The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl) quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells

International Journal of Oncology

Volumn 38, Issue 5, 2011, Pages 1357-1364

  Huang, Shih Ming ^a   Yang, Jai Sing ^a   Tsai, Shih Chang ^a   Chen, Ming Hua ^a   Hsu, Mei Hua ^a   Lin, Hui Yi ^a   Chou, Li Chen ^a   Chinag, Jo Hua ^b   Lee, Kuo Hsiung ^c   Huang, Li Jiau ^a   Kuo, Sheng Chu ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c University of North Carolina   (United States)

Author keywords

AKT; Apoptosis; CDK1; G2 M arrest; Human leukemia HL 60 cells; Smh 3

Indexed keywords

2 [3 (METHYLAMINO)PHENYL] 6 (PYRROLIDIN 1 YL)QUINOLIN 4 ONE; 4',6 DIAMIDINO 2 PHENYLINDOLE; ACTIN; ANTILEUKEMIC AGENT; APOPTOSIS INDUCING FACTOR; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 7; CASPASE 9; CASPASE INHIBITOR; CYCLIN A; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYTOCHROME C; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BAD; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMH 3; UNCLASSIFIED DRUG; Z VAD FMK;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; CHROMATIN CONDENSATION; COLORIMETRY; CONTROLLED STUDY; DNA FRAGMENTATION; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKEMIA CELL LINE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CASPASES; CDC2 PROTEIN KINASE; CELL DIVISION; G2 PHASE; HL-60 CELLS; HUMANS; LEUKEMIA; MITOCHONDRIA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLIDINES; QUINOLONES; REACTIVE OXYGEN SPECIES;

EID: 79955039905     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.952     Document Type: Article

References (28)

1. Smith FO: Personalized medicine for AML? Blood 116: 2622-2623, 2010.
2. Nau KC and Lewis WD: Multiple myeloma: diagnosis and treatment. Am Fam Physician 78: 853-859, 2008.
3. Jegham H, Roy J, Maltais R, Desnoyers S and Poirier D: A novel aminosteroid of the 5alpha-androstane-3alpha,17beta-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells. Invest New Drugs (In press).
4. Suryadinata R, Sadowski M and Sarcevic B: Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates. Biosci Rep 30: 243-255, 2010.
5. Krystof V and Uldrijan S: Cyclin-dependent kinase inhibitors as anticancer drugs. Curr Drug Targets 11: 291-302, 2010.
6. Davis CD, Emenaker NJ and Milner JA: Cellular proliferation, apoptosis and angiogenesis: molecular targets for nutritional preemption of cancer. Semin Oncol 37: 243-257, 2010.
7. Caroppi P, Sinibaldi F, Fiorucci L and Santucci R: Apoptosis and human diseases: mitochondrion damage and lethal role of released cytochrome c as proapoptotic protein. Curr Med Chem 16: 4058-4065, 2009.
8. Burz C, Berindan-Neagoe I, Balacescu O and Irimie A: Apoptosis in cancer: key molecular signaling pathways and therapy targets. Acta Oncol 48: 811-821, 2009.
9. Russo AE, Torrisi E, Bevelacqua Y, et al: Melanoma: molecular pathogenesis and emerging target therapies (Review). Int J Oncol 34: 1481-1489, 2009.
10. Danial NN: BAD: undertaker by night, candyman by day. Oncogene 27 (Suppl. 1): S53-S70, 2008.
11. Kowalczyk JE and Zablocka B: Protein kinases in mitochondria. Postepy Biochem 54: 209-216, 2008.
12. Harvey RD and Lonial S: PI3 kinase/AKT pathway as a therapeutic target in multiple myeloma. Future Oncol 3: 639-647, 2007.
13. Yang JS, Hour MJ, Huang WW, Lin KL, Kuo SC and Chung JG: MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells. J Pharmacol Exp Ther 334: 477-488, 2010.
14. Lu CC, Yang JS, Huang AC, et al: Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells. Mol Nutr Food Res 54: 967-976, 2010.
15. Lo C, Lai TY, Yang JH, et al: Gallic acid induces apoptosis in A375.S2 human melanoma cells through caspase-dependent and -independent pathways. Int J Oncol 37: 377-385, 2010.
16. Lin SY, Lai WW, Ho CC, et al: Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways. Anticancer Res 29: 327-335, 2009.
17. Ji BC, Hsu WH, Yang JS, et al: Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo. J Agric Food Chem 57: 7596-7604, 2009.
18. Chou LC, Yang JS, Huang LJ, et al: The synthesized 2-(2-fluoro-phenyl)-6, 7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells. J Gastroenterol 44: 1055-1063, 2009.
19. Chen NG, Chen KT, Lu CC, et al: Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway. Oncol Rep 24: 449-455, 2010.
20. Wang WJ: Acurhagin-C, an ECD disintegrin, inhibits integrin alphavbeta3-mediated human endothelial cell functions by inducing apoptosis via caspase-3 activation. Br J Pharmacol 160: 1338-1351, 2010.
21. Chen HY, Lu HF, Yang JS, et al: The novel quinolone CHM-1 induces DNA damage and inhibits DNA repair gene expressions in a human osterogenic sarcoma cell line. Anticancer Res 30: 4187-4192, 2010.
22. Hsu SC, Yang JS, Kuo CL, et al: Novel quinolone CHM-1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line. J Orthop Res 27: 1637-1644, 2009.
23. Allan LA and Clarke PR: Apoptosis and autophagy: regulation of caspase-9 by phosphorylation. FEBS J 276: 6063-6073, 2009.
24. Gupta S: Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review). Int J Oncol 22: 15-20, 2003.
25. Decaudin D, Marzo I, Brenner C and Kroemer G: Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (Review). Int J Oncol 12: 141-152, 1998. (Pubitemid 28027240)
26. Levine B, Sinha S and Kroemer G: Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 4: 600-606, 2008.
27. Bergmann A: Survival signaling goes BAD. Dev Cell 3: 607-608, 2002.
28. Jiang P, Du W and Wu M: p53 and Bad: remote strangers become close friends. Cell Res 17: 283-285, 2007. (Pubitemid 46639925)