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Volumn 3 JUL, Issue , 2012, Pages

Human pluripotent stem cells: Applications and challenges in neurological diseases

Author keywords

Disease modeling; Drug screening; Neurodegenerative diseases; Neurodevelopmental diseases; Neurological diseases; Pluripotent stem cells; Regenerative medicine

Indexed keywords


EID: 84866436991     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2012.00267     Document Type: Review
Times cited : (32)

References (221)
  • 2
    • 53049105819 scopus 로고    scopus 로고
    • ALS drug development: reflections from the past and a way forward
    • Aggarwal, S., and Cudkowicz, M. (2008). ALS drug development: reflections from the past and a way forward. Neurotherapeutics 5, 516-527.
    • (2008) Neurotherapeutics , vol.5 , pp. 516-527
    • Aggarwal, S.1    Cudkowicz, M.2
  • 4
    • 80053143413 scopus 로고    scopus 로고
    • Iso-genic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model
    • doi:10.1371/journal.pone.0025255
    • Ananiev, G., Williams, E. C., Li, H., and Chang, Q. (2011). Iso-genic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model. PLoS ONE 6, e25255. doi:10.1371/journal.pone.0025255
    • (2011) PLoS ONE , vol.6
    • Ananiev, G.1    Williams, E.C.2    Li, H.3    Chang, Q.4
  • 5
    • 33947691631 scopus 로고    scopus 로고
    • Gene expression changes in long term expanded human neural progenitor cells passaged by chopping lead to loss of neurogenic potential in vivo
    • Anderson, L., Burnstein, R. M., He, X., Luce, R., Furlong, R., Foltynie, T., Sykacek, P., Menon, D. K., and Cald-well, M. A. (2007). Gene expression changes in long term expanded human neural progenitor cells passaged by chopping lead to loss of neurogenic potential in vivo. Exp. Neurol. 204, 512-524.
    • (2007) Exp. Neurol. , vol.204 , pp. 512-524
    • Anderson, L.1    Burnstein, R.M.2    He, X.3    Luce, R.4    Furlong, R.5    Foltynie, T.6    Sykacek, P.7    Menon, D.K.8    Cald-well, M.A.9
  • 10
    • 0037176537 scopus 로고    scopus 로고
    • Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study
    • Bahn, S., Mimmack, M., Ryan, M., Caldwell, M., Jauniaux, E., Starkey, M., Svendsen, C., and Emson, P. (2002). Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study. Lancet 359, 310-315.
    • (2002) Lancet , vol.359 , pp. 310-315
    • Bahn, S.1    Mimmack, M.2    Ryan, M.3    Caldwell, M.4    Jauniaux, E.5    Starkey, M.6    Svendsen, C.7    Emson, P.8
  • 12
    • 79960063073 scopus 로고    scopus 로고
    • Animal models: inside the minds of mice and men
    • Baker, M. (2011). Animal models: inside the minds of mice and men. Nature 475, 123-128.
    • (2011) Nature , vol.475 , pp. 123-128
    • Baker, M.1
  • 13
    • 79959992876 scopus 로고    scopus 로고
    • Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells
    • Bar-Nur, O., Russ, H. A., Efrat, S., and Benvenisty, N. (2011). Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell 9, 17-23.
    • (2011) Cell Stem Cell , vol.9 , pp. 17-23
    • Bar-Nur, O.1    Russ, H.A.2    Efrat, S.3    Benvenisty, N.4
  • 14
    • 39149095271 scopus 로고    scopus 로고
    • PGD-derived human embryonic stem cell lines as a powerful tool for the study of human genetic disorders
    • Ben-Yosef, D., Malcov, M., and Eiges, R. (2008). PGD-derived human embryonic stem cell lines as a powerful tool for the study of human genetic disorders. Mol. Cell. Endocrinol. 282, 153-158.
    • (2008) Mol. Cell. Endocrinol. , vol.282 , pp. 153-158
    • Ben-Yosef, D.1    Malcov, M.2    Eiges, R.3
  • 15
    • 70450237623 scopus 로고    scopus 로고
    • A critical period in cortical interneuron neurogenesis in Down syndrome revealed by human neural progenitor cells
    • Bhattacharyya, A., Mcmillan, E., Chen, S. I., Wallace, K., and Svendsen, C. N. (2009). A critical period in cortical interneuron neurogenesis in Down syndrome revealed by human neural progenitor cells. Dev. Neurosci. 31, 497-510.
    • (2009) Dev. Neurosci. , vol.31 , pp. 497-510
    • Bhattacharyya, A.1    Mcmillan, E.2    Chen, S.I.3    Wallace, K.4    Svendsen, C.N.5
  • 17
    • 9444265273 scopus 로고    scopus 로고
    • Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants
    • Bieberich, E., Silva, J., Wang, G., Krishnamurthy, K., and Condie, B. G. (2004). Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants. J. CellBiol. 167, 723-734.
    • (2004) J. CellBiol. , vol.167 , pp. 723-734
    • Bieberich, E.1    Silva, J.2    Wang, G.3    Krishnamurthy, K.4    Condie, B.G.5
  • 18
    • 74849135201 scopus 로고    scopus 로고
    • The tumorigenicity of diploid and aneuploid human pluripotent stem cells
    • Blum, B., and Benvenisty, N. (2009). The tumorigenicity of diploid and aneuploid human pluripotent stem cells. Cell Cycle 8, 3822-3830.
    • (2009) Cell Cycle , vol.8 , pp. 3822-3830
    • Blum, B.1    Benvenisty, N.2
  • 22
    • 1842477467 scopus 로고    scopus 로고
    • Kary-otype of human ES cells during extended culture
    • Buzzard, J. J., Gough, N. M., Crook, J. M., and Colman, A. (2004). Kary-otype of human ES cells during extended culture. Nat. Biotechnol. 22, 381-382.
    • (2004) Nat. Biotechnol. , vol.22 , pp. 381-382
    • Buzzard, J.J.1    Gough, N.M.2    Crook, J.M.3    Colman, A.4
  • 26
    • 62149125434 scopus 로고    scopus 로고
    • Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
    • Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M., and Studer, L. (2009). Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 27, 275-280.
    • (2009) Nat. Biotechnol. , vol.27 , pp. 275-280
    • Chambers, S.M.1    Fasano, C.A.2    Papapetrou, E.P.3    Tomishima, M.4    Sadelain, M.5    Studer, L.6
  • 27
    • 81855206164 scopus 로고    scopus 로고
    • Brief report: phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient
    • Chang, T., Zheng, W., Tsark, W., Bates, S., Huang, H., Lin, R. J., and Yee, J. K. (2011). Brief report: phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient. Stem Cells 29, 2090-2093.
    • (2011) Stem Cells , vol.29 , pp. 2090-2093
    • Chang, T.1    Zheng, W.2    Tsark, W.3    Bates, S.4    Huang, H.5    Lin, R.J.6    Yee, J.K.7
  • 28
    • 81255210997 scopus 로고    scopus 로고
    • Modelling of Parkinson's disease in mice
    • Chesselet, M. F., and Richter, E (2011). Modelling of Parkinson's disease in mice. LancetNeurol. 10, 1108-1118.
    • (2011) LancetNeurol , vol.10 , pp. 1108-1118
    • Chesselet, M.F.1    Richter, E.2
  • 30
    • 79953048441 scopus 로고    scopus 로고
    • Integration-free induced pluripo-tent stem cells derived from schizo-phreniapatientswithaDISC1 mutation
    • Chiang, C. H., Su, Y., Wen, Z., Yorit-omo, N., Ross, C. A., Margolis, R. L., Song, H., and Ming, G. L. (2011). Integration-free induced pluripo-tent stem cells derived from schizo-phreniapatientswithaDISC1 mutation. Mol. Psychiatry 16, 358-360.
    • (2011) Mol. Psychiatry , vol.16 , pp. 358-360
    • Chiang, C.H.1    Su, Y.2    Wen, Z.3    Yorit-omo, N.4    Ross, C.A.5    Margolis, R.L.6    Song, H.7    Ming, G.L.8
  • 33
    • 84860660444 scopus 로고    scopus 로고
    • Toward understanding Machado-Joseph disease
    • Costa, M. D. C., and Paulson, H. L. (2012). Toward understanding Machado-Joseph disease. Prog. Neu-robiol. 97, 239-257.
    • (2012) Prog. Neu-robiol. , vol.97 , pp. 239-257
    • Costa, M.D.C.1    Paulson, H.L.2
  • 35
    • 0242363670 scopus 로고    scopus 로고
    • Molecular pathways of neu-rodegeneration in Parkinson's disease
    • Dawson, T. M., and Dawson, V. L. (2003). Molecular pathways of neu-rodegeneration in Parkinson's disease. Science 302, 819-822.
    • (2003) Science , vol.302 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 36
    • 81855175305 scopus 로고    scopus 로고
    • How to cross immunogenetic hurdles to human embryonic stem cell transplantation
    • De Rham, C., and Villard, J. (2011). How to cross immunogenetic hurdles to human embryonic stem cell transplantation. Semin. Immunopathol. 33, 525-534.
    • (2011) Semin. Immunopathol. , vol.33 , pp. 525-534
    • De Rham, C.1    Villard, J.2
  • 37
    • 44349152907 scopus 로고    scopus 로고
    • High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells
    • Desbordes, S. C., Placantonakis, D. G., Ciro, A., Socci, N. D., Lee, G., Djaballah, H., and Studer, L. (2008). High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2, 602-612.
    • (2008) Cell Stem Cell , vol.2 , pp. 602-612
    • Desbordes, S.C.1    Placantonakis, D.G.2    Ciro, A.3    Socci, N.D.4    Lee, G.5    Djaballah, H.6    Studer, L.7
  • 39
    • 0035007860 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis ALS riluzole-tocopherol Study Group
    • Desnuelle, C., Dib, M., Garrel, C., and Favier, A. (2001). A double-blind, placebo-controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis. ALS riluzole-tocopherol Study Group. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 2, 9-18.
    • (2001) Amyotroph. Lateral Scler. Other Motor Neuron Disord. , vol.2 , pp. 9-18
    • Desnuelle, C.1    Dib, M.2    Garrel, C.3    Favier, A.4
  • 41
    • 56549096129 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation
    • Di Giorgio, E P., Boulting, G. L., Bobrowicz, S., and Eggan, K. C. (2008). Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell 3, 637-648.
    • (2008) Cell Stem Cell , vol.3 , pp. 637-648
    • Di Giorgio, E.P.1    Boulting, G.L.2    Bobrowicz, S.3    Eggan, K.C.4
  • 42
    • 33751119892 scopus 로고    scopus 로고
    • Translating preclinical insights into effective human trials in ALS
    • Dibernardo, A. B., and Cudkowicz, M. E. (2006). Translating preclinical insights into effective human trials in ALS. Biochim. Biophys. Acta 1762, 1139-1149.
    • (2006) Biochim. Biophys. Acta , vol.1762 , pp. 1139-1149
    • Dibernardo, A.B.1    Cudkowicz, M.E.2
  • 45
    • 34748866686 scopus 로고    scopus 로고
    • Signaling pathways in cancer and embryonic stem cells
    • Dreesen, O., and Brivanlou, A. H. (2007). Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev. 3, 7-17.
    • (2007) Stem Cell Rev , vol.3 , pp. 7-17
    • Dreesen, O.1    Brivanlou, A.H.2
  • 50
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • Evans, M. J., and Kaufman, M. H. (1981). Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154-156.
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 51
    • 47549096256 scopus 로고    scopus 로고
    • Roles of Krüppel-like factor 4 in normal homeostasis, cancer and stem cells
    • Evans, P. M., and Liu, C. (2008). Roles of Krüppel-like factor 4 in normal homeostasis, cancer and stem cells. Acta Biochim. Biophys. Sin. (Shanghai) 40, 554-564.
    • (2008) Acta Biochim. Biophys. Sin. (Shanghai) , vol.40 , pp. 554-564
    • Evans, P.M.1    Liu, C.2
  • 52
    • 62949220231 scopus 로고    scopus 로고
    • Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells
    • Feng, B., Ng, J. H., Heng, J. C. D., and Ng, H. H. (2009). Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell 4, 301-312.
    • (2009) Cell Stem Cell , vol.4 , pp. 301-312
    • Feng, B.1    Ng, J.H.2    Heng, J.C.D.3    Ng, H.H.4
  • 53
    • 80755163102 scopus 로고    scopus 로고
    • Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
    • Ferraiuolo, L., Kirby, J., Grierson, A. J., Sendtner, M., and Shaw, P. J. (2011). Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis. Nat. Rev. Neurol. 7, 616-630.
    • (2011) Nat. Rev. Neurol. , vol.7 , pp. 616-630
    • Ferraiuolo, L.1    Kirby, J.2    Grierson, A.J.3    Sendtner, M.4    Shaw, P.J.5
  • 55
    • 77953216242 scopus 로고    scopus 로고
    • General aspects and neuropathology of X-linked adrenoleukodystrophy
    • Ferrer, I., Aubourg, P., and Pujol, A. (2010). General aspects and neuropathology of X-linked adrenoleukodystrophy. Brain Pathol. 20, 817-830.
    • (2010) Brain Pathol , vol.20 , pp. 817-830
    • Ferrer, I.1    Aubourg, P.2    Pujol, A.3
  • 58
    • 33745001244 scopus 로고    scopus 로고
    • Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation
    • Fukuda, H., Takahashi, J., Watanabe, K., Hayashi, H., Morizane, A., Koy-anagi, M., Sasai, Y., and Hashimoto, N. (2006). Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation. Stem Cells 24, 763-771.
    • (2006) Stem Cells , vol.24 , pp. 763-771
    • Fukuda, H.1    Takahashi, J.2    Watanabe, K.3    Hayashi, H.4    Morizane, A.5    Koy-anagi, M.6    Sasai, Y.7    Hashimoto, N.8
  • 59
    • 84860859564 scopus 로고    scopus 로고
    • Modeling human neurodegenerative diseases in trans-genic systems
    • Gama Sosa, M., De Gasperi, R., and Elder, G. (2012). Modeling human neurodegenerative diseases in trans-genic systems. Hum. Genet. 131, 535-563.
    • (2012) Hum. Genet. , vol.131 , pp. 535-563
    • Gama Sosa, M.1    De Gasperi, R.2    Elder, G.3
  • 62
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • Glass, C. K., Saijo, K., Winner, B., Mar-chetto, M. C., and Gage, E H. (2010). Mechanisms underlying inflammation in neurodegeneration. Cell 140, 918-934.
    • (2010) Cell , vol.140 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Mar-chetto, M.C.4    Gage, E.H.5
  • 67
    • 78149487692 scopus 로고    scopus 로고
    • Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues
    • Hanna, J. H., Saha, K., and Jaenisch, R. (2010). Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell 143, 508-525.
    • (2010) Cell , vol.143 , pp. 508-525
    • Hanna, J.H.1    Saha, K.2    Jaenisch, R.3
  • 68
    • 77957905690 scopus 로고    scopus 로고
    • Genetic analysis of pathways to Parkinson disease
    • Hardy, J. (2010). Genetic analysis of pathways to Parkinson disease. Neuron 68, 201-206.
    • (2010) Neuron , vol.68 , pp. 201-206
    • Hardy, J.1
  • 71
    • 34247188473 scopus 로고    scopus 로고
    • Telomere and telomerase in stem cells
    • Hiyama, E., and Hiyama, K. (2007). Telomere and telomerase in stem cells. Br. J. Cancer 96, 1020-1024.
    • (2007) Br. J. Cancer , vol.96 , pp. 1020-1024
    • Hiyama, E.1    Hiyama, K.2
  • 72
    • 18844392836 scopus 로고    scopus 로고
    • Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues
    • Hochedlinger, K., Yamada, Y., Beard, C., and Jaenisch, R. (2005). Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 121, 465-477.
    • (2005) Cell , vol.121 , pp. 465-477
    • Hochedlinger, K.1    Yamada, Y.2    Beard, C.3    Jaenisch, R.4
  • 76
    • 73949130191 scopus 로고    scopus 로고
    • Differentiation of human oligodendrocytes from pluripotent stem cells
    • Hu, B. Y., Du, Z. W., and Zhang, S. C. (2009). Differentiation of human oligodendrocytes from pluripotent stem cells. Nat. Protoc. 4, 1614-1622.
    • (2009) Nat. Protoc. , vol.4 , pp. 1614-1622
    • Hu, B.Y.1    Du, Z.W.2    Zhang, S.C.3
  • 77
    • 77749279749 scopus 로고    scopus 로고
    • Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
    • Hu, B. Y., Weick, J. P., Yu, J., Ma, L. X., Zhang, X. Q., Thomson, J. A., and Zhang, S. C. (2010). Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc. Natl. Acad. Sci. U.S.A. 107, 4335-4340.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 4335-4340
    • Hu, B.Y.1    Weick, J.P.2    Yu, J.3    Ma, L.X.4    Zhang, X.Q.5    Thomson, J.A.6    Zhang, S.C.7
  • 78
    • 70249133666 scopus 로고    scopus 로고
    • Differentiation of spinal motor neurons from pluripotent human stem cells
    • Hu, B. Y., and Zhang, S. C. (2009). Differentiation of spinal motor neurons from pluripotent human stem cells. Nat. Protoc. 4, 1295-1304.
    • (2009) Nat. Protoc. , vol.4 , pp. 1295-1304
    • Hu, B.Y.1    Zhang, S.C.2
  • 79
    • 77953089981 scopus 로고    scopus 로고
    • Directed differentiation of neural-stem cells and subtype-specific neurons from hESCs
    • Hu, B. Y., and Zhang, S. C. (2010). Directed differentiation of neural-stem cells and subtype-specific neurons from hESCs. MethodsMol. Biol. 636, 123-137.
    • (2010) MethodsMol. Biol. , vol.636 , pp. 123-137
    • Hu, B.Y.1    Zhang, S.C.2
  • 82
    • 79955464098 scopus 로고    scopus 로고
    • The use of induced pluripotent stem cells in drug development
    • Inoue, H., and Yamanaka, S. (2011). The use of induced pluripotent stem cells in drug development. Clin. Pharmacol. Ther. 89, 655-661.
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 655-661
    • Inoue, H.1    Yamanaka, S.2
  • 83
    • 79960884465 scopus 로고    scopus 로고
    • Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges
    • Israel, M., and Goldstein, L. S. (2011). Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges. Genome Med. 3, 49.
    • (2011) Genome Med , vol.3 , pp. 49
    • Israel, M.1    Goldstein, L.S.2
  • 85
    • 39149130361 scopus 로고    scopus 로고
    • Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
    • Jaenisch, R., and Young, R. (2008). Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 132, 567-582.
    • (2008) Cell , vol.132 , pp. 567-582
    • Jaenisch, R.1    Young, R.2
  • 87
    • 79951849153 scopus 로고    scopus 로고
    • Modeling retinal degeneration using patient-specific induced pluripotent stem cells
    • doi:10.1371/journal.pone.0017084
    • Jin, Z. B., Okamoto, S., Osakada, F., Homma, K., Assawachananont, J., Hirami, Y., Iwata, T., and Takahashi, M. (2011). Modeling retinal degeneration using patient-specific induced pluripotent stem cells. PLoS ONE 6, e 17084. doi:10.1371/journal.pone.0017084
    • (2011) PLoS ONE , vol.6
    • Jin, Z.B.1    Okamoto, S.2    Osakada, F.3    Homma, K.4    Assawachananont, J.5    Hirami, Y.6    Iwata, T.7    Takahashi, M.8
  • 89
    • 64749111225 scopus 로고    scopus 로고
    • Virus-free induction of pluripotency and subsequent excision of reprogramming factors
    • Kaji, K., Norrby, K., Paca, A., Mileikovsky, M., Mohseni, P., and Woltjen, K. (2009). Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 458, 771-775.
    • (2009) Nature , vol.458 , pp. 771-775
    • Kaji, K.1    Norrby, K.2    Paca, A.3    Mileikovsky, M.4    Mohseni, P.5    Woltjen, K.6
  • 90
    • 18644384444 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived oligo-dendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury
    • Keirstead, H. S., Nistor, G., Bernal, G., Totoiu, M., Cloutier, F., Sharp, K., and Steward, O. (2005). Human embryonic stem cell-derived oligo-dendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J. Neurosci. 25, 4694-4705.
    • (2005) J. Neurosci. , vol.25 , pp. 4694-4705
    • Keirstead, H.S.1    Nistor, G.2    Bernal, G.3    Totoiu, M.4    Cloutier, F.5    Sharp, K.6    Steward, O.7
  • 91
    • 18844396119 scopus 로고    scopus 로고
    • Embryonic stem cell differentiation: emergence of a new era in biology and medicine
    • Keller, G. (2005). Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev. 19, 1129-1155.
    • (2005) Genes Dev , vol.19 , pp. 1129-1155
    • Keller, G.1
  • 95
    • 80052155858 scopus 로고    scopus 로고
    • Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome
    • Kim, K. Y., Hysolli, E., and Park, I. H. (2011). Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome. Proc. Natl. Acad. Sci. U.S.A. 108, 14169-14174.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 14169-14174
    • Kim, K.Y.1    Hysolli, E.2    Park, I.H.3
  • 97
    • 66149179125 scopus 로고    scopus 로고
    • Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine
    • Knoepfler, P. S. (2009). Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells 27, 1050-1056.
    • (2009) Stem Cells , vol.27 , pp. 1050-1056
    • Knoepfler, P.S.1
  • 99
    • 79958128131 scopus 로고    scopus 로고
    • Specification of transplantable astroglial subtypes from human pluripotent stem cells
    • Krencik, R., Weick, J. P., Liu, Y., Zhang, Z. J., and Zhang, S.C. (2011).Specification of transplantable astroglial subtypes from human pluripotent stem cells. Nat. Biotechnol. 29, 528-534.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 528-534
    • Krencik, R.1    Weick, J.P.2    Liu, Y.3    Zhang, Z.J.4    Zhang, S.C.5
  • 102
    • 79960176338 scopus 로고    scopus 로고
    • Microarray characterization of human embryonic stem cell-derived retinal cultures
    • Lamba, D. A., and Reh, T. A. (2011). Microarray characterization of human embryonic stem cell-derived retinal cultures. Invest. Oph-thalmol. Vis. Sci. 52, 4897-4906.
    • (2011) Invest. Oph-thalmol. Vis. Sci. , vol.52 , pp. 4897-4906
    • Lamba, D.A.1    Reh, T.A.2
  • 103
    • 77954060569 scopus 로고    scopus 로고
    • Derivation of neural crest cells from human pluripotent stem cells
    • Lee, G., Chambers, S. M., Tomishima, M. J., and Studer, L. (2010). Derivation of neural crest cells from human pluripotent stem cells. Nat. Protoc. 5, 688-701.
    • (2010) Nat. Protoc. , vol.5 , pp. 688-701
    • Lee, G.1    Chambers, S.M.2    Tomishima, M.J.3    Studer, L.4
  • 104
    • 36849062137 scopus 로고    scopus 로고
    • Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells
    • Lee, G., Kim, H., Elkabetz, Y., Al-Shamy, G., Panagiotakos, G., Barberi, T., Tabar,V., and Studer, L. (2007). Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells. Nat. Biotechnol. 25, 1468-1475.
    • (2007) Nat. Biotechnol. , vol.25 , pp. 1468-1475
    • Lee, G.1    Kim, H.2    Elkabetz, Y.3    Al-Shamy, G.4    Panagiotakos, G.5    Barberi, T.6    Tabar, V.7    Studer, L.8
  • 107
    • 74049083797 scopus 로고    scopus 로고
    • Induced pluripotent stem cell technology for the study of human disease
    • Lee, G., and Studer, L. (2010). Induced pluripotent stem cell technology for the study of human disease. Nat. Methods 7, 25-27.
    • (2010) Nat. Methods , vol.7 , pp. 25-27
    • Lee, G.1    Studer, L.2
  • 110
    • 79251647135 scopus 로고    scopus 로고
    • Neuronal chromatin dynamics of imprinting in development and disease
    • Leung, K. N., Chamberlain, S. J., Lalande, M., and Lasalle, J. M. (2011). Neuronal chromatin dynamics of imprinting in development and disease. J. Cell. Biochem. 112, 365-373.
    • (2011) J. Cell. Biochem. , vol.112 , pp. 365-373
    • Leung, K.N.1    Chamberlain, S.J.2    Lalande, M.3    Lasalle, J.M.4
  • 111
    • 34547700773 scopus 로고    scopus 로고
    • Proposal of amodel of mammalian neural induction
    • Levine, A. J., and Brivanlou, A. H. (2007). Proposal of amodel of mammalian neural induction. Dev. Biol. 308, 247-256.
    • (2007) Dev. Biol. , vol.308 , pp. 247-256
    • Levine, A.J.1    Brivanlou, A.H.2
  • 114
    • 82255175070 scopus 로고    scopus 로고
    • Specification of neuronal and glial subtypes from human pluripotent stem cells
    • Liu, H., and Zhang, S. C. (2011). Specification of neuronal and glial subtypes from human pluripotent stem cells. Cell. Mol. Life Sci. 68, 3995-4008.
    • (2011) Cell. Mol. Life Sci. , vol.68 , pp. 3995-4008
    • Liu, H.1    Zhang, S.C.2
  • 117
    • 35948946526 scopus 로고    scopus 로고
    • Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
    • Lombardo, A. (2007). Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat. Biotechnol. 25, 1298-1306.
    • (2007) Nat. Biotechnol. , vol.25 , pp. 1298-1306
    • Lombardo, A.1
  • 118
    • 70349873363 scopus 로고    scopus 로고
    • Long-term safety and function of RPE from human embryonic stem cells in pre-clinical models of macular degeneration
    • Lu, B., Malcuit, C., Wang, S., Girman, S., Francis, P., Lemieux, L., Lanza, R., and Lund, R. (2009). Long-term safety and function of RPE from human embryonic stem cells in pre-clinical models of macular degeneration. Stem Cells 27, 2126-2135.
    • (2009) Stem Cells , vol.27 , pp. 2126-2135
    • Lu, B.1    Malcuit, C.2    Wang, S.3    Girman, S.4    Francis, P.5    Lemieux, L.6    Lanza, R.7    Lund, R.8
  • 119
    • 45249106162 scopus 로고    scopus 로고
    • Spinal muscular atrophy
    • Lunn, M. R., and Wang, C. H. (2008). Spinal muscular atrophy. Lancet 371, 2120-2133.
    • (2008) Lancet , vol.371 , pp. 2120-2133
    • Lunn, M.R.1    Wang, C.H.2
  • 120
    • 56549127713 scopus 로고    scopus 로고
    • Guidelines and techniques for the generation of induced pluripotent stem cells
    • Maherali, N., and Hochedlinger, K. (2008). Guidelines and techniques for the generation of induced pluripotent stem cells. Cell Stem Cell 3, 595-605.
    • (2008) Cell Stem Cell , vol.3 , pp. 595-605
    • Maherali, N.1    Hochedlinger, K.2
  • 122
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • Marchetto, M. C. N., Carromeu, C., Acab, A., Yu, D., Yeo, G. W., Mu, Y., Chen, G., Gage, F. H., and Muotri, A. R. (2010). A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 143, 527-539.
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.N.1    Carromeu, C.2    Acab, A.3    Yu, D.4    Yeo, G.W.5    Mu, Y.6    Chen, G.7    Gage, F.H.8    Muotri, A.R.9
  • 123
    • 56549115885 scopus 로고    scopus 로고
    • Non-cell-autonomous sffect of human SOD1G37R astrocytes on motor neurons derived from human embryonic stem cells
    • Marchetto, M. C. N., Muotri, A. R., Mu, Y., Smith, A. M., Cezar, G. G., and Gage, F. H. (2008). Non-cell-autonomous sffect of human SOD1G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 3, 649-657.
    • (2008) Cell Stem Cell , vol.3 , pp. 649-657
    • Marchetto, M.C.N.1    Muotri, A.R.2    Mu, Y.3    Smith, A.M.4    Cezar, G.G.5    Gage, F.H.6
  • 125
    • 77950688386 scopus 로고    scopus 로고
    • Prospective isolation of cortical interneuron precursors from mouse embryonic stem cells
    • Maroof, A. M., Brown, K., Shi, S. H., Studer, L., and Anderson, S. A. (2010). Prospective isolation of cortical interneuron precursors from mouse embryonic stem cells. J. Neu-rosci. 30, 4667-4675.
    • (2010) J. Neu-rosci. , vol.30 , pp. 4667-4675
    • Maroof, A.M.1    Brown, K.2    Shi, S.H.3    Studer, L.4    Anderson, S.A.5
  • 126
    • 84866270039 scopus 로고    scopus 로고
    • Generation and applications of human pluripotent stem cells induced into neural lineages and neural tissues
    • doi:10.3389/fphys.2012.00047
    • Martinez, Y., Dubois-Dauphin, M., and Krause, K. H. (2012). Generation and applications of human pluripotent stem cells induced into neural lineages and neural tissues. Front. Physiol. 3:47. doi:10.3389/fphys.2012.00047
    • (2012) Front. Physiol. , vol.3 , pp. 47
    • Martinez, Y.1    Dubois-Dauphin, M.2    Krause, K.H.3
  • 128
    • 79952710923 scopus 로고    scopus 로고
    • Induced pluripotent stem cells: a new revolution for clinical neurology?
    • Mattis,V.B.,and Svendsen,C.N. (2011). Induced pluripotent stem cells: a new revolution for clinical neurology? LancetNeurol. 10, 383-394.
    • (2011) LancetNeurol , vol.10 , pp. 383-394
    • Mattis, V.B.1    Svendsen, C.N.2
  • 133
    • 34447319080 scopus 로고    scopus 로고
    • An improved zinc-finger nuclease architecture for highly specific genome editing
    • Miller, J. C. (2007). An improved zinc-finger nuclease architecture for highly specific genome editing. Nat. Biotechnol. 25, 778-785.
    • (2007) Nat. Biotechnol. , vol.25 , pp. 778-785
    • Miller, J.C.1
  • 136
    • 33847682924 scopus 로고    scopus 로고
    • Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases
    • Moehle, E. A. (2007). Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases. Proc. Natl. Acad. Sci. U.S.A. 104, 3055-3060.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 3055-3060
    • Moehle, E.A.1
  • 137
    • 0036546980 scopus 로고    scopus 로고
    • Neural induction, the default model and embryonic stem cells
    • Munoz-Sanjuan, I., and Brivanlou, A. H. (2002). Neural induction, the default model and embryonic stem cells. Nat. Rev. Neurosci. 3, 271-280.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 271-280
    • Munoz-Sanjuan, I.1    Brivanlou, A.H.2
  • 139
    • 39349106325 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development
    • Murry, C. E., and Keller, G. (2008). Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 132, 661-680.
    • (2008) Cell , vol.132 , pp. 661-680
    • Murry, C.E.1    Keller, G.2
  • 145
    • 34249880066 scopus 로고    scopus 로고
    • Generation of germline-competent induced pluripotent stem cells
    • Okita, K., Ichisaka, T., and Yamanaka, S. (2007). Generation of germline-competent induced pluripotent stem cells. Nature 448, 313-317.
    • (2007) Nature , vol.448 , pp. 313-317
    • Okita, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 147
    • 70349347145 scopus 로고    scopus 로고
    • In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction
    • Osakada, F., Jin, Z. B., Hirami, Y., Ikeda, H., Danjyo, T., Watanabe, K., Sasai, Y., and Takahashi, M. (2009). In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J. Cell Sci. 122, 3169-3179.
    • (2009) J. Cell Sci. , vol.122 , pp. 3169-3179
    • Osakada, F.1    Jin, Z.B.2    Hirami, Y.3    Ikeda, H.4    Danjyo, T.5    Watanabe, K.6    Sasai, Y.7    Takahashi, M.8
  • 150
    • 34147131206 scopus 로고    scopus 로고
    • Dominantly inherited ataxias: lessons learned from Machado-Joseph dis-ease/spinocerebellar ataxia type 3
    • Paulson, H. L. (2007). Dominantly inherited ataxias: lessons learned from Machado-Joseph dis-ease/spinocerebellar ataxia type 3. Semin. Neurol. 27, 133-142.
    • (2007) Semin. Neurol. , vol.27 , pp. 133-142
    • Paulson, H.L.1
  • 152
    • 81855194037 scopus 로고    scopus 로고
    • Stem cell sources for regenerative medicine: the immunological point of view
    • Preynat-Seauve, O., and Krause, K. H. (2011). Stem cell sources for regenerative medicine: the immunological point of view. Semin. Immunopathol. 33, 519-524.
    • (2011) Semin. Immunopathol. , vol.33 , pp. 519-524
    • Preynat-Seauve, O.1    Krause, K.H.2
  • 154
    • 77957598016 scopus 로고    scopus 로고
    • iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to genomic instability
    • Ramos-Mejia, V., Munoz-Lopez, M., Garcia-Perez, J. L., and Menendez, P. (2010). iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to genomic instability. Cell Res. 20, 1092-1095.
    • (2010) Cell Res , vol.20 , pp. 1092-1095
    • Ramos-Mejia, V.1    Munoz-Lopez, M.2    Garcia-Perez, J.L.3    Menendez, P.4
  • 158
    • 33750706917 scopus 로고    scopus 로고
    • Functional engraftment of human ES cell-derived dopamin-ergic neurons enriched by cocul-ture with telomerase-immortalized midbrain astrocytes
    • Roy, N. S., Cleren, C., Singh, S. K., Yang, L., Beal, M. F., and Goldman, S. A. (2006). Functional engraftment of human ES cell-derived dopamin-ergic neurons enriched by cocul-ture with telomerase-immortalized midbrain astrocytes. Nat. Med. 12, 1259-1268.
    • (2006) Nat. Med. , vol.12 , pp. 1259-1268
    • Roy, N.S.1    Cleren, C.2    Singh, S.K.3    Yang, L.4    Beal, M.F.5    Goldman, S.A.6
  • 159
    • 71549120380 scopus 로고    scopus 로고
    • The role of Myc-induced protein synthesis in cancer
    • Ruggero, D. (2009). The role of Myc-induced protein synthesis in cancer. Cancer Res. 69, 8839-8843.
    • (2009) Cancer Res , vol.69 , pp. 8839-8843
    • Ruggero, D.1
  • 160
    • 49649095887 scopus 로고    scopus 로고
    • Neuroscience: standard model
    • Schnabel, J. (2008). Neuroscience: standard model. Nature 454, 682-685.
    • (2008) Nature , vol.454 , pp. 682-685
    • Schnabel, J.1
  • 161
    • 34247139885 scopus 로고    scopus 로고
    • Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation
    • Schneider, B. L., Seehus, C. R., Capowski, E. E.,Aebischer, P.,Zhang, S. C., and Svendsen, C. N. (2007). Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation. Hum. Mol. Genet. 16, 651-666.
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 651-666
    • Schneider, B.L.1    Seehus, C.R.2    Capowski, E.E.3    Aebischer, P.4    Zhang, S.C.5    Svendsen, C.N.6
  • 166
    • 79955786943 scopus 로고    scopus 로고
    • Mitochondrial Parkin recruitment is impaired in neu rons derived from mutant PINK1 induced pluripotent stem cells
    • Seibler, P., Graziotto, J., Jeong, H., Simunovic, F., Klein, C., and Krainc, D. (2011). Mitochondrial Parkin recruitment is impaired in neu rons derived from mutant PINK1 induced pluripotent stem cells. J. Neurosci. 31, 5970-5976.
    • (2011) J. Neurosci , vol.31 , pp. 5970-5976
    • Seibler, P.1    Graziotto, J.2    Jeong, H.3    Simunovic, F.4    Klein, C.5    Krainc, D.6
  • 167
    • 79956016292 scopus 로고    scopus 로고
    • Huntington's and myotonic dystrophy hESCs: down-regulated trinu-cleotide repeat instability and mismatch repair machinery expression upon differentiation
    • Seriola, A., Spits, C., Simard, J. P., Hilven, P., Haentjens, P., Pearson, C. E., and Sermon, K. (2011). Huntington's and myotonic dystrophy hESCs: down-regulated trinu-cleotide repeat instability and mismatch repair machinery expression upon differentiation. Hum. Mol. Genet. 20, 176-185.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 176-185
    • Seriola, A.1    Spits, C.2    Simard, J.P.3    Hilven, P.4    Haentjens, P.5    Pearson, C.E.6    Sermon, K.7
  • 168
    • 79953797190 scopus 로고    scopus 로고
    • Molecular and functional characterizations of gastrula organizer cells derived from human embryonic stem cells
    • Sharon, N., Mor, I., Golan-Lev, T., Fainsod, A., and Benvenisty, N. (2011). Molecular and functional characterizations of gastrula organizer cells derived from human embryonic stem cells. Stem Cells 29, 600-608.
    • (2011) Stem Cells , vol.29 , pp. 600-608
    • Sharon, N.1    Mor, I.2    Golan-Lev, T.3    Fainsod, A.4    Benvenisty, N.5
  • 170
    • 80053948646 scopus 로고    scopus 로고
    • Epige-netic characterization of the FMR1 gene and aberrant neurodevelop-ment in human induced pluripotent stem cell models of fragile X syndrome
    • doi:10.1371/journal.pone.0026203
    • Sheridan, S. D., Theriault, K. M., Reis, S. A., Zhou, F., Madison, J. M., Daheron, L., Loring, J. F., and Haggarty S. J. (2011). Epige-netic characterization of the FMR1 gene and aberrant neurodevelop-ment in human induced pluripotent stem cell models of fragile X syndrome. PLoS ONE 6, e26203. doi:10.1371/journal.pone.0026203
    • (2011) PLoS ONE , vol.6
    • Sheridan, S.D.1    Theriault, K.M.2    Reis, S.A.3    Zhou, F.4    Madison, J.M.5    Daheron, L.6    Loring, J.F.7    Haggarty, S.J.8
  • 171
    • 44349103591 scopus 로고    scopus 로고
    • A combined chemical and genetic approach for the generation of induced pluripotent stem cells
    • Shi, Y., Do, J. T., Desponts, C., Hahm, H. S., Schöler, H. R., and Ding, S. (2008). A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2, 525-528.
    • (2008) Cell Stem Cell , vol.2 , pp. 525-528
    • Shi, Y.1    Do, J.T.2    Desponts, C.3    Hahm, H.S.4    Schöler, H.R.5    Ding, S.6
  • 172
    • 37349052866 scopus 로고    scopus 로고
    • Inhibition of activin/nodal signaling promotes specification of human embryonic stem cells into neuroectoderm
    • Smith, J. R., Vallier, L., Lupo, G., Alexander, M., Harris, W. A., and Pedersen, R. A. (2008). Inhibition of activin/nodal signaling promotes specification of human embryonic stem cells into neuroectoderm. Dev. Biol. 313, 107-117.
    • (2008) Dev. Biol. , vol.313 , pp. 107-117
    • Smith, J.R.1    Vallier, L.2    Lupo, G.3    Alexander, M.4    Harris, W.A.5    Pedersen, R.A.6
  • 176
    • 45449094570 scopus 로고    scopus 로고
    • Repro-gramming of pancreatic beta cells into induced pluripotent stem cells
    • Stadtfeld, M., Brennand, K., and Hochedlinger, K. (2008). Repro-gramming of pancreatic beta cells into induced pluripotent stem cells. Curr. Biol. 18, 890-894.
    • (2008) Curr. Biol. , vol.18 , pp. 890-894
    • Stadtfeld, M.1    Brennand, K.2    Hochedlinger, K.3
  • 177
    • 57449109722 scopus 로고    scopus 로고
    • Preimplanta-tion genetic diagnosis as a source of human embryonic stem cells for disease research and drug discovery
    • Stephenson, E. L., Mason, C., and Braude, P. R. (2009). Preimplanta-tion genetic diagnosis as a source of human embryonic stem cells for disease research and drug discovery. BJOG 116, 158-165.
    • (2009) BJOG , vol.116 , pp. 158-165
    • Stephenson, E.L.1    Mason, C.2    Braude, P.R.3
  • 178
    • 19744364989 scopus 로고    scopus 로고
    • Neural induction: old problem, new findings, yet more questions
    • Stern, C. D. (2005). Neural induction: old problem, new findings, yet more questions. Development 132, 2007-2021.
    • (2005) Development , vol.132 , pp. 2007-2021
    • Stern, C.D.1
  • 179
    • 33750632535 scopus 로고    scopus 로고
    • Neural induction: 10 years on since the 'default model'
    • Stern, C. D. (2006). Neural induction: 10 years on since the 'default model.' Curr. Opin. Cell Biol. 18, 692-697.
    • (2006) Curr. Opin. Cell Biol. , vol.18 , pp. 692-697
    • Stern, C.D.1
  • 180
    • 49449102627 scopus 로고    scopus 로고
    • Neural commitment of embryonic stem cells: molecules, pathways and potential for cell therapy
    • Suter, D. M., and Krause, K. H. (2008). Neural commitment of embryonic stem cells: molecules, pathways and potential for cell therapy. J. Pathol. 215, 355-368.
    • (2008) J. Pathol. , vol.215 , pp. 355-368
    • Suter, D.M.1    Krause, K.H.2
  • 183
    • 22444449591 scopus 로고    scopus 로고
    • Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain
    • Tabar, V., Panagiotakos, G., Green-berg, E. D., Chan, B. K., Sadelain, M., Gutin, P. H., and Studer, L. (2005). Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain. Nat. Biotechnol. 23, 601-606.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 601-606
    • Tabar, V.1    Panagiotakos, G.2    Green-berg, E.D.3    Chan, B.K.4    Sadelain, M.5    Gutin, P.H.6    Studer, L.7
  • 185
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibrob-lasts by defined factors
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibrob-lasts by defined factors. Cell 131, 861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 186
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 188
    • 79956124889 scopus 로고    scopus 로고
    • Optimal reprogram-ming factor stoichiometry increases colony numbers and affects molecular characteristics of murine induced pluripotent stem cells
    • Tiemann, U., Sgodda, M., Warlich, E., Ballmaier, M., Schöler, H. R., Schambach, A., and Cantz, T. (2011). Optimal reprogram-ming factor stoichiometry increases colony numbers and affects molecular characteristics of murine induced pluripotent stem cells. Cytometry A 79A, 426-435.
    • (2011) Cytometry A , vol.79 A , pp. 426-435
    • Tiemann, U.1    Sgodda, M.2    Warlich, E.3    Ballmaier, M.4    Schöler, H.R.5    Schambach, A.6    Cantz, T.7
  • 190
    • 0035025619 scopus 로고    scopus 로고
    • Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism
    • Tropepe, V., Hitoshi, S., Sirard, C., Mak, T. W., Rossant, J., and Van Der Kooy, D. (2001). Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron 30, 65-78.
    • (2001) Neuron , vol.30 , pp. 65-78
    • Tropepe, V.1    Hitoshi, S.2    Sirard, C.3    Mak, T.W.4    Rossant, J.5    Van Der Kooy, D.6
  • 192
    • 77956214743 scopus 로고    scopus 로고
    • Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells
    • Urbach, A., Bar-Nur, O., Daley, G. Q., and Benvenisty, N. (2010). Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell 6, 407-411.
    • (2010) Cell Stem Cell , vol.6 , pp. 407-411
    • Urbach, A.1    Bar-Nur, O.2    Daley, G.Q.3    Benvenisty, N.4
  • 193
    • 3543030995 scopus 로고    scopus 로고
    • Modeling for Lesch-Nyhan disease by gene targeting in human embryonic stem cells
    • Urbach, A., Schuldiner, M., and Benvenisty, N. (2004). Modeling for Lesch-Nyhan disease by gene targeting in human embryonic stem cells. Stem Cells 22, 635-641.
    • (2004) Stem Cells , vol.22 , pp. 635-641
    • Urbach, A.1    Schuldiner, M.2    Benvenisty, N.3
  • 194
  • 198
    • 33846225133 scopus 로고    scopus 로고
    • Huntington's disease
    • Walker, F. O. (2007). Huntington's disease. Lancet 369, 218-228.
    • (2007) Lancet , vol.369 , pp. 218-228
    • Walker, F.O.1
  • 203
    • 37549008674 scopus 로고    scopus 로고
    • c-Myc is dispensable for direct reprogramming of mouse fibroblasts
    • Wernig, M., Meissner, A., Cassady, J. P., and Jaenisch, R. (2008). c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell 2, 10-12.
    • (2008) Cell Stem Cell , vol.2 , pp. 10-12
    • Wernig, M.1    Meissner, A.2    Cassady, J.P.3    Jaenisch, R.4
  • 205
    • 0037047320 scopus 로고    scopus 로고
    • Directed differentiation of embryonic stem cells into motor neurons
    • Wichterle, H., Lieberam, I., Porter, J. A., and Jessell, T. M. (2002). Directed differentiation of embryonic stem cells into motor neurons. Cell 110, 385-397.
    • (2002) Cell , vol.110 , pp. 385-397
    • Wichterle, H.1    Lieberam, I.2    Porter, J.A.3    Jessell, T.M.4
  • 206
    • 79952579942 scopus 로고    scopus 로고
    • Neurodegenerative disease and adult neurogenesis
    • Winner, B., Kohl, Z., and Gage, F. H. (2011). Neurodegenerative disease and adult neurogenesis. Eur. J. Neurosci. 33, 1139-1151.
    • (2011) Eur. J. Neurosci. , vol.33 , pp. 1139-1151
    • Winner, B.1    Kohl, Z.2    Gage, F.H.3
  • 210
    • 77953466536 scopus 로고    scopus 로고
    • Nuclear reprogramming to a pluripotent state by three approaches
    • Yamanaka, S., and Blau, H. M. (2010). Nuclear reprogramming to a pluripotent state by three approaches. Nature 465, 704-712.
    • (2010) Nature , vol.465 , pp. 704-712
    • Yamanaka, S.1    Blau, H.M.2
  • 214
    • 0037313844 scopus 로고    scopus 로고
    • Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
    • Ying, Q. L., Stavridis, M., Griffiths, D., Li, M., and Smith, A. (2003). Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat. Biotech-nol.21, 183-186.
    • (2003) Nat. Biotech-nol , vol.21 , pp. 183-186
    • Ying, Q.L.1    Stavridis, M.2    Griffiths, D.3    Li, M.4    Smith, A.5
  • 215
    • 65649116572 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells free of vector and transgene sequences
    • Yu, J., Hu, K., Smuga-Otto, K., Tian, S., Stewart, R., Slukvin, I.I., and Thomson, J. A. (2009). Human induced pluripotent stem cells free of vector and transgene sequences. Science 324, 797-801.
    • (2009) Science , vol.324 , pp. 797-801
    • Yu, J.1    Hu, K.2    Smuga-Otto, K.3    Tian, S.4    Stewart, R.5    Slukvin, I.I.6    Thomson, J.A.7
  • 218
    • 84873337576 scopus 로고    scopus 로고
    • Characterization of human Huntington's disease cell model from induced pluripotent stem cells
    • doi:10.1371/currents.RRN1193
    • Zhang, N., An, M. C., Montoro, D., and Ellerby, L. M. (2010). Characterization of human Huntington's disease cell model from induced pluripotent stem cells. PLoS Curr. 28, RRN1193. doi:10.1371/currents.RRN1193
    • (2010) PLoS Curr , vol.28
    • Zhang, N.1    An, M.C.2    Montoro, D.3    Ellerby, L.M.4
  • 220
    • 79952898021 scopus 로고    scopus 로고
    • Investigating monogenic and complex diseases with pluripotent stem cells
    • Zhu, H., Lensch, M. W., Cahan, P., and Daley, G. Q. (2011). Investigating monogenic and complex diseases with pluripotent stem cells. Nat. Rev. Genet. 12, 266-275.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 266-275
    • Zhu, H.1    Lensch, M.W.2    Cahan, P.3    Daley, G.Q.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.