Modeling retinal degeneration using patient-specific induced pluripotent stem cells

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Jin, Zi Bing ^a,b   Okamoto, Satoshi ^a   Osakada, Fumitaka ^c   Homma, Kohei ^a   Assawachananont, Juthaporn ^a   Hirami, Yasuhiko ^a   Iwata, Takeshi ^d   Takahashi, Masayo ^a,e  

^a RIKEN Center for Biosystems Dynamics Research   (Japan)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d NATIONAL HOSPITAL ORGANIZATION TOKYO MEDICAL CENTER   (Japan)

^e KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL STRESS; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENDOPLASMIC RETICULUM STRESS; FIBROBLAST; GENE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; NONHUMAN; OXIDATION; PHENOTYPE; PLURIPOTENT STEM CELL; PRPH2 GENE; RETINA DEGENERATION; RETINA ROD; RETINITIS PIGMENTOSA; RHO GENE; RP1 GENE; RP9 GENE; APOPTOSIS; BIOLOGICAL MODEL; CELL LINE; DRUG EFFECT; DRUG SCREENING; FEMALE; GENETICS; MALE; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY;

IPS;

ANTIOXIDANTS; APOPTOSIS; BASE SEQUENCE; CELL LINE; DRUG EVALUATION, PRECLINICAL; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; MODELS, BIOLOGICAL; MUTATION; RETINAL DEGENERATION; RETINAL ROD PHOTORECEPTOR CELLS;

EID: 79951849153     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017084     Document Type: Article

References (15)

1. Weleber RG, Gregory-Evans K, (2006) Retinitis Pigmentosa and Allied Disorders. In: Hilton DR, Schachat AP, Ryan SJ, editors. Retina. Elsevier Mosby pp. 395-498.
2. Berson EL, Rosner B, Sandberg MA, Hayes KC, Nicholson BW, et al. (1993) A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. Arch Ophthalmol 11: 761-772.
3. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-872.
4. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318: 1917-1920.
5. Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, et al. (2008) Disease-specific induced pluripotent stem cells. Cell 134: 877-886.
6. Raya A, Rodríguez-Pizà I, Guenechea G, Vassena R, Navarro S, et al. (2009) Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460: 53-59.
7. Yamanaka S, (2007) Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 1: 39-49.
8. Osakada F, Ikeda H, Mandai M, Wataya T, Watanabe K, et al. (2008) Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nat Biotechnol 26: 215-224.
9. Osakada F, Jin ZB, Hirami Y, Ikeda H, Danjyo T, et al. (2009) In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci 122: 3169-3179.
10. Hirami Y, Osakada F, Takahashi K, Okita K, Yamanaka S, et al. (2009) Generation of retinal cells from mouse and human induced pluripotent stem cells. Neurosci Lett 458: 126-131.
11. Jin ZB, Mandai M, Yokota T, Higuchi K, Ohmori K, et al. (2008) Identifying pathogenic genetic background of simplex or multiplex retinitis pigmentosa patients: a large scale mutation screening study. J Med Genet 45: 465-472.
12. Ikeda H, Osakada F, Watanabe K, Mizuseki K, Haraguchi T, et al. (2005) Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Proc Natl Acad Sci U S A 102: 11331-11336.
13. Sung CH, Davenport CM, Nathans J, (1993) Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa. Clustering of functional classes along the polypeptide chain. J Biol Chem 268: 26645-26649.
14. van Leeuwen R, Boekhoorn S, Vingerling JR, Witteman JC, Klaver CC, et al. (2005) Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA 294: 3101-3107.
15. van Helden YG, Keijer J, Heil SG, Picó C, Palou A, et al. (2009) Beta-carotene affects oxidative stress-related DNA damage in lung epithelial cells and in ferret lung. Carcinogenesis 30: 2070-2076.