Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway

Journal of Orthopaedic Research

Volumn 29, Issue 9, 2011, Pages 1448-1456

  Chiu, Yu Jen ^a   Hour, Mann Jen ^b   Lu, Chi Cheng ^c   Chung, Jing Gung ^b   Kuo, Sheng Chu ^b   Huang, Wen Wen ^b   Chen, Hui Jye ^b   Jin, Yi An ^a   Yang, Jai Sing ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

apoptosis; ATM; HMJ 30; human osteogenic sarcoma U 2 OS cells; p53

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ACETYLCYSTEINE; CAFFEINE; CASPASE 3; CASPASE 8; CASPASE 9; HMJ 30; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1; PROTEIN P53; PROTEIN T BID; QUINAZOLINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; CELL GROWTH; CELL STRAIN U 2 OS; CELL VIABILITY; COLORIMETRY; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MUTATION; OSTEOSARCOMA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SARCOMA CELL; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; COMET ASSAY; DNA DAMAGE; DNA, NEOPLASM; DNA-BINDING PROTEINS; HUMANS; OSTEOSARCOMA; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR STEM CELL ASSAY; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 79960259999     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21398     Document Type: Article

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