Novel quinolone CHM-1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line

Journal of Orthopaedic Research

Volumn 27, Issue 12, 2009, Pages 1637-1644

  Hsu, Shu Chun ^a   Yang, Jai Sing ^a   Kuo, Chao Lin ^a   Lo, Chyi ^a   Lin, Jing Pin ^a   Hsia, Te Chun ^a,b   Lin, Jen Jyh ^a,b   Lai, Kuang Chi ^a,c   Kuo, Hsiu Maan ^a   Huang, Li Jiau ^a   Kuo, Sheng Chu ^a   Wood, W Gibson ^d   Chung, Jing Gung ^a,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^e ASIA UNIVERSITY   (Taiwan)

Author keywords

Antimetastasis; Apoptosis; Caspase cascade; CHM 1; Human osterogenic sarcoma U 2 OS cells

Indexed keywords

20 FLUORO 6,7 METHYLENEDIOXY 2 PHENYL 4 QUINOLONE; 4',6 DIAMIDINO 2 PHENYLINDOLE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; GELATIN; GELATINASE A; GELATINASE B; MATRILYSIN; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL INVASION; CELL MIGRATION; CELL VIABILITY; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SEQUENCE; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; METASTASIS; OSTEOSARCOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; WOUND HEALING; ZYMOGRAPHY;

ANTINEOPLASTIC AGENTS; BONE NEOPLASMS; CASPASES; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; COMET ASSAY; DIOXOLES; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GENE EXPRESSION; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 9; MITOGEN-ACTIVATED PROTEIN KINASES; OSTEOSARCOMA; QUINOLONES; REACTIVE OXYGEN SPECIES;

EID: 71549161851     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20937     Document Type: Article

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