Sangkuhl K, Gardner EE, et al. Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-452C19 (CYP2C19) genotype and clopidogrel therapy. Clin Pharmacol Ther. 2011;90:328-332.
    • (2011) Clin Pharmacol Ther , vol.90 , pp. 328-332
    • Scott, S.A.1    Sangkuhl, K.2    Gardner, E.E.3
  • 7
    • 79951809968 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing
    • Relling MV, Gardner EE, Sandborn WJ, et al. Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing. Clin Pharmacol Ther. 2011;89:387-391.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 387-391
    • Relling, M.V.1    Gardner, E.E.2    Sandborn, W.J.3
  • 8
    • 84855968708 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype
    • Crews KR, Gaedigk A, Dunnenberger HM, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clin Pharmacol Ther. 2012;91:321-326.
    • (2012) Clin Pharmacol Ther , vol.91 , pp. 321-326
    • Crews, K.R.1    Gaedigk, A.2    Dunnenberger, H.M.3
  • 9
    • 33646344701 scopus 로고    scopus 로고
    • Persistent postsurgical pain: Risk factors and prevention
    • Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006;367:1618-1625.
    • (2006) Lancet , vol.367 , pp. 1618-1625
    • Kehlet, H.1    Jensen, T.S.2    Woolf, C.J.3
  • 10
    • 83755194835 scopus 로고    scopus 로고
    • Role of cytochrome P450 genotype in the steps toward personalized drug therapy
    • Cavallari L, Jeong H, Bress A. Role of cytochrome P450 genotype in the steps toward personalized drug therapy. Pharmgenomics Pers Med. 2011;4:123-136.
    • (2011) Pharmgenomics Pers Med , vol.4 , pp. 123-136
    • Cavallari, L.1    Jeong, H.2    Bress, A.3
  • 11
    • 60849102120 scopus 로고    scopus 로고
    • Individual differences in pain sensitivity: Measurement, causation, and consequences
    • Nielsen CS, Staud R, Price DD. Individual differences in pain sensitivity: measurement, causation, and consequences. J Pain. 2009;10:231-237.
    • (2009) J Pain , vol.10 , pp. 231-237
    • Nielsen, C.S.1    Staud, R.2    Price, D.D.3
  • 12
    • 42249086592 scopus 로고    scopus 로고
    • Variations in opioid responsiveness
    • Smith HS. Variations in opioid responsiveness. Pain Physician. 2008;11:237-248.
    • (2008) Pain Physician , vol.11 , pp. 237-248
    • Smith, H.S.1
  • 13
    • 77958085098 scopus 로고    scopus 로고
    • Opioid pharmacogenomics using a twin study paradigm: Methods and procedures for determining familial aggregation and heritability
    • Angst MS, Phillips NG, Drover DR, et al. Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability. Twin Res Hum Genet. 2010;13:412-425.
    • (2010) Twin Res Hum Genet , vol.13 , pp. 412-425
    • Angst, M.S.1    Phillips, N.G.2    Drover, D.R.3
  • 14
  • 17
    • 33845901486 scopus 로고    scopus 로고
    • An SCN9A channelopathy causes congenital inability to experience pain
    • Cox JJ, Reimann F, Nicholas AK, et al. An SCN9A channelopathy causes congenital inability to experience pain. Nature. 2006;444:894-898.
    • (2006) Nature , vol.444 , pp. 894-898
    • Cox, J.J.1    Reimann, F.2    Nicholas, A.K.3
  • 19
    • 84155170863 scopus 로고    scopus 로고
    • Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker
    • Goldberg YP, Price N, Namdari R, et al. Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker. Pain. 2012;153:80-85.
    • (2012) Pain , vol.153 , pp. 80-85
    • Goldberg, Y.P.1    Price, N.2    Namdari, R.3
  • 20
    • 84855657020 scopus 로고    scopus 로고
    • Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists
    • Nguyen HN, Bregman H, Buchanan JL, et al. Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists. Bioorg Med Chem Lett. 2012;22:1055-1060.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 1055-1060
    • Nguyen, H.N.1    Bregman, H.2    Buchanan, J.L.3
  • 21
    • 34247874778 scopus 로고    scopus 로고
    • Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations
    • Goldberg YP, MacFarlane J, MacDonald ML, et al. Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations. Clin Genet. 2007;71:311-319.
    • (2007) Clin Genet , vol.71 , pp. 311-319
    • Goldberg, Y.P.1    Macfarlane, J.2    Macdonald, M.L.3
  • 23
    • 36148976077 scopus 로고    scopus 로고
    • Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
    • Ingelman-Sundberg M, Sim SC, Gomez A, Rodriguez-Antona C. Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol Ther. 2007;116:496-526.
    • (2007) Pharmacol Ther , vol.116 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3    Rodriguez-Antona, C.4
  • 25
    • 70350044889 scopus 로고    scopus 로고
    • New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme
    • Wang B, Yang LP, Zhang XZ, Huang SQ, Bartlam M, Zhou SF. New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme. Drug Metab Rev. 2009;41:573-643.
    • (2009) Drug Metab Rev , vol.41 , pp. 573-643
    • Wang, B.1    Yang, L.P.2    Zhang, X.Z.3    Huang, S.Q.4    Bartlam, M.5    Zhou, S.F.6
  • 26
    • 70349386728 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part II
    • Zhou SF. Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. Clin Pharmacokinet. 2009;48:761-804.
    • (2009) Clin Pharmacokinet , vol.48 , pp. 761-804
    • Zhou, S.F.1
  • 28
    • 77952908167 scopus 로고    scopus 로고
    • Personalized therapy in pain management: Where do we stand?
    • Stamer UM, Zhang L, Stuber F. Personalized therapy in pain management: where do we stand? Pharmacogenomics. 2010;11:843-864.
    • (2010) Pharmacogenomics , vol.11 , pp. 843-864
    • Stamer, U.M.1    Zhang, L.2    Stuber, F.3
  • 29
    • 33847031732 scopus 로고    scopus 로고
    • CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure
    • Sistonen J, Sajantila A, Lao O, Corander J, Barbujani G, Fuselli S. CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure. Pharmacogenet Genomics. 2007;17:93-101.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 93-101
    • Sistonen, J.1    Sajantila, A.2    Lao, O.3    Corander, J.4    Barbujani, G.5    Fuselli, S.6
  • 30
    • 11144221180 scopus 로고    scopus 로고
    • Codeine intoxication associated with ultrarapid CYP2D6 metabolism
    • Gasche Y, Daali Y, Fathi M, et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Engl J Med. 2004;351:2827-2831.
    • (2004) N Engl J Med , vol.351 , pp. 2827-2831
    • Gasche, Y.1    Daali, Y.2    Fathi, M.3
  • 31
    • 51449102329 scopus 로고    scopus 로고
    • Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication
    • Stamer UM, Stuber F, Muders T, Musshoff F. Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication. Anesth Analg. 2008;107:926-929.
    • (2008) Anesth Analg , vol.107 , pp. 926-929
    • Stamer, U.M.1    Stuber, F.2    Muders, T.3    Musshoff, F.4
  • 32
    • 78649344837 scopus 로고    scopus 로고
    • Sex and gender differences in pain and analgesia
    • Mogil JS, Bailey AL. Sex and gender differences in pain and analgesia. Prog Brain Res. 2010;186:141-157.
    • (2010) Prog Brain Res , vol.186 , pp. 141-157
    • Mogil, J.S.1    Bailey, A.L.2
  • 33
    • 79952509224 scopus 로고    scopus 로고
    • Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures
    • Doehring A, Kusener N, Fluhr K, Neddermeyer TJ, Schneider G, Lotsch J. Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures. PloS One. 2011;6:e17724.
    • (2011) PloS One , vol.6
    • Doehring, A.1    Kusener, N.2    Fluhr, K.3    Neddermeyer, T.J.4    Schneider, G.5    Lotsch, J.6
  • 34
    • 79955685734 scopus 로고    scopus 로고
    • Clinically relevant genetic variations in drug metabolizing enzymes
    • Pinto N, Dolan ME. Clinically relevant genetic variations in drug metabolizing enzymes. Curr Drug Metab. 2011;12:487-497.
    • (2011) Curr Drug Metab , vol.12 , pp. 487-497
    • Pinto, N.1    Dolan, M.E.2
  • 36
    • 79551541573 scopus 로고    scopus 로고
    • Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity
    • Lee PJ, Delaney P, Keogh J, Sleeman D, Shorten GD. Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity. Clin J Pain. 2011;27:93-101.
    • (2011) Clin J Pain , vol.27 , pp. 93-101
    • Lee, P.J.1    Delaney, P.2    Keogh, J.3    Sleeman, D.4    Shorten, G.D.5
  • 37
    • 77952539265 scopus 로고    scopus 로고
    • Single dose oral codeine, as a single agent, for acute postoperative pain in adults
    • CD008099
    • Derry S, Moore RA, McQuay HJ. Single dose oral codeine, as a single agent, for acute postoperative pain in adults. Cochrane Database Syst Rev. 2010;4:CD008099.
    • (2010) Cochrane Database Syst Rev , vol.4
    • Derry, S.1    Moore, R.A.2    McQuay, H.J.3
  • 38
    • 80051793585 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms and codeine analgesia in postpartum pain management: A pilot study
    • VanderVaart S, Berger H, Sistonen J, et al. CYP2D6 polymorphisms and codeine analgesia in postpartum pain management: a pilot study. Ther Drug Monit. 2011;33:425-432.
    • (2011) Ther Drug Monit , vol.33 , pp. 425-432
    • Vandervaart, S.1    Berger, H.2    Sistonen, J.3
  • 40
    • 34250345279 scopus 로고    scopus 로고
    • Apnea in a child after oral codeine: A genetic variant - an ultra-rapid metabolizer
    • Voronov P, Przybylo HJ, Jagannathan N. Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer. Paediatr Anaesth. 2007;17:684-687.
    • (2007) Paediatr Anaesth , vol.17 , pp. 684-687
    • Voronov, P.1    Przybylo, H.J.2    Jagannathan, N.3
  • 41
    • 33747134323 scopus 로고    scopus 로고
    • Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother
    • Koren G, Cairns J, Chitayat D, Gaedigk A, Leeder SJ. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet. 2006;368:704.
    • (2006) Lancet , vol.368 , pp. 704
    • Koren, G.1    Cairns, J.2    Chitayat, D.3    Gaedigk, A.4    Leeder, S.J.5
  • 43
    • 33846465345 scopus 로고    scopus 로고
    • Safety of codeine during breastfeeding: Fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine
    • Madadi P, Koren G, Cairns J, et al. Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine. Can Fam Physician. 2007;53:33-35.
    • (2007) Can Fam Physician , vol.53 , pp. 33-35
    • Madadi, P.1    Koren, G.2    Cairns, J.3
  • 44
    • 70450240777 scopus 로고    scopus 로고
    • Risk to the breast-fed neonate from codeine treatment to the mother: A quantitative mechanistic modeling study
    • Willmann S, Edginton AN, Coboeken K, Ahr G, Lippert J. Risk to the breast-fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study. Clin Pharmacol Ther. 2009;86:634-643.
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 634-643
    • Willmann, S.1    Edginton, A.N.2    Coboeken, K.3    Ahr, G.4    Lippert, J.5
  • 45
    • 77954173921 scopus 로고    scopus 로고
    • A critical appraisal of human genotyping for pain therapy
    • Lotsch J, Geisslinger G. A critical appraisal of human genotyping for pain therapy. Trends Pharmacol Sci. 2010;31:312-317.
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 312-317
    • Lotsch, J.1    Geisslinger, G.2
  • 46
    • 57749180179 scopus 로고    scopus 로고
    • Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: A case-control study
    • Madadi P, Ross CJ, Hayden MR, et al. Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study. Clin Pharmacol Ther. 2009;85:31-35.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 31-35
    • Madadi, P.1    Ross, C.J.2    Hayden, M.R.3
  • 47
    • 55949130041 scopus 로고    scopus 로고
    • Establishing causality of CNS depression in breastfed infants following maternal codeine use
    • Madadi P, Shirazi F, Walter FG, Koren G. Establishing causality of CNS depression in breastfed infants following maternal codeine use. Paediatr Drugs. 2008;10:399-404.
    • (2008) Paediatr Drugs , vol.10 , pp. 399-404
    • Madadi, P.1    Shirazi, F.2    Walter, F.G.3    Koren, G.4
  • 48
    • 57749199462 scopus 로고    scopus 로고
    • The consequence of concomitantly present functional genetic variants for the identification of functional genotype-phenotype associations in pain
    • Lotsch J, Fluhr K, Neddermayer T, Doehring A, Geisslinger G. The consequence of concomitantly present functional genetic variants for the identification of functional genotype-phenotype associations in pain. Clin Pharmacol Ther. 2009;85:25-30.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 25-30
    • Lotsch, J.1    Fluhr, K.2    Neddermayer, T.3    Doehring, A.4    Geisslinger, G.5
  • 49
    • 29544447266 scopus 로고    scopus 로고
    • The AmpliChip CYP450 genotyping test: Integrating a new clinical tool
    • de Leon J, Susce MT, Murray-Carmichael E. The AmpliChip CYP450 genotyping test: integrating a new clinical tool. Mol Diagn Ther. 2006;10:135-151.
    • (2006) Mol Diagn Ther , vol.10 , pp. 135-151
    • de Leon, J.1    Susce, M.T.2    Murray-Carmichael, E.3
  • 50
    • 67349235560 scopus 로고    scopus 로고
    • Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation?
    • Lotsch J, Rohrbacher M, Schmidt H, Doehring A, Brockmoller J, Geisslinger G. Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation? Pain. 2009;144:119-124.
    • (2009) Pain , vol.144 , pp. 119-124
    • Lotsch, J.1    Rohrbacher, M.2    Schmidt, H.3    Doehring, A.4    Brockmoller, J.5    Geisslinger, G.6
  • 51
    • 0031839871 scopus 로고    scopus 로고
    • The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross-over study with extensive and quinidine-induced poor metabolizers
    • Wilder-Smith CH, Hufschmid E, Thormann W. The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross-over study with extensive and quinidine-induced poor metabolizers. Br J Clin Pharmacol. 1998;45:575-581.
    • (1998) Br J Clin Pharmacol , vol.45 , pp. 575-581
    • Wilder-Smith, C.H.1    Hufschmid, E.2    Thormann, W.3
  • 52
    • 0034825817 scopus 로고    scopus 로고
    • Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: A PK-PD modelling analysis
    • Webb JA, Rostami-Hodjegan A, Abdul-Manap R, Hofmann U, Mikus G, Kamali F. Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis. Br J Clin Pharmacol. 2001;52:35-43.
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 35-43
    • Webb, J.A.1    Rostami-Hodjegan, A.2    Abdul-Manap, R.3    Hofmann, U.4    Mikus, G.5    Kamali, F.6
  • 54
    • 1542359666 scopus 로고    scopus 로고
    • CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes
    • Hutchinson MR, Menelaou A, Foster DJ, Coller JK, Somogyi AA. CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. Br J Clin Pharmacol. 2004;57:287-297.
    • (2004) Br J Clin Pharmacol , vol.57 , pp. 287-297
    • Hutchinson, M.R.1    Menelaou, A.2    Foster, D.J.3    Coller, J.K.4    Somogyi, A.A.5
  • 55
    • 0030999676 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 2D6 metabolism of hydrocodone to hydromorphone does not importantly affect abuse liability
    • Kaplan HL, Busto UE, Baylon GJ, et al. Inhibition of cytochrome P450 2D6 metabolism of hydrocodone to hydromorphone does not importantly affect abuse liability. J Pharmacol Exp Ther. 1997;281:103-108.
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 103-108
    • Kaplan, H.L.1    Busto, U.E.2    Baylon, G.J.3
  • 56
    • 77957694829 scopus 로고    scopus 로고
    • Fatal hydrocodone overdose in a child: Pharmacogenetics and drug interactions
    • Madadi P, Hildebrandt D, Gong IY, et al. Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions. Pediatrics. 2010;126:e986-e989.
    • (2010) Pediatrics , vol.126
    • Madadi, P.1    Hildebrandt, D.2    Gong, I.Y.3
  • 57
    • 7444229920 scopus 로고    scopus 로고
    • Clinical pharmacology of tramadol
    • Grond S, Sablotzki A. Clinical pharmacology of tramadol. Clin Pharmacokinet. 2004;43:879-923.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 879-923
    • Grond, S.1    Sablotzki, A.2
  • 58
    • 29844453632 scopus 로고    scopus 로고
    • The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6
    • Enggaard TP, Poulsen L, Arendt-Nielsen L, Brosen K, Ossig J, Sindrup SH. The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6. Anesth Analg. 2006;102:146-150.
    • (2006) Anesth Analg , vol.102 , pp. 146-150
    • Enggaard, T.P.1    Poulsen, L.2    Arendt-Nielsen, L.3    Brosen, K.4    Ossig, J.5    Sindrup, S.H.6
  • 59
    • 33846598505 scopus 로고    scopus 로고
    • Pharmacokinetics of tramadol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype
    • Garcia-Quetglas E, Azanza JR, Sadaba B, Munoz MJ, Gil I, Campanero MA. Pharmacokinetics of tramadol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype. Pharmacol Res. 2007;55:122-130.
    • (2007) Pharmacol Res , vol.55 , pp. 122-130
    • Garcia-Quetglas, E.1    Azanza, J.R.2    Sadaba, B.3    Munoz, M.J.4    Gil, I.5    Campanero, M.A.6
  • 60
    • 38349163777 scopus 로고    scopus 로고
    • Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol
    • Kirchheiner J, Keulen JT, Bauer S, Roots I, Brockmoller J. Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol. J Clin Psychopharmacol. 2008;28:78-83.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. 78-83
    • Kirchheiner, J.1    Keulen, J.T.2    Bauer, S.3    Roots, I.4    Brockmoller, J.5
  • 61
    • 20444477620 scopus 로고    scopus 로고
    • Tramadol as a new probe for cytochrome P450 2D6 phenotyping: A population study
    • Pedersen RS, Damkier P, Brosen K. Tramadol as a new probe for cytochrome P450 2D6 phenotyping: a population study. Clin Pharmacol Ther. 2005;77:458-467.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 458-467
    • Pedersen, R.S.1    Damkier, P.2    Brosen, K.3
  • 62
    • 33745699160 scopus 로고    scopus 로고
    • Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers
    • Pedersen RS, Damkier P, Brosen K. Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers. Eur J Clin Pharmacol. 2006;62:513-521.
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 513-521
    • Pedersen, R.S.1    Damkier, P.2    Brosen, K.3
  • 63
    • 0141626841 scopus 로고    scopus 로고
    • Impact of CYP2D6 genotype on postoperative tramadol analgesia
    • Stamer UM, Lehnen K, Hothker F, et al. Impact of CYP2D6 genotype on postoperative tramadol analgesia. Pain. 2003;105:231-238.
    • (2003) Pain , vol.105 , pp. 231-238
    • Stamer, U.M.1    Lehnen, K.2    Hothker, F.3
  • 64
    • 34250614223 scopus 로고    scopus 로고
    • Concentrations of tramadol and O-desmethyl-tramadol enantiomers in different CYP2D6 genotypes
    • Stamer UM, Musshoff F, Kobilay M, Madea B, Hoeft A, Stuber F. Concentrations of tramadol and O-desmethyl-tramadol enantiomers in different CYP2D6 genotypes. Clin Pharmacol Ther. 2007;82:41-47.
    • (2007) Clin Pharmacol Ther , vol.82 , pp. 41-47
    • Stamer, U.M.1    Musshoff, F.2    Kobilay, M.3    Madea, B.4    Hoeft, A.5    Stuber, F.6
  • 65
    • 33750492934 scopus 로고    scopus 로고
    • Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population
    • Wang G, Zhang H, He F, Fang X. Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population. Eur J Clin Pharmacol. 2006;62:927-931.
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 927-931
    • Wang, G.1    Zhang, H.2    He, F.3    Fang, X.4
  • 66
    • 78650102389 scopus 로고    scopus 로고
    • Chronic dizziness in a pain patient - pharmacogenomic identification of tramadol as cause [German]
    • Eichhorn A, Barth J. Chronic dizziness in a pain patient - pharmacogenomic identification of tramadol as cause [German]. Rehabilitation (Stuttg). 2010;49:393-395.
    • (2010) Rehabilitation (Stuttg) , vol.49 , pp. 393-395
    • Eichhorn, A.1    Barth, J.2
  • 67
    • 79960950709 scopus 로고    scopus 로고
    • Near-fatal tramadol cardiotoxicity in a CYP2D6 ultrarapid metabolizer
    • Elkalioubie A, Allorge D, Robriquet L, et al. Near-fatal tramadol cardiotoxicity in a CYP2D6 ultrarapid metabolizer. Eur J Clin Pharmacol. 2011;67:855-858.
    • (2011) Eur J Clin Pharmacol , vol.67 , pp. 855-858
    • Elkalioubie, A.1    Allorge, D.2    Robriquet, L.3
  • 68
    • 80054783598 scopus 로고    scopus 로고
    • Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk
    • Salman S, Sy SK, Ilett KF, Page-Sharp M, Paech MJ. Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk. Eur J Clin Pharmacol. 2011;67:899-908.
    • (2011) Eur J Clin Pharmacol , vol.67 , pp. 899-908
    • Salman, S.1    Sy, S.K.2    Ilett, K.F.3    Page-Sharp, M.4    Paech, M.J.5
  • 69
    • 42149142835 scopus 로고    scopus 로고
    • Use of a sparse sampling study design to assess transfer of tramadol and its O-desmethyl metabolite into transitional breast milk
    • Ilett KF, Paech MJ, Page-Sharp M, et al. Use of a sparse sampling study design to assess transfer of tramadol and its O-desmethyl metabolite into transitional breast milk. Br J Clin Pharmacol. 2008;65:661-666.
    • (2008) Br J Clin Pharmacol , vol.65 , pp. 661-666
    • Ilett, K.F.1    Paech, M.J.2    Page-Sharp, M.3
  • 70
    • 79959375990 scopus 로고    scopus 로고
    • Genetically polymorphic OCT1: Another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol
    • Tzvetkov MV, Saadatmand AR, Lotsch J, Tegeder I, Stingl JC, Brockmoller J. Genetically polymorphic OCT1: another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol. Clin Pharmacol Ther. 2011;90:143-150.
    • (2011) Clin Pharmacol Ther , vol.90 , pp. 143-150
    • Tzvetkov, M.V.1    Saadatmand, A.R.2    Lotsch, J.3    Tegeder, I.4    Stingl, J.C.5    Brockmoller, J.6
  • 71
    • 77957268761 scopus 로고    scopus 로고
    • Glucuronidation of racemic O-desmethyl-tramadol, the active metabolite of tramadol
    • Lehtonen P, Sten T, Aitio O, et al. Glucuronidation of racemic O-desmethyl-tramadol, the active metabolite of tramadol. Eur J Pharm Sci. 2010;41:523-530.
    • (2010) Eur J Pharm Sci , vol.41 , pp. 523-530
    • Lehtonen, P.1    Sten, T.2    Aitio, O.3
  • 73
    • 33646183072 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites
    • Lalovic B, Kharasch E, Hoffer C, Risler L, Liu-Chen LY, Shen DD. Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. Clin Pharmacol Ther. 2006;79:461-479.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 461-479
    • Lalovic, B.1    Kharasch, E.2    Hoffer, C.3    Risler, L.4    Liu-Chen, L.Y.5    Shen, D.D.6
  • 74
    • 77952808783 scopus 로고    scopus 로고
    • The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone
    • Samer CF, Daali Y, Wagner M, et al. The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone. Br J Pharmacol. 2010;160:907-918.
    • (2010) Br J Pharmacol , vol.160 , pp. 907-918
    • Samer, C.F.1    Daali, Y.2    Wagner, M.3
  • 75
    • 79751502059 scopus 로고    scopus 로고
    • Effect of inhibition of cytochrome P450 enzymes 2D6 and 3A4 on the pharmacokinetics of intravenous oxycodone: A randomized, three-phase, crossover, placebo-controlled study
    • Gronlund J, Saari TI, Hagelberg NM, Neuvonen PJ, Laine K, Olkkola KT. Effect of inhibition of cytochrome P450 enzymes 2D6 and 3A4 on the pharmacokinetics of intravenous oxycodone: a randomized, three-phase, crossover, placebo-controlled study. Clin Drug Investig. 2011;31:143-153.
    • (2011) Clin Drug Investig , vol.31 , pp. 143-153
    • Gronlund, J.1    Saari, T.I.2    Hagelberg, N.M.3    Neuvonen, P.J.4    Laine, K.5    Olkkola, K.T.6
  • 76
    • 77953517945 scopus 로고    scopus 로고
    • Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone
    • Gronlund J, Saari TI, Hagelberg NM, Neuvonen PJ, Olkkola KT, Laine K. Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. Br J Clin Pharmacol. 2010;70:78-87.
    • (2010) Br J Clin Pharmacol , vol.70 , pp. 78-87
    • Gronlund, J.1    Saari, T.I.2    Hagelberg, N.M.3    Neuvonen, P.J.4    Olkkola, K.T.5    Laine, K.6
  • 77
    • 79151472756 scopus 로고    scopus 로고
    • Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone
    • Kummer O, Hammann F, Moser C, Schaller O, Drewe J, Krahenbuhl S. Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone. Eur J Clin Pharmacol. 2011;67:63-71.
    • (2011) Eur J Clin Pharmacol , vol.67 , pp. 63-71
    • Kummer, O.1    Hammann, F.2    Moser, C.3    Schaller, O.4    Drewe, J.5    Krahenbuhl, S.6
  • 78
    • 79955608886 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 3A by clarithromycin uniformly affects the pharmacokinetics and pharmacodynamics of oxycodone in young and elderly volunteers
    • Liukas A, Hagelberg NM, Kuusniemi K, Neuvonen PJ, Olkkola KT. Inhibition of cytochrome P450 3A by clarithromycin uniformly affects the pharmacokinetics and pharmacodynamics of oxycodone in young and elderly volunteers. J Clin Psychopharmacol. 2011;31:302-308.
    • (2011) J Clin Psychopharmacol , vol.31 , pp. 302-308
    • Liukas, A.1    Hagelberg, N.M.2    Kuusniemi, K.3    Neuvonen, P.J.4    Olkkola, K.T.5
  • 79
    • 77957657935 scopus 로고    scopus 로고
    • Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir
    • Nieminen TH, Hagelberg NM, Saari TI, et al. Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir. Eur J Clin Pharmacol. 2010;66:977-985.
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 977-985
    • Nieminen, T.H.1    Hagelberg, N.M.2    Saari, T.I.3
  • 80
    • 67049159390 scopus 로고    scopus 로고
    • Rifampin greatly reduces the plasma concentrations of intravenous and oral oxycodone
    • Nieminen TH, Hagelberg NM, Saari TI, et al. Rifampin greatly reduces the plasma concentrations of intravenous and oral oxycodone. Anesthesiology. 2009;110:1371-1378.
    • (2009) Anesthesiology , vol.110 , pp. 1371-1378
    • Nieminen, T.H.1    Hagelberg, N.M.2    Saari, T.I.3
  • 81
    • 72749095791 scopus 로고    scopus 로고
    • Effect of telithromycin on the pharmacokinetics and pharmacodynamics of oral oxycodone
    • Gronlund J, Saari T, Hagelberg N, et al. Effect of telithromycin on the pharmacokinetics and pharmacodynamics of oral oxycodone. J Clin Pharmacol. 2010;50:101-108.
    • (2010) J Clin Pharmacol , vol.50 , pp. 101-108
    • Gronlund, J.1    Saari, T.2    Hagelberg, N.3
  • 83
    • 60549095602 scopus 로고    scopus 로고
    • Voriconazole drastically increases exposure to oral oxycodone
    • Hagelberg NM, Nieminen TH, Saari TI, et al. Voriconazole drastically increases exposure to oral oxycodone. Eur J Clin Pharmacol. 2009;65:263-271.
    • (2009) Eur J Clin Pharmacol , vol.65 , pp. 263-271
    • Hagelberg, N.M.1    Nieminen, T.H.2    Saari, T.I.3
  • 84
    • 79960940740 scopus 로고    scopus 로고
    • Interaction of oxycodone and voriconazole - a case series of patients with cancer pain supports the findings of randomised controlled studies with healthy subjects
    • Hagelberg NM, Nieminen TH, Saari TI, et al. Interaction of oxycodone and voriconazole - a case series of patients with cancer pain supports the findings of randomised controlled studies with healthy subjects. Eur J Clin Pharmacol. 2011;67:863-864.
    • (2011) Eur J Clin Pharmacol , vol.67 , pp. 863-864
    • Hagelberg, N.M.1    Nieminen, T.H.2    Saari, T.I.3
  • 85
    • 77956057096 scopus 로고    scopus 로고
    • St John's wort greatly reduces the concentrations of oral oxycodone
    • Nieminen TH, Hagelberg NM, Saari TI, et al. St John's wort greatly reduces the concentrations of oral oxycodone. Eur J Pain. 2010;14:854-859.
    • (2010) Eur J Pain , vol.14 , pp. 854-859
    • Nieminen, T.H.1    Hagelberg, N.M.2    Saari, T.I.3
  • 86
    • 77953955145 scopus 로고    scopus 로고
    • Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone
    • Saari TI, Gronlund J, Hagelberg NM, et al. Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone. Eur J Clin Pharmacol. 2010;66:387-397.
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 387-397
    • Saari, T.I.1    Gronlund, J.2    Hagelberg, N.M.3
  • 89
    • 0030246852 scopus 로고    scopus 로고
    • Attenuation of morphine-induced delirium in palliative care by substitution with infusion of oxycodone
    • Maddocks I, Somogyi A, Abbott F, Hayball P, Parker D. Attenuation of morphine-induced delirium in palliative care by substitution with infusion of oxycodone. J Pain Symptom Manage. 1996;12:182-189.
    • (1996) J Pain Symptom Manage , vol.12 , pp. 182-189
    • Maddocks, I.1    Somogyi, A.2    Abbott, F.3    Hayball, P.4    Parker, D.5
  • 90
    • 0032436459 scopus 로고    scopus 로고
    • Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone
    • Heiskanen T, Olkkola KT, Kalso E. Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone. Clin Pharmacol Ther. 1998;64:603-611.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 603-611
    • Heiskanen, T.1    Olkkola, K.T.2    Kalso, E.3
  • 92
    • 77952869071 scopus 로고    scopus 로고
    • Genetic polymorphisms and drug interactions modulating CYP2D6 and CYP3A activities have a major effect on oxycodone analgesic efficacy and safety
    • Samer CF, Daali Y, Wagner M, et al. Genetic polymorphisms and drug interactions modulating CYP2D6 and CYP3A activities have a major effect on oxycodone analgesic efficacy and safety. Br J Pharmacol. 2010;160:919-930.
    • (2010) Br J Pharmacol , vol.160 , pp. 919-930
    • Samer, C.F.1    Daali, Y.2    Wagner, M.3
  • 93
    • 62549125960 scopus 로고    scopus 로고
    • The hypoalgesic effect of oxycodone in human experimental pain models in relation to the CYP2D6 oxidation polymorphism
    • Zwisler ST, Enggaard TP, Noehr-Jensen L, et al. The hypoalgesic effect of oxycodone in human experimental pain models in relation to the CYP2D6 oxidation polymorphism. Basic Clin Pharmacol Toxicol. 2009;104:335-344.
    • (2009) Basic Clin Pharmacol Toxicol , vol.104 , pp. 335-344
    • Zwisler, S.T.1    Enggaard, T.P.2    Noehr-Jensen, L.3
  • 95
    • 84857045805 scopus 로고    scopus 로고
    • Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study
    • Andreassen TN, Eftedal I, Klepstad P, et al. Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study. Eur J Clin Pharmacol. 2012;68:55-64.
    • (2012) Eur J Clin Pharmacol , vol.68 , pp. 55-64
    • Andreassen, T.N.1    Eftedal, I.2    Klepstad, P.3
  • 96
    • 77951251693 scopus 로고    scopus 로고
    • Methadone maintenance dosing guideline for opioid dependence, a literature review
    • Fareed A, Casarella J, Amar R, Vayalapalli S, Drexler K. Methadone maintenance dosing guideline for opioid dependence, a literature review. J Addict Dis. 2010;29:1-14.
    • (2010) J Addict Dis , vol.29 , pp. 1-14
    • Fareed, A.1    Casarella, J.2    Amar, R.3    Vayalapalli, S.4    Drexler, K.5
  • 97
    • 44449128180 scopus 로고    scopus 로고
    • Consensus guideline on parenteral methadone use in pain and palliative care
    • Shaiova L, Berger A, Blinderman CD, et al. Consensus guideline on parenteral methadone use in pain and palliative care. Palliat Support Care. 2008;6:165-176.
    • (2008) Palliat Support Care , vol.6 , pp. 165-176
    • Shaiova, L.1    Berger, A.2    Blinderman, C.D.3
  • 99
    • 77950973210 scopus 로고    scopus 로고
    • Substitution of (R,S)-methadone by (R)-methadone: Impact on QTc interval
    • Ansermot N, Albayrak O, Schlapfer J, et al. Substitution of (R,S)-methadone by (R)-methadone: impact on QTc interval. Arch Intern Med. 2010;170:529-536.
    • (2010) Arch Intern Med , vol.170 , pp. 529-536
    • Ansermot, N.1    Albayrak, O.2    Schlapfer, J.3
  • 100
    • 84921704680 scopus 로고    scopus 로고
    • Opioid switching to improve pain relief and drug tolerability
    • CD004847
    • Quigley C. Opioid switching to improve pain relief and drug tolerability. Cochrane Database Syst Rev. 2004;(3):CD004847.
    • (2004) Cochrane Database Syst Rev , Issue.3
    • Quigley, C.1
  • 101
    • 33847686540 scopus 로고    scopus 로고
    • Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone
    • Coller JK, Joergensen C, Foster DJ, et al. Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone. Int J Clin Pharmacol Ther. 2007;45:410-417.
    • (2007) Int J Clin Pharmacol Ther , vol.45 , pp. 410-417
    • Coller, J.K.1    Joergensen, C.2    Foster, D.J.3
  • 102
    • 33845533592 scopus 로고    scopus 로고
    • ABCB1 and cytochrome P450 genotypes and phenotypes: Influence on methadone plasma levels and response to treatment
    • Crettol S, Deglon JJ, Besson J, et al. ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment. Clin Pharmacol Ther. 2006;80:668-681.
    • (2006) Clin Pharmacol Ther , vol.80 , pp. 668-681
    • Crettol, S.1    Deglon, J.J.2    Besson, J.3
  • 103
    • 79955939841 scopus 로고    scopus 로고
    • Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response
    • Fonseca F, de la Torre R, Diaz L, et al. Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response. PloS One. 2011;6:e19527.
    • (2011) PloS One , vol.6
    • Fonseca, F.1    de la Torre, R.2    Diaz, L.3
  • 104
    • 58149129287 scopus 로고    scopus 로고
    • Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment
    • Shiran MR, Lennard MS, Iqbal MZ, et al. Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment. Br J Clin Pharmacol. 2009;67:29-37.
    • (2009) Br J Clin Pharmacol , vol.67 , pp. 29-37
    • Shiran, M.R.1    Lennard, M.S.2    Iqbal, M.Z.3
  • 105
  • 106
    • 46349104685 scopus 로고    scopus 로고
    • ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence
    • Levran O, O'Hara K, Peles E, et al. ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence. Hum Mol Genet. 2008;17:2219-2227.
    • (2008) Hum Mol Genet , vol.17 , pp. 2219-2227
    • Levran, O.1    O'Hara, K.2    Peles, E.3
  • 109
    • 84866548954 scopus 로고    scopus 로고
    • CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction
    • July 25, 2011
    • Levran O, Peles E, Hamon S, Randesi M, Adelson M, Kreek MJ. CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction. Addict Biol. Epub July 25, 2011.
    • Addict Biol. Epub
    • Levran, O.1    Peles, E.2    Hamon, S.3    Randesi, M.4    Adelson, M.5    Kreek, M.J.6
  • 110
    • 79960598589 scopus 로고    scopus 로고
    • CYP2B6 polymorphisms influence the plasma concentration and clearance of the methadone S-enantiomer
    • Wang SC, Ho IK, Tsou HH, et al. CYP2B6 polymorphisms influence the plasma concentration and clearance of the methadone S-enantiomer. J Clin Psychopharmacol. 2011;31:463-469.
    • (2011) J Clin Psychopharmacol , vol.31 , pp. 463-469
    • Wang, S.C.1    Ho, I.K.2    Tsou, H.H.3
  • 112
    • 0038637894 scopus 로고    scopus 로고
    • Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations
    • Tan EC, Tan CH, Karupathivan U, Yap EP. Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations. Neuroreport. 2003;14:569-572.
    • (2003) Neuroreport , vol.14 , pp. 569-572
    • Tan, E.C.1    Tan, C.H.2    Karupathivan, U.3    Yap, E.P.4
  • 113
    • 0041331546 scopus 로고    scopus 로고
    • A genetic association study of the mu opioid receptor and severe opioid dependence
    • Crowley JJ, Oslin DW, Patkar AA, et al. A genetic association study of the mu opioid receptor and severe opioid dependence. Psychiatr Genet. 2003;13:169-173.
    • (2003) Psychiatr Genet , vol.13 , pp. 169-173
    • Crowley, J.J.1    Oslin, D.W.2    Patkar, A.A.3
  • 114
    • 34548653719 scopus 로고    scopus 로고
    • The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor
    • Kroslak T, Laforge KS, Gianotti RJ, Ho A, Nielsen DA, Kreek MJ. The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. J Neurochem. 2007;103:77-87.
    • (2007) J Neurochem , vol.103 , pp. 77-87
    • Kroslak, T.1    Laforge, K.S.2    Gianotti, R.J.3    Ho, A.4    Nielsen, D.A.5    Kreek, M.J.6
  • 115
    • 13144261678 scopus 로고    scopus 로고
    • Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction
    • Bond C, LaForge KS, Tian M, et al. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci U S A. 1998;95:9608-9613.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 9608-9613
    • Bond, C.1    Laforge, K.S.2    Tian, M.3
  • 116
    • 25444491710 scopus 로고    scopus 로고
    • Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G
    • Zhang Y, Wang D, Johnson AD, Papp AC, Sadee W. Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J Biol Chem. 2005;280:32618-32624.
    • (2005) J Biol Chem , vol.280 , pp. 32618-32624
    • Zhang, Y.1    Wang, D.2    Johnson, A.D.3    Papp, A.C.4    Sadee, W.5
  • 117
    • 2042527666 scopus 로고    scopus 로고
    • Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor
    • Beyer A, Koch T, Schroder H, Schulz S, Hollt V. Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor. J Neurochem. 2004;89:553-560.
    • (2004) J Neurochem , vol.89 , pp. 553-560
    • Beyer, A.1    Koch, T.2    Schroder, H.3    Schulz, S.4    Hollt, V.5
  • 118
    • 65249146144 scopus 로고    scopus 로고
    • A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain
    • Oertel BG, Kettner M, Scholich K, et al. A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain. J Biol Chem. 2009;284:6530-6535.
    • (2009) J Biol Chem , vol.284 , pp. 6530-6535
    • Oertel, B.G.1    Kettner, M.2    Scholich, K.3
  • 119
    • 80055014810 scopus 로고    scopus 로고
    • Pharmacological consequence of the A118G mu opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca(2) channels in humanized mouse sensory neurons
    • Mahmoud S, Thorsell A, Sommer WH, et al. Pharmacological consequence of the A118G mu opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca(2) channels in humanized mouse sensory neurons. Anesthesiology. 2011;115:1054-1062.
    • (2011) Anesthesiology , vol.115 , pp. 1054-1062
    • Mahmoud, S.1    Thorsell, A.2    Sommer, W.H.3
  • 120
    • 14944361565 scopus 로고    scopus 로고
    • The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans
    • Fillingim RB, Kaplan L, Staud R, et al. The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. J Pain. 2005;6:159-167.
    • (2005) J Pain , vol.6 , pp. 159-167
    • Fillingim, R.B.1    Kaplan, L.2    Staud, R.3
  • 121
    • 58149263474 scopus 로고    scopus 로고
    • Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females
    • Huang CJ, Liu HF, Su NY, et al. Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females. Anaesthesia. 2008;63:1288-1295.
    • (2008) Anaesthesia , vol.63 , pp. 1288-1295
    • Huang, C.J.1    Liu, H.F.2    Su, N.Y.3
  • 122
    • 78149456950 scopus 로고    scopus 로고
    • The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status
    • Vossen H, Kenis G, Rutten B, van Os J, Hermens H, Lousberg R. The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status. PloS One. 2010;5:e13641.
    • (2010) PloS One , vol.5
    • Vossen, H.1    Kenis, G.2    Rutten, B.3    van Os, J.4    Hermens, H.5    Lousberg, R.6
  • 123
    • 77954398116 scopus 로고    scopus 로고
    • The antinociceptive effect and adverse drug reactions of oxycodone in human experimental pain in relation to genetic variations in the OPRM1 and ABCB1 genes
    • Zwisler ST, Enggaard TP, Noehr-Jensen L, et al. The antinociceptive effect and adverse drug reactions of oxycodone in human experimental pain in relation to genetic variations in the OPRM1 and ABCB1 genes. Fundam Clin Pharmacol. 2010;24:517-524.
    • (2010) Fundam Clin Pharmacol , vol.24 , pp. 517-524
    • Zwisler, S.T.1    Enggaard, T.P.2    Noehr-Jensen, L.3
  • 124
    • 51549101026 scopus 로고    scopus 로고
    • Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women
    • Landau R, Kern C, Columb MO, Smiley RM, Blouin JL. Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women. Pain. 2008;139:5-14.
    • (2008) Pain , vol.139 , pp. 5-14
    • Landau, R.1    Kern, C.2    Columb, M.O.3    Smiley, R.M.4    Blouin, J.L.5
  • 125
    • 77952007675 scopus 로고    scopus 로고
    • Observational study of the effect of mu-opioid receptor genetic polymorphism on intrathecal opioid labor analgesia and post-cesarean delivery analgesia
    • Wong CA, McCarthy RJ, Blouin J, Landau R. Observational study of the effect of mu-opioid receptor genetic polymorphism on intrathecal opioid labor analgesia and post-cesarean delivery analgesia. Int J Obstet Anesth. 2010;19:246-253.
    • (2010) Int J Obstet Anesth , vol.19 , pp. 246-253
    • Wong, C.A.1    McCarthy, R.J.2    Blouin, J.3    Landau, R.4
  • 126
    • 84855830042 scopus 로고    scopus 로고
    • Effect of mu-opioid receptor A118G polymorphism on the ED50 of epidural sufentanil for labor analgesia
    • Camorcia M, Capogna G, Stirparo S, Berritta C, Blouin JL, Landau R. Effect of mu-opioid receptor A118G polymorphism on the ED50 of epidural sufentanil for labor analgesia. Int J Obstet Anesth. 2012;21:40-44.
    • (2012) Int J Obstet Anesth , vol.21 , pp. 40-44
    • Camorcia, M.1    Capogna, G.2    Stirparo, S.3    Berritta, C.4    Blouin, J.L.5    Landau, R.6
  • 127
    • 52649103910 scopus 로고    scopus 로고
    • A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia
    • Sia AT, Lim Y, Lim EC, et al. A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia. Anesthesiology. 2008;109:520-526.
    • (2008) Anesthesiology , vol.109 , pp. 520-526
    • Sia, A.T.1    Lim, Y.2    Lim, E.C.3
  • 128
    • 49849099129 scopus 로고    scopus 로고
    • Ethnic differences in pain perception and patient-controlled analgesia usage for postoperative pain
    • Tan EC, Lim Y, Teo YY, Goh R, Law HY, Sia AT. Ethnic differences in pain perception and patient-controlled analgesia usage for postoperative pain. J Pain. 2008;9:849-855.
    • (2008) J Pain , vol.9 , pp. 849-855
    • Tan, E.C.1    Lim, Y.2    Teo, Y.Y.3    Goh, R.4    Law, H.Y.5    Sia, A.T.6
  • 129
    • 67651009389 scopus 로고    scopus 로고
    • Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain
    • Tan EC, Lim EC, Teo YY, Lim Y, Law HY, Sia AT. Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain. Mol Pain. 2009;5:32.
    • (2009) Mol Pain , vol.5 , pp. 32
    • Tan, E.C.1    Lim, E.C.2    Teo, Y.Y.3    Lim, Y.4    Law, H.Y.5    Sia, A.T.6
  • 130
    • 33746603524 scopus 로고    scopus 로고
    • One size does not fit all: Genetic variability of mu-opioid receptor and postoperative morphine consumption
    • Landau R. One size does not fit all: genetic variability of mu-opioid receptor and postoperative morphine consumption. Anesthesiology. 2006;105:235-237.
    • (2006) Anesthesiology , vol.105 , pp. 235-237
    • Landau, R.1
  • 131
    • 79961091158 scopus 로고    scopus 로고
    • Challenges in interpreting joined allelic combinations of OPRM1 and COMT genes
    • Landau R, Ortner C, Carvalho B. Challenges in interpreting joined allelic combinations of OPRM1 and COMT genes. Anesth Analg. 2011;113:432.
    • (2011) Anesth Analg , vol.113 , pp. 432
    • Landau, R.1    Ortner, C.2    Carvalho, B.3
  • 132
    • 33746608902 scopus 로고    scopus 로고
    • Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy
    • Chou WY, Wang CH, Liu PH, Liu CC, Tseng CC, Jawan B. Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy. Anesthesiology. 2006;105:334-337.
    • (2006) Anesthesiology , vol.105 , pp. 334-337
    • Chou, W.Y.1    Wang, C.H.2    Liu, P.H.3    Liu, C.C.4    Tseng, C.C.5    Jawan, B.6
  • 133
    • 33745813212 scopus 로고    scopus 로고
    • Association of mu-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty
    • Chou WY, Yang LC, Lu HF, et al. Association of mu-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty. Acta Anaesthesiol Scand. 2006;50:787-792.
    • (2006) Acta Anaesthesiol Scand , vol.50 , pp. 787-792
    • Chou, W.Y.1    Yang, L.C.2    Lu, H.F.3
  • 134
    • 33646116562 scopus 로고    scopus 로고
    • Environmental and genetic factors associated with morphine response in the postoperative period
    • Coulbault L, Beaussier M, Verstuyft C, et al. Environmental and genetic factors associated with morphine response in the postoperative period. Clin Pharmacol Ther. 2006;79:316-324.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 316-324
    • Coulbault, L.1    Beaussier, M.2    Verstuyft, C.3
  • 135
    • 79251624059 scopus 로고    scopus 로고
    • Combined catechol-O-methyltransferase and mu-opioid receptor gene polymorphisms affect morphine postoperative analgesia and central side effects
    • Kolesnikov Y, Gabovits B, Levin A, Voiko E, Veske A. Combined catechol-O-methyltransferase and mu-opioid receptor gene polymorphisms affect morphine postoperative analgesia and central side effects. Anesth Analg. 2011;112:448-453.
    • (2011) Anesth Analg , vol.112 , pp. 448-453
    • Kolesnikov, Y.1    Gabovits, B.2    Levin, A.3    Voiko, E.4    Veske, A.5
  • 136
    • 73449088010 scopus 로고    scopus 로고
    • Association of human micro-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients
    • Zhang W, Chang YZ, Kan QC, et al. Association of human micro-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients. Anaesthesia. 2010;65:130-135.
    • (2010) Anaesthesia , vol.65 , pp. 130-135
    • Zhang, W.1    Chang, Y.Z.2    Kan, Q.C.3
  • 137
    • 82655170374 scopus 로고    scopus 로고
    • Diversity of opioid requirements for postoperative pain control following oral surgery - is it affected by polymorphism of the mu-opioid receptor?
    • Fukuda K, Hayashida M, Ikeda K, Koukita Y, Ichinohe T, Kaneko Y. Diversity of opioid requirements for postoperative pain control following oral surgery - is it affected by polymorphism of the mu-opioid receptor? Anesth Prog. 2010;57:145-149.
    • (2010) Anesth Prog , vol.57 , pp. 145-149
    • Fukuda, K.1    Hayashida, M.2    Ikeda, K.3    Koukita, Y.4    Ichinohe, T.5    Kaneko, Y.6
  • 138
    • 70449685767 scopus 로고    scopus 로고
    • Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery
    • Fukuda K, Hayashida M, Ide S, et al. Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery. Pain. 2009;147:194-201.
    • (2009) Pain , vol.147 , pp. 194-201
    • Fukuda, K.1    Hayashida, M.2    Ide, S.3
  • 139
    • 70349678381 scopus 로고    scopus 로고
    • Polymorphism of the micro-opioid receptor gene (OPRM1 118 A. G) affects fentanyl-induced analgesia during anesthesia and recovery
    • Wu WD, Wang Y, Fang YM, Zhou HY. Polymorphism of the micro-opioid receptor gene (OPRM1 118 A. G) affects fentanyl-induced analgesia during anesthesia and recovery. Mol Diagn Ther. 2009;13:331-337.
    • (2009) Mol Diagn Ther , vol.13 , pp. 331-337
    • Wu, W.D.1    Wang, Y.2    Fang, Y.M.3    Zhou, H.Y.4
  • 140
    • 79951495474 scopus 로고    scopus 로고
    • Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanyl intravenous analgesia
    • Zhang W, Yuan JJ, Kan QC, Zhang LR, Chang YZ, Wang ZY. Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanyl intravenous analgesia. Minerva Anestesiol. 2011;77:33-39.
    • (2011) Minerva Anestesiol , vol.77 , pp. 33-39
    • Zhang, W.1    Yuan, J.J.2    Kan, Q.C.3    Zhang, L.R.4    Chang, Y.Z.5    Wang, Z.Y.6
  • 141
    • 69049108798 scopus 로고    scopus 로고
    • Mu-opioid receptor (A118G) single-nucleotide polymorphism affects alfentanil requirements for extracorporeal shock wave lithotripsy: A pharmacokinetic-pharmacodynamic study
    • Ginosar Y, Davidson EM, Meroz Y, Blotnick S, Shacham M, Caraco Y. Mu-opioid receptor (A118G) single-nucleotide polymorphism affects alfentanil requirements for extracorporeal shock wave lithotripsy: a pharmacokinetic-pharmacodynamic study. Br J Anaesth. 2009;103:420-427.
    • (2009) Br J Anaesth , vol.103 , pp. 420-427
    • Ginosar, Y.1    Davidson, E.M.2    Meroz, Y.3    Blotnick, S.4    Shacham, M.5    Caraco, Y.6
  • 142
    • 8544257029 scopus 로고    scopus 로고
    • The 118 A. G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease
    • Klepstad P, Rakvag TT, Kaasa S, et al. The 118 A. G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol Scand. 2004;48:1232-1239.
    • (2004) Acta Anaesthesiol Scand , vol.48 , pp. 1232-1239
    • Klepstad, P.1    Rakvag, T.T.2    Kaasa, S.3
  • 143
    • 40949150784 scopus 로고    scopus 로고
    • Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief
    • Campa D, Gioia A, Tomei A, Poli P, Barale R. Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief. Clin Pharmacol Ther. 2008;83:559-566.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 559-566
    • Campa, D.1    Gioia, A.2    Tomei, A.3    Poli, P.4    Barale, R.5
  • 144
    • 34249794271 scopus 로고    scopus 로고
    • Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene
    • Reyes-Gibby CC, Shete S, Rakvag T, et al. Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain. 2007;130:25-30.
    • (2007) Pain , vol.130 , pp. 25-30
    • Reyes-Gibby, C.C.1    Shete, S.2    Rakvag, T.3
  • 145
    • 79954583889 scopus 로고    scopus 로고
    • Influence from genetic variability on opioid use for cancer pain: A European genetic association study of 2294 cancer pain patients
    • Klepstad P, Fladvad T, Skorpen F, et al. Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients. Pain. 2011;152:1139-1145.
    • (2011) Pain , vol.152 , pp. 1139-1145
    • Klepstad, P.1    Fladvad, T.2    Skorpen, F.3
  • 146
    • 70149109673 scopus 로고    scopus 로고
    • Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers
    • Lotsch J, von Hentig N, Freynhagen R, et al. Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers. Pharmacogenet Genomics. 2009;19:429-436.
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 429-436
    • Lotsch, J.1    von Hentig, N.2    Freynhagen, R.3
  • 147
    • 80052773921 scopus 로고    scopus 로고
    • COMT genetic variants and pain
    • Belfer I, Segall S. COMT genetic variants and pain. Drugs Today (Barc). 2011;47:457-467.
    • (2011) Drugs Today (Barc) , vol.47 , pp. 457-467
    • Belfer, I.1    Segall, S.2
  • 149
    • 67650308690 scopus 로고    scopus 로고
    • Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism
    • Jensen KB, Lonsdorf TB, Schalling M, Kosek E, Ingvar M. Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism. PloS One. 2009;4:e6016.
    • (2009) PloS One , vol.4
    • Jensen, K.B.1    Lonsdorf, T.B.2    Schalling, M.3    Kosek, E.4    Ingvar, M.5
  • 150
    • 33750028470 scopus 로고    scopus 로고
    • Warriors versus worriers: The role of COMT gene variants
    • Stein DJ, Newman TK, Savitz J, Ramesar R. Warriors versus worriers: the role of COMT gene variants. CNS Spectr. 2006;11:745-748.
    • (2006) CNS Spectr , vol.11 , pp. 745-748
    • Stein, D.J.1    Newman, T.K.2    Savitz, J.3    Ramesar, R.4
  • 151
    • 33750697663 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
    • Diatchenko L, Nackley AG, Slade GD, et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain. 2006;125:216-224.
    • (2006) Pain , vol.125 , pp. 216-224
    • Diatchenko, L.1    Nackley, A.G.2    Slade, G.D.3
  • 152
    • 0037458277 scopus 로고    scopus 로고
    • COMT val158 met genotype affects mu-opioid neurotransmitter responses to a pain stressor
    • Zubieta JK, Heitzeg MM, Smith YR, et al. COMT val158 met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science. 2003;299:1240-1243.
    • (2003) Science , vol.299 , pp. 1240-1243
    • Zubieta, J.K.1    Heitzeg, M.M.2    Smith, Y.R.3
  • 153
    • 66849104583 scopus 로고    scopus 로고
    • Variation in the COMT gene: Implications for pain perception and pain treatment
    • Andersen S, Skorpen F. Variation in the COMT gene: implications for pain perception and pain treatment. Pharmacogenomics. 2009;10: 669-684.
    • (2009) Pharmacogenomics , vol.10 , pp. 669-684
    • Andersen, S.1    Skorpen, F.2
  • 154
    • 33847616664 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors
    • Nackley AG, Tan KS, Fecho K, Flood P, Diatchenko L, Maixner W. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain. 2007;128:199-208.
    • (2007) Pain , vol.128 , pp. 199-208
    • Nackley, A.G.1    Tan, K.S.2    Fecho, K.3    Flood, P.4    Diatchenko, L.5    Maixner, W.6
  • 155
    • 77950678456 scopus 로고    scopus 로고
    • Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: A randomized, double-blind, placebo-controlled, crossover pilot study
    • Tchivileva IE, Lim PF, Smith SB, et al. Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study. Pharmacogenet Genomics. 2010;20:239-248.
    • (2010) Pharmacogenet Genomics , vol.20 , pp. 239-248
    • Tchivileva, I.E.1    Lim, P.F.2    Smith, S.B.3
  • 156
    • 81455127299 scopus 로고    scopus 로고
    • The catechol-O-methyltransferase (COMT) val158 met polymorphism affects brain responses to repeated painful stimuli
    • Loggia ML, Jensen K, Gollub RL, Wasan AD, Edwards RR, Kong J. The catechol-O-methyltransferase (COMT) val158 met polymorphism affects brain responses to repeated painful stimuli. PloS One. 2011;6:e27764.
    • (2011) PloS One , vol.6
    • Loggia, M.L.1    Jensen, K.2    Gollub, R.L.3    Wasan, A.D.4    Edwards, R.R.5    Kong, J.6
  • 157
    • 70350620288 scopus 로고    scopus 로고
    • Meta-analysis of the relevance of the OPRM1 118A. G genetic variant for pain treatment
    • Walter C, Lotsch J. Meta-analysis of the relevance of the OPRM1 118A. G genetic variant for pain treatment. Pain. 2009;146:270-275.
    • (2009) Pain , vol.146 , pp. 270-275
    • Walter, C.1    Lotsch, J.2
  • 158
    • 67449138597 scopus 로고    scopus 로고
    • Genetic contributions to clinical pain and analgesia: Avoiding pitfalls in genetic research
    • Kim H, Clark D, Dionne RA. Genetic contributions to clinical pain and analgesia: avoiding pitfalls in genetic research. J Pain. 2009;10:663-693.
    • (2009) J Pain , vol.10 , pp. 663-693
    • Kim, H.1    Clark, D.2    Dionne, R.A.3
  • 159
    • 65549163464 scopus 로고    scopus 로고
    • Genome-wide association study of acute post-surgical pain in humans
    • Kim H, Ramsay E, Lee H, Wahl S, Dionne RA. Genome-wide association study of acute post-surgical pain in humans. Pharmacogenomics. 2009;10:171-179.
    • (2009) Pharmacogenomics , vol.10 , pp. 171-179
    • Kim, H.1    Ramsay, E.2    Lee, H.3    Wahl, S.4    Dionne, R.A.5
  • 160
    • 73949111798 scopus 로고    scopus 로고
    • A clinical trial of gene therapy for chronic pain
    • Wolfe D, Wechuck J, Krisky D, Mata M, Fink DJ. A clinical trial of gene therapy for chronic pain. Pain Med. 2009;10:1325-1330.
    • (2009) Pain Med , vol.10 , pp. 1325-1330
    • Wolfe, D.1    Wechuck, J.2    Krisky, D.3    Mata, M.4    Fink, D.J.5
  • 161
    • 64549107536 scopus 로고    scopus 로고
    • Gene therapy for pain: Introduction to the special issue
    • Glorioso JC, Fink DJ. Gene therapy for pain: introduction to the special issue. Gene Ther. 2009;16:453-454.
    • (2009) Gene Ther , vol.16 , pp. 453-454
    • Glorioso, J.C.1    Fink, D.J.2
  • 162
    • 80051551575 scopus 로고    scopus 로고
    • Gene therapy for pain: Results of a phase I clinical trial
    • Fink DJ, Wechuck J, Mata M, et al. Gene therapy for pain: results of a phase I clinical trial. Ann Neurol. 2011;70:207-212.
    • (2011) Ann Neurol , vol.70 , pp. 207-212
    • Fink, D.J.1    Wechuck, J.2    Mata, M.3


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