Emodin has cytotoxic and protective effects in rat C6 glioma cells: Roles of Mdr1a and nuclear factor κB in cell survival

Journal of Pharmacology and Experimental Therapeutics

Volumn 330, Issue 3, 2009, Pages 736-744

  Kuo, Tzu Ching ^a   Yang, Jai Sing ^a   Lin, Meng Wei ^a   Hsu, Shu Chun ^a   Lin, Jen Jyh ^a,b   Lin, Hui Ju ^b   Hsia, Te Chun ^a,b   Liao, Ching Lung ^a   Yang, Mei Due ^b   Fan, Ming Jen ^c   Wood, W G ^d   Chung, Jing Gung ^a,c  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c ASIA UNIVERSITY   (Taiwan)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CATALASE; EMODIN; FAS ANTIGEN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 6; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MDR1A; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; XRCC1 PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; GEL MOBILITY SHIFT ASSAY; GLIOMA CELL; MITOCHONDRION; NEUROPROTECTION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; DNA FRAGMENTATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EMODIN; FLUORESCEINS; FLUORESCENT DYES; MICROSCOPY, FLUORESCENCE; NF-KAPPA B; P-GLYCOPROTEINS; PROTECTIVE AGENTS; PROTEIN KINASE INHIBITORS; RATS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 70349126349     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.153007     Document Type: Article

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