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Volumn 90, Issue 2, 2011, Pages 328-332

Clinical pharmacogenetics implementation consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL; CYTOCHROME P450 2C19;

EID: 79960613122     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2011.132     Document Type: Article
Times cited : (407)

References (30)
  • 1
    • 79951809825 scopus 로고    scopus 로고
    • CPIC: Clinical pharmacogenetics implementation consortium of the pharmacogenomics research network
    • Relling, M.V. & Klein, T.E. CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network. Clin. Pharmacol. Ther. 89, 464-467 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 464-467
    • Relling, M.V.1    Klein, T.E.2
  • 2
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • Hulot, J.S. et al. Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood 108, 2244-2247 (2006).
    • (2006) Blood , vol.108 , pp. 2244-2247
    • Hulot, J.S.1
  • 4
    • 47649111604 scopus 로고    scopus 로고
    • The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects
    • DOI 10.1111/j.1538-7836.2008.03050.x
    • Umemura, K., Furuta, T. & Kondo, K. The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects. J. Thromb. Haemost. 6, 1439-1441 (2008). (Pubitemid 352016331)
    • (2008) Journal of Thrombosis and Haemostasis , vol.6 , Issue.8 , pp. 1439-1441
    • Umemura, K.1    Furuta, T.2    Kondo, K.3
  • 5
    • 58249135635 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: A cohort study
    • Collet, J.P. et al. Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study. Lancet 373, 309-317 (2009).
    • (2009) Lancet , vol.373 , pp. 309-317
    • Collet, J.P.1
  • 6
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome p-450 polymorphisms and response to clopidogrel
    • Mega, J.L. et al. Cytochrome p-450 polymorphisms and response to clopidogrel. N. Engl. J. Med. 360, 354-362 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 354-362
    • Mega, J.L.1
  • 7
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    • Shuldiner, A.R. et al. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA 302, 849-857 (2009).
    • (2009) JAMA , vol.302 , pp. 849-857
    • Shuldiner, A.R.1
  • 8
    • 67949120411 scopus 로고    scopus 로고
    • The CYP2C19*17 allele is associated with better platelet response to clopidogrel in patients admitted for non-ST acute coronary syndrome
    • Frére, C., Cuisset, T., Gaborit, B., Alessi, M.C. & Hulot, J.S. The CYP2C19*17 allele is associated with better platelet response to clopidogrel in patients admitted for non-ST acute coronary syndrome. J. Thromb. Haemost. 7, 1409-1411 (2009).
    • (2009) J. Thromb. Haemost. , vol.7 , pp. 1409-1411
    • Frére, C.1    Cuisset, T.2    Gaborit, B.3    Alessi, M.C.4    Hulot, J.S.5
  • 9
    • 77955416969 scopus 로고    scopus 로고
    • Isolated and interactive impact of common CYP2C19 genetic variants on the antiplatelet effect of chronic clopidogrel therapy
    • Sibbing, D. et al. Isolated and interactive impact of common CYP2C19 genetic variants on the antiplatelet effect of chronic clopidogrel therapy. J. Thromb. Haemost. 8, 1685-1693 (2010).
    • (2010) J. Thromb. Haemost. , vol.8 , pp. 1685-1693
    • Sibbing, D.1
  • 10
    • 77956353400 scopus 로고    scopus 로고
    • Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events
    • Tiroch, K.A. et al. Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events. Am. Heart J. 160, 506-512 (2010).
    • (2010) Am. Heart J. , vol.160 , pp. 506-512
    • Tiroch, K.A.1
  • 11
    • 76349098199 scopus 로고    scopus 로고
    • Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    • Sibbing, D. et al. Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement. Circulation 121, 512-518 (2010).
    • (2010) Circulation , vol.121 , pp. 512-518
    • Sibbing, D.1
  • 12
    • 55449137355 scopus 로고    scopus 로고
    • CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation
    • Geisler, T. et al. CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation. Pharmacogenomics 9, 1251-1259 (2008).
    • (2008) Pharmacogenomics , vol.9 , pp. 1251-1259
    • Geisler, T.1
  • 13
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators
    • Simon, T. et al.; French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators. Genetic determinants of response to clopidogrel and cardiovascular events. N. Engl. J. Med. 360, 363-375 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 363-375
    • Simon, T.1
  • 14
    • 78651239845 scopus 로고    scopus 로고
    • Paraoxonase-1 is a major determinant of clopidogrel efficacy
    • Bouman, H.J. et al. Paraoxonase-1 is a major determinant of clopidogrel efficacy. Nat. Med. 17, 110-116 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 110-116
    • Bouman, H.J.1
  • 15
    • 45249088224 scopus 로고    scopus 로고
    • The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: A possible mechanism for clopidogrel resistance
    • Kim, K.A., Park, P.W., Hong, S.J. & Park, J.Y. The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: a possible mechanism for clopidogrel resistance. Clin. Pharmacol. Ther. 84, 236-242 (2008).
    • (2008) Clin. Pharmacol. Ther. , vol.84 , pp. 236-242
    • Kim, K.A.1    Park, P.W.2    Hong, S.J.3    Park, J.Y.4
  • 16
    • 61349191612 scopus 로고    scopus 로고
    • Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis
    • Giusti, B. et al. Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis. Am. J. Cardiol. 103, 806-811 (2009).
    • (2009) Am. J. Cardiol. , vol.103 , pp. 806-811
    • Giusti, B.1
  • 17
    • 65249145201 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention
    • S ibbing, D. et al. Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention. Eur. Heart J. 30, 916-922 (2009).
    • (2009) Eur. Heart J. , vol.30 , pp. 916-922
    • Sibbing, D.1
  • 18
    • 78049326068 scopus 로고    scopus 로고
    • Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis
    • Mega, J.L. et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. JAMA 304, 1821-1830 (2010).
    • (2010) JAMA , vol.304 , pp. 1821-1830
    • Mega, J.L.1
  • 19
    • 78049433100 scopus 로고    scopus 로고
    • Effects of CYP2C19 genotype on outcomes of clopidogrel treatment
    • Paré, G. et al. Effects of CYP2C19 genotype on outcomes of clopidogrel treatment. N. Engl. J. Med. 363, 1704-1714 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1704-1714
    • Paré, G.1
  • 20
    • 77958100874 scopus 로고    scopus 로고
    • Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLAT O trial
    • PLAT O investigators
    • Wallentin, L. et al.; PLAT O investigators. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLAT O trial. Lancet 376, 1320-1328 (2010).
    • (2010) Lancet , vol.376 , pp. 1320-1328
    • Wallentin, L.1
  • 21
    • 77955638355 scopus 로고    scopus 로고
    • ACCF/AHA clopidogrel clinical alert: Approaches to the FDA "boxed warning": A report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents and the American Heart Association endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons
    • Holmes, D.R. Jr, Dehmer, G.J., Kaul, S., Leifer, D., O'Gara, P.T. & Stein, C.M. ACCF/AHA clopidogrel clinical alert: approaches to the FDA "boxed warning": a report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents and the American Heart Association endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. J. Am. Coll. Cardiol. 56, 321-341 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.56 , pp. 321-341
    • Holmes Jr., D.R.1    Dehmer, G.J.2    Kaul, S.3    Leifer, D.4    O'Gara, P.T.5    Stein, C.M.6
  • 23
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • PLAT O Investigators
    • Wallentin, L. et al.; PLAT O Investigators. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 361, 1045-1057 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1045-1057
    • Wallentin, L.1
  • 24
    • 77958567291 scopus 로고    scopus 로고
    • Prasugrel vs. clopidogrel for cytochrome P450 2C19-genotyped subgroups: Integration of the TRITON-TIMI 38 trial data
    • Sorich, M.J., Vitry, A., Ward, M.B., Horowitz, J.D. & McKinnon, R.A. Prasugrel vs. clopidogrel for cytochrome P450 2C19-genotyped subgroups: integration of the TRITON-TIMI 38 trial data. J. Thromb. Haemost. 8, 1678-1684 (2010).
    • (2010) J. Thromb. Haemost. , vol.8 , pp. 1678-1684
    • Sorich, M.J.1    Vitry, A.2    Ward, M.B.3    Horowitz, J.D.4    McKinnon, R.A.5
  • 25
    • 37849002889 scopus 로고    scopus 로고
    • Prasugrel achieves greater and faster P2Y12receptormediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease
    • Wallentin, L. et al. Prasugrel achieves greater and faster P2Y12receptormediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease. Eur. Heart J. 29, 21-30 (2008).
    • (2008) Eur. Heart J. , vol.29 , pp. 21-30
    • Wallentin, L.1
  • 26
    • 66349133650 scopus 로고    scopus 로고
    • Cytochrome P450 genetic polymorphisms and the response to prasugrel: Relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes
    • Mega, J.L. et al. Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation 119, 2553-2560 (2009).
    • (2009) Circulation , vol.119 , pp. 2553-2560
    • Mega, J.L.1
  • 27
    • 67649204721 scopus 로고    scopus 로고
    • Can we override clopidogrel resistance?
    • Pena, A. et al. Can we override clopidogrel resistance? Circulation 119, 2854-2857 (2009).
    • (2009) Circulation , vol.119 , pp. 2854-2857
    • Pena, A.1
  • 28
    • 74249088972 scopus 로고    scopus 로고
    • Prasugrel compared with high-dose clopidogrel in acute coronary syndrome. The randomised, double-blind ACAPULCO study
    • Montalescot, G. et al. Prasugrel compared with high-dose clopidogrel in acute coronary syndrome. The randomised, double-blind ACAPULCO study. Thromb. Haemost. 103, 213-223 (2010).
    • (2010) Thromb. Haemost. , vol.103 , pp. 213-223
    • Montalescot, G.1
  • 29
    • 77958573028 scopus 로고    scopus 로고
    • Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19*2 loss of function polymorphism
    • Bonello, L. et al. Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19*2 loss of function polymorphism. J. Am. Coll. Cardiol. 56, 1630-1636 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.56 , pp. 1630-1636
    • Bonello, L.1
  • 30
    • 79952598836 scopus 로고    scopus 로고
    • Standard-vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: The GRAVITAS randomized trial
    • GRAVITAS Investigators
    • Price, M.J. et al.; GRAVITAS Investigators. Standard-vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial. JAMA 305, 1097-1105 (2011).
    • (2011) JAMA , vol.305 , pp. 1097-1105
    • Price, M.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.