Observational study of the effect of μ-opioid receptor genetic polymorphism on intrathecal opioid labor analgesia and post-cesarean delivery analgesia

International Journal of Obstetric Anesthesia

Volumn 19, Issue 3, 2010, Pages 246-253

  Wong, C A ^a   McCarthy, R J ^a   Blouin, J ^b,c   Landau, R ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

opioid receptor polymorphism; Cesarean delivery analgesia; Intrathecal analgesia; Labor analgesia; Obstetric analgesia; Opioid analgesia; Opioids

Indexed keywords

FENTANYL; MORPHINE; MU OPIATE RECEPTOR; OPIATE;

ADULT; ARTICLE; CESAREAN SECTION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENETIC POLYMORPHISM; HOMOZYGOSITY; HUMAN; NAUSEA AND VOMITING; OBSERVATIONAL STUDY; OBSTETRIC ANALGESIA; PAIN; POSTOPERATIVE PERIOD; PROSPECTIVE STUDY; PRURITUS; SINGLE NUCLEOTIDE POLYMORPHISM; SPINAL ANESTHESIA; TREATMENT OUTCOME;

ADULT; ANALGESIA, OBSTETRICAL; ANESTHESIA, SPINAL; ANESTHETICS, INTRAVENOUS; CESAREAN SECTION; DNA; FEMALE; FENTANYL; HUMANS; INFANT, NEWBORN; INJECTIONS, SPINAL; KAPLAN-MEIER ESTIMATE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTOPERATIVE NAUSEA AND VOMITING; PREGNANCY; PRURITUS; RECEPTORS, OPIOID, MU; SAMPLE SIZE; TREATMENT OUTCOME;

EID: 77952007675     PISSN: 0959289X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijoa.2009.09.005     Document Type: Article

References (40)

1. S.N. Palmer, N.M. Giesecke, S.C. Body, S.K. Shernan, A.A. Fox, and C.D. Collard Pharmacogenetics of anesthetic and analgesic agents Anesthesiology 102 2005 663 671
2. e!Ensembl. ENSG00000112038. < http://www.ensembl.org/Homo-sapiens/ > [accessed 10.10.09].
3. Single nucleotide polymorphism. < http://www.ncbi.nlm.nih.gov/SNP/snp- ref.cgi?type=rs&rs=rs1799971 > [accessed 10.10.09].
4. J. Lotsch, and G. Geisslinger Current evidence for a genetic modulation of the response to analgesics Pain 121 2006 1 5
5. den Dunnen J. Nomenclature for the description of sequence variations. < http://www.hgvs.org/mutnomen/ > [accessed 10.10.09].
6. C.M. Palmer, R.C. Cork, R. Hays, G. Van Maren, and D. Alves The dose-response relation of intrathecal fentanyl for labor analgesia Anesthesiology 88 1998 355 361
7. K.E. Nelson, T. Rauch, V. Terebuh, and R. D'Angelo A comparison of intrathecal fentanyl and sufentanil for labor analgesia Anesthesiology 96 2002 1070 1073
8. R. Landau, C. Kern, M.O. Columb, R.M. Smiley, and J.L. Blouin Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women Pain 139 2008 5 14
9. W.Y. Chou, C.H. Wang, P.H. Liu, C.C. Liu, C.C. Tseng, and B. Jawan Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy Anesthesiology 105 2006 334 337
10. W.Y. Chou, L.C. Yang, and H.F. Lu Association of mu-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty Acta Anaesthesiol Scand 50 2006 787 792
11. M. Hayashida, M. Nagashima, and Y. Satoh Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype Pharmacogenomics 9 2008 1605 1616
12. A.T. Sia, Y. Lim, and E.C. Lim A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia Anesthesiology 109 2008 520 526
13. R. Landau, A. Cahana, R.M. Smiley, S.E. Antonarakis, and J.L. Blouin Genetic variability of mu-opioid receptor in an obstetric population Anesthesiology 100 2004 1030 1033
14. E.C. Tan, C.H. Tan, U. Karupathivan, and E.P. Yap Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations Neuroreport 14 2003 569 572
15. B.G. Oertel, M. Kettner, and K. Scholich A common human mu-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain J Biol Chem 284 2009 6530 6535
16. C. Bond, K.S. LaForge, and M. Tian Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction Proc Natl Acad Sci USA 95 1998 9608 9613
17. I. Belfer, T. Wu, A. Kingman, R.K. Krishnaraju, D. Goldman, and M.B. Max Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample size Anesthesiology 100 2004 1562 1572
18. K. Befort, D. Filliol, F.M. Decaillot, C. Gaveriaux-Ruff, M.R. Hoehe, and B.L. Kieffer A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling J Biol Chem 276 2001 3130 3137
19. A.A. Somogyi, D.T. Barratt, and J.K. Coller Pharmacogenetics of opioids Clin Pharmacol Ther 81 2007 429 444
20. H. Iwasaki, J.G. Collins, Y. Saito, and A. Kerman-Hinds Naloxone-sensitive, pregnancy-induced changes in behavioral responses to colorectal distention: pregnancy-induced analgesia to visceral stimulation Anesthesiology 74 1991 927 933
21. R. Cogan, and J.A. Spinnato Pain and discomfort thresholds in late pregnancy Pain 27 1986 63 68
22. R.J. Palahniuk, S.M. Shnider, and E.I. Eger 2nd Pregnancy decreases the requirement for inhaled anesthetic agents Anesthesiology 41 1974 82 83
23. R.B. Fillingim, L. Kaplan, and R. Staud The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans J Pain 6 2005 159 167
24. N.L. Herman, K.C. Choi, and P.J. Affleck Analgesia, pruritus, and ventilation exhibit a dose-response relationship in parturients receiving intrathecal fentanyl during labor Anesth Analg 89 1999 378 383
25. C.M. Palmer, S. Emerson, D. Volgoropolous, and D. Alves Dose-response relationship of intrathecal morphine for postcesarean analgesia Anesthesiology 90 1999 437 444
26. C.A. Wong Epidural and spinal analgesia/anesthesia for labor and vaginal delivery D.H. Chestnut, L.S. Polley, L.C. Tsen, C.A. Wong, Chestnut's Obstetric Anesthesia: Principles and Practice 4th ed. 2009 Mosby-Elsevier Philadelphia 593 630
27. Carvalho B, Butwick A. Postoperative analgesia: epidural and spinal techniques. In: Chestnut DH, Polley LS, Tsen LC, Wong CA, eds. Chestnut's obstetric anesthesia: principles and practice. Philadelphia: Mosby-Elsevier; 2009. p. 593-630.
28. G. Iohom, D. Fitzgerald, and A.J. Cunningham Principles of pharmacogenetics-implications for the anaesthetist Br J Anaesth 93 2004 440 450
29. R. Landau One size does not fit all: genetic variability of mu-opioid receptor and postoperative morphine consumption Anesthesiology 105 2006 235 237
30. R.R. Romberg, E. Olofsen, and H. Bijl Polymorphism of mu-opioid receptor gene (OPRM1:c.118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response Anesthesiology 102 2005 522 530
31. B.G. Oertel, R. Schmidt, A. Schneider, G. Geisslinger, and J. Lotsch The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers Pharmacogenet Genomics 16 2006 625 636
32. J. Shi, L. Hui, Y. Xu, F. Wang, W. Huang, and G. Hu Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin Hum Mutat 19 2002 459 460
33. C. Skarke, J. Darimont, H. Schmidt, G. Geisslinger, and J. Lotsch Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers Clin Pharmacol Ther 73 2003 107 121
34. L. Coulbault, M. Beaussier, and C. Verstuyft Environmental and genetic factors associated with morphine response in the postoperative period Clin Pharmacol Ther 79 2006 316 324
35. C.M. Viscomi, J.P. Rathmell, and N.L. Pace Duration of intrathecal labor analgesia: early versus advanced labor Anesth Analg 84 1997 1108 1112
36. A. Beyer, T. Koch, H. Schroder, S. Schulz, and V. Hollt Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor J Neurochem 89 2004 553 560
37. C.M. Palmer, G. Van Maren, W.M. Nogami, and D. Alves Bupivacaine augments intrathecal fentanyl for labor analgesia Anesthesiology 91 1999 84 89
38. R.R. Gaiser, T.G. Cheek, and B.B. Gutsche Comparison of three different doses of intrathecal fentanyl and sufentanil for labor analgesia J Clin Anesth 10 1998 488 493
39. A. Buvanendran, R.J. McCarthy, J.S. Kroin, W. Leong, P. Perry, and K.J. Tuman Intrathecal magnesium prolongs fentanyl analgesia: a prospective, randomized, controlled trial Anesth Analg 95 2002 661 666
40. J.B. Dahl, I.S. Jeppesen, H. Jorgensen, J. Wetterslev, and S. Moiniche Intraoperative and postoperative analgesic efficacy and adverse effects of intrathecal opioids in patients undergoing cesarean section with spinal anesthesia: a qualitative and quantitative systematic review of randomized controlled trials Anesthesiology 91 1999 1919 1927