A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species

Free Radical Biology and Medicine

Volumn 50, Issue 9, 2011, Pages 1151-1162

  Chen, Huei Mei ^a,b   Chang, Fang Rong ^b,c,d   Hsieh, Ya Ching ^a   Cheng, Yu Jen ^a   Hsieh, Kun Chou ^a   Tsai, Lih Min ^a   Lin, An Shen ^b   Wu, Yang Chang ^b,e,f   Yuan, Shyng Shiou ^a,g  

^a E DA HOSPITAL   (Taiwan)

^b Department of Biological Science and Technology   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^e School of Chinese Medicine   (Taiwan)

^f CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^g I SHOU UNIVERSITY   (Taiwan)

Author keywords

mdecrease; H2A.X; Free radicals; Prostate cancer; ROS; WYCO2 9

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CASPASE 9; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; FLAVONOID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; WYC02 9;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL STRAIN DU145; DNA DAMAGE; GROWTH INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; RAT; XENOGRAFT;

ACETYLCYSTEINE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL CYCLE; CELL LINE, TUMOR; CYCLOHEXANONES; DNA DAMAGE; FLAVONES; GENE EXPRESSION; HISTONES; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, NUDE; MITOCHONDRIA; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; POLY(ADP-RIBOSE) POLYMERASES; PROSTATIC NEOPLASMS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

MUS MUSCULUS;

EID: 79953254783     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.01.015     Document Type: Article

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