Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone

European Journal of Clinical Pharmacology

Volumn 66, Issue 4, 2010, Pages 387-397

  Saari, Teijo I ^a   Grönlund, Juha ^a   Hagelberg, Nora M ^a   Neuvonen, Mikko ^b   Laine, Kari ^a   Neuvonen, Pertti J ^b   Olkkola, Klaus T ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

CYP enzymes; Intravenous oral drug administration; Itraconazole; Opioid effects; Oxycodone; Pharmacodynamics; Pharmacokinetics

Indexed keywords

DRUG METABOLITE; ITRACONAZOLE; NOROXYCODONE; NOROXYMORPHONE; OXYCODONE; OXYMORPHONE; PLACEBO; UNCLASSIFIED DRUG; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; MORPHINAN DERIVATIVE; NARCOTIC ANALGESIC AGENT;

ANALGESIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG COMPETITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXPOSURE; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENTIATION; HUMAN; HUMAN EXPERIMENT; MAXIMUM PLASMA CONCENTRATION; MORNING DOSAGE; NORMAL HUMAN; PAIN THRESHOLD; PATIENT COMPLIANCE; PHARMACODYNAMICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TIME TO MAXIMUM PLASMA CONCENTRATION; DRUG ANTAGONISM; INTRAVENOUS DRUG ADMINISTRATION; OXIDATION REDUCTION REACTION;

ANALGESICS, OPIOID; AREA UNDER CURVE; CROSS-OVER STUDIES; CYTOCHROME P-450 CYP3A; HUMANS; INJECTIONS, INTRAVENOUS; ITRACONAZOLE; MORPHINANS; OXIDATION-REDUCTION; OXYCODONE; OXYMORPHONE;

EID: 77953955145     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-009-0775-8     Document Type: Article

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