Individual differences in pain sensitivity: Genetic and environmental contributions

Pain

Volumn 136, Issue 1-2, 2008, Pages 21-29

  Nielsen, Christopher S ^a   Stubhaug, Audun ^b   Price, Donald D ^c   Vassend, Olav ^b   Czajkowski, Nikolai ^a   Harris, Jennifer R ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

Behavioral genetics; Genetics; Heritability; Individual differences; Pain; Twins

Indexed keywords

ADULT; ARTICLE; BEHAVIOR GENETICS; COLD PRESSOR TEST; CONTACT EXAMINATION; CONTROLLED STUDY; DIZYGOTIC TWINS; ENVIRONMENTAL FACTOR; FEMALE; GENETIC ASSOCIATION; GENETIC DIFFERENCE; HEREDITY; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; NOCICEPTION; PAIN ASSESSMENT; PHENOTYPE; PRIORITY JOURNAL; VALIDITY;

ADULT; COLD; ENVIRONMENT; FEMALE; HEALTH SURVEYS; HUMANS; INDIVIDUALITY; MALE; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PHYSICAL STIMULATION; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 41749112010     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2007.06.008     Document Type: Article

References (52)

1. al'Absi M., and Petersen K.L. Blood pressure but not cortisol mediates stress effects on subsequent pain perception in healthy men and women. Pain 106 (2003) 285-295
2. Backonja M., Howland E.W., Wang J., Smith J., Salinsky M., and Cleeland C.S. Tonic changes in alpha power during immersion of the hand in cold water. Electroen Clin Neuro 79 (1991) 192-203
3. Battie M.C., Videman T., Levalahti E., Gill K., and Kaprio J. Heritability of low back pain and the role of disc degeneration. Pain (2007)
4. Chen A.C., Dworkin S.F., Haug J., and Gehrig J. Human pain responsivity in a tonic pain model: psychological determinants. Pain 37 (1989) 143-160
5. Diatchenko L., Nackley A.G., Slade G.D., Bhalang K., Belfer I., Max M.B., et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 125 (2006) 216-224
6. Diatchenko L., Slade G.D., Nackley A.G., Bhalang K., Sigurdsson A., Belfer I., et al. Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet 14 (2005) 135-143
7. Dionne R.A., Bartoshuk L., Mogil J., and Witter J. Individual responder analyses for pain: does one pain scale fit all?. Trends Pharmacol Sci 26 (2005) 125-130
8. Efron B., and Tibshirani R. Bootstrap methods for standard errors, confidence intervals, and other measures of statistical accuracy. Stat Sci 1 (1986) 54-75
9. Fejer R., Hartvigsen J., and Kyvik K.O. Heritability of neck pain: a population-based study of 33,794 Danish twins. Rheumatology (Oxford) 45 (2006) 589-594
10. Fillingim R.B., Kaplan L., Staud R., Ness T.J., Glover T.L., Campbell C.M., et al. The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. J Pain 6 (2005) 159-167
11. Ghione S. Hypertension-associated hypalgesia. Evidence in experimental animals and humans, pathophysiological mechanisms, and potential clinical consequences. Hypertension 28 (1996) 494-504
12. Hagen K., Stovner L.J., Vatten L., Holmen J., Zwart J.A., and Bovim G. Blood pressure and risk of headache: a prospective study of 22 685 adults in Norway. J Neurol Neurosurg Psychiatry 72 (2002) 463-466
13. Hagen K., Zwart J.A., Holmen J., Svebak S., Bovim G., and Stovner L.J. Does hypertension protect against chronic musculoskeletal complaints? The Nord-Trondelag Health Study. Arch Intern Med 165 (2005) 916-922
14. Hakim A.J., Cherkas L., El Zayat S., MacGregor A.J., and Spector T.D. The genetic contribution to carpal tunnel syndrome in women: a twin study. Arthritis Rheum 47 (2002) 275-279
15. Harris J.R., Magnus P., and Tambs K. The Norwegian Institute of Public Health Twin Panel: a description of the sample and program of research. Twin Res 5 (2002) 415-423
16. Janal M.N., Glusman M., Kuhl J.P., and Clark W.C. On the absence of correlation between responses to noxious heat, cold, electrical and ischemic stimulation. Pain 58 (1994) 403-411
17. Kasch H., Qerama E., Bach F.W., and Jensen T.S. Reduced cold pressor pain tolerance in non-recovered whiplash patients: a 1-year prospective study. Eur J Pain 9 (2005) 561-569
18. Kim H., and Dionne R.A. Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans. Mol Pain 3 (2007) 6
19. Kim H., Neubert J.K., San Miguel A., Xu K., Krishnaraju R.K., Iadarola M.J., et al. Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain 109 (2004) 488-496
20. Klement W., and Arndt J.O. The role of nociceptors of cutaneous veins in the mediation of cold pain in man. J Physiol 449 (1992) 73-83
21. Lariviere W.R., Wilson S.G., Laughlin T.M., Kokayeff A., West E.E., Adhikari S.M., et al. Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity. Pain 97 (2002) 75-86
22. Larsson B., Bille B., and Pedersen N.L. Genetic influence in headaches: a Swedish twin study. Headache 35 (1995) 513-519
23. LeResche L. Gender considerations in the epidemiology of chronic pain. In: Crombie I.K., Croft P.R., Linton S.J., LeResche L., and Von Korff M. (Eds). Epidemiology of pain (1999), IASP Press, Seattle 43-52
24. Lotsch J., Stuck B., and Hummel T. The human mu-opioid receptor gene polymorphism 118A > G decreases cortical activation in response to specific nociceptive stimulation. Behav Neurosci 120 (2006) 1218-1224
25. Lynn B., and Perl E.R. A comparison of four tests for assessing the pain sensitivity of different subjects and test areas. Pain 3 (1977) 353-365
26. MacGregor A.J., Griffiths G.O., Baker J., and Spector T.D. Determinants of pressure pain threshold in adult twins: evidence that shared environmental influences predominate. Pain 73 (1997) 253-257
27. Mogil J.S. The genetic mediation of individual differences in sensitivity to pain and its inhibition. Proc Natl Acad Sci USA 96 (1999) 7744-7751
28. Mogil J.S. Interaction between sex and genotype in the mediation of pain and pain inhibition. Semin Pain Med 1 (2003) 197-205
29. Mogil J.S., and Adhikari S.M. Hot and cold nociception are genetically correlated. J Neurosci 19 (1999) RC25
30. Mogil J.S., and Devor M. Introduction to pain genetics. In: Mogil J.S. (Ed). The genetics of pain (2004), IASP Press, Seattle (WA) 1-17
31. Mogil J.S., Seltzer Z., and Devor M. Gene-environment interactions affecting pain phenotype. In: Mogil J.S. (Ed). The genetics of pain (2004), IASP Press, Seattle (WA) 257-282
32. Mogil J.S., Wilson S.G., Bon K., Lee S.E., Chung K., Raber P., et al. Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception. Pain 80 (1999) 67-82
33. Mogil J.S., Wilson S.G., Bon K., Lee S.E., Chung K., Raber P., et al. Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis. Pain 80 (1999) 83-93
34. Mogil J.S., Wilson S.G., Chesler E.J., Rankin A.L., Nemmani K.V., Lariviere W.R., et al. The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc Natl Acad Sci USA 100 (2003) 4867-4872
35. Morris-Yates A., Talley N.J., Boyce P.M., Nandurkar S., and Andrews G. Evidence of a genetic contribution to functional bowel disorder. Am J Gastroenterol 93 (1998) 1311-1317
36. Neale M.C., Boker S.M., Xie G., and Maes H.H. Mx: statistical modeling (2002), Virginia Commonwealth University, Richmond, VA
37. Nielsen C.S., Price D.D., Vassend O., Stubhaug A., and Harris J.R. Characterizing individual differences in heat-pain sensitivity. Pain 119 (2005) 65-74
38. Plomin R., DeFries J.C., Craig I.W., and McGuffin P. Behavioral genetics. In: Plomin R., DeFries J.C., Craig I.W., and McGuffin P. (Eds). Behavioral genetics in the postgenomic era (2006), American Psychological Association, Washington (DC) 3-15
39. Posthuma D., Beem A.L., de Geus E.J., van Baal G.C., von Hjelmborg J.B., Iachine I., et al. Theory and practice in quantitative genetics. Twin Res 6 (2003) 361-376
40. Price D.D. Psychological and neural mechanisms of the affective dimension of pain. Science 288 (2000) 1769-1772
41. Price D.D., Bush F.M., Long S., and Harkins S.W. A comparison of pain measurement characteristics of mechanical visual analogue and simple numerical rating scales. Pain 56 (1994) 217-226
42. Price D.D., McGrath P.A., Rafii A., and Buckingham B. The validation of visual analogue scales as ratio scale measures for chronic and experimental pain. Pain 17 (1983) 45-56
43. Price D.D., McHaffie J.G., and Stein B.E. The psychophysical attributes of heat-induced pain and their relationships to neural mechanisms. J Cogn Neurosci 4 (1992) 1-14
44. Raja S.N., Meyer R.A., and Campbell J.N. Peripheral mechanisms of somatic pain. Anesthesiology 68 (1988) 571-590
45. Sheifer S.E., Gersh B.J., Yanez III N.D., Ades P.A., Burke G.L., and Manolio T.A. Prevalence, predisposing factors, and prognosis of clinically unrecognized myocardial infarction in the elderly. J Am Coll Cardiol 35 (2000) 119-126
46. Shir Y., and Seltzer Z. Heat hyperalgesia following partial sciatic ligation in rats: interacting nature and nurture. Neuroreport 12 (2001) 809-813
47. Shir Y., Zeltser R., Vatine J.J., Carmi G., Belfer I., Zangen A., et al. Correlation of intact sensibility and neuropathic pain-related behaviors in eight inbred and outbred rat strains and selection lines. Pain 90 (2001) 75-82
48. Simone D.A., and Kajander K.C. Responses of cutaneous A-fiber nociceptors to noxious cold. J Neurophysiol 77 (1997) 2049-2060
49. Tegeder I., Costigan M., Griffin R.S., Abele A., Belfer I., Schmidt H., et al. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 12 (2006) 1269-1277
50. Treloar S.A., Martin N.G., and Heath A.C. Longitudinal genetic analysis of menstrual flow, pain, and limitation in a sample of Australian twins. Behav Genet 28 (1998) 107-116
51. Zondervan K.T., Cardon L.R., Kennedy S.H., Martin N.G., and Treloar S.A. Multivariate genetic analysis of chronic pelvic pain and associated phenotypes. Behav Genet 35 (2005) 177-188
52. Zubieta J.K., Heitzeg M.M., Smith Y.R., Bueller J.A., Xu K., Xu Y., et al. COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science 299 (2003) 1240-1243