Influence from genetic variability on opioid use for cancer pain: A European genetic association study of 2294 cancer pain patients

Pain

Volumn 152, Issue 5, 2011, Pages 1139-1145

  Klepstad, P ^a,n   Fladvad, T ^a   Skorpen, F ^a   Bjordal, K ^b   Caraceni, A ^c   Dale, O ^a,n   Davies, A ^d   Kloke, M ^e   Lundstrom S ^f,g   Maltoni, M ^h   Radbruch, L ⁱ   Sabatowski, R ^j   Sigurdardottir, V ^k   Strasser, F ^l   Fayers, P M ^a,m   Kaasa, S ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c NATIONAL CANCER INSTITUTE   (Italy)

^d ROYAL MARSDEN HOSPITAL   (United Kingdom)

^e KLINIKEN ESSEN MITTE   (Germany)

^f Stockholms Sjukhem Foundation   (Sweden)

^g KAROLINSKA INSTITUTE   (Sweden)

^h Palliative Care Unit   (Italy)

ⁱ RWTH AACHEN UNIVERSITY   (Germany)

^j UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^k Hospital of Iceland   (Iceland)

^l CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^m UNIVERSITY OF ABERDEEN   (United Kingdom)

ⁿ TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

more..

Author keywords

Cancer; Genetic; Opioid; Pain; Polymorphism

Indexed keywords

ALBUMIN; CORTICOSTEROID; CREATININE; FENTANYL; GABAPENTIN; GENE PRODUCT; MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE RECEPTOR; OXYCODONE; PARACETAMOL; PREGABALIN;

ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; BONE METASTASIS; BONE SOFT TISSUE PAIN; BREAST TUMOR; BRIEF PAIN INVENTORY; CANCER PAIN; CANCER PATIENT; CENTRAL NERVOUS SYSTEM METASTASIS; CLINICAL ASSESSMENT; CLINICAL STUDY; COGNITION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DNA EXTRACTION; DRUG USE; ETHNICITY; EUROPE; FEMALE; FEMALE GENITAL SYSTEM; GASTROINTESTINAL TUMOR; GENE FREQUENCY; GENE LOCATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEMATOLOGIC MALIGNANCY; HUMAN; KARNOFSKY PERFORMANCE STATUS; LIVER METASTASIS; LUNG METASTASIS; LUNG TUMOR; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MIXED PAIN; NEUROPATHIC PAIN; PAIN; PAIN ASSESSMENT; PHARMACOGENETICS; PRIORITY JOURNAL; PROSTATE TUMOR; SINGLE NUCLEOTIDE POLYMORPHISM; UNKNOWN PAIN; URINARY TRACT CANCER; VALIDATION STUDY; VISCERAL PAIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANALGESICS, OPIOID; CHI-SQUARE DISTRIBUTION; EUROPE; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; OPIOID-RELATED DISORDERS; PAIN; PAIN MEASUREMENT; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OPIOID; SIGNAL TRANSDUCTION;

EID: 79954583889     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2011.01.040     Document Type: Article

References (42)

1. N. Agarwal, P. Pacher, I. Tegeder, F. Amaya, C.E. Constatin, G.J. Brenner, T. Rubino, C.W. Michalski, G. Marsicano, K. Monory, K. Mackie, C. Marian, S. Batkai, D. Parolaro, M.J. Fischer, P. Reeh, G. Kunos, M. Kress, B. Lutz, C.J. Woolf, and R. Kuner Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors Nat Neurosci 10 2007 870 879 (Pubitemid 47013432)
2. American College of Physicians. 2004: Dosing and conversion chart of opioid analgesics. Available at: http://www.acponline.org/clinical-information/ journals-publications/acp-internist/dec04/pain/dosing-conv.pdf (accessed 2.10.2008).
3. Y. Benjamini, and Y. Hochberg On the adaptive control of the false discovery rate in multiple testing with independent statistics J Educ Behav Stat 25 2000 60 83
4. D. Campa, A. Gioia, A. Tomei, P. Poli, and R. Barale Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief Clin Pharmacol Ther 83 2008 559 566 (Pubitemid 351417058)
5. N. Cherny, C. Ripamonti, J. Pereira, C. Davis, M. Fallon, H. McQuay, S. Mercadante, G. Pasternak, and V. Ventafridda Expert Working Group of the European Association of Palliative Care Network. Strategies to manage the adverse effects of oral morphine: an evidence-based report J Clin Oncol 19 2001 2542 2554
6. C.D. Cook, J.S. Roedefer, and M.J. Picker Selective attenuation of the antinociceptive effects of mu opioids by the putative dopamine D3 agonist 7-OH-DPAT Psychopharmacology 144 1999 239 247 (Pubitemid 29307275)
7. S. Crettol, J. Besson, M. Croquette-Krokar, R. Hämmig, I. Githuey, D. Monnat, J.J. Déglon, M. Preisig, and C.B. Eap Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment Prog Neuropsychopharmacol Biol Psychiatry 32 2008 1722 1727
8. R.L. Daut, C.S. Cleeland, and R.C. Flanery Development of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseases Pain 17 1983 197 210 (Pubitemid 13012221)
9. L. Diatchenko, A.D. Anderson, G.D. Slade, R.B. Fillingim, S.A. Shabalina, T.J. Higgins, S. Sama, I. Belfer, D. Goldman, M.B. Max, B.S. Weir, and W. Maixner Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musceloskeletal pain disorder Am J Med Genet B Neuropsychatr Genet 141 2006 449 462 (Pubitemid 44024438)
10. R.L. Fainsinger, C.L. Nekolaichuk, P.G. Lawlor, C.M. Neumann, J. Hanson, and A. Vigano A multicenter study of the revised Edmonton staging system for classifying cancer pain in advanced cancer patients J Pain Symptom Manage 29 2005 224 237 (Pubitemid 40386739)
11. M.F. Folstein, S.E. Folstein, and P.R. McHugh "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 12 1975 189 198
12. W. Guang, S.H. Wang, T. Su, I.B. Weinstein, and J.B. Wang Role of mPKCI, a novel mu-opioid receptor interactive protein, in receptor desensitization, phosphorylation, and morphine-induced analgesia Mol Pharmacol 66 2004 1285 1292 (Pubitemid 39411068)
13. J.N. Hirschhorn, K. Lohmueller, E. Byrne, and K. Hirschhorn A comprehensive review of genetic association studies Genet Med 4 2002 45 61 (Pubitemid 44698579)
14. D.A. Karnofsky, W.H. Abelmann, L.F. Craver, and J.H. Burchenal The use of nitrogen mustards in the palliative treatment of carcinoma Cancer 1 1948 634 656
15. -/- knock-out male mice Pain 130 2007 235 248 (Pubitemid 46994702)
16. H. Kim, J.K. Neubert, A.S. San Miguel, K. Xu, R.K. Krishnaraju, M.J. Iadarola, D. Goldman, and R.A. Dionne Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament Pain 109 2004 488 496 (Pubitemid 38638726)
17. H. Kim, D. Clark, and R.A. Dionne Genetic contributions to clinical pain and analgesia: avoiding pitfalls in genetic research J Pain 10 2009 663 693
18. T. King, L.R. Gardell, R. Wang, A. Vardanyan, M.H. Ossipov, T.P. Malan, T.W. Vanderah, S.P. Hunt, V.J. Hruby, J. Lai, and F. Porreca Role of NK-1 neurotransmission in opioid-induced hyperalgesia Pain 116 2005 276 288 (Pubitemid 40957131)
19. P. Klepstad, S. Kaasa, N. Cherny, G. Hanks, and F. De Conno Research Steering Committee of the EAPC. Pain and pain treatments in European palliative care units. A cross sectional survey from the European Association for Palliative Care Research Network Palliat Med 19 2005 477 484 (Pubitemid 41430821)
20. P. Klepstad, T.T. Rakvg, S. Kaasa, M. Holthe, O. Dale, P.C. Borchgrevink, C. Baar, T. Vikan, H.E. Krokan, and F. Skorpen The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease Acta Anaesthesiol Scand 48 2004 1232 1239 (Pubitemid 39490855)
21. P. Klepstad Pharmacogenetic considerations in the treatment of cancer pain E. Bruera, R.K. Portenoy, Cancer pain 2010 Cambridge University Press New York 180 194
22. M.L. Lacroix-Fralish, J.B. Ledoux, and J.S. Mogil The Pain Genes Database: an interactive Web browser of pain-related transgenic knockout studies Pain 131 2007 3.e1 3.e4
23. K.J. Leck, S.E. Bartlett, M.T. Smith, D. Megirian, J. Holgate, K.L. Powell, K.I. MAtthael, and I.A. Hendry Deletion of guanine nucleotide binding protein alpha z subunit in mice induces a gene dose dependent tolerance to morphine Neuropharmacology 46 2004 836 846 (Pubitemid 38368916)
24. J. Lötsch, K. Flühr, T. Neddermayer, A. Doehring, and G. Geisslinger The consequence of concomitantly present functional genetic variants for the identification of functional genotype-phenotype associations in pain Clin Pharmacol Ther 85 2009 25 30
25. J. Lötsch, C. Skarke, S. Grösch, J. Darimont, H. Scmidt, and G. Geisslinger The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine Pharmacogenetics 12 2002 3 9 (Pubitemid 34112237)
26. J. Lötsch, P. Klepstad, A. Doehring, and O. Dale A GTP cyclohydrolase 1 genetic variant delays cancer pain Pain 148 2010 103 106
27. J. Lötsch, and G. Geisslinger A critical appraisal of human geotyping for pain therapy Trends Pharmacol Sci 31 2010 312 317
28. J.I. Mobarakeh, S. Sakurada, S. Katsuyma, M. Kutsuwa, A. Kuramasu, Z.Y. Lin, T. Watanabe, Y. Hashimoto, T. Watanabe, and K. Yanai Role of histamine H(1) receptor in pain perception: a study of the receptor gene konck-out mouse Eur J Pharmacol 391 2000 81 89 (Pubitemid 30138083)
29. J.S. Mogil, J. Ritchie, S.B. Smith, K. Strasburg, L. Kaplan, M.R. Wallace, R.R. Romberg, H. Bijl, E.Y. Sarton, R.B. Fillingim, and A. Dahan Melanonocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans J Med Genet 42 2005 583 587 (Pubitemid 40993835)
30. J.S. Mogil Are we getting anywhere with human pain genetics? Pain 146 2009 231 232
31. B.G. Oertel, R. Schmidt, A. Schneider, G. Geisslinger, and J. Lötsch The mu-opioid receptor gene polymorphism 118A > G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers Pharmacogenet Genomics 16 2006 625 636 (Pubitemid 44223074)
32. T.T. Rakvg, P. Klepstad, C. Baar, T.M. Kvam, O. Dale, S. Kaasa, H.E. Krokan, and F. Skorpen The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients Pain 116 2005 73 78 (Pubitemid 40828502)
33. A. Ravindranathan, G. Joslyn, M. Robertson, M.A. Schuckit, J.L. Whistler, and R.L. White Functional characterization of human variants of the mu-opioid receptor gene Proc Natl Acad Sci USA 106 2009 10811 10816
34. C.C. Reyes-Gibby, S. Shete, T. Rakvg, S.V. Bhat, F. Skorpen, E. Bruera, S. Kaasa, and P. Klepstad Exploring joints effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene Pain 130 2007 25 30 (Pubitemid 46850782)
35. J.R. Ross, J. Riley, A.B. Taegetmeyer, H. Sato, S. Gretton, R.M. du Bois, and K.I. Welsh Genetic variation and response to morphine in cancer patients: catechol-O-methyltransferase and multi-drug resistance-1 gene polymorphisms are associated with central side-effects Cancer 112 2008 1390 1403 (Pubitemid 351429755)
36. J.R. Ross, D. Rutter, K. Welsh, S.P. Joel, K. Goller, A.U. Wells, R. Du Bois, and J. Riley Clinical response to morphine in cancer patients and genetic variation in candidate genes Pharmacogenomics J 5 2005 324 336 (Pubitemid 41486231)
37. F. Simonin, and O. Valverde Smadja C; Slowe S, Kitchen I, Dierich A, Le Meur M, Roques BP, Maldonado R, Kieffer BL. Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50, 488H and attentuates morphine withdrawal EMBO J 17 1998 886 897 (Pubitemid 28077643)
38. A. Somogyi, D.T. Barratt, and J.K. Coller Pharmacogenetics of opioids Clin Pharmacol Ther 81 2007 429 444 (Pubitemid 46364493)
39. C. Walter, and J. Lötsch Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment Pain 146 2009 270 275
40. L. Watkins, M.R. Hutchinson, A.M. Ledeboer, J. Wieseler-Frank, E.D. Milligan, and S.F. Maier Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids Brain Behav Immun 21 2007 131 146 (Pubitemid 46038918)
41. J.K. Zubieta, M.M. Heitzeg, Y.R. Smith, J.A. Bueller, K. Xu, Y. Xu, R.A. Koeppe, and C.S. Stohler Goldman D COMT val158 met genotype affects mu-opioid neurotransmitter responses to a pain stressor Science 299 2003 1240 1243 (Pubitemid 36237467)
42. Z. Zuo The role of opioid receptor internalization and beta-arrestins in the development of opioid tolerance Anesth Analg 101 2005 728 734 (Pubitemid 41208503)