메뉴 건너뛰기




Volumn 3, Issue 7, 2011, Pages

Capturing alzheimer's disease genomes with induced pluripotent stem cells: Prospects and challenges

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ALPHA CHEMOKINE; ALPHA SECRETASE; AMPHIPHYSIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; BETA SECRETASE; BRAIN DERIVED NEUROTROPHIC FACTOR; CLATHRIN ASSEMBLY PROTEIN; CLUSTERIN; COMPLEMENT COMPONENT C3B RECEPTOR; GAMMA SECRETASE; HEPATOCYTE NUCLEAR FACTOR 3BETA; INTERLEUKIN 9; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; NEUROGENIC DIFFERENTIATION FACTOR; OCTAMER TRANSCRIPTION FACTOR 4; PHOSPHATIDYLINOSITOL; PRESENILIN 1; PRESENILIN 2; PROTEIN TYROSINE KINASE; SORTILIN; SURVIVAL MOTOR NEURON PROTEIN 1; SURVIVAL MOTOR NEURON PROTEIN 2; TRANSCRIPTION FACTOR MASH1; TRANSCRIPTION FACTOR SOX2; TYROSINE 3 MONOOXYGENASE; UNINDEXED DRUG;

EID: 79960884465     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/gm265     Document Type: Review
Times cited : (21)

References (87)
  • 1
    • 75449102536 scopus 로고    scopus 로고
    • Alzheimer's disease.
    • 10.1056/NEJMra0909142, 20107219
    • Querfurth HW, LaFerla FM. Alzheimer's disease. N Engl J Med 2010, 362:329-344. 10.1056/NEJMra0909142, 20107219.
    • (2010) N Engl J Med , vol.362 , pp. 329-344
    • Querfurth, H.W.1    LaFerla, F.M.2
  • 2
    • 77951776829 scopus 로고    scopus 로고
    • Alzheimer's disease: strategies for disease modification.
    • 10.1038/nrd2896, 20431570
    • Citron M. Alzheimer's disease: strategies for disease modification. Nat Rev Drug Discov 2010, 9:387-398. 10.1038/nrd2896, 20431570.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 387-398
    • Citron, M.1
  • 3
    • 0000293742 scopus 로고
    • About a peculiar disease of the cortex (in German).
    • Alzheimer A. About a peculiar disease of the cortex (in German). Allg Z Psychiat Med 1907, 64:146-148.
    • (1907) Allg Z Psychiat Med , vol.64 , pp. 146-148
    • Alzheimer, A.1
  • 4
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the Alzheimer s disease amyloid hypothesis: a genetic perspective.
    • 10.1016/j.cell.2005.02.008, 15734686
    • Tanzi RE, Bertram L. Twenty years of the Alzheimer s disease amyloid hypothesis: a genetic perspective. Cell 2005, 120:545-555. 10.1016/j.cell.2005.02.008, 15734686.
    • (2005) Cell , vol.120 , pp. 545-555
    • Tanzi, R.E.1    Bertram, L.2
  • 5
    • 0033869715 scopus 로고    scopus 로고
    • Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.
    • 10.1016/S0002-9440(10)64538-5, 1850219, 10880397
    • Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol 2000, 157:277-286. 10.1016/S0002-9440(10)64538-5, 1850219, 10880397.
    • (2000) Am J Pathol , vol.157 , pp. 277-286
    • Cataldo, A.M.1    Peterhoff, C.M.2    Troncoso, J.C.3    Gomez-Isla, T.4    Hyman, B.T.5    Nixon, R.A.6
  • 12
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.
    • 10.1126/science.1072994, 12130773
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356. 10.1126/science.1072994, 12130773.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 13
    • 78149488153 scopus 로고    scopus 로고
    • Amyloid-independent mechanisms in Alzheimer's disease pathogenesis.
    • 10.1523/JNEUROSCI.4305-10.2010, 21068297
    • Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai L-H. Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci 2010, 30:14946-14954. 10.1523/JNEUROSCI.4305-10.2010, 21068297.
    • (2010) J Neurosci , vol.30 , pp. 14946-14954
    • Pimplikar, S.W.1    Nixon, R.A.2    Robakis, N.K.3    Shen, J.4    Tsai, L.-.H.5
  • 14
    • 0036303818 scopus 로고    scopus 로고
    • Genetically engineered mouse models of neurodegenerative diseases.
    • 10.1038/nn0702-633, 12085093
    • Wong PC, Cai H, Borchelt DR, Price DL. Genetically engineered mouse models of neurodegenerative diseases. Nat Neurosci 2002, 5:633-639. 10.1038/nn0702-633, 12085093.
    • (2002) Nat Neurosci , vol.5 , pp. 633-639
    • Wong, P.C.1    Cai, H.2    Borchelt, D.R.3    Price, D.L.4
  • 15
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction.
    • 10.1016/S0896-6273(03)00434-3, 12895417
    • Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction. Neuron 2003, 39:409-421. 10.1016/S0896-6273(03)00434-3, 12895417.
    • (2003) Neuron , vol.39 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5    Kayed, R.6    Metherate, R.7    Mattson, M.P.8    Akbari, Y.9    LaFerla, F.M.10
  • 16
    • 0031824782 scopus 로고    scopus 로고
    • Aging renders the brain vulnerable to amyloid β-protein neurotoxicity.
    • 10.1038/nm0798-827, 9662375
    • Guela C, Wu C-K, Saroff D, Lorenzo A, Yuan M, Yankner BA. Aging renders the brain vulnerable to amyloid β-protein neurotoxicity. Nat Med 1998, 4:827-831. 10.1038/nm0798-827, 9662375.
    • (1998) Nat Med , vol.4 , pp. 827-831
    • Guela, C.1    Wu, C.-.K.2    Saroff, D.3    Lorenzo, A.4    Yuan, M.5    Yankner, B.A.6
  • 19
    • 77953886784 scopus 로고    scopus 로고
    • Current status on Alzheimer disease molecular genetics: from past, to present, to future.
    • 10.1093/hmg/ddq142, 2875058, 20388643
    • Bettens K, Sleegers K, Van Broeckhoven C. Current status on Alzheimer disease molecular genetics: from past, to present, to future. Hum Mol Genet 2010, 19:R4-R11. 10.1093/hmg/ddq142, 2875058, 20388643.
    • (2010) Hum Mol Genet , vol.19
    • Bettens, K.1    Sleegers, K.2    Van Broeckhoven, C.3
  • 24
    • 68249134074 scopus 로고    scopus 로고
    • The role of Apolipoprotein E in Alzheimer's disease.
    • 10.1016/j.neuron.2009.06.026, 3044446, 19679070
    • Kim J, Basak JM, Holtzman DM. The role of Apolipoprotein E in Alzheimer's disease. Neuron 2009, 63:287-303. 10.1016/j.neuron.2009.06.026, 3044446, 19679070.
    • (2009) Neuron , vol.63 , pp. 287-303
    • Kim, J.1    Basak, J.M.2    Holtzman, D.M.3
  • 25
    • 77953248905 scopus 로고    scopus 로고
    • Formation and function of apolipoprotein E-containing lipoproteins in the nervous system.
    • Vance JE, Hayashi H. Formation and function of apolipoprotein E-containing lipoproteins in the nervous system. BBA - Mol Cell Biol L 2010, 1801:806-818.
    • (2010) BBA - Mol Cell Biol L , vol.1801 , pp. 806-818
    • Vance, J.E.1    Hayashi, H.2
  • 26
    • 75149138378 scopus 로고    scopus 로고
    • The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects.
    • 10.1016/j.tig.2009.12.004, 20080314
    • Sleegers K, Lambert J-C, Bertram L, Cruts M, Amouyel P, Van Broeckhoven C. The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects. Trends Genet 2010, 26:84-93. 10.1016/j.tig.2009.12.004, 20080314.
    • (2010) Trends Genet , vol.26 , pp. 84-93
    • Sleegers, K.1    Lambert, J.-.C.2    Bertram, L.3    Cruts, M.4    Amouyel, P.5    Van Broeckhoven, C.6
  • 27
    • 77957927865 scopus 로고    scopus 로고
    • The genetics of Alzheimer disease: back to the future.
    • 10.1016/j.neuron.2010.10.013, 20955934
    • Bertram L, Lill CM, Tanzi RE. The genetics of Alzheimer disease: back to the future. Neuron 2010, 68:270-281. 10.1016/j.neuron.2010.10.013, 20955934.
    • (2010) Neuron , vol.68 , pp. 270-281
    • Bertram, L.1    Lill, C.M.2    Tanzi, R.E.3
  • 29
    • 38849199843 scopus 로고    scopus 로고
    • Evidence for CALM in directing VAMP2 trafficking.
    • 10.1111/j.1600-0854.2007.00694.x, 18182011
    • Harel A, Wu F, Mattson MP, Morris CM, Yao PJ. Evidence for CALM in directing VAMP2 trafficking. Traffic 2008, 9:417-429. 10.1111/j.1600-0854.2007.00694.x, 18182011.
    • (2008) Traffic , vol.9 , pp. 417-429
    • Harel, A.1    Wu, F.2    Mattson, M.P.3    Morris, C.M.4    Yao, P.J.5
  • 30
    • 11444267601 scopus 로고    scopus 로고
    • Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases.
    • 10.1016/j.neurobiolaging.2004.09.018, 15639316
    • Nixon RA. Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases. Neurobiol Aging 2005, 26:373-382. 10.1016/j.neurobiolaging.2004.09.018, 15639316.
    • (2005) Neurobiol Aging , vol.26 , pp. 373-382
    • Nixon, R.A.1
  • 31
    • 77953879152 scopus 로고    scopus 로고
    • Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases.
    • 10.1093/hmg/ddq159, 2875052, 20418487
    • Marchetto MCN, Winner B, Gage FH. Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases. Hum Mol Genet 2010, 19:R71-R76. 10.1093/hmg/ddq159, 2875052, 20418487.
    • (2010) Hum Mol Genet , vol.19
    • Marchetto, M.C.N.1    Winner, B.2    Gage, F.H.3
  • 32
    • 79952898021 scopus 로고    scopus 로고
    • Investigating monogenic and complex diseases with pluripotent stem cells.
    • 10.1038/nrg2951, 21386866
    • Zhu H, Lensch MW, Cahan P, Daley GQ. Investigating monogenic and complex diseases with pluripotent stem cells. Nat Rev Genet 2011, 12:266-275. 10.1038/nrg2951, 21386866.
    • (2011) Nat Rev Genet , vol.12 , pp. 266-275
    • Zhu, H.1    Lensch, M.W.2    Cahan, P.3    Daley, G.Q.4
  • 33
    • 79952899995 scopus 로고    scopus 로고
    • Methods for making induced pluripotent stem cells: reprogramming a la carte.
    • Gonzalez F, Boue S, Belmonte JCI. Methods for making induced pluripotent stem cells: reprogramming a la carte. Nat Rev Genet 2011, 12:231-242.
    • (2011) Nat Rev Genet , vol.12 , pp. 231-242
    • Gonzalez, F.1    Boue, S.2    Belmonte, J.C.I.3
  • 39
    • 0037336820 scopus 로고    scopus 로고
    • Homologous recombination in human embryonic stem cells.
    • Zwaka TP, Thomson JA. Homologous recombination in human embryonic stem cells. Nat Biotech 2003, 21:319-321.
    • (2003) Nat Biotech , vol.21 , pp. 319-321
    • Zwaka, T.P.1    Thomson, J.A.2
  • 42
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure.
    • 10.1126/science.1074069, 12399581
    • Selkoe DJ. Alzheimer's disease is a synaptic failure. Science 2002, 298:789-791. 10.1126/science.1074069, 12399581.
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 43
    • 77955164446 scopus 로고    scopus 로고
    • Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons.
    • Nilbratt M, Porras O, Marutle A, Hovatta O, Nordberg A. Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons. J Cell Mol Med 2010, 14:1476-1484.
    • (2010) J Cell Mol Med , vol.14 , pp. 1476-1484
    • Nilbratt, M.1    Porras, O.2    Marutle, A.3    Hovatta, O.4    Nordberg, A.5
  • 44
    • 79955411486 scopus 로고    scopus 로고
    • The controlled generation of functional basal forebrain cholinergic neurons from human embryonic stem cells.
    • 10.1002/stem.626, 3107131, 21381151
    • Bissonnette CJ, Lyass L, Bhattacharyya BJ, Belmadani A, Miller RJ, Kessler JA. The controlled generation of functional basal forebrain cholinergic neurons from human embryonic stem cells. Stem Cells 2011, 29:802-811. 10.1002/stem.626, 3107131, 21381151.
    • (2011) Stem Cells , vol.29 , pp. 802-811
    • Bissonnette, C.J.1    Lyass, L.2    Bhattacharyya, B.J.3    Belmadani, A.4    Miller, R.J.5    Kessler, J.A.6
  • 45
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.
    • 10.1016/j.cell.2010.10.016, 21074045
    • Marchetto MCN, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri AR. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 2010, 143:527-539. 10.1016/j.cell.2010.10.016, 21074045.
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.N.1    Carromeu, C.2    Acab, A.3    Yu, D.4    Yeo, G.W.5    Mu, Y.6    Chen, G.7    Gage, F.H.8    Muotri, A.R.9
  • 46
    • 73349120240 scopus 로고    scopus 로고
    • CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells.
    • Pruszak J, Ludwig W, Blak A, Alavian K, Isacson O. CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells. Stem Cells 2009, 27:2928-2940.
    • (2009) Stem Cells , vol.27 , pp. 2928-2940
    • Pruszak, J.1    Ludwig, W.2    Blak, A.3    Alavian, K.4    Isacson, O.5
  • 48
    • 0031922062 scopus 로고    scopus 로고
    • Astrocytes containing amyloid beta-protein (Aβ)-positive granules are associated with Aβ40-positive diffuse plaques in the aged human brain.
    • 1858251, 9546359
    • Funato H, Yoshimura M, Yamazaki T, Saido TC, Ito Y, Yokofujita J, Okeda R, Ihara Y. Astrocytes containing amyloid beta-protein (Aβ)-positive granules are associated with Aβ40-positive diffuse plaques in the aged human brain. Am J Pathol 1998, 152:983-992. 1858251, 9546359.
    • (1998) Am J Pathol , vol.152 , pp. 983-992
    • Funato, H.1    Yoshimura, M.2    Yamazaki, T.3    Saido, T.C.4    Ito, Y.5    Yokofujita, J.6    Okeda, R.7    Ihara, Y.8
  • 49
    • 0037119422 scopus 로고    scopus 로고
    • Accelerated phagocytosis of amyloid-β by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor.
    • 10.1074/jbc.M200868200, 12032144
    • Mitrasinovic OM, Murphy GM. Accelerated phagocytosis of amyloid-β by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor. J Biol Chem 2002, 277:29889-29896. 10.1074/jbc.M200868200, 12032144.
    • (2002) J Biol Chem , vol.277 , pp. 29889-29896
    • Mitrasinovic, O.M.1    Murphy, G.M.2
  • 50
    • 34247473080 scopus 로고    scopus 로고
    • Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model.
    • 10.1038/nn1885, 3139463, 17435754
    • Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T, Eggan K. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat Neurosci 2007, 10:608-614. 10.1038/nn1885, 3139463, 17435754.
    • (2007) Nat Neurosci , vol.10 , pp. 608-614
    • Di Giorgio, F.P.1    Carrasco, M.A.2    Siao, M.C.3    Maniatis, T.4    Eggan, K.5
  • 51
    • 56549115885 scopus 로고    scopus 로고
    • Non-cell-autonomous effect of human SOD1G37R astrocytes on motor neurons derived from human embryonic stem cells.
    • 10.1016/j.stem.2008.10.001, 19041781
    • Marchetto MCN, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH. Non-cell-autonomous effect of human SOD1G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 2008, 3:649-657. 10.1016/j.stem.2008.10.001, 19041781.
    • (2008) Cell Stem Cell , vol.3 , pp. 649-657
    • Marchetto, M.C.N.1    Muotri, A.R.2    Mu, Y.3    Smith, A.M.4    Cezar, G.G.5    Gage, F.H.6
  • 52
    • 56549096129 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation.
    • 10.1016/j.stem.2008.09.017, 19041780
    • Di Giorgio FP, Boulting GL, Bobrowicz S, Eggan KC. Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell 2008, 3:637-648. 10.1016/j.stem.2008.09.017, 19041780.
    • (2008) Cell Stem Cell , vol.3 , pp. 637-648
    • Di Giorgio, F.P.1    Boulting, G.L.2    Bobrowicz, S.3    Eggan, K.C.4
  • 55
    • 33748790666 scopus 로고    scopus 로고
    • Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus.
    • 10.1016/j.nbd.2006.04.017, 16814555
    • Boekhoorn K, Joels M, Lucassen PJ. Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus. Neurobiol Dis 2006, 24:1-14. 10.1016/j.nbd.2006.04.017, 16814555.
    • (2006) Neurobiol Dis , vol.24 , pp. 1-14
    • Boekhoorn, K.1    Joels, M.2    Lucassen, P.J.3
  • 57
    • 4444269849 scopus 로고    scopus 로고
    • Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw, Ind) mice.
    • 10.1073/pnas.0403678101, 516572, 15340159
    • Jin K, Galvan V, Xie L, Mao XO, Gorostiza OF, Bredesen DE, Greenberg DA. Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw, Ind) mice. Proc Natl Acad Sci USA 2004, 101:13363-13367. 10.1073/pnas.0403678101, 516572, 15340159.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13363-13367
    • Jin, K.1    Galvan, V.2    Xie, L.3    Mao, X.O.4    Gorostiza, O.F.5    Bredesen, D.E.6    Greenberg, D.A.7
  • 58
    • 0036358623 scopus 로고    scopus 로고
    • Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid β-peptide.
    • Haughey N, Liu D, Nath A, Borchard A, Mattson M. Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid β-peptide. NeuroMol Med 2002, 1:125-135.
    • (2002) NeuroMol Med , vol.1 , pp. 125-135
    • Haughey, N.1    Liu, D.2    Nath, A.3    Borchard, A.4    Mattson, M.5
  • 59
    • 58249110796 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from a spinal muscular atrophy patient.
    • 10.1038/nature07677, 2659408, 19098894
    • Ebert AD, Yu J, Rose FF, Mattis VB, Lorson CL, Thomson JA, Svendsen CN. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009, 457:277-280. 10.1038/nature07677, 2659408, 19098894.
    • (2009) Nature , vol.457 , pp. 277-280
    • Ebert, A.D.1    Yu, J.2    Rose, F.F.3    Mattis, V.B.4    Lorson, C.L.5    Thomson, J.A.6    Svendsen, C.N.7
  • 63
    • 0141506887 scopus 로고    scopus 로고
    • Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy.
    • 10.1093/hmg/ddg256, 12915451
    • Brichta L, Hofmann Y, Hahnen E, Siebzehnrubl FA, Raschke H, Blumcke I, Eyupoglu IY, Wirth B. Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy. Hum Mol Genet 2003, 12:2481-2489. 10.1093/hmg/ddg256, 12915451.
    • (2003) Hum Mol Genet , vol.12 , pp. 2481-2489
    • Brichta, L.1    Hofmann, Y.2    Hahnen, E.3    Siebzehnrubl, F.A.4    Raschke, H.5    Blumcke, I.6    Eyupoglu, I.Y.7    Wirth, B.8
  • 65
    • 18144431041 scopus 로고    scopus 로고
    • A non-sequence-specific requirement for SMN protein activity: the role of aminoglycosides in inducing elevated SMN protein levels.
    • 10.1093/hmg/ddi131, 15790598
    • Wolstencroft EC, Mattis V, Bajer AA, Young PJ, Lorson CL. A non-sequence-specific requirement for SMN protein activity: the role of aminoglycosides in inducing elevated SMN protein levels. Hum Mol Genet 2005, 14:1199-1210. 10.1093/hmg/ddi131, 15790598.
    • (2005) Hum Mol Genet , vol.14 , pp. 1199-1210
    • Wolstencroft, E.C.1    Mattis, V.2    Bajer, A.A.3    Young, P.J.4    Lorson, C.L.5
  • 68
    • 34547727312 scopus 로고    scopus 로고
    • Development of α-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease.
    • 10.1007/s00401-007-0244-3, 17576580
    • Braak H, Sastre M, Del Tredici K. Development of α-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease. Acta Neuropathol 2007, 114:231-241. 10.1007/s00401-007-0244-3, 17576580.
    • (2007) Acta Neuropathol , vol.114 , pp. 231-241
    • Braak, H.1    Sastre, M.2    Del Tredici, K.3
  • 69
    • 0035409575 scopus 로고    scopus 로고
    • Alpha-synuclein and neurodegenerative diseases.
    • 10.1038/35081564, 11433374
    • Goedert M. Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci 2001, 2:492-501. 10.1038/35081564, 11433374.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 492-501
    • Goedert, M.1
  • 75
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment.
    • 10.1002/ana.410300410, 1789684
    • Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991, 30:572-580. 10.1002/ana.410300410, 1789684.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 76
    • 42649130264 scopus 로고    scopus 로고
    • Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.
    • 10.1073/pnas.0801677105, 2311361, 18391196
    • Wernig M, Zhao J-P, Pruszak J, Hedlund E, Fu D, Soldner F, Broccoli V, Constantine-Paton M, Isacson O, Jaenisch R. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci USA 2008, 105:5856-5861. 10.1073/pnas.0801677105, 2311361, 18391196.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 5856-5861
    • Wernig, M.1    Zhao, J.-.P.2    Pruszak, J.3    Hedlund, E.4    Fu, D.5    Soldner, F.6    Broccoli, V.7    Constantine-Paton, M.8    Isacson, O.9    Jaenisch, R.10
  • 78
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
    • 10.1038/ng1934, 17192785
    • Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 2007, 39:17-23. 10.1038/ng1934, 17192785.
    • (2007) Nat Genet , vol.39 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3    Blacker, D.4    Tanzi, R.E.5
  • 84
    • 10144219962 scopus 로고    scopus 로고
    • Polymorphisms in the human apolipoprotein-J/clusterin gene: ethnic variation and distribution in Alzheimer's disease.
    • 10.1007/s004390050234, 8792817
    • Tycko B, Feng L, Nguyen L, Francis A, Hays A, Chung W-Y, Tang M-X, Stern Y, Sahota A, Hendrie H, Mayeux R. Polymorphisms in the human apolipoprotein-J/clusterin gene: ethnic variation and distribution in Alzheimer's disease. Hum Genet 1996, 98:430-436. 10.1007/s004390050234, 8792817.
    • (1996) Hum Genet , vol.98 , pp. 430-436
    • Tycko, B.1    Feng, L.2    Nguyen, L.3    Francis, A.4    Hays, A.5    Chung, W.-.Y.6    Tang, M.-.X.7    Stern, Y.8    Sahota, A.9    Hendrie, H.10    Mayeux, R.11
  • 87
    • 60749091489 scopus 로고    scopus 로고
    • Interaction between interleukin-8 and methylenetetrahydrofolate reductase genes modulates Alzheimer's disease risk.
    • 10.1159/000204766, 19246914
    • Li K, Liu S, Yao S, Wang B, Dai D, Yao L. Interaction between interleukin-8 and methylenetetrahydrofolate reductase genes modulates Alzheimer's disease risk. Dement Geriatr Cogn Disord 2009, 27:286-291. 10.1159/000204766, 19246914.
    • (2009) Dement Geriatr Cogn Disord , vol.27 , pp. 286-291
    • Li, K.1    Liu, S.2    Yao, S.3    Wang, B.4    Dai, D.5    Yao, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.