Opioid pharmacogenomics using a twin study paradigm: Methods and procedures for determining familial aggregation and heritability

Twin Research and Human Genetics

Volumn 13, Issue 5, 2010, Pages 412-425

  Angst, Martin S ^a   Phillips, Nicholas G ^a   Drover, David R ^a   Tingle, Martha ^a   Galinkin, Jeffrey L ^b   Christians, Uwe ^b   Swan, Gary E ^c   Lazzeroni, Laura C ^a   Clark, J David ^a,d  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL COLORADO   (United States)

^c SRI INTERNATIONAL   (United States)

^d VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Alfentanil; Analgesia; Cold pressor pain; Familial aggregation; Heat pain; Heritability; Liking; Nausea; Opioid; Pain sensitivity; Pharmacodynamics; Pharmacogenomics; Positive affective response; Pruritus; Quantitative sensory test; Respiratory depression; Sedation; Twin

Indexed keywords

ALFENTANIL; PLACEBO;

ADULT; AGED; ANALGESIC ACTIVITY; ANXIETY; ARTICLE; BLOOD PRESSURE; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DEPRESSION; DIZYGOTIC TWINS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG INFUSION; DRUG RESPONSE; ENVIRONMENTAL FACTOR; FEMALE; HERITABILITY; HUMAN; INFORMATION PROCESSING; INFUSION PUMP; INTERVENTION STUDY; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; NAUSEA; NOCICEPTION; PAIN; PAIN ASSESSMENT; PHARMACODYNAMICS; PHARMACOGENOMICS; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; SEDATION; STATISTICAL ANALYSIS; TWINS;

ADULT; ALFENTANIL; ANALGESICS, OPIOID; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PAIN; PAIN MEASUREMENT; PAIN PERCEPTION; PHARMACOGENETICS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC; YOUNG ADULT;

EID: 77958085098     PISSN: 18324274     EISSN: None     Source Type: Journal    
DOI: 10.1375/twin.13.5.412     Document Type: Article

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