메뉴 건너뛰기




Volumn 12, Issue 5, 2011, Pages 487-497

Clinically relevant genetic variations in drug metabolizing enzymes

Author keywords

Adverse drug reactions; Cytochrome P450; Drug metabolizing enzymes; Pharmacogenetics; Pharmacogenomics; Single nucleotide polymorphisms

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARBAMAZEPINE; CIMETIDINE; CLOPIDOGREL; CYTOCHROME P450 1A2; CYTOCHROME P450 2C; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; DRUG METABOLIZING ENZYME; FLUOXETINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPERFORIN; IMMUNOSUPPRESSIVE AGENT; MACROLIDE; NELFINAVIR; NEUROLEPTIC AGENT; OPIATE DERIVATIVE; ORAL CONTRACEPTIVE AGENT; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PRASUGREL; RIFAMPICIN; RITONAVIR; TAMOXIFEN; UNINDEXED DRUG; WARFARIN;

EID: 79955685734     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920011795495321     Document Type: Article
Times cited : (102)

References (146)
  • 1
    • 70449136457 scopus 로고
    • Drug reactions enzymes, and biochemical genetics
    • Motulsky, A. G. Drug reactions enzymes, and biochemical genetics. J. Am. Med. Assoc., 1957, 165, 835-837.
    • (1957) J. Am. Med. Assoc , vol.165 , pp. 835-837
    • Motulsky, A.G.1
  • 2
    • 0002150481 scopus 로고
    • Moderne Probleme der Humangenetik
    • Vogel, F. Moderne Probleme der Humangenetik. Ergeb Inn Med Kinderheilkd, 1959, 12, 52-125.
    • (1959) Ergeb Inn Med Kinderheilkd , vol.12 , pp. 52-125
    • Vogel, F.1
  • 4
    • 0000289267 scopus 로고
    • Substrate-induced synthesis and other properties of benzpyrene hydroxylase in rat liver
    • Conney, A. H.; Miller, E. C.; Miller, J. A. Substrate-induced synthesis and other properties of benzpyrene hydroxylase in rat liver. J. Biol. Chem., 1957, 228, 753-766.
    • (1957) J. Biol. Chem , vol.228 , pp. 753-766
    • Conney, A.H.1    Miller, E.C.2    Miller, J.A.3
  • 5
    • 0000759380 scopus 로고
    • Enzymatic metabolism of drugs and other foreign compounds
    • Brodie, B. B.; Gillette, J. R.; La Du, B.N. Enzymatic metabolism of drugs and other foreign compounds. Annu. Rev. Biochem., 1958, 27, 427-454.
    • (1958) Annu. Rev. Biochem , vol.27 , pp. 427-454
    • Brodie, B.B.1    Gillette, J.R.2    La Du, B.N.3
  • 6
    • 0001045385 scopus 로고
    • A new cytochrome in liver microsomes
    • Omura, T.; Sato, R. A new cytochrome in liver microsomes. J. Biol. Chem., 1962, 237, 1375-1376.
    • (1962) J. Biol. Chem , vol.237 , pp. 1375-1376
    • Omura, T.1    Sato, R.2
  • 7
    • 0345405458 scopus 로고
    • The stoichiometry of C21 hydroxylation of steroids by adrenocortical microsomes
    • Cooper, D. Y.; Estabrook, R. W.; Rosenthal, O. The stoichiometry of C21 hydroxylation of steroids by adrenocortical microsomes. J. Biol. Chem., 1963, 238, 1320-1323.
    • (1963) J. Biol. Chem , vol.238 , pp. 1320-1323
    • Cooper, D.Y.1    Estabrook, R.W.2    Rosenthal, O.3
  • 8
    • 0001426302 scopus 로고
    • Photochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase Systems
    • Cooper, D. Y.; Levin, S.; Narasimhulu, S.; Rosenthal, O. Photochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase Systems. Science, 1965, 147, 400-402.
    • (1965) Science , vol.147 , pp. 400-402
    • Cooper, D.Y.1    Levin, S.2    Narasimhulu, S.3    Rosenthal, O.4
  • 9
    • 0014486037 scopus 로고
    • Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital
    • Sladek, N. E.; Mannering, G. J. Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital. Mol. Pharmacol., 1969, 5, 186-199.
    • (1969) Mol. Pharmacol , vol.5 , pp. 186-199
    • Sladek, N.E.1    Mannering, G.J.2
  • 10
    • 0014489501 scopus 로고
    • Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal Ndemethylating systems
    • Sladek, N. E.; Mannering, G. J. Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal Ndemethylating systems. Mol. Pharmacol., 1969, 5, 174-185.
    • (1969) Mol. Pharmacol , vol.5 , pp. 174-185
    • Sladek, N.E.1    Mannering, G.J.2
  • 12
    • 0020429903 scopus 로고
    • Dissection of cytochrome P-450 isozymes (RLM) from fractions of untreated rat liver microsomal proteins
    • DOI 10.1016/S0006-291X(82)80171-X
    • Schenkman, J. B.; Jansson, I.; Backes, W. L.; Cheng, K. C.; Smith, C. Dissection of cytochrome P-450 isozymes (RLM) from fractions of untreated rat liver microsomal proteins. Biochem. Biophys. Res. Commun., 1982, 107, 1517-1523. (Pubitemid 13222444)
    • (1982) Biochemical and Biophysical Research Communications , vol.107 , Issue.4 , pp. 1517-1523
    • Schenkman, J.B.1    Jansson, I.2    Backes, W.L.3
  • 14
    • 0023122517 scopus 로고
    • The P450 gene superfamily: Recommended nomenclature
    • Nebert, D. W.; Adesnik, M.; Coon, M. J.; Estabrook, R. W.; Gonzalez, F. J.; Guengerich, F. P.; Gunsalus, I. C.; Johnson, E. F.; Kemper, B.; Levin, W. & et al. The P450 gene superfamily: recommended nomenclature. DNA, 1987, 6, 1-11. (Pubitemid 17033547)
    • (1987) DNA , vol.6 , Issue.1 , pp. 1-11
    • Nebert, D.W.1    Adesnik, M.2    Coon, M.J.3
  • 18
    • 63849159848 scopus 로고    scopus 로고
    • International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature
    • Maguire, J. J.; Parker, W. A.; Foord, S. M.; Bonner, T. I.; Neubig, R. R.; Davenport, A.P. International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. Pharmacol. Rev., 2009, 61, 1-8.
    • (2009) Pharmacol. Rev , vol.61 , pp. 1-8
    • Maguire, J.J.1    Parker, W.A.2    Foord, S.M.3    Bonner, T.I.4    Neubig, R.R.5    Davenport, A.P.6
  • 19
    • 74049098559 scopus 로고    scopus 로고
    • Human aldehyde dehydrogenase genes: Alternatively spliced transcriptional variants and their suggested nomenclature
    • Black, W. J.; Stagos, D.; Marchitti, S. A.; Nebert, D. W.; Tipton, K. F.; Bairoch, A.; Vasiliou, V. Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature. Pharmacogenet. Genomics, 2009, 19, 893-902.
    • (2009) Pharmacogenet. Genomics , vol.19 , pp. 893-902
    • Black, W.J.1    Stagos, D.2    Marchitti, S.A.3    Nebert, D.W.4    Tipton, K.F.5    Bairoch, A.6    Vasiliou, V.7
  • 21
    • 40549083731 scopus 로고    scopus 로고
    • Changes in consensus arylamine N-acetyltransferase gene nomenclature
    • DOI 10.1097/FPC.0b013e3282f60db0, PII 0121301120080400000010
    • Hein, D.W.; Boukouvala, S.; Grant, D.M.; Minchin, R.F.; Sim, E. Changes in consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenet. Genomics, 2008, 18, 367-368. (Pubitemid 351367530)
    • (2008) Pharmacogenetics and Genomics , vol.18 , Issue.4 , pp. 367-368
    • Hein, D.W.1    Boukouvala, S.2    Grant, D.M.3    Minchin, R.F.4    Sim, E.5
  • 22
    • 0017695082 scopus 로고
    • Polymorphic hydroxylation of debrisoquine in man
    • Mahgoub, A.; Idle, J. R.; Dring, L.G.; Lancaster, R.; Smith, R.L. Polymorphic hydroxylation of Debrisoquine in man. Lancet, 1977, 2, 584-586. (Pubitemid 8176607)
    • (1977) Lancet , vol.2 , Issue.8038 , pp. 584-586
    • Mahgoub, A.1    Idle, J.R.2    Dring, L.G.3
  • 24
    • 0018900001 scopus 로고
    • A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population
    • Evans, D. A.; Mahgoub, A.; Sloan, T. P.; Idle, J. R.; Smith, R. L. A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population. J. Med. Genet., 1980, 17, 102-105. (Pubitemid 10107632)
    • (1980) Journal of Medical Genetics , vol.17 , Issue.2 , pp. 102-105
    • Evans, D.A.P.1    Mahgoub, A.2    Sloan, T.P.3
  • 25
    • 0018874242 scopus 로고
    • Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine
    • Bertilsson, L.; Dengler, H.J.; Eichelbaum, M.; Schulz, H.U. Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine. Eur. J. Clin. Pharmacol., 1980, 17, 153-155. (Pubitemid 10149749)
    • (1980) European Journal of Clinical Pharmacology , vol.17 , Issue.2 , pp. 153-155
    • Bertilsson, L.1    Dengler, H.J.2    Eichelbaum, M.3    Schulz, H.U.4
  • 26
    • 0019199097 scopus 로고
    • Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man
    • DOI 10.1016/0024-3205(80)90642-6
    • Bertilsson, L.; Eichelbaum, M.; Mellstrom, B.; Sawe, J.; Schulz, H. U. Sjoqvist, F. Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man. Life Sci., 1980, 27, 1673-1677. (Pubitemid 11220225)
    • (1980) Life Sciences , vol.27 , Issue.18 , pp. 1673-1677
    • Bertilsson, L.1    Eichelbaum, M.2    Mellstrom, B.3
  • 27
    • 0014128388 scopus 로고
    • Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds
    • Hammer, W.; Sjoqvist, F. Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds. Life Sci., 1967, 6, 1895-1903.
    • (1967) Life Sci , vol.6 , pp. 1895-1903
    • Hammer, W.1    Sjoqvist, F.2
  • 28
    • 0014693146 scopus 로고
    • Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapy
    • Alexanderson, B.; Evans, D. A.; Sjoqvist, F. Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy. Br. Med. J., 1969, 4, 764-768.
    • (1969) Br. Med. J , vol.4 , pp. 764-768
    • Alexanderson, B.1    Evans, D.A.2    Sjoqvist, F.3
  • 29
    • 0025080352 scopus 로고
    • Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification
    • DOI 10.1016/0140-6736(90)92086-W
    • Heim, M.; Meyer, U. A. Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification. Lancet, 1990, 336, 529-532. (Pubitemid 20278099)
    • (1990) Lancet , vol.336 , Issue.8714 , pp. 529-532
    • Heim, M.1    Meyer, U.A.2
  • 31
    • 0025805934 scopus 로고
    • Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism
    • Gaedigk, A.; Blum, M.; Gaedigk, R.; Eichelbaum, M.; Meyer, U.A. Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Am. J. Hum. Genet., 1991, 48, 943-950. (Pubitemid 21891638)
    • (1991) American Journal of Human Genetics , vol.48 , Issue.5 , pp. 943-950
    • Gaedigk, A.1    Blum, M.2    Gaedigk, R.3    Eichelbaum, M.4    Meyer, U.A.5
  • 32
    • 0025243460 scopus 로고
    • 1934→A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3′ splice recognition site
    • Hanioka, N.; Kimura, S.; Meyer, U. A.; Gonzalez, F. J. The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site. Am. J. Hum. Genet., 1990, 47, 994-1001. (Pubitemid 120024070)
    • (1990) American Journal of Human Genetics , vol.47 , Issue.6 , pp. 994-1001
    • Hanioka, N.1    Kimura, S.2    Meyer, U.A.3    Gonzalez, F.J.4
  • 34
    • 24644445302 scopus 로고    scopus 로고
    • The human genome project and novel aspects of cytochrome P450 research
    • Ingelman-Sundberg, M. The human genome project and novel aspects of cytochrome P450 research. Toxicol. Appl. Pharmacol., 2005, 207, 52-56.
    • (2005) Toxicol. Appl. Pharmacol , vol.207 , pp. 52-56
    • Ingelman-Sundberg, M.1
  • 35
    • 0037198965 scopus 로고    scopus 로고
    • Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain
    • DOI 10.1016/S0169-328X(02)00177-8, PII S0169328X02001778
    • Chinta, S. J.; Pai, H.V.; Upadhya, S.C.; Boyd, M.R.; Ravindranath, V. Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain. Brain Res. Mol. Brain Res., 2002, 103, 49-61. (Pubitemid 34775033)
    • (2002) Molecular Brain Research , vol.103 , Issue.1-2 , pp. 49-61
    • Chinta, S.J.1    Pai, H.V.2    Upadhya, S.C.3    Boyd, M.R.4    Ravindranath, V.5
  • 36
    • 0028793072 scopus 로고
    • (+)-bufuralol 1'- hydroxylation activity in human and rhesus monkey intestine and liver
    • Prueksaritanont, T.; Dwyer, L. M.; Cribb, A. E. (+)-bufuralol 1'- hydroxylation activity in human and rhesus monkey intestine and liver. Biochem. Pharmacol, 1995, 50, 1521-1525.
    • (1995) Biochem. Pharmacol , vol.50 , pp. 1521-1525
    • Prueksaritanont, T.1    Dwyer, L.M.2    Cribb, A.E.3
  • 38
    • 36148976077 scopus 로고    scopus 로고
    • Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
    • DOI 10.1016/j.pharmthera.2007.09.004, PII S016372580700201X
    • Ingelman-Sundberg, M.; Sim, S. C.; Gomez, A.; Rodriguez- Antona, C. Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol. Ther., 2007, 116, 496-526. (Pubitemid 350116943)
    • (2007) Pharmacology and Therapeutics , vol.116 , Issue.3 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3    Rodriguez-Antona, C.4
  • 40
    • 77955082077 scopus 로고    scopus 로고
    • Genetic variation in metabolizing enzyme and transporter genes: Comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans
    • Man, M.; Farmen, M.; Dumaual, C.; Teng, C. H.; Moser, B.; Irie, S.; Noh, G. J.; Njau, R.; Close, S.; Wise, S.; Hockett, R. Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans. J. Clin. Pharmacol., 2010, 50, 929-940.
    • (2010) J. Clin. Pharmacol. , vol.50 , pp. 929-940
    • Man, M.1    Farmen, M.2    Dumaual, C.3    Teng, C.H.4    Moser, B.5    Irie, S.6    Noh, G.J.7    Njau, R.8    Close, S.9    Wise, S.10    Hockett, R.11
  • 41
    • 0021921831 scopus 로고
    • Interethnic dissociation between debrisoquine and desipramine hydroxylation
    • Rudorfer, M.V.; Lane, E. A.; Potter, W. Z. Interethnic dissociation between debrisoquine and desipramine hydroxylation. J. Clin. Psychopharmacol., 1985, 5, 89-92. (Pubitemid 15149498)
    • (1985) Journal of Clinical Psychopharmacology , vol.5 , Issue.2 , pp. 89-92
    • Rudorfer, M.V.1    Lane, E.A.2    Potter, W.Z.3
  • 42
    • 36448976865 scopus 로고    scopus 로고
    • Profiles of tamoxifen-related side effects by race and smoking status in women with breast cancer
    • DOI 10.1016/j.cdp.2007.10.004, PII S0361090X07001274
    • Zhan, M.; Flaws, J. A.; Gallicchio, L.; Tkaczuk, K.; Lewis, L. M.; Royak-Schaler, R. Profiles of tamoxifen-related side effects by race and smoking status in women with breast cancer. Cancer Detect. Prev., 2007, 31, 384-390. (Pubitemid 350166794)
    • (2007) Cancer Detection and Prevention , vol.31 , Issue.5 , pp. 384-390
    • Zhan, M.1    Flaws, J.A.2    Gallicchio, L.3    Tkaczuk, K.4    Lewis, L.M.5    Royak-Schaler, R.6
  • 43
    • 0033046088 scopus 로고    scopus 로고
    • Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects
    • Caraco, Y.; Sheller, J.; Wood, A.J. Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects. J. Pharmacol. Exp. Ther., 1999, 290, 413-422. (Pubitemid 29302351)
    • (1999) Journal of Pharmacology and Experimental Therapeutics , vol.290 , Issue.1 , pp. 413-422
    • Caraco, Y.1    Sheller, J.2    Wood, A.J.J.3
  • 44
    • 62449153701 scopus 로고    scopus 로고
    • The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells
    • Wu, X.; Hawse, J. R.; Subramaniam, M.; Goetz, M. P.; Ingle, J. N.; Spelsberg, T. C. The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. Cancer Res., 2009, 69, 1722-1727.
    • (2009) Cancer Res , vol.69 , pp. 1722-1727
    • Wu, X.1    Hawse, J.R.2    Subramaniam, M.3    Goetz, M.P.4    Ingle, J.N.5    Spelsberg, T.C.6
  • 49
    • 77956242845 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms as predictors of outcome in breast cancer patients treated with tamoxifen: Expanded polymorphism coverage improves risk stratification
    • Schroth, W.; Hamann, U.; Fasching, P. A.; Dauser, S.; Winter, S.; Eichelbaum, M.; Schwab, M.; Brauch, H. CYP2D6 polymorphisms as predictors of outcome in breast cancer patients treated with tamoxifen: expanded polymorphism coverage improves risk stratification. Clin. Cancer Res., 2010, 16, 4468-4477.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4468-4477
    • Schroth, W.1    Hamann, U.2    Fasching, P.A.3    Dauser, S.4    Winter, S.5    Eichelbaum, M.6    Schwab, M.7    Brauch, H.8
  • 53
    • 57749180179 scopus 로고    scopus 로고
    • Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: A case-control study
    • Madadi, P.; Ross, C. J.; Hayden, M. R.; Carleton, B. C.; Gaedigk, A.; Leeder, J. S.; Koren, G. Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study. Clin. Pharmacol. Ther., 2009, 85, 31-35.
    • (2009) Clin. Pharmacol. Ther , vol.85 , pp. 31-35
    • Madadi, P.1    Ross, C.J.2    Hayden, M.R.3    Carleton, B.C.4    Gaedigk, A.5    Leeder, J.S.6    Koren, G.7
  • 54
    • 84980108559 scopus 로고
    • The excretion of drugs in human milk; A review
    • Sapeika, N. The excretion of drugs in human milk; a review. J. Obstet. Gynaecol. Br. Emp., 1947, 54, 426-431.
    • (1947) J. Obstet. Gynaecol. Br. Emp , vol.54 , pp. 426-431
    • Sapeika, N.1
  • 57
    • 0021237993 scopus 로고
    • Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man
    • Kupfer, A.; Preisig, R. Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man. Eur. J. Clin. Pharmacol., 1984, 26, 753-759. (Pubitemid 14074652)
    • (1984) European Journal of Clinical Pharmacology , vol.26 , Issue.6 , pp. 753-759
    • Kupfer, A.1    Preisig, R.2
  • 58
    • 0028260641 scopus 로고
    • The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
    • de Morais, S. M.; Wilkinson, G. R.; Blaisdell, J.; Nakamura, K.; Meyer, U. A.; Goldstein, J. A. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J. Biol. Chem., 1994, 269, 15419-15422.
    • (1994) J. Biol. Chem , vol.269 , pp. 15419-15422
    • De Morais, S.M.1    Wilkinson, G.R.2    Blaisdell, J.3    Nakamura, K.4    Meyer, U.A.5    Goldstein, J.A.6
  • 59
    • 0029085322 scopus 로고
    • Drug interactions and the cytochrome P450 system. the role of cytochrome P450 2C19
    • Flockhart, D. A. Drug interactions and the cytochrome P450 system. The role of cytochrome P450 2C19. Clin. Pharmacokinet., 1995, 29 Suppl 1, 45-52.
    • (1995) Clin. Pharmacokinet , vol.29 , Issue.SUPPL. 1 , pp. 45-52
    • Flockhart, D.A.1
  • 60
    • 79955697985 scopus 로고    scopus 로고
    • Home Page of the Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    • Home Page of the Human Cytochrome P450 (CYP) Allele Nomenclature Committee
  • 61
    • 0036394942 scopus 로고    scopus 로고
    • Clinical significance of the cytochrome P450 2C19 genetic polymorphism
    • Desta, Z.; Zhao, X.; Shin, J. G.; Flockhart, D. A. Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin. Pharmacokinet., 2002, 41, 913-958. (Pubitemid 35168437)
    • (2002) Clinical Pharmacokinetics , vol.41 , Issue.12 , pp. 913-958
    • Desta, Z.1    Zhao, X.2    Shin, J.-G.3    Flockhart, D.A.4
  • 62
    • 0028787051 scopus 로고
    • Cytochrome P450 isozymes and antiepileptic drug interactions
    • Levy, R. H. Cytochrome P450 isozymes and antiepileptic drug interactions. Epilepsia, 1995, 36 Suppl 5, S8-13.
    • (1995) Epilepsia , vol.36 , Issue.SUPPL. 5
    • Levy, R.H.1
  • 65
    • 70749149366 scopus 로고    scopus 로고
    • Clopidogrel pharmacogenomics and risk of inadequate platelet inhibition: US FDA recommendations
    • Ellis, K. J.; Stouffer, G. A.; McLeod, H. L.; Lee, C. R. Clopidogrel pharmacogenomics and risk of inadequate platelet inhibition: US FDA recommendations. Pharmacogenomics, 2009, 10, 1799-1817.
    • (2009) Pharmacogenomics , vol.10 , pp. 1799-1817
    • Ellis, K.J.1    Stouffer, G.A.2    McLeod, H.L.3    Lee, C.R.4
  • 66
    • 79957485944 scopus 로고    scopus 로고
    • Cytochrome P450 2C19(*)2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: A metaanalysis
    • Sofi, F.; Giusti, B.; Marcucci, R.; Gori, A. M.; Abbate, R.; Gensini, G. F. Cytochrome P450 2C19(*)2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a metaanalysis. Pharmacogenomics J., 2010.
    • (2010) Pharmacogenomics J.
    • Sofi, F.1    Giusti, B.2    Marcucci, R.3    Gori, A.M.4    Abbate, R.5    Gensini, G.F.6
  • 67
    • 76349098199 scopus 로고    scopus 로고
    • Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    • Sibbing, D.; Koch, W.; Gebhard, D.; Schuster, T.; Braun, S.; Stegherr, J.; Morath, T.; Schomig, A.; von Beckerath, N. Kastrati, A. Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement. Circulation, 2010, 121, 512-518.
    • (2010) Circulation , vol.121 , pp. 512-518
    • Sibbing, D.1    Koch, W.2    Gebhard, D.3    Schuster, T.4    Braun, S.5    Stegherr, J.6    Morath, T.7    Schomig, A.8    Von Beckerath, N.9    Kastrati, A.10
  • 69
    • 77958567291 scopus 로고    scopus 로고
    • Prasugrel vs. clopidogrel for cytochrome P450 2C19- genotyped subgroups: Integration of the TRITON-TIMI 38 trial data
    • Sorich, M. J.; Vitry, A.; Ward, M. B.; Horowitz, J. D.; McKinnon, R. A. Prasugrel vs. clopidogrel for cytochrome P450 2C19- genotyped subgroups: integration of the TRITON-TIMI 38 trial data. J. Thromb. Haemost., 2010, 8, 1678-1684.
    • (2010) J. Thromb. Haemost. , vol.8 , pp. 1678-1684
    • Sorich, M.J.1    Vitry, A.2    Ward, M.B.3    Horowitz, J.D.4    McKinnon, R.A.5
  • 70
    • 38649131003 scopus 로고    scopus 로고
    • *2 allele on clopidogrel responsiveness
    • DOI 10.1016/j.thromres.2007.06.012, PII S0049384807002526
    • Fontana, P.; Senouf, D.; Mach, F. Biological effect of increased maintenance dose of clopidogrel in cardiovascular outpatients and influence of the cytochrome P450 2C19*2 allele on clopidogrel responsiveness. Thromb. Res., 2008, 121, 463-468. (Pubitemid 351174278)
    • (2008) Thrombosis Research , vol.121 , Issue.4 , pp. 463-468
    • Fontana, P.1    Senouf, D.2    Mach, F.3
  • 72
    • 0033608466 scopus 로고    scopus 로고
    • Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
    • DOI 10.1016/S0140-6736(98)04474-2
    • Aithal, G. P.; Day, C. P.; Kesteven, P. J.; Daly, A.K. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet, 1999, 353, 717-719. (Pubitemid 29103806)
    • (1999) Lancet , vol.353 , Issue.9154 , pp. 717-719
    • Aithal, G.P.1    Day, C.P.2    Kesteven, P.J.L.3    Daly, A.K.4
  • 73
    • 0037131892 scopus 로고    scopus 로고
    • CYP2C9 allelic variants: Ethnic distribution and functional significance
    • DOI 10.1016/S0169-409X(02)00076-5, PII S0169409X02000765
    • Xie, H. G.; Prasad, H. C.; Kim, R. B.; Stein, C. M. CYP2C9 allelic variants: ethnic distribution and functional significance. Adv. Drug Deliv. Rev., 2002, 54, 1257-1270. (Pubitemid 35284252)
    • (2002) Advanced Drug Delivery Reviews , vol.54 , Issue.10 , pp. 1257-1270
    • Xie, H.-G.1    Prasad, H.C.2    Kim, R.B.3    Stein, C.M.4
  • 78
    • 78649969067 scopus 로고    scopus 로고
    • Prospective alpha allocation in the clarification of optimal anticoagulation through genetics (COAG) trial
    • Joo, J.; Geller, N. L.; French, B.; Kimmel, S.E.; Rosenberg, Y.; Ellenberg, J.H. Prospective alpha allocation in the clarification of optimal anticoagulation through genetics (COAG) trial. Clin. Trials, 2010, 7, 597-604.
    • (2010) Clin. Trials , vol.7 , pp. 597-604
    • Joo, J.1    Geller, N.L.2    French, B.3    Kimmel, S.E.4    Rosenberg, Y.5    Ellenberg, J.H.6
  • 79
    • 79955688994 scopus 로고    scopus 로고
    • Genetics Informatics Trial (GIFT) of Warfarin to Prevent DVT
    • Genetics Informatics Trial (GIFT) of Warfarin to Prevent DVT,
  • 80
    • 58849142451 scopus 로고    scopus 로고
    • A regulatory science perspective on warfarin therapy: A pharmacogenetic opportunity
    • Kim, M. J.; Huang, S. M.; Meyer, U. A.; Rahman, A.; Lesko, L. J. A regulatory science perspective on warfarin therapy: a pharmacogenetic opportunity. J. Clin. Pharmacol., 2009, 49, 138-146.
    • (2009) J. Clin. Pharmacol , vol.49 , pp. 138-146
    • Kim, M.J.1    Huang, S.M.2    Meyer, U.A.3    Rahman, A.4    Lesko, L.J.5
  • 81
    • 43749104916 scopus 로고    scopus 로고
    • Intestinal first-pass metabolism of CYP3A4 substrates
    • Kato, M. Intestinal first-pass metabolism of CYP3A4 substrates. Drug Metab. Pharmacokinet., 2008, 23, 87-94.
    • (2008) Drug Metab. Pharmacokinet , vol.23 , pp. 87-94
    • Kato, M.1
  • 82
    • 31344443943 scopus 로고    scopus 로고
    • Significance of the minor cytochrome P450 3A isoforms
    • DOI 10.2165/00003088-200645010-00002
    • Daly, A. K. Significance of the minor cytochrome P450 3A isoforms. Clin. Pharmacokinet., 2006, 45, 13-31. (Pubitemid 43145013)
    • (2006) Clinical Pharmacokinetics , vol.45 , Issue.1 , pp. 13-31
    • Daly, A.K.1
  • 83
    • 0037131879 scopus 로고    scopus 로고
    • Genetic contribution to variable human CYP3A-mediated metabolism
    • DOI 10.1016/S0169-409X(02)00066-2, PII S0169409X02000662
    • Lamba, J. K.; Lin, Y. S.; Schuetz, E. G.; Thummel, K. E. Genetic contribution to variable human CYP3A-mediated metabolism. Adv. Drug Deliv. Rev., 2002, 54, 1271-1294. (Pubitemid 35284253)
    • (2002) Advanced Drug Delivery Reviews , vol.54 , Issue.10 , pp. 1271-1294
    • Lamba, J.K.1    Lin, Y.S.2    Schuetz, E.G.3    Thummel, K.E.4
  • 84
    • 30644478786 scopus 로고    scopus 로고
    • Activation of oxazaphosphorines by cytochrome P450: Application to gene-directed enzyme prodrug therapy for cancer
    • DOI 10.1016/j.tiv.2005.06.046, PII S0887233305002079
    • Roy, P.; Waxman, D. J. Activation of oxazaphosphorines by cytochrome P450: application to gene-directed enzyme prodrug therapy for cancer. Toxicol. In Vitro, 2006, 20, 176-186. (Pubitemid 43087701)
    • (2006) Toxicology in Vitro , vol.20 , Issue.2 , pp. 176-186
    • Roy, P.1    Waxman, D.J.2
  • 87
    • 36448929757 scopus 로고    scopus 로고
    • Genetic variability in CYP2A6 and the pharmacokinetics of nicotine
    • DOI 10.2217/14622416.8.10.1385
    • Mwenifumbo, J. C.; Tyndale, R. F. Genetic variability in CYP2A6 and the pharmacokinetics of nicotine. Pharmacogenomics, 2007, 8, 1385-1402. (Pubitemid 350162852)
    • (2007) Pharmacogenomics , vol.8 , Issue.10 , pp. 1385-1402
    • Mwenifumbo, J.C.1    Tyndale, R.F.2
  • 88
    • 67349284846 scopus 로고    scopus 로고
    • Association of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokers
    • Ho, M. K.; Mwenifumbo, J. C.; Al Koudsi, N.; Okuyemi, K. S.; Ahluwalia, J. S.; Benowitz, N. L.; Tyndale, R. F. Association of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokers. Clin. Pharmacol. Ther., 2009, 85, 635-643.
    • (2009) Clin. Pharmacol. Ther , vol.85 , pp. 635-643
    • Ho, M.K.1    Mwenifumbo, J.C.2    Al Koudsi, N.3    Okuyemi, K.S.4    Ahluwalia, J.S.5    Benowitz, N.L.6    Tyndale, R.F.7
  • 90
    • 50849104253 scopus 로고    scopus 로고
    • Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients
    • Bohanec Grabar, P.; Rozman, B.; Tomsic, M.; Suput, D.; Logar, D.; Dolzan, V. Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients. Eur. J. Clin. Pharmacol., 2008, 64, 871-876.
    • (2008) Eur. J. Clin. Pharmacol , vol.64 , pp. 871-876
    • Bohanec Grabar, P.1    Rozman, B.2    Tomsic, M.3    Suput, D.4    Logar, D.5    Dolzan, V.6
  • 93
    • 0000616920 scopus 로고
    • Enzymatic deficiency in primaquine-sensitive erythrocytes
    • Alving, A. S.; Carson, P. E.; Flanagan, C. L.; Ickes, C. E. Enzymatic deficiency in primaquine-sensitive erythrocytes. Science, 1956, 124, 484-485.
    • (1956) Science , vol.124 , pp. 484-485
    • Alving, A.S.1    Carson, P.E.2    Flanagan, C.L.3    Ickes, C.E.4
  • 94
    • 0004497053 scopus 로고
    • Molecular cloning and nucleotide sequence of cDNA for human glucose-6-phosphate dehydrogenase variant A(-)
    • Hirono, A.; Beutler, E. Molecular cloning and nucleotide sequence of cDNA for human glucose-6-phosphate dehydrogenase variant A(-). Proc. Natl. Acad. Sci. U S A, 1988, 85, 3951-3954.
    • (1988) Proc. Natl. Acad. Sci. U S A , vol.85 , pp. 3951-3954
    • Hirono, A.1    Beutler, E.2
  • 95
    • 0026879729 scopus 로고
    • Both mutations in G6PD A- are necessary to produce the G6PD deficient phenotype
    • Town, M.; Bautista, J. M.; Mason, P. J.; Luzzatto, L. Both mutations in G6PD A- are necessary to produce the G6PD deficient phenotype. Hum. Mol. Genet., 1992, 1, 171-174.
    • (1992) Hum. Mol. Genet , vol.1 , pp. 171-174
    • Town, M.1    Bautista, J.M.2    Mason, P.J.3    Luzzatto, L.4
  • 96
    • 0025075429 scopus 로고
    • Molecular genetics of the glucose-6-phosphate dehydrogenase (G6PD) Mediterranean variant and description of a new G6PD mutant. G6PD Andalus1361A
    • Vives-Corrons, J. L.; Kuhl, W.; Pujades, M. A.; Beutler, E. Molecular genetics of the glucose-6-phosphate dehydrogenase (G6PD) Mediterranean variant and description of a new G6PD mutant, G6PD Andalus1361A. Am. J. Hum. Genet., 1990, 47, 575-579.
    • (1990) Am. J. Hum. Genet , vol.47 , pp. 575-579
    • Vives-Corrons, J.L.1    Kuhl, W.2    Pujades, M.A.3    Beutler, E.4
  • 97
    • 12244262239 scopus 로고    scopus 로고
    • Pharmacogenetic and clinical aspects of dihydropyrimidine dehydrogenase deficiency
    • DOI 10.1258/000456303321016150
    • van Kuilenburg, A. B.; De Abreu, R. A.; van Gennip, A. H. Pharmacogenetic and clinical aspects of dihydropyrimidine dehydrogenase deficiency. Ann. Clin. Biochem., 2003, 40, 41-45. (Pubitemid 36051408)
    • (2003) Annals of Clinical Biochemistry , vol.40 , Issue.1 , pp. 41-45
    • Van Kuilenburg, A.B.P.1    De Abreu, R.A.2    Van Gennip, A.H.3
  • 98
    • 1942453306 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil
    • DOI 10.1016/j.ejca.2003.12.004, PII S0959804903010694
    • van Kuilenburg, A. B. Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil. Eur. J. Cancer, 2004, 40, 939-950. (Pubitemid 38496249)
    • (2004) European Journal of Cancer , vol.40 , Issue.7 , pp. 939-950
    • Van Kuilenburg, A.B.P.1
  • 100
    • 0031912432 scopus 로고    scopus 로고
    • Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer: Implication for 5-fluorouracil-based chemotherapy
    • Lu, Z.; Zhang, R.; Carpenter, J. T.; Diasio, R. B. Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer: implication for 5-fluorouracil-based chemotherapy. Clin. Cancer Res., 1998, 4, 325-329. (Pubitemid 28122745)
    • (1998) Clinical Cancer Research , vol.4 , Issue.2 , pp. 325-329
    • Lu, Z.1    Zhang, R.2    Carpenter, J.T.3    Diasio, R.B.4
  • 105
    • 33947588763 scopus 로고    scopus 로고
    • Should DPD analysis be required prior to prescribing fluoropyrimidines?
    • DOI 10.1016/j.ejca.2007.01.030, PII S0959804907000950
    • Yen, J. L.; McLeod, H. L. Should DPD analysis be required prior to prescribing fluoropyrimidines? Eur. J. Cancer, 2007, 43, 1011-1016. (Pubitemid 46483039)
    • (2007) European Journal of Cancer , vol.43 , Issue.6 , pp. 1011-1016
    • Yen, J.L.1    McLeod, H.L.2
  • 106
    • 0030885948 scopus 로고    scopus 로고
    • Semi-automated radioassay for determination of dihydropyrimidine dehydrogenase (DPD) activity Screening cancer patients for DPD deficiency, a condition associated with 5-fluorouracil toxicity
    • DOI 10.1016/S0378-4347(97)00253-3, PII S0378434797002533
    • Johnson, M. R.; Yan, J.; Shao, L.; Albin, N.; Diasio, R. B. Semiautomated radioassay for determination of dihydropyrimidine dehydrogenase (DPD) activity. Screening cancer patients for DPD deficiency, a condition associated with 5-fluorouracil toxicity. J. Chromatogr. B. Biomed. Sci. Appl., 1997, 696, 183-191. (Pubitemid 27387445)
    • (1997) Journal of Chromatography B: Biomedical Applications , vol.696 , Issue.2 , pp. 183-191
    • Johnson, M.R.1    Yan, J.2    Shao, L.3    Albin, N.4    Diasio, R.B.5
  • 110
    • 28444441585 scopus 로고    scopus 로고
    • Flavin-containing monooxygenase genetic polymorphism: Impact on chemical metabolism and drug development
    • DOI 10.2217/14622416.6.8.807
    • Koukouritaki, S. B.; Hines, R. N. Flavin-containing monooxygenase genetic polymorphism: impact on chemical metabolism and drug development. Pharmacogenomics, 2005, 6, 807-822. (Pubitemid 41724355)
    • (2005) Pharmacogenomics , vol.6 , Issue.8 , pp. 807-822
    • Koukouritaki, S.B.1    Hines, R.N.2
  • 111
    • 65249101597 scopus 로고    scopus 로고
    • Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations
    • Peng, G. S.; Yin, S. J. Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations. Hum. Genomics, 2009, 3, 121-127.
    • (2009) Hum. Genomics , vol.3 , pp. 121-127
    • Peng, G.S.1    Yin, S.J.2
  • 112
    • 34547433163 scopus 로고    scopus 로고
    • The genetics of alcohol metabolism: Role of alcohol dehydrogenase and aldehyde dehydrogenase variants
    • Edenberg, H. J. The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res. Health, 2007, 30, 5-13.
    • (2007) Alcohol Res. Health , vol.30 , pp. 5-13
    • Edenberg, H.J.1
  • 113
    • 75149129592 scopus 로고    scopus 로고
    • Metaanalysis of the association between the monoamine oxidase-A gene and mood disorders
    • Fan, M.; Liu, B.; Jiang, T.; Jiang, X.; Zhao, H.; Zhang, J. Metaanalysis of the association between the monoamine oxidase-A gene and mood disorders. Psychiatr. Genet., 2010, 20, 1-7.
    • (2010) Psychiatr. Genet. , vol.20 , pp. 1-7
    • Fan, M.1    Liu, B.2    Jiang, T.3    Jiang, X.4    Zhao, H.5    Zhang, J.6
  • 115
    • 0006948626 scopus 로고
    • Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis
    • Hughes, H. B.; Biehl, J. P.; Jones, A. P.; Schmidt, L. H. Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis. Am. Rev. Tuberc., 1954, 70, 266-273.
    • (1954) Am. Rev. Tuberc , vol.70 , pp. 266-273
    • Hughes, H.B.1    Biehl, J.P.2    Jones, A.P.3    Schmidt, L.H.4
  • 116
    • 26444539817 scopus 로고
    • Genetic control of isoniazid metabolism in man
    • Evans, D. A.; Manley, K. A.; Mc, K. V. Genetic control of isoniazid metabolism in man. Br. Med. J., 1960, 2, 485-491.
    • (1960) Br. Med. J , vol.2 , pp. 485-491
    • Evans, D.A.1    Manley, K.A.2    Mc, K.V.3
  • 117
    • 0004779878 scopus 로고
    • Comparison of isoniazid concentrations in the blood of people of Japanese and European descent; Therapeutic and genetic implications
    • Harris, H. W.; Knight, R. A.; Selin, M. J. Comparison of isoniazid concentrations in the blood of people of Japanese and European descent; therapeutic and genetic implications. Am. Rev. Tuberc., 1958, 78, 944-948.
    • (1958) Am. Rev. Tuberc , vol.78 , pp. 944-948
    • Harris, H.W.1    Knight, R.A.2    Selin, M.J.3
  • 120
    • 0025887858 scopus 로고
    • N-acetyltransferase polymorphism. Comparison of phenotype and genotype in humans
    • Hickman, D.; Sim, E. N-acetyltransferase polymorphism. Comparison of phenotype and genotype in humans. Biochem. Pharmacol., 1991, 42, 1007-1014.
    • (1991) Biochem. Pharmacol , vol.42 , pp. 1007-1014
    • Hickman, D.1    Sim, E.2
  • 122
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum, R. M.; Sladek, S. L. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am. J. Hum. Genet., 1980, 32, 651-662. (Pubitemid 10061685)
    • (1980) American Journal of Human Genetics , vol.32 , Issue.5 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 123
    • 0023119219 scopus 로고
    • Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations
    • Lennard, L.; Van Loon, J. A.; Lilleyman, J. S.; Weinshilboum, R. M. Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations. Clin. Pharmacol. Ther., 1987, 41, 18-25. (Pubitemid 17008125)
    • (1987) Clinical Pharmacology and Therapeutics , vol.41 , Issue.1 , pp. 18-25
    • Lennard, L.1    Van Loon, J.A.2    Lilleyman, J.S.3    Weinshilboum, R.M.4
  • 125
    • 0029919807 scopus 로고    scopus 로고
    • Thiopurine S-methyltransferase deficiency: Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians
    • Tai, H. L.; Krynetski, E. Y.; Yates, C. R.; Loennechen, T.; Fessing, M. Y.; Krynetskaia, N. F.; Evans, W. E. Thiopurine Smethyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians. Am. J. Hum. Genet., 1996, 58, 694-702. (Pubitemid 26086658)
    • (1996) American Journal of Human Genetics , vol.58 , Issue.4 , pp. 694-702
    • Tai, H.-L.1    Krynetski, E.Y.2    Yates, C.R.3    Loennechen, T.4    Fessing, M.Y.5    Krynetskaia, N.F.6    Evans, W.E.7
  • 127
    • 33947287144 scopus 로고    scopus 로고
    • Thiopurine treatment in inflammatory bowel disease: Clinical pharmacology and implication of pharmacogenetically guided dosing
    • DOI 10.2165/00003088-200746030-00001
    • Teml, A.; Schaeffeler, E.; Herrlinger, K. R.; Klotz, U.; Schwab, M. Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing. Clin. Pharmacokinet., 2007, 46, 187-208. (Pubitemid 46425646)
    • (2007) Clinical Pharmacokinetics , vol.46 , Issue.3 , pp. 187-208
    • Teml, A.1    Schaeffeler, E.2    Herrlinger, K.R.3    Klotz, U.4    Schwab, M.5
  • 128
    • 70649097090 scopus 로고    scopus 로고
    • Individualization of thiopurine therapy: Thiopurine S-methyltransferase and beyond
    • Karas-Kuzelicki, N.; Mlinaric-Rascan, I. Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond. Pharmacogenomics, 2009, 10, 1309-1322.
    • (2009) Pharmacogenomics , vol.10 , pp. 1309-1322
    • Karas-Kuzelicki, N.1    Mlinaric-Rascan, I.2
  • 131
    • 0030030762 scopus 로고    scopus 로고
    • Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome
    • DOI 10.1016/S0140-6736(96)91273-8
    • Monaghan, G.; Ryan, M.; Seddon, R.; Hume, R.; Burchell, B. Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome. Lancet, 1996, 347, 578-581. (Pubitemid 26070740)
    • (1996) Lancet , vol.347 , Issue.9001 , pp. 578-581
    • Monaghan, G.1    Ryan, M.2    Seddon, R.3    Hume, R.4    Burchell, B.5
  • 132
    • 0032519431 scopus 로고    scopus 로고
    • Genetic predisposition to the metabolism of irinotecan (CPT-11): Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
    • Iyer, L.; King, C. D.; Whitington, P. F.; Green, M. D.; Roy, S. K.; Tephly, T. R.; Coffman, B. L.; Ratain, M. J. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J. Clin. Invest., 1998, 101, 847-854. (Pubitemid 28096082)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.4 , pp. 847-854
    • Iyer, L.1    King, C.D.2    Whitington, P.F.3    Green, M.D.4    Roy, S.K.5    Tephly, T.R.6    Coffman, B.L.7    Ratain, M.J.8
  • 134
    • 34547788826 scopus 로고    scopus 로고
    • Role of UGT1A1*6, UGT1A1*28 and ABCG2 c.421C>A polymorphisms in irinotecan-induced neutropenia in Asian cancer patients
    • DOI 10.1111/j.1349-7006.2007.00541.x
    • Jada, S. R.; Lim, R.; Wong, C. I.; Shu, X.; Lee, S. C.; Zhou, Q.; Goh, B. C.; Chowbay, B. Role of UGT1A1*6, UGT1A1*28 and ABCG2 c.421C>A polymorphisms in irinotecan-induced neutropenia in Asian cancer patients. Cancer Sci;, 2007, 98, 1461-1467. (Pubitemid 47241771)
    • (2007) Cancer Science , vol.98 , Issue.9 , pp. 1461-1467
    • Jada, S.R.1    Lim, R.2    Wong, C.I.3    Shu, X.4    Lee, S.C.5    Zhou, Q.6    Goh, B.C.7    Chowbay, B.8
  • 137
    • 33749008249 scopus 로고    scopus 로고
    • The pharmacogenomics of warfarin: Closing in on personalized medicine
    • DOI 10.1124/mi.6.4.8
    • Rettie, A. E.; Tai, G. The pharmocogenomics of warfarin: closing in on personalized medicine. Mol. Interv., 2006, 6, 223-227. (Pubitemid 44455204)
    • (2006) Molecular Interventions , vol.6 , Issue.4 , pp. 223-227
    • Rettie, A.E.1    Tai, G.2
  • 140
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 2004, 116, 281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 141
    • 77951611567 scopus 로고    scopus 로고
    • MicroRNAs and pharmacogenomics
    • Shomron, N. MicroRNAs and pharmacogenomics. Pharmacogenomics, 2010, 11, 629-632.
    • (2010) Pharmacogenomics , vol.11 , pp. 629-632
    • Shomron, N.1
  • 142
    • 78049359286 scopus 로고    scopus 로고
    • Genomics 1000 Genomes Project gives new map of genetic diversity
    • Pennisi, E. Genomics. 1000 Genomes Project gives new map of genetic diversity. Science, 2010, 330, 574-575.
    • (2010) Science , vol.330 , pp. 574-575
    • Pennisi, E.1
  • 143
    • 70449103049 scopus 로고    scopus 로고
    • Genetic association studies in druginduced liver injury
    • Daly, A. K.; Day, C. P. Genetic association studies in druginduced liver injury. Semin. Liver Dis., 2009, 29, 400-411.
    • (2009) Semin. Liver Dis , vol.29 , pp. 400-411
    • Daly, A.K.1    Day, C.P.2
  • 144
    • 77950354310 scopus 로고    scopus 로고
    • Drug-induced hypersensitivity reactions and pharmacogenomics: Past, present and future
    • Alfirevic, A.; Pirmohamed, M. Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future. Pharmacogenomics, 2010, 11, 497-499.
    • (2010) Pharmacogenomics , vol.11 , pp. 497-499
    • Alfirevic, A.1    Pirmohamed, M.2
  • 146
    • 70349386728 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part i
    • Zhou, S. F. Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clin. Pharmacokinet., 2009, 48, 689-723.
    • (2009) Clin. Pharmacokinet , vol.48 , pp. 689-723
    • Zhou, S.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.