Subretinal transplantation of forebrain progenitor cells in nonhuman primates: Survival and intact retinal function

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 7, 2009, Pages 3425-3431

  Francis, Peter J ^a   Wang, Shaomei ^a   Zhang, Yi ^a   Brown, Anna ^a   Hwang, Thomas ^a   McFarland, Trevor J ^a   Jeffrey, Brett G ^b   Lu, Bin ^a   Wright, Lynda ^c,d   Appukuttan, Binoy ^a   Wilson, David J ^a   Timothy Stout, J ^a   Neuringer, Martha ^b   Gamm, David M ^c,d   Lund, Raymond D ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; DEXAMETHASONE; GREEN FLUORESCENT PROTEIN; OFLOXACIN; PREDNISOLONE; ENHANCED GREEN FLUORESCENT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; ELECTRORETINOGRAPHY; ENGRAFTMENT; EYE MOVEMENT; FEMALE; FOREBRAIN; GENETIC TRANSDUCTION; GRAFT INFECTION; GRAFT REJECTION; GRAFT SURVIVAL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MACACA; NEURAL STEM CELL; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; OUTCOME ASSESSMENT; PRIMATE; PRIORITY JOURNAL; RAT; RETINA DEGENERATION; RETINA DISEASE; TREATMENT OUTCOME; VISUAL ACUITY; VITRECTOMY; ANIMAL; BRAIN CORTEX; CYTOMEGALOVIRUS; FETAL STEM CELL; FLUORESCENCE ANGIOGRAPHY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; RAT STRAIN; RETINA; STEM CELL TRANSPLANTATION; TRANSPLANTATION; XENOGRAFT;

ANIMALS; CELL SURVIVAL; CEREBRAL CORTEX; CYTOMEGALOVIRUS; ELECTRORETINOGRAPHY; FEMALE; FETAL STEM CELLS; FLUORESCEIN ANGIOGRAPHY; GENE EXPRESSION; GRAFT SURVIVAL; GREEN FLUORESCENT PROTEINS; HUMANS; MACACA MULATTA; MICROSCOPY, FLUORESCENCE; RATS; RATS, MUTANT STRAINS; RETINA; RETINAL DEGENERATION; STEM CELL TRANSPLANTATION; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; VISUAL ACUITY;

EID: 67649995736     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2908     Document Type: Article

References (21)

1. Lund RD, Wang S, Klimanskaya I, et al. Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats. Cloning Stem Cells. 2006;8:189-199.
2. Lund RD, Wang S, Lu B, et al. Cells isolated from umbilical cord tissue rescue photoreceptors and visual functions in a rodent model of retinal disease. Stem Cells. 2007;25:602-611.
3. McGill TJ, Lund RD, Douglas RM, et al. Syngeneic Schwann cell transplantation preserves vision in RCS rat without immunosuppression. Invest Ophthalmol Vis Sci. 2007;48:1906-1912.
4. Gamm DM, Wang S, Lu B, et al. Protection of visual functions by human neural progenitors in a rat model of retinal disease. PLoS ONE. 2007;2:e338.
5. Wang S, Girman S, Lu B, et al. Long-term vision rescue by human neural progenitors in a rat model of photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2008;49:3201-3206.
6. Svendsen CN, Borg MG, Armstrong RJ, et al. A new method for the rapid and long term growth of human neural precursor cells. J Neurosci Methods. 1998;85:141-152.
7. Sapru MK, Yates JW, Hogan S, Jiang L, Halter J, Bohn MC. Silencing of human alpha-synuclein in vitro and in rat brain using lentiviralmediated RNAi. Exp Neurol. 2006;198:382-390.
8. Prusky GT, Alam NM, Beekman S, Douglas RM. Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system. Invest Ophthalmol Vis Sci. 2004;45:4611-4616.
9. Sheng Y, Gouras P, Cao H, et al. Patch transplants of human fetal retinal-pigment epithelium in rabbit and monkey retina. Invest Ophthalmol Vis Sci. 1995;36:381-390.
10. Warfvinge K, Kiilgaard JF, Klassen H, et al. Retinal progenitor cell xenografts to the pig retina: immunological reactions. Cell Transplant. 2006;15:603-612.
11. Stanga PE, Kychenthal A, Fitzke FW, et al. Retinal pigment epithelium translocation and central visual function in age related macular degeneration: preliminary results. Int Ophthalmol. 2001;23:297-307.
12. Tezel TH, Del Priore LV, Berger AS, Kaplan HJ. Adult retinal pigment epithelial transplantation in exudative age-related macular degeneration. Am J Ophthalmol. 2007;143:584-595.
13. MacLaren RE, Uppal GS, Balaggan KS, et al. Autologous transplantation of the retinal pigment epithelium and choroid in the treatment of neovascular age-related macular degeneration. Ophthalmology. 2007;114:561-570.
14. Joussen AM, Heussen FM, Joeres S, et al. Autologous translocation of the choroid and retinal pigment epithelium in age-related macular degeneration. Am J Ophthalmol. 2006;142:17-30.
15. Lewis GP, Linberg KA, Geller SF, Guerin CJ, Fisher SK. Effects of the neurotrophin brain-derived neurotrophic factor in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci.1999;40:1530-1544.
16. Wu WC, Lai CC, Chen SL, et al. Gene therapy for detached retina by adeno-associated virus vector expressing glial cell line-derived neurotrophic factor. Invest Ophthalmol Vis Sci. 2002;43:3480-3488.
17. Zhang X, Bok D. Transplantation of retinal pigment epithelial cells and immune response in the subretinal space. Invest Ophthalmol Vis Sci. 1998;39:1021-1027.
18. Del Priore LV, Ishida O, Johnson EW, et al. Triple immune suppression increases short-term survival of porcine fetal retinal pigment epithelium xenografts. Invest Ophthalmol Vis Sci. 2003;44:4044-4053.
19. Berglin L, Gouras P, Sheng Y, et al. Tolerance of human fetal retinal pigment epithelium xenografts in monkey retina. Graefes Arch Clin Exp Ophthalmol. 1997;235:103-110.
20. Niederkorn JY. Immune privilege and immune regulation in the eye. Adv Immunol. 1990;48:191-226.
21. Tompsett E, Abi-Hanna D, Wakefield D. Immunological privilege in the eye: a review. Curr Eye Res. 1990;9:1141-1145.