Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk

European Journal of Clinical Pharmacology

Volumn 67, Issue 9, 2011, Pages 899-908

  Salman, Sam ^a   Sy, Sherwin K B ^b   Ilett, Kenneth F ^a,c,d   Page Sharp, Madhu ^a,d   Paech, Michael J ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

^c Path West Laboratory Medicine   (Australia)

^d CURTIN UNIVERSITY   (Australia)

Author keywords

Infant dose; Milk; O desmethyltramadol; Pediatrics; Population pharmacokinetics; Tramadol

Indexed keywords

CYTOCHROME P450 2D6; O NORTRAMADOL; TRAMADOL;

ADULT; ARTICLE; BREAST MILK; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG EXCRETION; DRUG METABOLISM; DRUG MILK LEVEL; DRUG TRANSPORT; FEMALE; FLUID INTAKE; HUMAN; LACTATION; POPULATION MODEL; POSTPARTUM PAIN; PRIORITY JOURNAL;

ADULT; ANALGESICS, OPIOID; CESAREAN SECTION; CYTOCHROME P-450 CYP2D6; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MILK, HUMAN; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; PAIN, POSTOPERATIVE; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; TISSUE DISTRIBUTION; TRAMADOL;

EID: 80054783598     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-011-1023-6     Document Type: Article

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