The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7- methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells

Oncology Reports

Volumn 28, Issue 4, 2012, Pages 1482-1490

  Cheng, Yung Yi ^a   Yang, Jai Sing ^a   Tsai, Shih Chang ^a   Liaw, Chih Chuang ^b   Chung, Jing Gung ^a,c   Huang, Li Jiau ^a   Lee, Kuo Hsiung ^d,e   Lu, Chi Cheng ^f   Chien, Hsi Cheng ^a   Tsuzuki, Minoru ^a,g   Kuo, Sheng Chu ^a,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c ASIA UNIVERSITY   (Taiwan)

^d UNC Hamner Institute for Drug Safety Sciences   (United States)

^e CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^g NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; HL 60 leukemia cells; p38 MAPK; Reactive oxygen species; YYK1

Indexed keywords

2 (3 HYDROXY 5 METHOXYPHENYL) 6,7 METHYLENEDIOXYQUINOLIN 4 ONE; ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; YYK 1;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; COLORIMETRY; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NICK END LABELING; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ACETYLCYSTEINE; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZODIOXOLES; CASPASES; CELL SURVIVAL; FREE RADICAL SCAVENGERS; HL-60 CELLS; HUMANS; LEUKEMIA; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; QUINOLONES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84866462308     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1923     Document Type: Article

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