-
1
-
-
79951809825
-
CPIC: Clinical pharmacogenetics implementation consortium of the pharmacogenomics research network
-
Relling, M.V. & Klein, T.E. CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network. Clin. Pharmacol. Ther. 89, 464-467 (2011).
-
(2011)
Clin. Pharmacol. Ther.
, vol.89
, pp. 464-467
-
-
Relling, M.V.1
Klein, T.E.2
-
2
-
-
33749339075
-
Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
-
Hulot, J.S. et al. Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood 108, 2244-2247 (2006).
-
(2006)
Blood
, vol.108
, pp. 2244-2247
-
-
Hulot, J.S.1
-
3
-
-
36348943475
-
Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
-
DOI 10.1111/j.1538-7836.2007.02775.x
-
Brandt, J.T. et al. Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J. Thromb. Haemost. 5, 2429-2436 (2007). (Pubitemid 350154353)
-
(2007)
Journal of Thrombosis and Haemostasis
, vol.5
, Issue.12
, pp. 2429-2436
-
-
Brandt, J.T.1
Close, S.L.2
Iturria, S.J.3
Payne, C.D.4
Farid, N.A.5
Ernest, C.S.6
Lachno, D.R.7
Salazar, D.8
Winters, K.J.9
-
4
-
-
47649111604
-
The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects
-
DOI 10.1111/j.1538-7836.2008.03050.x
-
Umemura, K., Furuta, T. & Kondo, K. The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects. J. Thromb. Haemost. 6, 1439-1441 (2008). (Pubitemid 352016331)
-
(2008)
Journal of Thrombosis and Haemostasis
, vol.6
, Issue.8
, pp. 1439-1441
-
-
Umemura, K.1
Furuta, T.2
Kondo, K.3
-
5
-
-
58249135635
-
Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: A cohort study
-
Collet, J.P. et al. Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study. Lancet 373, 309-317 (2009).
-
(2009)
Lancet
, vol.373
, pp. 309-317
-
-
Collet, J.P.1
-
6
-
-
58749094444
-
Cytochrome p-450 polymorphisms and response to clopidogrel
-
Mega, J.L. et al. Cytochrome p-450 polymorphisms and response to clopidogrel. N. Engl. J. Med. 360, 354-362 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 354-362
-
-
Mega, J.L.1
-
7
-
-
69249219296
-
Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
-
Shuldiner, A.R. et al. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA 302, 849-857 (2009).
-
(2009)
JAMA
, vol.302
, pp. 849-857
-
-
Shuldiner, A.R.1
-
8
-
-
67949120411
-
The CYP2C19*17 allele is associated with better platelet response to clopidogrel in patients admitted for non-ST acute coronary syndrome
-
Frére, C., Cuisset, T., Gaborit, B., Alessi, M.C. & Hulot, J.S. The CYP2C19*17 allele is associated with better platelet response to clopidogrel in patients admitted for non-ST acute coronary syndrome. J. Thromb. Haemost. 7, 1409-1411 (2009).
-
(2009)
J. Thromb. Haemost.
, vol.7
, pp. 1409-1411
-
-
Frére, C.1
Cuisset, T.2
Gaborit, B.3
Alessi, M.C.4
Hulot, J.S.5
-
9
-
-
77955416969
-
Isolated and interactive impact of common CYP2C19 genetic variants on the antiplatelet effect of chronic clopidogrel therapy
-
Sibbing, D. et al. Isolated and interactive impact of common CYP2C19 genetic variants on the antiplatelet effect of chronic clopidogrel therapy. J. Thromb. Haemost. 8, 1685-1693 (2010).
-
(2010)
J. Thromb. Haemost.
, vol.8
, pp. 1685-1693
-
-
Sibbing, D.1
-
10
-
-
77956353400
-
Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events
-
Tiroch, K.A. et al. Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events. Am. Heart J. 160, 506-512 (2010).
-
(2010)
Am. Heart J.
, vol.160
, pp. 506-512
-
-
Tiroch, K.A.1
-
11
-
-
76349098199
-
Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
-
Sibbing, D. et al. Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement. Circulation 121, 512-518 (2010).
-
(2010)
Circulation
, vol.121
, pp. 512-518
-
-
Sibbing, D.1
-
12
-
-
55449137355
-
CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation
-
Geisler, T. et al. CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation. Pharmacogenomics 9, 1251-1259 (2008).
-
(2008)
Pharmacogenomics
, vol.9
, pp. 1251-1259
-
-
Geisler, T.1
-
13
-
-
58749090547
-
Genetic determinants of response to clopidogrel and cardiovascular events
-
French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators
-
Simon, T. et al.; French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators. Genetic determinants of response to clopidogrel and cardiovascular events. N. Engl. J. Med. 360, 363-375 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 363-375
-
-
Simon, T.1
-
14
-
-
78651239845
-
Paraoxonase-1 is a major determinant of clopidogrel efficacy
-
Bouman, H.J. et al. Paraoxonase-1 is a major determinant of clopidogrel efficacy. Nat. Med. 17, 110-116 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 110-116
-
-
Bouman, H.J.1
-
15
-
-
45249088224
-
The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: A possible mechanism for clopidogrel resistance
-
Kim, K.A., Park, P.W., Hong, S.J. & Park, J.Y. The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: a possible mechanism for clopidogrel resistance. Clin. Pharmacol. Ther. 84, 236-242 (2008).
-
(2008)
Clin. Pharmacol. Ther.
, vol.84
, pp. 236-242
-
-
Kim, K.A.1
Park, P.W.2
Hong, S.J.3
Park, J.Y.4
-
16
-
-
61349191612
-
Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis
-
Giusti, B. et al. Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis. Am. J. Cardiol. 103, 806-811 (2009).
-
(2009)
Am. J. Cardiol.
, vol.103
, pp. 806-811
-
-
Giusti, B.1
-
17
-
-
65249145201
-
Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention
-
S ibbing, D. et al. Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention. Eur. Heart J. 30, 916-922 (2009).
-
(2009)
Eur. Heart J.
, vol.30
, pp. 916-922
-
-
Sibbing, D.1
-
18
-
-
78049326068
-
Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis
-
Mega, J.L. et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. JAMA 304, 1821-1830 (2010).
-
(2010)
JAMA
, vol.304
, pp. 1821-1830
-
-
Mega, J.L.1
-
19
-
-
78049433100
-
Effects of CYP2C19 genotype on outcomes of clopidogrel treatment
-
Paré, G. et al. Effects of CYP2C19 genotype on outcomes of clopidogrel treatment. N. Engl. J. Med. 363, 1704-1714 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 1704-1714
-
-
Paré, G.1
-
20
-
-
77958100874
-
Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLAT O trial
-
PLAT O investigators
-
Wallentin, L. et al.; PLAT O investigators. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLAT O trial. Lancet 376, 1320-1328 (2010).
-
(2010)
Lancet
, vol.376
, pp. 1320-1328
-
-
Wallentin, L.1
-
21
-
-
77955638355
-
ACCF/AHA clopidogrel clinical alert: Approaches to the FDA "boxed warning": A report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents and the American Heart Association endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons
-
Holmes, D.R. Jr, Dehmer, G.J., Kaul, S., Leifer, D., O'Gara, P.T. & Stein, C.M. ACCF/AHA clopidogrel clinical alert: approaches to the FDA "boxed warning": a report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents and the American Heart Association endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. J. Am. Coll. Cardiol. 56, 321-341 (2010).
-
(2010)
J. Am. Coll. Cardiol.
, vol.56
, pp. 321-341
-
-
Holmes Jr., D.R.1
Dehmer, G.J.2
Kaul, S.3
Leifer, D.4
O'Gara, P.T.5
Stein, C.M.6
-
22
-
-
36148983750
-
Prasugrel versus clopidogrel in patients with acute coronary syndromes
-
DOI 10.1056/NEJMoa0706482
-
Wiviott, S.D. et al.; TRITON-TIMI 38 Investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 357, 2001-2015 (2007). (Pubitemid 350106708)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.20
, pp. 2001-2015
-
-
Wiviott, S.D.1
Braunwald, E.2
McCabe, C.H.3
Montalescot, G.4
Ruzyllo, W.5
Gottlieb, S.6
Neumann, F.-J.7
Ardissino, D.8
De Servi, S.9
Murphy, S.A.10
Riesmeyer, J.11
Weerakkody, G.12
Gibson, C.M.13
Antman, E.M.14
-
23
-
-
70149101223
-
Ticagrelor versus clopidogrel in patients with acute coronary syndromes
-
PLAT O Investigators
-
Wallentin, L. et al.; PLAT O Investigators. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 361, 1045-1057 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1045-1057
-
-
Wallentin, L.1
-
24
-
-
77958567291
-
Prasugrel vs. clopidogrel for cytochrome P450 2C19-genotyped subgroups: Integration of the TRITON-TIMI 38 trial data
-
Sorich, M.J., Vitry, A., Ward, M.B., Horowitz, J.D. & McKinnon, R.A. Prasugrel vs. clopidogrel for cytochrome P450 2C19-genotyped subgroups: integration of the TRITON-TIMI 38 trial data. J. Thromb. Haemost. 8, 1678-1684 (2010).
-
(2010)
J. Thromb. Haemost.
, vol.8
, pp. 1678-1684
-
-
Sorich, M.J.1
Vitry, A.2
Ward, M.B.3
Horowitz, J.D.4
McKinnon, R.A.5
-
25
-
-
37849002889
-
Prasugrel achieves greater and faster P2Y12receptormediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease
-
Wallentin, L. et al. Prasugrel achieves greater and faster P2Y12receptormediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease. Eur. Heart J. 29, 21-30 (2008).
-
(2008)
Eur. Heart J.
, vol.29
, pp. 21-30
-
-
Wallentin, L.1
-
26
-
-
66349133650
-
Cytochrome P450 genetic polymorphisms and the response to prasugrel: Relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes
-
Mega, J.L. et al. Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation 119, 2553-2560 (2009).
-
(2009)
Circulation
, vol.119
, pp. 2553-2560
-
-
Mega, J.L.1
-
27
-
-
67649204721
-
Can we override clopidogrel resistance?
-
Pena, A. et al. Can we override clopidogrel resistance? Circulation 119, 2854-2857 (2009).
-
(2009)
Circulation
, vol.119
, pp. 2854-2857
-
-
Pena, A.1
-
28
-
-
74249088972
-
Prasugrel compared with high-dose clopidogrel in acute coronary syndrome. The randomised, double-blind ACAPULCO study
-
Montalescot, G. et al. Prasugrel compared with high-dose clopidogrel in acute coronary syndrome. The randomised, double-blind ACAPULCO study. Thromb. Haemost. 103, 213-223 (2010).
-
(2010)
Thromb. Haemost.
, vol.103
, pp. 213-223
-
-
Montalescot, G.1
-
29
-
-
77958573028
-
Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19*2 loss of function polymorphism
-
Bonello, L. et al. Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19*2 loss of function polymorphism. J. Am. Coll. Cardiol. 56, 1630-1636 (2010).
-
(2010)
J. Am. Coll. Cardiol.
, vol.56
, pp. 1630-1636
-
-
Bonello, L.1
-
30
-
-
79952598836
-
Standard-vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: The GRAVITAS randomized trial
-
GRAVITAS Investigators
-
Price, M.J. et al.; GRAVITAS Investigators. Standard-vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial. JAMA 305, 1097-1105 (2011).
-
(2011)
JAMA
, vol.305
, pp. 1097-1105
-
-
Price, M.J.1
|