CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation

Journal of Biological Chemistry

Volumn 285, Issue 8, 2010, Pages 5497-5506

  Tsai, An Chi ^a   Pan, Shiow Lin ^a,b   Sun, Hui Lung ^a   Wang, Chih Ya ^a   Peng, Chieh Yu ^a   Wang, Shih Wei ^a   Chang, Ya Ling ^a   Kuo, Sheng Chu ^c   Lee, Kuo Hsiung ^d   Teng, Che Ming ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TUMOR AGENTS; ANTI-TUMORS; ANTIANGIOGENIC; ANTIVASCULAR; APOPTOSIS; APOPTOTIC CELL DEATH; CONCENTRATION-DEPENDENT; DEATH-RECEPTOR; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION LEVELS; HEPATOCELLULAR CARCINOMA; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; IMMUNOFLUORESCENCE MICROSCOPY; INDUCED APOPTOSIS; POLY POLYMERASE; PROCASPASE; QUINOLONES; SMALL INTERFERING RNA; THERAPEUTIC AGENTS; TUBE FORMATION; TUMOR ANGIOGENESIS; TUMOR GROWTH; UP-REGULATION; VASCULAR TARGETING AGENT; WESTERN BLOTTING;

BLOOD VESSEL PROSTHESES; CELL DEATH; DRUG PRODUCTS; FLOW CYTOMETRY; RNA; SELF ASSEMBLY; TUMORS;

ENDOTHELIAL CELLS;

2' FLUORO 6,7 METHYLENEDIOXY 2 PHENYL 4 QUINOLONE; ANGIOGENESIS INHIBITOR; CASPASE; DEATH RECEPTOR 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; PROCASPASE 7; PROCASPASE 8; PROTEIN P53; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; 2'-FLUORO-6,7-METHYLENEDIOXY-2-PHENYL-4-QUINOLONE; ANTINEOPLASTIC AGENT; FAS ANTIGEN; FAS PROTEIN, HUMAN; QUINOLONE DERIVATIVE; TP53 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME DEGRADATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT; UMBILICAL VEIN; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL MOTION; CYTOLOGY; DRUG EFFECT; DRUG SCREENING; MALE; METABOLISM; MOUSE MUTANT; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL MOVEMENT; DIOXOLES; ENDOTHELIAL CELLS; HUMANS; MALE; MICE; MICE, SCID; POLY(ADP-RIBOSE) POLYMERASES; QUINOLONES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR SUPPRESSOR PROTEIN P53; UMBILICAL VEINS; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77949331349     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.036277     Document Type: Article

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