COMT val158 genotype affects μ-opioid neurotransmitter responses to a pain stressor

Science

Volumn 299, Issue 5610, 2003, Pages 1240-1243

  Zubieta, Jon Kar ^a,b   Heitzeg, Mary M ^a   Smith, Yolanda R ^b   Bueller, Joshua A ^a   Xu, Ke ^d   Xu, Yanjun ^a   Koeppe, Robert A ^b   Stohler, Christian S ^c   Goldmans, David ^d  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d National Institute of Alcohol Abuse and Alcoholism   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; GENETIC ENGINEERING; METABOLISM;

NEUROTRANSMITTER RESPONSES;

NEUROLOGY;

CATECHOL METHYLTRANSFERASE; METHIONINE; MU OPIATE RECEPTOR; NEUROTRANSMITTER; VALINE;

GENOTYPE; POLYMORPHISM; SENSORY SYSTEM;

ADAPTATION; AFFECT; ALLELE; ARTICLE; CATECHOLAMINE METABOLISM; EXPERIENCE; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; NOCICEPTION; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; RATING SCALE; STRESS; ADULT; AMINO ACID SUBSTITUTION; ANALYSIS OF VARIANCE; BRAIN; BRAIN MAPPING; CEREBELLUM; CHEMISTRY; FEMALE; GENETICS; MALE; METABOLISM; NERVE TRACT; NUCLEAR MAGNETIC RESONANCE IMAGING; SCINTISCANNING; SYNAPTIC TRANSMISSION; THALAMUS;

ADULT; AFFECT; AMINO ACID SUBSTITUTION; ANALYSIS OF VARIANCE; BRAIN; BRAIN MAPPING; CATECHOL O-METHYLTRANSFERASE; CEREBELLUM; FEMALE; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; NEURAL PATHWAYS; PAIN; POLYMORPHISM, GENETIC; RECEPTORS, OPIOID, MU; SYNAPTIC TRANSMISSION; THALAMUS;

EID: 0037458277     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1078546     Document Type: Article

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41. Supported by grants R01 DE 12743 to J.-K.Z. and R01 DE 12059 to C.S.S. and the Office of the Vice-President for Research at the University of Michigan. The authors also wish to acknowledge the contributions of T. Woike and the PET Center Nuclear Medicine Technologists (J. M. Rothley, E. J. McKenna, A. R. Weeden, P. Kison, and S. Huber).