CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells

European Journal of Pharmacology

Volumn 670, Issue 1, 2011, Pages 96-104

  Lee, Jang Chang ^a   Chou, Li Chen ^a   Huang, Chi Hung ^b   Chung, Jing Gung ^a   Huang, Li Jiau ^a   Lee, Kuo Hsiung ^c   Hung, Mien Chie ^a,d   Way, Tzong Der ^a,e   Kuo, Sheng Chu ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b Taiwan Advance Biopharm Inc   (Taiwan)

^c University of North Carolina   (United States)

^d UNIVERSITY OF TEXAS   (United States)

^e NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; CHM 1; Death receptor 5; Ovarian cancer; p38

Indexed keywords

6,7 METHYLENEDIOXYQUINOLIN 4 ONE DERIVATIVE; ANTINEOPLASTIC AGENT; CASPASE 8; DEATH RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE P38; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER REGRESSION; CANCER SURVIVAL; CELL ASSAY; CELL PROLIFERATION; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIFESPAN; LUNG CANCER; MALE; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; SKIN FIBROBLAST; TUMOR VOLUME; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 8; CELL LINE, TUMOR; CELL PROLIFERATION; DIOXOLES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; OVARIAN NEOPLASMS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; QUINOLINES; QUINOLONES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80054760950     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.08.006     Document Type: Article

References (38)

1. C. Adrain, and S.J. Martin The mitochondrial apoptosome: a killer unleashed by the cytochrome seas Trends Biochem. Sci. 26 2001 390 397 (Pubitemid 32530658)
2. D. Armstrong, B. Bundy, L. Wenzel, H.Q. Huang, R. Baergen, S. Lele, L.J. Copeland, J.L. Walker, and R.A. Burger Gynecologic oncology group: intraperitoneal cisplatin and paclitaxel in ovarian cancer N. Engl. J. Med. 354 2006 34 43 (Pubitemid 43048949)
3. A. Ashkenazi Targeting death and decoy receptors of the tumor-necrosis factor super-family Nat. Rev. Cancer 2 2002 420 430 (Pubitemid 37328939)
4. A. Ashkenazi, R.C. Pai, S. Fong, S. Leung, D.A. Lawrence, S.A. Marsters, C. Blackie, L. Chang, A.E. McMurtrey, A. Hebert, L. DeForge, I.L. Koumenis, D. Lewis, L. Harris, J. Bussiere, H. Koeppen, Z. Shahrokh, and R.H. Schwall Safety and antitumor activity of recombinant soluble Apo2 ligand J. Clin. Invest. 104 1999 155 162
5. P. Boyle, and B. Levin World Cancer Report IARC/WHO 2008
6. I. Budihardjo, H. Oliver, and M. Lutter Biochemical pathway of caspase activation during apoptosis Annu. Rev. Cell Dev. 15 1999 269 290 (Pubitemid 32250377)
7. J.J. Chen, C.W. Chou, Y.F. Chang, and C.C. Chen Proteasome inhibitors enhance TRAIL-induced apoptosis through the intrinsic regulation of DR5: involvement of NF-κB and reactive oxygen species-mediated p53 activation J. Immunol. 180 2008 8030 8039
8. L.C. Chou, C.T. Chen, J.C. Lee, T.D. Way, C.H. Huang, S.M. Huang, C.M. Teng, T. Yamori, T.S. Wu, C.M. Sun, D.S. Chien, K. Qian, S.L. Morris-Natschke, K.H. Lee, L.J. Huang, and S.C. Kuo Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent J. Med. Chem. 53 2010 1616 1626
9. T.G. Cotter Apoptosis and cancer: the genesis of a research field Nat. Rev. Cancer 9 2009 501 507
10. N. Craft, K.W. Bruhn, B.D. Nguyen, R. Prins, L.M. Liau, E.A. Collisson, A. De, M.S. Kolodney, S.S. Gambhir, and J.F. Miller Bioluminescent imaging of melanoma in live mice J. Invest. Dermatol. 125 2005 159 165 (Pubitemid 40981437)
11. N.N. Daniel, and S.J. Korsmeyer Cell death: critical control points Cell 116 2004 205 219 (Pubitemid 38167313)
12. K.F. Ferri, and F.G. Kroemer Organelle-specific initiation of cell death pathways Nat. Cell Biol. 3 2001 55 63
13. M.A. Hall, and J.L. Cleveland Clearing the TRAIL for cancer therapy Cancer Cell 12 2007 4 6 (Pubitemid 47001789)
14. F. Jin, X. Liu, Z. Zhou, P. Yue, R. Lotan, F.R. Khuri, L.W. Chung, and S.Y. Sun Activation of nuclear factor-κ B contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells Cancer Res. 65 2005 6354 6363 (Pubitemid 40994422)
15. T.R. Johnson, K. Stone, M. Nikrad, T. Yeh, W.X. Zong, C.B. Thompson, A. Nesterov, and A.S. Kraft The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells Oncogene 22 2003 4953 4963 (Pubitemid 37026394)
16. A.F. Kabore, J. Sun, X. Hu, K. McCrea, J.B. Johnston, and S.B. Gibson The TRAIL apoptotic pathway mediates proteasome inhibitor induced apoptosis in primary chronic lymphocytic leukemia cells Apoptosis 11 2006 1175 1193 (Pubitemid 44035966)
17. S.K. Kelley, and A. Ashkenazi Targeting death receptors in cancer with Apo2L/TRAIL Curr. Opin. Pharmacol. 4 2004 333 339 (Pubitemid 38987058)
18. R. Kim, K. Tanabe, Y. Uchida, M. Emi, H. Inoue, and T. Toge Current status of the molecular mechanisms of anticancer drug-induced apoptosis Cancer Chemother. Pharmacol. 50 2002 343 352
19. H. Kim, E.H. Kim, Y.W. Eom, W.H. Kim, T.K. Kwon, S.J. Lee, and K.S. Choi Sulforaphane sensitizes tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5 Cancer Res. 66 2006 1740 1750 (Pubitemid 43259959)
20. I. Lavrik, A. Golks, and P.H. Krammer Death receptor signaling J. Cell Sci. 118 2005 265 267 (Pubitemid 40277339)
21. D. Lawrence, Z. Shahrokh, S. Marsters, K. Achilles, D. Shih, B. Mounho, K. Hillan, K. Totpal, L. DeForge, P. Schow, J. Hooley, S. Sherwood, R. Pai, S. Leung, L. Khan, B. Gliniak, J. Bussiere, C.A. Smith, S.S. Strom, S.S. Kelley, J.A. Fox, D. Thomas, and A. Ashkenazi Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions Nat. Med. 7 2001 383 385
22. J.C. Lee, C.Y. Tsai, J.Y. Kao, M.C. Kao, S.C. Tsai, C.S. Chang, L.J. Huang, S.C. Kuo, J.K. Lin, and T.D. Way Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells Mol. Nutr. Food Res. 52 2008 655 663
23. X. Liu, P. Yue, Z. Zhou, F.R. Khuri, and S.Y. Sun Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells J. Natl. Cancer Inst. 96 2004 1769 1780 (Pubitemid 39654571)
24. F. Modugno Ovarian cancer and high risk women-implications for prevention, screening, and early detection Gynecol. Oncol. 91 2003 15 31 (Pubitemid 37203405)
25. M. Muzio, A.M. Chinnaiyan, and F.C. Kischkel FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex Cell 85 1996 817 827 (Pubitemid 26193033)
26. R. Ozols Update on the management of ovarian cancer Cancer 1 2003 22 30
27. G. Pearson, F. Robinson, T. Beers Gibson, B.E. Xu, M. Karandikar, K. Berman, and M.H. Cobb Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions Endocr. Rev. 22 2001 153 183 (Pubitemid 32458157)
28. J. Permuth-Wey, and T.A. Sellers Epidemiology of ovarian cancer Methods Mol. Biol. 472 2009 413 437
29. M.L. Rothenberg, P.Y. Liu, P.S. Braly, S.P. Wilczynski, E.V. Hannigan, S. Wadler, G. Stuart, C. Jiang, M. Markman, and D.S. Alberts Combined intraperitoneal and intravenous chemotherapy for women with optimally de-bulked ovarian cancer: results from an intergroup phase II trial J. Clin. Oncol. 21 2003 1313 1319 (Pubitemid 46606409)
30. J. Saklatvala, L. Rawlinson, R.J. Waller, S. Sarsfield, J.C. Lee, L.F. Morton, M.J. Barnes, and R.W. Farndale Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue J. Biol. Chem. 22 1996 6586 6589 (Pubitemid 26104083)
31. M.M. Tomayko, and C.P. Reynolds Determination of subcutaneous tumor size in athymic (nude) mice Cancer Chemother. Pharmacol. 24 1989 148 154 (Pubitemid 19163397)
32. A.C. Tsai, S.I. Pan, H.L. Sun, C.Y. Wang, C.Y. Peng, S.W. Wang, Y.L. Chang, S.C. Kuo, K.H. Lee, and C.M. Teng CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulations J. Biol. Chem. 19 2010 497 506
33. V. Vassileva, E.H. Moriyama, R. De Souza, J. Grant, C.J. Allen, B.C. Wilson, and M. Piquette-Miller Efficacy assessment of sustained intraperitoneal paclitaxel therapy in a murine model of ovarian cancer using bioluminescent imaging Br. J. Cancer 99 2008 2037 2043
34. H. Walczak, R.E. Miller, K. Ariail, B. Gliniak, T.S. Griffith, M. Kubin, W. Chin, J. Jones, A. Woodward, T. Le, C. Smith, P. Smolak, R.G. Goodwin, C.T. Rauch, J.C. Schuh, and D.H. Lynch Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo Nat. Med. 5 1999 157 163 (Pubitemid 29068521)
35. J.L. Walker, D.K. Armstrong, H.Q. Huang, J. Fowler, K. Webster, R.A. Burger, and D. Clarke-Pearson Intraperitoneal catheter outcomes in a phase III trial of intravenous vs. intraperitoneal chemotherapy in optimal stage III ovarian and primary peritoneal cancer: a Gynecologic Oncology Group Study Gynecol. Oncol. 100 2006 27 32 (Pubitemid 41815045)
36. T.D. Way, J.C. Lee, D.H. Kuo, L.L. Fan, C.H. Huang, H.Y. Lin, P.C. Shieh, P.T. Kuo, C.F. Liao, H. Liu, and J.Y. Kao Inhibition of epidermal growth factor receptor signaling by Saussurea involucrata, a rare traditional Chinese medicinal herb, in human hormone-resistant prostate cancer PC-3 Cells J. Agric. Food Chem. 58 2010 3356 3365
37. C.C. Yeh, Y.T. Deng, D.Y. Sha, M. Hsiao, and M.Y. Kuo Suberoylanilide hydroxamic acid sensitizes human oral cancer cells to TRAIL-induced apoptosis through increase DR5 expression Mol. Cancer Ther. 8 2009 2718 2725
38. S. Yodkeeree, B. Sung, P. Limtrakul, and B.B. Aggarwal Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: evidence for an essential role of reactive oxygen species Cancer Res. 69 2009 6581 6589