Near-fatal tramadol cardiotoxicity in a CYP2D6 ultrarapid metabolizer

European Journal of Clinical Pharmacology

Volumn 67, Issue 8, 2011, Pages 855-858

  Elkalioubie, Ahmed ^a,c   Allorge, Delphine ^a,b   Robriquet, Laurent ^a,c   Wiart, Jean François ^a   Garat, Anne ^a,b   Broly, Franck ^a,b   Fourrier, François ^a,c  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b UFR3S Pharmacie   (France)

^c UNIV LILLE   (France)

Author keywords

Cardiotoxicity; CYP2D6; Opioids; Tramadol; Ultra rapid metabolism

Indexed keywords

ADRENALIN; CYTOCHROME P450 2D6; O NORTRAMADOL; TRAMADOL;

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; BLOOD ANALYSIS; CARDIOGENIC SHOCK; CARDIOTOXICITY; CASE REPORT; CLINICAL FEATURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG METABOLISM; DRUG SAFETY; DRUG USE; ENZYME METABOLISM; EXTRACORPOREAL OXYGENATION; FEMALE; GENE DUPLICATION; GENETIC VARIABILITY; HEART ARREST; HETEROZYGOTE DETECTION; HUMAN; HYPOTHERMIA; LIQUID CHROMATOGRAPHY; MULTIPLE ORGAN FAILURE; MYDRIASIS; NORADRENALIN UPTAKE; OUTCOME ASSESSMENT; PHENOTYPIC VARIATION; PRIORITY JOURNAL; RESUSCITATION; RISK ASSESSMENT; STUNNED HEART MUSCLE; TANDEM MASS SPECTROMETRY;

ADULT; ANALGESICS, OPIOID; CYTOCHROME P-450 CYP2D6; DRUG MONITORING; EPINEPHRINE; FEMALE; GENOTYPE; HEART ARREST; HUMANS; METABOLIC DETOXICATION, PHASE I; MYOCARDIAL STUNNING; OPIOID-RELATED DISORDERS; OVERDOSE; TRAMADOL; YOUNG ADULT;

EID: 79960950709     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-011-1080-x     Document Type: Article

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