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Volumn 11, Issue 5, 2012, Pages 363-382

Innate immunity in cystic fibrosis lung disease

Author keywords

Bacteria; Chemokines; Cystic fibrosis; Host defense; IL 17; Immunity; Innate immunity; Lung disease; Macrophages; Migration; Neutrophils; Pattern recognition; PGP; Phagocytosis; Pseudomonas; Toll like receptors

Indexed keywords

CHEMOKINE; CYTOKINE; GLYCINE; HIGH MOBILITY GROUP B1 PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PROLINE;

EID: 84866182329     PISSN: 15691993     EISSN: 18735010     Source Type: Journal    
DOI: 10.1016/j.jcf.2012.07.003     Document Type: Review
Times cited : (179)

References (286)
  • 2
    • 33745191871 scopus 로고    scopus 로고
    • What's new in CF airway inflammation: an update
    • Ratjen F. What's new in CF airway inflammation: an update. Paediatr Respir Rev 2006, 7(Suppl. 1):S70-S72.
    • (2006) Paediatr Respir Rev , vol.7 , Issue.SUPPL. 1
    • Ratjen, F.1
  • 3
    • 33745210997 scopus 로고    scopus 로고
    • Diagnosing and managing infection in CF
    • Ratjen F. Diagnosing and managing infection in CF. Paediatr Respir Rev 2006, 7(Suppl. 1):S151-S153.
    • (2006) Paediatr Respir Rev , vol.7 , Issue.SUPPL. 1
    • Ratjen, F.1
  • 4
    • 0036012522 scopus 로고    scopus 로고
    • Bacterial colonization and infection in the CF lung
    • Sagel S.D., Dowell E.B., Accurso F.J. Bacterial colonization and infection in the CF lung. Methods Mol Med 2002, 70:433-446.
    • (2002) Methods Mol Med , vol.70 , pp. 433-446
    • Sagel, S.D.1    Dowell, E.B.2    Accurso, F.J.3
  • 5
    • 0036194724 scopus 로고    scopus 로고
    • Mucus clearance as a primary innate defense mechanism for mammalian airways
    • Knowles M.R., Boucher R.C. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest Mar 2002, 109(5):571-577.
    • (2002) J Clin Invest , vol.109 , Issue.5 , pp. 571-577
    • Knowles, M.R.1    Boucher, R.C.2
  • 6
    • 45949094270 scopus 로고    scopus 로고
    • Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: Lessons from mouse models
    • Mall M.A. Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: Lessons from mouse models. J Aerosol Med Pulm Drug Deliv Mar 2008, 21(1):13-24.
    • (2008) J Aerosol Med Pulm Drug Deliv , vol.21 , Issue.1 , pp. 13-24
    • Mall, M.A.1
  • 7
    • 0032906408 scopus 로고    scopus 로고
    • The innate immune system in cystic fibrosis lung disease
    • Bals R., Weiner D.J., Wilson J.M. The innate immune system in cystic fibrosis lung disease. J Clin Invest Feb 1999, 103(3):303-307.
    • (1999) J Clin Invest , vol.103 , Issue.3 , pp. 303-307
    • Bals, R.1    Weiner, D.J.2    Wilson, J.M.3
  • 8
    • 66849099549 scopus 로고    scopus 로고
    • Innate immune receptors on neutrophils and their role in chronic lung disease
    • Koller B., Bals R., Roos D., Korting H.C., Griese M., Hartl D. Innate immune receptors on neutrophils and their role in chronic lung disease. Eur J Clin Invest Jul 2009, 39(7):535-547.
    • (2009) Eur J Clin Invest , vol.39 , Issue.7 , pp. 535-547
    • Koller, B.1    Bals, R.2    Roos, D.3    Korting, H.C.4    Griese, M.5    Hartl, D.6
  • 9
    • 12444322678 scopus 로고    scopus 로고
    • TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells
    • Greene C.M., Carroll T.P., Smith S.G.J., Taggart C.C., Devaney J., Griffin S., et al. TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells. J Immunol Feb 1 2005, 174(3):1638-1646.
    • (2005) J Immunol , vol.174 , Issue.3 , pp. 1638-1646
    • Greene, C.M.1    Carroll, T.P.2    Smith, S.G.J.3    Taggart, C.C.4    Devaney, J.5    Griffin, S.6
  • 10
    • 29244437861 scopus 로고    scopus 로고
    • The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A
    • Thelin W.R., Kesimer M., Tarran R., Kreda S.M., Grubb B.R., Sheehan J.K., et al. The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A. J Biol Chem Dec 16 2005, 280(50):41512-41520.
    • (2005) J Biol Chem , vol.280 , Issue.50 , pp. 41512-41520
    • Thelin, W.R.1    Kesimer, M.2    Tarran, R.3    Kreda, S.M.4    Grubb, B.R.5    Sheehan, J.K.6
  • 11
    • 18244377969 scopus 로고    scopus 로고
    • Characterization of wild-type and Delta F508 cystic fibrosis transmembrane regulator in human respiratory epithelia
    • Kreda S.M., Mall M., Mengos A., Rochelle L., Yankaskas J., Riordan J.R., et al. Characterization of wild-type and Delta F508 cystic fibrosis transmembrane regulator in human respiratory epithelia. Mol Biol Cell May 2005, 16(5):2154-2167.
    • (2005) Mol Biol Cell , vol.16 , Issue.5 , pp. 2154-2167
    • Kreda, S.M.1    Mall, M.2    Mengos, A.3    Rochelle, L.4    Yankaskas, J.5    Riordan, J.R.6
  • 12
    • 0025931429 scopus 로고
    • Nucleoside Triphosphates Are Required to Open the Cftr Chloride Channel
    • Anderson M.P., Berger H.A., Rich D.P., Gregory R.J., Smith A.E., Welsh M.J. Nucleoside Triphosphates Are Required to Open the Cftr Chloride Channel. Cell Nov 15 1991, 67(4):775-784.
    • (1991) Cell , vol.67 , Issue.4 , pp. 775-784
    • Anderson, M.P.1    Berger, H.A.2    Rich, D.P.3    Gregory, R.J.4    Smith, A.E.5    Welsh, M.J.6
  • 13
    • 0025868103 scopus 로고
    • Demonstration That Cftr Is a Chloride Channel by Alteration of Its Anion Selectivity
    • Anderson M.P., Gregory R.J., Thompson S., Souza D.W., Paul S., Mulligan R.C., et al. Demonstration That Cftr Is a Chloride Channel by Alteration of Its Anion Selectivity. Science Jul 12 1991, 253(5016):202-205.
    • (1991) Science , vol.253 , Issue.5016 , pp. 202-205
    • Anderson, M.P.1    Gregory, R.J.2    Thompson, S.3    Souza, D.W.4    Paul, S.5    Mulligan, R.C.6
  • 14
    • 54949112835 scopus 로고    scopus 로고
    • TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity
    • Caputo A., Caci E., Ferrera L., Pedemonte N., Barsanti C., Sondo E., et al. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science Oct 24 2008, 322(5901):590-594.
    • (2008) Science , vol.322 , Issue.5901 , pp. 590-594
    • Caputo, A.1    Caci, E.2    Ferrera, L.3    Pedemonte, N.4    Barsanti, C.5    Sondo, E.6
  • 16
    • 58449116969 scopus 로고    scopus 로고
    • Role of the amiloride-sensitive epithelial Na+ channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease
    • Mall M.A. Role of the amiloride-sensitive epithelial Na+ channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease. Exp Physiol Feb 2009, 94(2):171-174.
    • (2009) Exp Physiol , vol.94 , Issue.2 , pp. 171-174
    • Mall, M.A.1
  • 17
    • 0032433707 scopus 로고    scopus 로고
    • Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    • Matsui H., Grubb B.R., Tarran R., Randell S.H., Gatzy J.T., Davis C.W., et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell Dec 23 1998, 95(7):1005-1015.
    • (1998) Cell , vol.95 , Issue.7 , pp. 1005-1015
    • Matsui, H.1    Grubb, B.R.2    Tarran, R.3    Randell, S.H.4    Gatzy, J.T.5    Davis, C.W.6
  • 18
    • 33645964965 scopus 로고    scopus 로고
    • Regulation of normal and cystic fibrosis airway surface liquid volume by phasic shear stress
    • Tarran R., Button B., Boucher R.C. Regulation of normal and cystic fibrosis airway surface liquid volume by phasic shear stress. Annu Rev Physiol 2006, 68:543-561.
    • (2006) Annu Rev Physiol , vol.68 , pp. 543-561
    • Tarran, R.1    Button, B.2    Boucher, R.C.3
  • 19
    • 79958142002 scopus 로고    scopus 로고
    • The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease
    • Zhou Z., Duerr J., Johannesson B., Schubert S.C., Treis D., Harm M., et al. The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease. J Cyst Fibros Jun 2011, 10(Suppl. 2):S172-S182.
    • (2011) J Cyst Fibros , vol.10 , Issue.SUPPL. 2
    • Zhou, Z.1    Duerr, J.2    Johannesson, B.3    Schubert, S.C.4    Treis, D.5    Harm, M.6
  • 21
    • 85012499363 scopus 로고    scopus 로고
    • The CF mouse: an important tool for studying cystic fibrosis
    • Davidson D.J., Dorin J.R. The CF mouse: an important tool for studying cystic fibrosis. Expert Rev Mol Med Mar 12 2001, 2001:1-27.
    • (2001) Expert Rev Mol Med , vol.2001 , pp. 1-27
    • Davidson, D.J.1    Dorin, J.R.2
  • 22
    • 0035479148 scopus 로고    scopus 로고
    • Mouse models of cystic fibrosis
    • Davidson D.J., Rolfe M. Mouse models of cystic fibrosis. Trends Genet Oct 2001, 17(10):S29-S37.
    • (2001) Trends Genet , vol.17 , Issue.10
    • Davidson, D.J.1    Rolfe, M.2
  • 23
    • 0032962320 scopus 로고    scopus 로고
    • Pathophysiology of gene-targeted mouse models for cystic fibrosis
    • Grubb B.R., Boucher R.C. Pathophysiology of gene-targeted mouse models for cystic fibrosis. Physiol Rev Jan 1999, 79(1 Suppl):S193-S214.
    • (1999) Physiol Rev , vol.79 , Issue.1 SUPPL.
    • Grubb, B.R.1    Boucher, R.C.2
  • 24
    • 2442718786 scopus 로고    scopus 로고
    • Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
    • Mall M., Grubb B.R., Harkema J.R., O'Neal W.K., Boucher R.C. Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice. Nat Med May 2004, 10(5):487-493.
    • (2004) Nat Med , vol.10 , Issue.5 , pp. 487-493
    • Mall, M.1    Grubb, B.R.2    Harkema, J.R.3    O'Neal, W.K.4    Boucher, R.C.5
  • 25
    • 41749115751 scopus 로고    scopus 로고
    • Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice
    • Mall M.A., Harkema J.R., Trojanek J.B., Treis D., Livraghi A., Schubert S., et al. Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice. Am J Respir Crit Care Med Apr 1 2008, 177(7):730-742.
    • (2008) Am J Respir Crit Care Med , vol.177 , Issue.7 , pp. 730-742
    • Mall, M.A.1    Harkema, J.R.2    Trojanek, J.B.3    Treis, D.4    Livraghi, A.5    Schubert, S.6
  • 26
    • 57149104917 scopus 로고    scopus 로고
    • Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice
    • Zhou Z., Treis D., Schubert S.C., Harm M., Schatterny J., Hirtz S., et al. Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice. Am J Respir Crit Care Med Dec 15 2008, 178(12):1245-1256.
    • (2008) Am J Respir Crit Care Med , vol.178 , Issue.12 , pp. 1245-1256
    • Zhou, Z.1    Treis, D.2    Schubert, S.C.3    Harm, M.4    Schatterny, J.5    Hirtz, S.6
  • 27
    • 41849092177 scopus 로고    scopus 로고
    • Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis
    • Teichgraber V., Ulrich M., Endlich N., Riethmuller J., Wilker B., De Oliveira-Munding C.C., et al. Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Nat Med Apr 2008, 14(4):382-391.
    • (2008) Nat Med , vol.14 , Issue.4 , pp. 382-391
    • Teichgraber, V.1    Ulrich, M.2    Endlich, N.3    Riethmuller, J.4    Wilker, B.5    De Oliveira-Munding, C.C.6
  • 28
    • 77954504913 scopus 로고    scopus 로고
    • Alterations in Ceramide Concentration and pH Determine the Release of Reactive Oxygen Species by Cftr-Deficient Macrophages on Infection
    • Zhang Y., Li X., Grassme H., Doring G., Gulbins E. Alterations in Ceramide Concentration and pH Determine the Release of Reactive Oxygen Species by Cftr-Deficient Macrophages on Infection. J Immunol May 1 2010, 184(9):5104-5111.
    • (2010) J Immunol , vol.184 , Issue.9 , pp. 5104-5111
    • Zhang, Y.1    Li, X.2    Grassme, H.3    Doring, G.4    Gulbins, E.5
  • 30
    • 4444279595 scopus 로고    scopus 로고
    • Molecular epidemiology of Pseudomonas aeruginosa, Burkholderia cepacia complex and methicillin-resistant Staphylococcus aureus in a cystic fibrosis center
    • Campana S., Taccetti G., Ravenni N., Masi I., Audino S., Sisi B., et al. Molecular epidemiology of Pseudomonas aeruginosa, Burkholderia cepacia complex and methicillin-resistant Staphylococcus aureus in a cystic fibrosis center. J Cyst Fibros Aug 2004, 3(3):159-163.
    • (2004) J Cyst Fibros , vol.3 , Issue.3 , pp. 159-163
    • Campana, S.1    Taccetti, G.2    Ravenni, N.3    Masi, I.4    Audino, S.5    Sisi, B.6
  • 31
    • 3343023861 scopus 로고    scopus 로고
    • Early intervention and prevention of lung disease in cystic fibrosis: a European consensus
    • Doring G., Hoiby N. Early intervention and prevention of lung disease in cystic fibrosis: a European consensus. J Cyst Fibros Jun 2004, 3(2):67-91.
    • (2004) J Cyst Fibros , vol.3 , Issue.2 , pp. 67-91
    • Doring, G.1    Hoiby, N.2
  • 32
    • 0035991525 scopus 로고    scopus 로고
    • The role of inflammation in the pathophysiology of CF lung disease
    • Chmiel J.F., Berger M., Konstan M.W. The role of inflammation in the pathophysiology of CF lung disease. Clin Rev Allergy Immunol Aug 2002, 23(1):5-27.
    • (2002) Clin Rev Allergy Immunol , vol.23 , Issue.1 , pp. 5-27
    • Chmiel, J.F.1    Berger, M.2    Konstan, M.W.3
  • 34
    • 84861780622 scopus 로고    scopus 로고
    • Immune responses in Cystic Fibrosis; are they intrinsically defective?
    • Ratner D., Mueller C. Immune responses in Cystic Fibrosis; are they intrinsically defective?. Am J Respir Cell Mol Biol Mar 2012, 46(6):715-722.
    • (2012) Am J Respir Cell Mol Biol , vol.46 , Issue.6 , pp. 715-722
    • Ratner, D.1    Mueller, C.2
  • 35
    • 80455162465 scopus 로고    scopus 로고
    • A CFTR potentiator in patients with cystic fibrosis and the G551D mutation
    • Ramsey B.W., Davies J., McElvaney N.G., Tullis E., Bell S.C., Drevinek P., et al. A CFTR potentiator in patients with cystic fibrosis and the G551D mutation. N Engl J Med Nov 3 2011, 365(18):1663-1672.
    • (2011) N Engl J Med , vol.365 , Issue.18 , pp. 1663-1672
    • Ramsey, B.W.1    Davies, J.2    McElvaney, N.G.3    Tullis, E.4    Bell, S.C.5    Drevinek, P.6
  • 36
    • 78549279173 scopus 로고    scopus 로고
    • Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation
    • Accurso F.J., Rowe S.M., Clancy J.P., Boyle M.P., Dunitz J.M., Durie P.R., et al. Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation. N Engl J Med Nov 18 2010, 363(21):1991-2003.
    • (2010) N Engl J Med , vol.363 , Issue.21 , pp. 1991-2003
    • Accurso, F.J.1    Rowe, S.M.2    Clancy, J.P.3    Boyle, M.P.4    Dunitz, J.M.5    Durie, P.R.6
  • 37
    • 5144232620 scopus 로고    scopus 로고
    • CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis
    • Hirtz S., Gonska T., Seydewitz H.H., Thomas J., Greiner P., Kuehr J., et al. CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis. Gastroenterology Oct 2004, 127(4):1085-1095.
    • (2004) Gastroenterology , vol.127 , Issue.4 , pp. 1085-1095
    • Hirtz, S.1    Gonska, T.2    Seydewitz, H.H.3    Thomas, J.4    Greiner, P.5    Kuehr, J.6
  • 38
    • 80052328287 scopus 로고    scopus 로고
    • The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients
    • Roth E.K., Hirtz S., Duerr J., Wenning D., Eichler I., Seydewitz H.H., et al. The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients. PLoS One 2011, 6(8):e24445.
    • (2011) PLoS One , vol.6 , Issue.8
    • Roth, E.K.1    Hirtz, S.2    Duerr, J.3    Wenning, D.4    Eichler, I.5    Seydewitz, H.H.6
  • 39
    • 77958113699 scopus 로고    scopus 로고
    • Allergic bronchopulmonary aspergillosis and Aspergillus infection in cystic fibrosis
    • Moss R.B. Allergic bronchopulmonary aspergillosis and Aspergillus infection in cystic fibrosis. Curr Opin Pulm Med Nov 2010, 16(6):598-603.
    • (2010) Curr Opin Pulm Med , vol.16 , Issue.6 , pp. 598-603
    • Moss, R.B.1
  • 40
    • 77957868732 scopus 로고    scopus 로고
    • Sputum Candida albicans presages FEV(1) decline and hospital-treated exacerbations in cystic fibrosis
    • Chotirmall S.H., O'Donoghue E., Bennett K., Gunaratnam C., O'Neill S.J., McElvaney N.G. Sputum Candida albicans presages FEV(1) decline and hospital-treated exacerbations in cystic fibrosis. Chest Nov 2010, 138(5):1186-1195.
    • (2010) Chest , vol.138 , Issue.5 , pp. 1186-1195
    • Chotirmall, S.H.1    O'Donoghue, E.2    Bennett, K.3    Gunaratnam, C.4    O'Neill, S.J.5    McElvaney, N.G.6
  • 42
    • 70350449606 scopus 로고    scopus 로고
    • The approach to Pseudomonas aeruginosa in cystic fibrosis
    • Bendiak G.N., Ratjen F. The approach to Pseudomonas aeruginosa in cystic fibrosis. Semin Respir Crit Care Med Oct 2009, 30(5):587-595.
    • (2009) Semin Respir Crit Care Med , vol.30 , Issue.5 , pp. 587-595
    • Bendiak, G.N.1    Ratjen, F.2
  • 43
    • 68449101095 scopus 로고    scopus 로고
    • Immunological mechanisms behind the cystic fibrosis-ABPA link
    • Hartl D. Immunological mechanisms behind the cystic fibrosis-ABPA link. Med Mycol 2009, 47:S183-S191.
    • (2009) Med Mycol , vol.47
    • Hartl, D.1
  • 44
    • 84866183562 scopus 로고    scopus 로고
    • What Is the Significance of Aspergillus Fumigatus in Bal in Children with Cystic Fibrosis
    • Thursfield R.M., Holden K., Bush A., Adams A., Nicholson A.G. What Is the Significance of Aspergillus Fumigatus in Bal in Children with Cystic Fibrosis. Pediatr Pulmonol 2011, 304-305.
    • (2011) Pediatr Pulmonol , pp. 304-305
    • Thursfield, R.M.1    Holden, K.2    Bush, A.3    Adams, A.4    Nicholson, A.G.5
  • 45
    • 29544436136 scopus 로고    scopus 로고
    • Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis
    • Hartl D., Griese M., Kappler M., Zissel G., Reinhardt D., Rebhan C., et al. Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis. J Allergy Clin Immunol 2006, 117(1):204-211.
    • (2006) J Allergy Clin Immunol , vol.117 , Issue.1 , pp. 204-211
    • Hartl, D.1    Griese, M.2    Kappler, M.3    Zissel, G.4    Reinhardt, D.5    Rebhan, C.6
  • 46
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • Kawai T., Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol May 2010, 11(5):373-384.
    • (2010) Nat Immunol , vol.11 , Issue.5 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 47
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
    • Kawai T., Akira S. Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity. Immunity May 27 2011, 34(5):637-650.
    • (2011) Immunity , vol.34 , Issue.5 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 48
    • 77950343791 scopus 로고    scopus 로고
    • Pattern Recognition Receptors and Inflammation
    • Takeuchi O., Akira S. Pattern Recognition Receptors and Inflammation. Cell Mar 19 2010, 140(6):805-820.
    • (2010) Cell , vol.140 , Issue.6 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 50
    • 0037297756 scopus 로고    scopus 로고
    • Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung
    • Droemann D., Goldmann T., Branscheid D., Clark R., Dalhoff K., Zabel P., et al. Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung. Histochem Cell Biol Feb 2003, 119(2):103-108.
    • (2003) Histochem Cell Biol , vol.119 , Issue.2 , pp. 103-108
    • Droemann, D.1    Goldmann, T.2    Branscheid, D.3    Clark, R.4    Dalhoff, K.5    Zabel, P.6
  • 51
    • 57549085708 scopus 로고    scopus 로고
    • Toll-like receptors as therapeutic targets in cystic fibrosis
    • Greene C.M., Branagan P., McElvaney N.G. Toll-like receptors as therapeutic targets in cystic fibrosis. Expert Opin Ther Targets Dec 2008, 12(12):1481-1495.
    • (2008) Expert Opin Ther Targets , vol.12 , Issue.12 , pp. 1481-1495
    • Greene, C.M.1    Branagan, P.2    McElvaney, N.G.3
  • 54
    • 3142661103 scopus 로고    scopus 로고
    • Microbial DNA induces a host defense reaction of human respiratory epithelial cells
    • Platz J., Beisswenger C., Dalpke A., Koczulla R., Pinkenburg O., Vogelmeier C., et al. Microbial DNA induces a host defense reaction of human respiratory epithelial cells. J Immunol Jul 15 2004, 173(2):1219-1223.
    • (2004) J Immunol , vol.173 , Issue.2 , pp. 1219-1223
    • Platz, J.1    Beisswenger, C.2    Dalpke, A.3    Koczulla, R.4    Pinkenburg, O.5    Vogelmeier, C.6
  • 55
    • 12444322678 scopus 로고    scopus 로고
    • TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells
    • Greene C.M., Carroll T.P., Smith S.G., Taggart C.C., Devaney J., Griffin S., et al. TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells. J Immunol Feb 1 2005, 174(3):1638-1646.
    • (2005) J Immunol , vol.174 , Issue.3 , pp. 1638-1646
    • Greene, C.M.1    Carroll, T.P.2    Smith, S.G.3    Taggart, C.C.4    Devaney, J.5    Griffin, S.6
  • 56
    • 2342535902 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM1 and toll-like receptor 2 as well as toll-like receptor 5
    • Adamo R., Sokol S., Soong G., Gomez M.I., Prince A. Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM1 and toll-like receptor 2 as well as toll-like receptor 5. Am J Respir Cell Mol Biol May 2004, 30(5):627-634.
    • (2004) Am J Respir Cell Mol Biol , vol.30 , Issue.5 , pp. 627-634
    • Adamo, R.1    Sokol, S.2    Soong, G.3    Gomez, M.I.4    Prince, A.5
  • 57
    • 0347362785 scopus 로고    scopus 로고
    • Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin
    • Monick M.M., Yarovinsky T.O., Powers L.S., Butler N.S., Carter A.B., Gudmundsson G., et al. Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J Biol Chem Dec 26 2003, 278(52):53035-53044.
    • (2003) J Biol Chem , vol.278 , Issue.52 , pp. 53035-53044
    • Monick, M.M.1    Yarovinsky, T.O.2    Powers, L.S.3    Butler, N.S.4    Carter, A.B.5    Gudmundsson, G.6
  • 58
    • 2942532924 scopus 로고    scopus 로고
    • TLR2 is mobilized into an apical lipid raft receptor complex to signal infection in airway epithelial cells
    • Soong G., Reddy B., Sokol S., Adamo R., Prince A. TLR2 is mobilized into an apical lipid raft receptor complex to signal infection in airway epithelial cells. J Clin Invest May 2004, 113(10):1482-1489.
    • (2004) J Clin Invest , vol.113 , Issue.10 , pp. 1482-1489
    • Soong, G.1    Reddy, B.2    Sokol, S.3    Adamo, R.4    Prince, A.5
  • 60
    • 16344389339 scopus 로고    scopus 로고
    • Toll-like receptors 4 and 2 expression in the bronchial mucosa of patients with cystic fibrosis
    • Hauber H.P., Tulic M.K., Tsicopoulos A., Wallaert B., Olivenstein R., Daigneault P., et al. Toll-like receptors 4 and 2 expression in the bronchial mucosa of patients with cystic fibrosis. Can Respir J Jan-Feb 2005, 12(1):13-18.
    • (2005) Can Respir J , vol.12 , Issue.1 , pp. 13-18
    • Hauber, H.P.1    Tulic, M.K.2    Tsicopoulos, A.3    Wallaert, B.4    Olivenstein, R.5    Daigneault, P.6
  • 62
    • 79960723018 scopus 로고    scopus 로고
    • Reduced surface toll-like receptor-4 expression and absent interferon-gamma-inducible protein-10 induction in cystic fibrosis airway cells
    • John G., Chillappagari S., Rubin B.K., Gruenert D.C., Henke M.O. Reduced surface toll-like receptor-4 expression and absent interferon-gamma-inducible protein-10 induction in cystic fibrosis airway cells. Exp Lung Res 2011, 37(6):319-326.
    • (2011) Exp Lung Res , vol.37 , Issue.6 , pp. 319-326
    • John, G.1    Chillappagari, S.2    Rubin, B.K.3    Gruenert, D.C.4    Henke, M.O.5
  • 63
    • 84859620802 scopus 로고    scopus 로고
    • Cystic fibrosis: a mucosal immunodeficiency syndrome
    • Cohen T.S., Prince A. Cystic fibrosis: a mucosal immunodeficiency syndrome. Nat Med 2012, 18(4):509-519.
    • (2012) Nat Med , vol.18 , Issue.4 , pp. 509-519
    • Cohen, T.S.1    Prince, A.2
  • 64
    • 27744459408 scopus 로고    scopus 로고
    • Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5
    • Zhang Z., Louboutin J.P., Weiner D.J., Goldberg J.B., Wilson J.M. Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5. Infect Immun 2005, 73(11):7151-7160.
    • (2005) Infect Immun , vol.73 , Issue.11 , pp. 7151-7160
    • Zhang, Z.1    Louboutin, J.P.2    Weiner, D.J.3    Goldberg, J.B.4    Wilson, J.M.5
  • 66
    • 47249131603 scopus 로고    scopus 로고
    • Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease
    • Blohmke C.J., Victor R.E., Hirschfeld A.F., Elias I.M., Hancock D.G., Lane C.R., et al. Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease. J Immunol 2008, 180(11):7764-7773.
    • (2008) J Immunol , vol.180 , Issue.11 , pp. 7764-7773
    • Blohmke, C.J.1    Victor, R.E.2    Hirschfeld, A.F.3    Elias, I.M.4    Hancock, D.G.5    Lane, C.R.6
  • 68
    • 79952454406 scopus 로고    scopus 로고
    • P. aeruginosa drives CXCL8 synthesis via redundant toll-like receptors and NADPH oxidase in CFTRF508 airway epithelial cells
    • Roussel L., Martel G., Berube J., Rousseau S. P. aeruginosa drives CXCL8 synthesis via redundant toll-like receptors and NADPH oxidase in CFTRF508 airway epithelial cells. J Cyst Fibros 2011, 10(2):107-113.
    • (2011) J Cyst Fibros , vol.10 , Issue.2 , pp. 107-113
    • Roussel, L.1    Martel, G.2    Berube, J.3    Rousseau, S.4
  • 69
    • 58149388163 scopus 로고    scopus 로고
    • Aspergillus/allergic bronchopulmonary aspergillosis in an Irish cystic fibrosis population: a diagnostically challenging entity
    • Chotirmall S.H., Branagan P., Gunaratnam C., McElvaney N.G. Aspergillus/allergic bronchopulmonary aspergillosis in an Irish cystic fibrosis population: a diagnostically challenging entity. Respir Care 2008, 53(8):1035-1041.
    • (2008) Respir Care , vol.53 , Issue.8 , pp. 1035-1041
    • Chotirmall, S.H.1    Branagan, P.2    Gunaratnam, C.3    McElvaney, N.G.4
  • 70
    • 84856738301 scopus 로고    scopus 로고
    • Aspergillus fumigatus conidia induce interferon-beta signalling in respiratory epithelial cells
    • Beisswenger C., Hess C., Bals R. Aspergillus fumigatus conidia induce interferon-beta signalling in respiratory epithelial cells. Eur Respir J 2012, 39(2):411-418.
    • (2012) Eur Respir J , vol.39 , Issue.2 , pp. 411-418
    • Beisswenger, C.1    Hess, C.2    Bals, R.3
  • 71
    • 56149127705 scopus 로고    scopus 로고
    • TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation
    • Da Silva C.A., Hartl D., Liu W., Lee C.G., Elias J.A. TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation. J Immunol 2008, 181(6):4279-4286.
    • (2008) J Immunol , vol.181 , Issue.6 , pp. 4279-4286
    • Da Silva, C.A.1    Hartl, D.2    Liu, W.3    Lee, C.G.4    Elias, J.A.5
  • 72
    • 0035929634 scopus 로고    scopus 로고
    • Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium
    • Walsh D.E., Greene C.M., Carroll T.P., Taggart C.C., Gallagher P.M., O'Neill S.J., et al. Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium. J Biol Chem 2001, 276(38):35494-35499.
    • (2001) J Biol Chem , vol.276 , Issue.38 , pp. 35494-35499
    • Walsh, D.E.1    Greene, C.M.2    Carroll, T.P.3    Taggart, C.C.4    Gallagher, P.M.5    O'Neill, S.J.6
  • 74
    • 24744464353 scopus 로고    scopus 로고
    • Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme
    • Shao M.X., Nadel J.A. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J Immunol 2005, 175(6):4009-4016.
    • (2005) J Immunol , vol.175 , Issue.6 , pp. 4009-4016
    • Shao, M.X.1    Nadel, J.A.2
  • 75
    • 57649136396 scopus 로고    scopus 로고
    • Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway
    • Bergin D.A., Greene C.M., Sterchi E.E., Kenna C., Geraghty P., Belaaouaj A., et al. Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway. J Biol Chem 2008, 283(46):31736-31744.
    • (2008) J Biol Chem , vol.283 , Issue.46 , pp. 31736-31744
    • Bergin, D.A.1    Greene, C.M.2    Sterchi, E.E.3    Kenna, C.4    Geraghty, P.5    Belaaouaj, A.6
  • 76
    • 79953232042 scopus 로고    scopus 로고
    • Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway
    • Cosgrove S., Chotirmall S.H., Greene C.M., McElvaney N.G. Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway. J Biol Chem 2011, 286(9):7692-7704.
    • (2011) J Biol Chem , vol.286 , Issue.9 , pp. 7692-7704
    • Cosgrove, S.1    Chotirmall, S.H.2    Greene, C.M.3    McElvaney, N.G.4
  • 78
    • 0037072766 scopus 로고    scopus 로고
    • Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination
    • Taggart C.C., Greene C.M., McElvaney N.G., O'Neill S. Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination. J Biol Chem 2002, 277(37):33648-33653.
    • (2002) J Biol Chem , vol.277 , Issue.37 , pp. 33648-33653
    • Taggart, C.C.1    Greene, C.M.2    McElvaney, N.G.3    O'Neill, S.4
  • 79
    • 2542533920 scopus 로고    scopus 로고
    • Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells
    • Greene C.M., McElvaney N.G., O'Neill S.J., Taggart C.C. Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells. Infect Immun 2004, 72(6):3684-3687.
    • (2004) Infect Immun , vol.72 , Issue.6 , pp. 3684-3687
    • Greene, C.M.1    McElvaney, N.G.2    O'Neill, S.J.3    Taggart, C.C.4
  • 80
    • 29144439305 scopus 로고    scopus 로고
    • Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding
    • Taggart C.C., Cryan S.A., Weldon S., Gibbons A., Greene C.M., Kelly E., et al. Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding. J Exp Med 2005, 202(12):1659-1668.
    • (2005) J Exp Med , vol.202 , Issue.12 , pp. 1659-1668
    • Taggart, C.C.1    Cryan, S.A.2    Weldon, S.3    Gibbons, A.4    Greene, C.M.5    Kelly, E.6
  • 81
    • 77949890696 scopus 로고    scopus 로고
    • MiR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression
    • Oglesby I.K., Bray I.M., Chotirmall S.H., Stallings R.L., O'Neill S.J., McElvaney N.G., et al. miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression. J Immunol 2010, 184(4):1702-1709.
    • (2010) J Immunol , vol.184 , Issue.4 , pp. 1702-1709
    • Oglesby, I.K.1    Bray, I.M.2    Chotirmall, S.H.3    Stallings, R.L.4    O'Neill, S.J.5    McElvaney, N.G.6
  • 82
    • 0035260881 scopus 로고    scopus 로고
    • Chemokines and disease
    • Gerard C., Rollins B.J. Chemokines and disease. Nat Immunol 2001, 2(2):108-115.
    • (2001) Nat Immunol , vol.2 , Issue.2 , pp. 108-115
    • Gerard, C.1    Rollins, B.J.2
  • 83
    • 0035257205 scopus 로고    scopus 로고
    • Lymphocyte traffic control by chemokines
    • Moser B., Loetscher P. Lymphocyte traffic control by chemokines. Nat Immunol 2001, 2(2):123-128.
    • (2001) Nat Immunol , vol.2 , Issue.2 , pp. 123-128
    • Moser, B.1    Loetscher, P.2
  • 84
    • 0037363770 scopus 로고    scopus 로고
    • Chemokines and their receptors in asthma and chronic obstructive pulmonary disease
    • Panina-Bordignon P., D'Ambrosio D. Chemokines and their receptors in asthma and chronic obstructive pulmonary disease. Curr Opin Pulm Med 2003, 9(2):104-110.
    • (2003) Curr Opin Pulm Med , vol.9 , Issue.2 , pp. 104-110
    • Panina-Bordignon, P.1    D'Ambrosio, D.2
  • 85
    • 80053159409 scopus 로고    scopus 로고
    • Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling
    • Zemans R.L., Briones N., Campbell M., McClendon J., Young S.K., Suzuki T., et al. Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling. Proc Natl Acad Sci U S A 2011, 108(38):15990-15995.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.38 , pp. 15990-15995
    • Zemans, R.L.1    Briones, N.2    Campbell, M.3    McClendon, J.4    Young, S.K.5    Suzuki, T.6
  • 86
    • 65349157884 scopus 로고    scopus 로고
    • Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury
    • Zemans R.L., Colgan S.P., Downey G.P. Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol 2009, 40(5):519-535.
    • (2009) Am J Respir Cell Mol , vol.40 , Issue.5 , pp. 519-535
    • Zemans, R.L.1    Colgan, S.P.2    Downey, G.P.3
  • 87
    • 58349104978 scopus 로고    scopus 로고
    • Neutrophils in cystic fibrosis
    • Downey D.G., Bell S.C., Elborn J.S. Neutrophils in cystic fibrosis. Thorax 2009, 64(1):81-88.
    • (2009) Thorax , vol.64 , Issue.1 , pp. 81-88
    • Downey, D.G.1    Bell, S.C.2    Elborn, J.S.3
  • 89
    • 34547731349 scopus 로고    scopus 로고
    • The effect of treatment of cystic fibrosis pulmonary exacerbations on airways and systemic inflammation
    • Downey D.G., Brockbank S., Martin S.L., Ennis M., Elborn J.S. The effect of treatment of cystic fibrosis pulmonary exacerbations on airways and systemic inflammation. Pediatr Pulmonol 2007, 42(8):729-735.
    • (2007) Pediatr Pulmonol , vol.42 , Issue.8 , pp. 729-735
    • Downey, D.G.1    Brockbank, S.2    Martin, S.L.3    Ennis, M.4    Elborn, J.S.5
  • 90
    • 33644936021 scopus 로고    scopus 로고
    • Adherence of airway neutrophils and inflammatory response are increased in CF airway epithelial cell-neutrophil interactions
    • Tabary O., Corvol H., Boncoeur E., Chadelat K., Fitting C., Cavaillon J.M., et al. Adherence of airway neutrophils and inflammatory response are increased in CF airway epithelial cell-neutrophil interactions. Am J Physiol Lung Cell Mol Physiol 2006, 290(3):L588-L596.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290 , Issue.3
    • Tabary, O.1    Corvol, H.2    Boncoeur, E.3    Chadelat, K.4    Fitting, C.5    Cavaillon, J.M.6
  • 91
    • 0034930435 scopus 로고    scopus 로고
    • Chemokine receptors in airway disease: which receptors to target?
    • Owen C. Chemokine receptors in airway disease: which receptors to target?. Pulm Pharmacol Ther 2001, 14(3):193-202.
    • (2001) Pulm Pharmacol Ther , vol.14 , Issue.3 , pp. 193-202
    • Owen, C.1
  • 93
    • 67651101168 scopus 로고    scopus 로고
    • Alarmins and antimicrobial immunity
    • Yang D., Oppenheim J.J. Alarmins and antimicrobial immunity. Med Mycol 2009, 47(Suppl. 1):S146-S153.
    • (2009) Med Mycol , vol.47 , Issue.SUPPL. 1
    • Yang, D.1    Oppenheim, J.J.2
  • 94
    • 0035991531 scopus 로고    scopus 로고
    • Monitoring inflammation in CF. Cytokines
    • Sagel S.D., Accurso F.J. Monitoring inflammation in CF. Cytokines. Clin Rev Allergy Immunol 2002, 23(1):41-57.
    • (2002) Clin Rev Allergy Immunol , vol.23 , Issue.1 , pp. 41-57
    • Sagel, S.D.1    Accurso, F.J.2
  • 95
    • 48649104569 scopus 로고    scopus 로고
    • Chronic inflammation in the cystic fibrosis lung: alterations in inter- and intracellular signaling
    • Nichols D., Chmiel J., Berger M. Chronic inflammation in the cystic fibrosis lung: alterations in inter- and intracellular signaling. Clin Rev Allergy Immunol 2008, 34(2):146-162.
    • (2008) Clin Rev Allergy Immunol , vol.34 , Issue.2 , pp. 146-162
    • Nichols, D.1    Chmiel, J.2    Berger, M.3
  • 96
    • 39449133330 scopus 로고    scopus 로고
    • Airway inflammation in cystic fibrosis
    • Elizur A., Cannon C.L., Ferkol T.W. Airway inflammation in cystic fibrosis. Chest 2008, 133(2):489-495.
    • (2008) Chest , vol.133 , Issue.2 , pp. 489-495
    • Elizur, A.1    Cannon, C.L.2    Ferkol, T.W.3
  • 97
    • 0023181249 scopus 로고
    • Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities
    • Le J., Vilcek J. Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities. Lab Invest 1987, 56(3):234-248.
    • (1987) Lab Invest , vol.56 , Issue.3 , pp. 234-248
    • Le, J.1    Vilcek, J.2
  • 98
    • 84860877293 scopus 로고    scopus 로고
    • Emerging roles of pulmonary macrophages in driving the development of severe asthma
    • Yang M., Kumar R.K., Hansbro P.M., Foster P.S. Emerging roles of pulmonary macrophages in driving the development of severe asthma. J Leukoc Biol 2012, 91(4):557-569.
    • (2012) J Leukoc Biol , vol.91 , Issue.4 , pp. 557-569
    • Yang, M.1    Kumar, R.K.2    Hansbro, P.M.3    Foster, P.S.4
  • 99
    • 0029670051 scopus 로고    scopus 로고
    • TNF-alpha, IL-8, soluble ICAM-1, and neutrophils in sputum of cystic fibrosis patients
    • Salva P.S., Doyle N.A., Graham L., Eigen H., Doerschuk C.M. TNF-alpha, IL-8, soluble ICAM-1, and neutrophils in sputum of cystic fibrosis patients. Pediatr Pulmonol 1996, 21(1):11-19.
    • (1996) Pediatr Pulmonol , vol.21 , Issue.1 , pp. 11-19
    • Salva, P.S.1    Doyle, N.A.2    Graham, L.3    Eigen, H.4    Doerschuk, C.M.5
  • 100
    • 0032864036 scopus 로고    scopus 로고
    • Distinct sputum cytokine profiles in cystic fibrosis and other chronic inflammatory airway disease
    • Osika E., Cavaillon J.M., Chadelat K., Boule M., Fitting C., Tournier G., et al. Distinct sputum cytokine profiles in cystic fibrosis and other chronic inflammatory airway disease. Eur Respir J 1999, 14(2):339-346.
    • (1999) Eur Respir J , vol.14 , Issue.2 , pp. 339-346
    • Osika, E.1    Cavaillon, J.M.2    Chadelat, K.3    Boule, M.4    Fitting, C.5    Tournier, G.6
  • 101
    • 0030883124 scopus 로고    scopus 로고
    • Randomised controlled trial of inhaled corticosteroids (fluticasone propionate) in cystic fibrosis
    • Balfour-Lynn I.M., Klein N.J., Dinwiddie R. Randomised controlled trial of inhaled corticosteroids (fluticasone propionate) in cystic fibrosis. Arch Dis Child 1997, 77(2):124-130.
    • (1997) Arch Dis Child , vol.77 , Issue.2 , pp. 124-130
    • Balfour-Lynn, I.M.1    Klein, N.J.2    Dinwiddie, R.3
  • 102
    • 80051752469 scopus 로고    scopus 로고
    • Analysis of inflammatory and immune response biomarkers in sputum and exhaled breath condensate by a multi-parametric biochip array in cystic fibrosis
    • Colombo C., Faelli N., Tirelli A.S., Fortunato F., Biffi A., Claut L., et al. Analysis of inflammatory and immune response biomarkers in sputum and exhaled breath condensate by a multi-parametric biochip array in cystic fibrosis. Int J Immunopathol Pharmacol 2011, 24(2):423-432.
    • (2011) Int J Immunopathol Pharmacol , vol.24 , Issue.2 , pp. 423-432
    • Colombo, C.1    Faelli, N.2    Tirelli, A.S.3    Fortunato, F.4    Biffi, A.5    Claut, L.6
  • 103
    • 79953813107 scopus 로고    scopus 로고
    • Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
    • Dinarello C.A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011, 117(14):3720-3732.
    • (2011) Blood , vol.117 , Issue.14 , pp. 3720-3732
    • Dinarello, C.A.1
  • 104
    • 0028177145 scopus 로고
    • Plasma interleukin-1 alpha and beta, tumor necrosis factor-alpha, and lipopolysaccharide concentrations during pulmonary exacerbations of cystic fibrosis
    • Wilmott R.W., Frenzke M., Kociela V., Peng L. Plasma interleukin-1 alpha and beta, tumor necrosis factor-alpha, and lipopolysaccharide concentrations during pulmonary exacerbations of cystic fibrosis. Pediatr Pulmonol 1994, 18(1):21-27.
    • (1994) Pediatr Pulmonol , vol.18 , Issue.1 , pp. 21-27
    • Wilmott, R.W.1    Frenzke, M.2    Kociela, V.3    Peng, L.4
  • 105
    • 0027173625 scopus 로고
    • Serum interleukin-1 alpha and soluble interleukin-2 receptor concentrations in cystic fibrosis
    • Greally P., Hussain M.J., Vergani D., Price J.F. Serum interleukin-1 alpha and soluble interleukin-2 receptor concentrations in cystic fibrosis. Arch Dis Child 1993, 68(6):785-787.
    • (1993) Arch Dis Child , vol.68 , Issue.6 , pp. 785-787
    • Greally, P.1    Hussain, M.J.2    Vergani, D.3    Price, J.F.4
  • 106
    • 0025281628 scopus 로고
    • Increased levels of interleukin-1 in bronchoalveolar washings from children with bacterial pulmonary infections
    • Wilmott R.W., Kassab J.T., Kilian P.L., Benjamin W.R., Douglas S.D., Wood R.E. Increased levels of interleukin-1 in bronchoalveolar washings from children with bacterial pulmonary infections. Am Rev Respir Dis 1990, 142(2):365-368.
    • (1990) Am Rev Respir Dis , vol.142 , Issue.2 , pp. 365-368
    • Wilmott, R.W.1    Kassab, J.T.2    Kilian, P.L.3    Benjamin, W.R.4    Douglas, S.D.5    Wood, R.E.6
  • 108
    • 59649123905 scopus 로고    scopus 로고
    • Acquisition and eradication of P. aeruginosa in young children with cystic fibrosis
    • Douglas T.A., Brennan S., Gard S., Berry L., Gangell C., Stick S.M., et al. Acquisition and eradication of P. aeruginosa in young children with cystic fibrosis. Eur Respir J 2009, 33(2):305-311.
    • (2009) Eur Respir J , vol.33 , Issue.2 , pp. 305-311
    • Douglas, T.A.1    Brennan, S.2    Gard, S.3    Berry, L.4    Gangell, C.5    Stick, S.M.6
  • 109
    • 0029372481 scopus 로고
    • Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis
    • Bonfield T.L., Konstan M.W., Burfeind P., Panuska J.R., Hilliard J.B., Berger M. Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis. Am J Respir Cell Mol Biol 1995, 13(3):257-261.
    • (1995) Am J Respir Cell Mol Biol , vol.13 , Issue.3 , pp. 257-261
    • Bonfield, T.L.1    Konstan, M.W.2    Burfeind, P.3    Panuska, J.R.4    Hilliard, J.B.5    Berger, M.6
  • 110
    • 2442581515 scopus 로고    scopus 로고
    • Quantitative cytokine gene expression in CF airway
    • Muhlebach M.S., Reed W., Noah T.L. Quantitative cytokine gene expression in CF airway. Pediatr Pulmonol 2004, 37(5):393-399.
    • (2004) Pediatr Pulmonol , vol.37 , Issue.5 , pp. 393-399
    • Muhlebach, M.S.1    Reed, W.2    Noah, T.L.3
  • 111
    • 77952425348 scopus 로고    scopus 로고
    • IL-10 delivery by AAV5 vector attenuates inflammation in mice with Pseudomonas pneumonia
    • Buff S.M., Yu H., McCall J.N., Caldwell S.M., Ferkol T.W., Flotte T.R., et al. IL-10 delivery by AAV5 vector attenuates inflammation in mice with Pseudomonas pneumonia. Gene Ther 2010, 17(5):567-576.
    • (2010) Gene Ther , vol.17 , Issue.5 , pp. 567-576
    • Buff, S.M.1    Yu, H.2    McCall, J.N.3    Caldwell, S.M.4    Ferkol, T.W.5    Flotte, T.R.6
  • 112
    • 0142010653 scopus 로고    scopus 로고
    • Noninvasive biomarkers of airway inflammation in cystic fibrosis
    • Sagel S.D. Noninvasive biomarkers of airway inflammation in cystic fibrosis. Curr Opin Pulm Med 2003, 9(6):516-521.
    • (2003) Curr Opin Pulm Med , vol.9 , Issue.6 , pp. 516-521
    • Sagel, S.D.1
  • 113
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • Bongartz T., Sutton A.J., Sweeting M.J., Buchan I., Matteson E.L., Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 2006, 295(19):2275-2285.
    • (2006) JAMA , vol.295 , Issue.19 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3    Buchan, I.4    Matteson, E.L.5    Montori, V.6
  • 114
    • 32144454172 scopus 로고    scopus 로고
    • The many roles of chemokines and chemokine receptors in inflammation
    • Charo I.F., Ransohoff R.M. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 2006, 354(6):610-621.
    • (2006) N Engl J Med , vol.354 , Issue.6 , pp. 610-621
    • Charo, I.F.1    Ransohoff, R.M.2
  • 116
    • 0038664195 scopus 로고    scopus 로고
    • Role of cytokines and other inflammatory mediators
    • Winkler M. Role of cytokines and other inflammatory mediators. BJOG 2003, 110(Suppl. 20):118-123.
    • (2003) BJOG , vol.110 , Issue.SUPPL. 20 , pp. 118-123
    • Winkler, M.1
  • 117
    • 36849020586 scopus 로고    scopus 로고
    • Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease
    • Hartl D., Latzin P., Hordijk P., Marcos V., Rudolph C., Woischnik M., et al. Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. Nat Med 2007, 13(12):1423-1430.
    • (2007) Nat Med , vol.13 , Issue.12 , pp. 1423-1430
    • Hartl, D.1    Latzin, P.2    Hordijk, P.3    Marcos, V.4    Rudolph, C.5    Woischnik, M.6
  • 119
    • 0035888715 scopus 로고    scopus 로고
    • Airway inflammation in children with cystic fibrosis and healthy children assessed by sputum induction
    • Sagel S.D., Kapsner R., Osberg I., Sontag M.K., Accurso F.J. Airway inflammation in children with cystic fibrosis and healthy children assessed by sputum induction. Am J Respir Crit Care Med 2001, 164(8):1425-1431.
    • (2001) Am J Respir Crit Care Med , vol.164 , Issue.8 , pp. 1425-1431
    • Sagel, S.D.1    Kapsner, R.2    Osberg, I.3    Sontag, M.K.4    Accurso, F.J.5
  • 120
    • 0027274608 scopus 로고
    • Interleukin-8 concentrations are elevated in bronchoalveolar lavage, sputum, and sera of children with cystic fibrosis
    • Dean T.P., Dai Y., Shute J.K., Church M.K., Warner J.O. Interleukin-8 concentrations are elevated in bronchoalveolar lavage, sputum, and sera of children with cystic fibrosis. Pediatr Res 1993, 34(2):159-161.
    • (1993) Pediatr Res , vol.34 , Issue.2 , pp. 159-161
    • Dean, T.P.1    Dai, Y.2    Shute, J.K.3    Church, M.K.4    Warner, J.O.5
  • 121
    • 0033953158 scopus 로고    scopus 로고
    • TNF-alpha and IL-8 in consecutive sputum samples from cystic fibrosis patients during antibiotic treatment
    • Karpati F., Hjelte F.L., Wretlind B. TNF-alpha and IL-8 in consecutive sputum samples from cystic fibrosis patients during antibiotic treatment. Scand J Infect Dis 2000, 32(1):75-79.
    • (2000) Scand J Infect Dis , vol.32 , Issue.1 , pp. 75-79
    • Karpati, F.1    Hjelte, F.L.2    Wretlind, B.3
  • 123
    • 4544275759 scopus 로고    scopus 로고
    • Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot study
    • Mahler D.A., Huang S., Tabrizi M., Bell G.M. Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot study. Chest 2004, 126(3):926-934.
    • (2004) Chest , vol.126 , Issue.3 , pp. 926-934
    • Mahler, D.A.1    Huang, S.2    Tabrizi, M.3    Bell, G.M.4
  • 125
    • 70349095833 scopus 로고    scopus 로고
    • Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis
    • Brennan S., Sly P.D., Gangell C.L., Sturges N., Winfield K., Wikstrom M., et al. Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis. Eur Respir J 2009, 34(3):655-661.
    • (2009) Eur Respir J , vol.34 , Issue.3 , pp. 655-661
    • Brennan, S.1    Sly, P.D.2    Gangell, C.L.3    Sturges, N.4    Winfield, K.5    Wikstrom, M.6
  • 126
    • 0037218939 scopus 로고    scopus 로고
    • Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motif
    • Estell K., Braunstein G., Tucker T., Varga K., Collawn J.F., Schwiebert L.M. Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motif. Mol Cell Biol 2003, 23(2):594-606.
    • (2003) Mol Cell Biol , vol.23 , Issue.2 , pp. 594-606
    • Estell, K.1    Braunstein, G.2    Tucker, T.3    Varga, K.4    Collawn, J.F.5    Schwiebert, L.M.6
  • 127
    • 0032955681 scopus 로고    scopus 로고
    • Chemokine expression in CF epithelia: implications for the role of CFTR in RANTES expression
    • [Research Support, Non-U.S. Gov't]
    • Schwiebert L.M., Estell K., Propst S.M. Chemokine expression in CF epithelia: implications for the role of CFTR in RANTES expression. Am J Physiol 1999, 276(3):C700-C710. [Research Support, Non-U.S. Gov't].
    • (1999) Am J Physiol , vol.276 , Issue.3
    • Schwiebert, L.M.1    Estell, K.2    Propst, S.M.3
  • 128
    • 66549116733 scopus 로고    scopus 로고
    • Allergic bronchopulmonary aspergillosis: the hunt for a diagnostic serological marker in cystic fibrosis patients
    • Hafen G.M., Hartl D., Regamey N., Casaulta C., Latzin P. Allergic bronchopulmonary aspergillosis: the hunt for a diagnostic serological marker in cystic fibrosis patients. Expert Rev Mol Diagn 2009, 9(2):157-164.
    • (2009) Expert Rev Mol Diagn , vol.9 , Issue.2 , pp. 157-164
    • Hafen, G.M.1    Hartl, D.2    Regamey, N.3    Casaulta, C.4    Latzin, P.5
  • 129
    • 33845601159 scopus 로고    scopus 로고
    • Chemokines in allergic aspergillosis-from animal models to human lung diseases
    • Hartl D., Buckland K.F., Hogaboam C.M. Chemokines in allergic aspergillosis-from animal models to human lung diseases. Inflamm Allergy Drug Targets 2006, 5(4):219-228.
    • (2006) Inflamm Allergy Drug Targets , vol.5 , Issue.4 , pp. 219-228
    • Hartl, D.1    Buckland, K.F.2    Hogaboam, C.M.3
  • 130
    • 33745179493 scopus 로고    scopus 로고
    • Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis
    • Hartl D., Latzin P., Zissel G., Krane M., Krauss-Etschmann S., Griese M. Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. Am J Respir Crit Care Med 2006, 173(12):1370-1376.
    • (2006) Am J Respir Crit Care Med , vol.173 , Issue.12 , pp. 1370-1376
    • Hartl, D.1    Latzin, P.2    Zissel, G.3    Krane, M.4    Krauss-Etschmann, S.5    Griese, M.6
  • 132
    • 45849115137 scopus 로고    scopus 로고
    • Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis
    • Latzin P., Hartl D., Regamey N., Frey U., Schoeni M.H., Casaulta C. Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis. Eur Respir J 2008, 31(1):36-42.
    • (2008) Eur Respir J , vol.31 , Issue.1 , pp. 36-42
    • Latzin, P.1    Hartl, D.2    Regamey, N.3    Frey, U.4    Schoeni, M.H.5    Casaulta, C.6
  • 133
    • 59849113942 scopus 로고    scopus 로고
    • Attacking the multi-tiered proteolytic pathology of COPD: new insights from basic and translational studies
    • Djekic U.V., Gaggar A., Weathington N.M. Attacking the multi-tiered proteolytic pathology of COPD: new insights from basic and translational studies. Pharmacol Ther 2009, 121(2):132-146.
    • (2009) Pharmacol Ther , vol.121 , Issue.2 , pp. 132-146
    • Djekic, U.V.1    Gaggar, A.2    Weathington, N.M.3
  • 135
    • 33644828187 scopus 로고    scopus 로고
    • A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation
    • Weathington N.M., van Houwelingen A.H., Noerager B.D., Jackson P.L., Kraneveld A.D., Galin F.S., et al. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nat Med 2006, 12(3):317-323.
    • (2006) Nat Med , vol.12 , Issue.3 , pp. 317-323
    • Weathington, N.M.1    van Houwelingen, A.H.2    Noerager, B.D.3    Jackson, P.L.4    Kraneveld, A.D.5    Galin, F.S.6
  • 136
    • 45949089501 scopus 로고    scopus 로고
    • A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation
    • Gaggar A., Jackson P.L., Noerager B.D., O'Reilly P.J., McQuaid D.B., Rowe S.M., et al. A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation. J Immunol 2008, 180(8):5662-5669.
    • (2008) J Immunol , vol.180 , Issue.8 , pp. 5662-5669
    • Gaggar, A.1    Jackson, P.L.2    Noerager, B.D.3    O'Reilly, P.J.4    McQuaid, D.B.5    Rowe, S.M.6
  • 137
    • 77957344556 scopus 로고    scopus 로고
    • A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation
    • Snelgrove R.J., Jackson P.L., Hardison M.T., Noerager B.D., Kinloch A., Gaggar A., et al. A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation. Science 2010, 330(6000):90-94.
    • (2010) Science , vol.330 , Issue.6000 , pp. 90-94
    • Snelgrove, R.J.1    Jackson, P.L.2    Hardison, M.T.3    Noerager, B.D.4    Kinloch, A.5    Gaggar, A.6
  • 138
    • 35748967851 scopus 로고    scopus 로고
    • High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
    • Bianchi M.E., Manfredi A.A. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev 2007, 220:35-46.
    • (2007) Immunol Rev , vol.220 , pp. 35-46
    • Bianchi, M.E.1    Manfredi, A.A.2
  • 139
  • 140
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • Scaffidi P., Misteli T., Bianchi M.E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002, 418(6894):191-195.
    • (2002) Nature , vol.418 , Issue.6894 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 141
    • 84860361435 scopus 로고    scopus 로고
    • HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
    • Schiraldi M., Raucci A., Munoz L.M., Livoti E., Celona B., Venereau E., et al. HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. J Exp Med 2012, 209(3):551-563.
    • (2012) J Exp Med , vol.209 , Issue.3 , pp. 551-563
    • Schiraldi, M.1    Raucci, A.2    Munoz, L.M.3    Livoti, E.4    Celona, B.5    Venereau, E.6
  • 142
    • 77953428335 scopus 로고    scopus 로고
    • Proline-Glycine-Proline (PGP) and High Mobility Group Box Protein-1 (HMGB1): Potential Mediators of Cystic Fibrosis Airway Inflammation
    • Gaggar A., Rowe S.M., Matthew H., Blalock J.E. Proline-Glycine-Proline (PGP) and High Mobility Group Box Protein-1 (HMGB1): Potential Mediators of Cystic Fibrosis Airway Inflammation. Open Respir Med J 2010, 4:32-38.
    • (2010) Open Respir Med J , vol.4 , pp. 32-38
    • Gaggar, A.1    Rowe, S.M.2    Matthew, H.3    Blalock, J.E.4
  • 143
    • 0033485733 scopus 로고    scopus 로고
    • Novel trends in neutrophil structure, function and development
    • Mollinedo F., Borregaard N., Boxer L.A. Novel trends in neutrophil structure, function and development. Immunol Today 1999, 20(12):535-537.
    • (1999) Immunol Today , vol.20 , Issue.12 , pp. 535-537
    • Mollinedo, F.1    Borregaard, N.2    Boxer, L.A.3
  • 144
    • 79960829290 scopus 로고    scopus 로고
    • Neutrophils in the activation and regulation of innate and adaptive immunity
    • Mantovani A., Cassatella M.A., Costantini C., Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 2011, 11(8):519-531.
    • (2011) Nat Rev Immunol , vol.11 , Issue.8 , pp. 519-531
    • Mantovani, A.1    Cassatella, M.A.2    Costantini, C.3    Jaillon, S.4
  • 145
    • 45949103092 scopus 로고    scopus 로고
    • The role of chloride anion and CFTR in killing of Pseudomonas aeruginosa by normal and CF neutrophils
    • Painter R.G., Bonvillain R.W., Valentine V.G., Lombard G.A., LaPlace S.G., Nauseef W.M., et al. The role of chloride anion and CFTR in killing of Pseudomonas aeruginosa by normal and CF neutrophils. J Leukoc Biol 2008, 83(6):1345-1353.
    • (2008) J Leukoc Biol , vol.83 , Issue.6 , pp. 1345-1353
    • Painter, R.G.1    Bonvillain, R.W.2    Valentine, V.G.3    Lombard, G.A.4    LaPlace, S.G.5    Nauseef, W.M.6
  • 147
    • 33748654201 scopus 로고    scopus 로고
    • CFTR Expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis
    • Painter R.G., Valentine V.G., Lanson N.A., Leidal K., Zhang Q., Lombard G., et al. CFTR Expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis. Biochemistry (US) 2006, 45(34):10260-10269.
    • (2006) Biochemistry (US) , vol.45 , Issue.34 , pp. 10260-10269
    • Painter, R.G.1    Valentine, V.G.2    Lanson, N.A.3    Leidal, K.4    Zhang, Q.5    Lombard, G.6
  • 149
    • 0035152203 scopus 로고    scopus 로고
    • Directed neutrophil migration to IL-8 is increased in cystic fibrosis: a study of the effect of erythromycin
    • Brennan S., Cooper D., Sly P.D. Directed neutrophil migration to IL-8 is increased in cystic fibrosis: a study of the effect of erythromycin. Thorax 2001, 56(1):62-64.
    • (2001) Thorax , vol.56 , Issue.1 , pp. 62-64
    • Brennan, S.1    Cooper, D.2    Sly, P.D.3
  • 150
    • 31344442586 scopus 로고    scopus 로고
    • Attenuation of host defense function of lung phagocytes in young cystic fibrosis patients
    • Alexis N.E., Muhlebach M.S., Peden D.B., Noah T.L. Attenuation of host defense function of lung phagocytes in young cystic fibrosis patients. J Cyst Fibros 2006, 5(1):17-25.
    • (2006) J Cyst Fibros , vol.5 , Issue.1 , pp. 17-25
    • Alexis, N.E.1    Muhlebach, M.S.2    Peden, D.B.3    Noah, T.L.4
  • 152
    • 77953510488 scopus 로고    scopus 로고
    • Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation
    • McKeon D.J., Cadwallader K.A., Idris S., Cowburn A.S., Pasteur M.C., Barker H., et al. Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation. Eur Respir J 2010, 35(6):1264-1272.
    • (2010) Eur Respir J , vol.35 , Issue.6 , pp. 1264-1272
    • McKeon, D.J.1    Cadwallader, K.A.2    Idris, S.3    Cowburn, A.S.4    Pasteur, M.C.5    Barker, H.6
  • 153
    • 17644379559 scopus 로고    scopus 로고
    • Cystic fibrosis sputum stimulates CD18-independent neutrophil migration across endothelial cells
    • Mackarel A.J., Plant B.J., FitzGerald M.X., O'Connor C.M. Cystic fibrosis sputum stimulates CD18-independent neutrophil migration across endothelial cells. Exp Lung Res 2005, 31(4):377-390.
    • (2005) Exp Lung Res , vol.31 , Issue.4 , pp. 377-390
    • Mackarel, A.J.1    Plant, B.J.2    FitzGerald, M.X.3    O'Connor, C.M.4
  • 154
    • 47049094330 scopus 로고    scopus 로고
    • Prolonged survival of neutrophils from patients with Delta F508 CFTR mutations
    • McKeon D.J., Condliffe A.M., Cowburn A.S., Cadwallader K.C., Farahi N., Bilton D., et al. Prolonged survival of neutrophils from patients with Delta F508 CFTR mutations. Thorax 2008, 63(7):660-661.
    • (2008) Thorax , vol.63 , Issue.7 , pp. 660-661
    • McKeon, D.J.1    Condliffe, A.M.2    Cowburn, A.S.3    Cadwallader, K.C.4    Farahi, N.5    Bilton, D.6
  • 156
    • 67449164303 scopus 로고    scopus 로고
    • Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients
    • Moriceau S., Kantari C., Mocek J., Davezac N., Gabillet J., Guerrera I.C., et al. Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients. J Immunol 2009, 182(11):7254-7263.
    • (2009) J Immunol , vol.182 , Issue.11 , pp. 7254-7263
    • Moriceau, S.1    Kantari, C.2    Mocek, J.3    Davezac, N.4    Gabillet, J.5    Guerrera, I.C.6
  • 157
    • 77951497702 scopus 로고    scopus 로고
    • In cystic fibrosis homozygotes and heterozygotes, neutrophil apoptosis is delayed and modulated by diamide or roscovitine: evidence for an innate neutrophil disturbance
    • Moriceau S., Lenoir G., Witko-Sarsat V. In cystic fibrosis homozygotes and heterozygotes, neutrophil apoptosis is delayed and modulated by diamide or roscovitine: evidence for an innate neutrophil disturbance. J Innate Immun 2010, 2(3):260-266.
    • (2010) J Innate Immun , vol.2 , Issue.3 , pp. 260-266
    • Moriceau, S.1    Lenoir, G.2    Witko-Sarsat, V.3
  • 158
    • 80053063761 scopus 로고    scopus 로고
    • The role of matrix metalloproteinases in cystic fibrosis lung disease
    • Gaggar A., Hector A., Bratcher P.E., Mall M.A., Griese M., Hartl D. The role of matrix metalloproteinases in cystic fibrosis lung disease. Eur Respir J 2011, 38(3):721-727.
    • (2011) Eur Respir J , vol.38 , Issue.3 , pp. 721-727
    • Gaggar, A.1    Hector, A.2    Bratcher, P.E.3    Mall, M.A.4    Griese, M.5    Hartl, D.6
  • 162
    • 21244455537 scopus 로고    scopus 로고
    • Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis
    • McAllister F., Henry A., Kreindler J.L., Dubin P.J., Ulrich L., Steele C., et al. Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J Immunol 2005, 175(1):404-412.
    • (2005) J Immunol , vol.175 , Issue.1 , pp. 404-412
    • McAllister, F.1    Henry, A.2    Kreindler, J.L.3    Dubin, P.J.4    Ulrich, L.5    Steele, C.6
  • 163
    • 16244368754 scopus 로고    scopus 로고
    • Induced sputum matrix metalloproteinase-9 correlates with lung function and airway inflammation in children with cystic fibrosis
    • Sagel S.D., Kapsner R.K., Osberg I. Induced sputum matrix metalloproteinase-9 correlates with lung function and airway inflammation in children with cystic fibrosis. Pediatr Pulmonol 2005, 39(3):224-232.
    • (2005) Pediatr Pulmonol , vol.39 , Issue.3 , pp. 224-232
    • Sagel, S.D.1    Kapsner, R.K.2    Osberg, I.3
  • 164
    • 66149085990 scopus 로고    scopus 로고
    • Relationship Between Antimicrobial Proteins and Airway Inflammation and Infection in Cystic Fibrosis
    • Sagel S.D., Sontag M.K., Accurso F.J. Relationship Between Antimicrobial Proteins and Airway Inflammation and Infection in Cystic Fibrosis. Pediatr Pulmonol 2009, 44(4):402-409.
    • (2009) Pediatr Pulmonol , vol.44 , Issue.4 , pp. 402-409
    • Sagel, S.D.1    Sontag, M.K.2    Accurso, F.J.3
  • 165
    • 0036907325 scopus 로고    scopus 로고
    • Induced sputum inflammatory measures correlate with lung function in children with cystic fibrosis
    • Sagel S.D., Sontag M.K., Wagener J.S., Kapsner R.K., Osberg L., Accurso F.J. Induced sputum inflammatory measures correlate with lung function in children with cystic fibrosis. J Pediatr 2002, 141(6):811-817.
    • (2002) J Pediatr , vol.141 , Issue.6 , pp. 811-817
    • Sagel, S.D.1    Sontag, M.K.2    Wagener, J.S.3    Kapsner, R.K.4    Osberg, L.5    Accurso, F.J.6
  • 166
    • 84866161122 scopus 로고    scopus 로고
    • Development of sputum calprotectin as a biomarker of cystic fibrosis lung disease activity: Evidence from cross sectional and longitudinal studies
    • Gray R.D., Imrie M., Boyd A.C., Innes J.A., Porteous D., Greening A.P. Development of sputum calprotectin as a biomarker of cystic fibrosis lung disease activity: Evidence from cross sectional and longitudinal studies. Thorax 2006, (61):Ii34-Ii35.
    • (2006) Thorax , Issue.61
    • Gray, R.D.1    Imrie, M.2    Boyd, A.C.3    Innes, J.A.4    Porteous, D.5    Greening, A.P.6
  • 167
    • 0030020437 scopus 로고    scopus 로고
    • Calprotectin as a marker of inflammation in cystic fibrosis
    • Golden B.E., Clohessy P.A., Russell G., Fagerhol M.K. Calprotectin as a marker of inflammation in cystic fibrosis. Arch Dis Child 1996, 74(2):136-139.
    • (1996) Arch Dis Child , vol.74 , Issue.2 , pp. 136-139
    • Golden, B.E.1    Clohessy, P.A.2    Russell, G.3    Fagerhol, M.K.4
  • 168
    • 0036845446 scopus 로고    scopus 로고
    • Matrix metalloproteases in BAL fluid of patients with cystic fibrosis and their modulation by treatment with dornase alpha
    • Ratjen F., Hartog C.M., Paul K., Wermelt J., Braun J. Matrix metalloproteases in BAL fluid of patients with cystic fibrosis and their modulation by treatment with dornase alpha. Thorax 2002, 57(11):930-934.
    • (2002) Thorax , vol.57 , Issue.11 , pp. 930-934
    • Ratjen, F.1    Hartog, C.M.2    Paul, K.3    Wermelt, J.4    Braun, J.5
  • 170
    • 0032849238 scopus 로고    scopus 로고
    • Proteinase 3 mRNA expression is induced in monocytes but not in neutrophils of patients with cystic fibrosis
    • Just J., Moog-Lutz C., Houzel-Charavel A., Canteloup S., Grimfeld A., Witko-Sarsat V., et al. Proteinase 3 mRNA expression is induced in monocytes but not in neutrophils of patients with cystic fibrosis. FEBS Lett 1999, 457(3):437-440.
    • (1999) FEBS Lett , vol.457 , Issue.3 , pp. 437-440
    • Just, J.1    Moog-Lutz, C.2    Houzel-Charavel, A.3    Canteloup, S.4    Grimfeld, A.5    Witko-Sarsat, V.6
  • 173
    • 84874408702 scopus 로고    scopus 로고
    • Protease anti-protease balance and innate defence proteins levels in the lungs of children with cystic fibrosis: Relationship to P. aeruginosa colonisation status
    • McNally P.G., Doyle M., Taggart C., O'Neill S., Elnazir B., Greene C., et al. Protease anti-protease balance and innate defence proteins levels in the lungs of children with cystic fibrosis: Relationship to P. aeruginosa colonisation status. Pediatr Pulmonol 2007, 262-263.
    • (2007) Pediatr Pulmonol , pp. 262-263
    • McNally, P.G.1    Doyle, M.2    Taggart, C.3    O'Neill, S.4    Elnazir, B.5    Greene, C.6
  • 174
    • 18644377252 scopus 로고    scopus 로고
    • Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease
    • Taggart C.C., Greene C.M., Carroll T.P., O'Neill S.J., McElvaney N.G. Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease. Am J Respir Crit Care Med 2005, 171(10):1070-1076.
    • (2005) Am J Respir Crit Care Med , vol.171 , Issue.10 , pp. 1070-1076
    • Taggart, C.C.1    Greene, C.M.2    Carroll, T.P.3    O'Neill, S.J.4    McElvaney, N.G.5
  • 176
    • 77953488154 scopus 로고    scopus 로고
    • Neutrophil granules in health and disease
    • Hager M., Cowland J.B., Borregaard N. Neutrophil granules in health and disease. J Intern Med 2010, 268(1):25-34.
    • (2010) J Intern Med , vol.268 , Issue.1 , pp. 25-34
    • Hager, M.1    Cowland, J.B.2    Borregaard, N.3
  • 177
    • 33947263039 scopus 로고    scopus 로고
    • The relationship of clinical and inflammatory markers to outcome in stable patients with cystic fibrosis
    • Downey D.G., Martin S.L., Dempster M., Moore J.E., Keogan M.T., Starcher B., et al. The relationship of clinical and inflammatory markers to outcome in stable patients with cystic fibrosis. Pediatr Pulmonol 2007, 42(3):216-220.
    • (2007) Pediatr Pulmonol , vol.42 , Issue.3 , pp. 216-220
    • Downey, D.G.1    Martin, S.L.2    Dempster, M.3    Moore, J.E.4    Keogan, M.T.5    Starcher, B.6
  • 178
    • 84858291535 scopus 로고    scopus 로고
    • A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis
    • Reeves E.P., Bergin D.A., Fitzgerald S., Hayes E., Keenan J., Henry M., et al. A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis. J Cyst Fibros 2011, 11(2):100-107.
    • (2011) J Cyst Fibros , vol.11 , Issue.2 , pp. 100-107
    • Reeves, E.P.1    Bergin, D.A.2    Fitzgerald, S.3    Hayes, E.4    Keenan, J.5    Henry, M.6
  • 180
    • 0034641962 scopus 로고    scopus 로고
    • Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
    • Singh P.K., Schaefer A.L., Parsek M.R., Moninger T.O., Welsh M.J., Greenberg E.P. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 2000, 407(6805):762-764.
    • (2000) Nature , vol.407 , Issue.6805 , pp. 762-764
    • Singh, P.K.1    Schaefer, A.L.2    Parsek, M.R.3    Moninger, T.O.4    Welsh, M.J.5    Greenberg, E.P.6
  • 181
    • 65649093014 scopus 로고    scopus 로고
    • Neutrophil enhancement of Pseudomonas aeruginosa biofilm development: human F-actin and DNA as targets for therapy
    • Parks Q.M., Young R.L., Poch K.R., Malcolm K.C., Vasil M.L., Nick J.A. Neutrophil enhancement of Pseudomonas aeruginosa biofilm development: human F-actin and DNA as targets for therapy. J Med Microbiol 2009, 58(Pt 4):492-502.
    • (2009) J Med Microbiol , vol.58 , Issue.PART 4 , pp. 492-502
    • Parks, Q.M.1    Young, R.L.2    Poch, K.R.3    Malcolm, K.C.4    Vasil, M.L.5    Nick, J.A.6
  • 182
    • 0141955237 scopus 로고    scopus 로고
    • Compromised host defense on Pseudomonas aeruginosa biofilms: characterization of neutrophil and biofilm interactions
    • Jesaitis A.J., Franklin M.J., Berglund D., Sasaki M., Lord C.I., Bleazard J.B., et al. Compromised host defense on Pseudomonas aeruginosa biofilms: characterization of neutrophil and biofilm interactions. J Immunol 2003, 171(8):4329-4339.
    • (2003) J Immunol , vol.171 , Issue.8 , pp. 4329-4339
    • Jesaitis, A.J.1    Franklin, M.J.2    Berglund, D.3    Sasaki, M.4    Lord, C.I.5    Bleazard, J.B.6
  • 183
    • 0023235837 scopus 로고
    • Priming of neutrophils for enhanced oxidative burst by sputum from cystic fibrosis patients with Pseudomonas aeruginosa infection
    • Kharazmi A., Rechnitzer C., Schiotz P.O., Jensen T., Baek L., Hoiby N. Priming of neutrophils for enhanced oxidative burst by sputum from cystic fibrosis patients with Pseudomonas aeruginosa infection. Eur J Clin Invest 1987, 17(3):256-261.
    • (1987) Eur J Clin Invest , vol.17 , Issue.3 , pp. 256-261
    • Kharazmi, A.1    Rechnitzer, C.2    Schiotz, P.O.3    Jensen, T.4    Baek, L.5    Hoiby, N.6
  • 184
    • 73449143182 scopus 로고    scopus 로고
    • Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis
    • Kolpen M., Hansen C.R., Bjarnsholt T., Moser C., Christensen L.D., van Gennip M., et al. Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis. Thorax 2010, 65(1):57-62.
    • (2010) Thorax , vol.65 , Issue.1 , pp. 57-62
    • Kolpen, M.1    Hansen, C.R.2    Bjarnsholt, T.3    Moser, C.4    Christensen, L.D.5    van Gennip, M.6
  • 185
    • 53149151884 scopus 로고    scopus 로고
    • TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease
    • Koller B., Kappler M., Latzin P., Gaggar A., Schreiner M., Takyar S., et al. TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease. J Immunol 2008, 181(4):2753-2763.
    • (2008) J Immunol , vol.181 , Issue.4 , pp. 2753-2763
    • Koller, B.1    Kappler, M.2    Latzin, P.3    Gaggar, A.4    Schreiner, M.5    Takyar, S.6
  • 186
    • 0037083467 scopus 로고    scopus 로고
    • Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: a potential mechanism of persistent infection
    • Usher L.R., Lawson R.A., Geary I., Taylor C.J., Bingle C.D., Taylor G.W., et al. Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: a potential mechanism of persistent infection. J Immunol 2002, 168(4):1861-1868.
    • (2002) J Immunol , vol.168 , Issue.4 , pp. 1861-1868
    • Usher, L.R.1    Lawson, R.A.2    Geary, I.3    Taylor, C.J.4    Bingle, C.D.5    Taylor, G.W.6
  • 187
    • 80052373194 scopus 로고    scopus 로고
    • Neutrophil Extracellular Trap (NET)-Mediated Killing of Pseudomonas aeruginosa: Evidence of Acquired Resistance within the CF Airway, Independent of CFTR
    • Young R.L., Malcolm K.C., Kret J.E., Caceres S.M., Poch K.R., Nichols D.P., et al. Neutrophil Extracellular Trap (NET)-Mediated Killing of Pseudomonas aeruginosa: Evidence of Acquired Resistance within the CF Airway, Independent of CFTR. PLoS One 2011, 6(9).
    • (2011) PLoS One , vol.6 , Issue.9
    • Young, R.L.1    Malcolm, K.C.2    Kret, J.E.3    Caceres, S.M.4    Poch, K.R.5    Nichols, D.P.6
  • 188
    • 0034103142 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa cystic fibrosis isolates induce rapid, type III secretion-dependent, but ExoU-independent, oncosis of macrophages and polymorphonuclear neutrophils
    • Dacheux D., Toussaint B., Richard M., Brochier G., Croize J., Attree I. Pseudomonas aeruginosa cystic fibrosis isolates induce rapid, type III secretion-dependent, but ExoU-independent, oncosis of macrophages and polymorphonuclear neutrophils. Infect Immun 2000, 68(5):2916-2924.
    • (2000) Infect Immun , vol.68 , Issue.5 , pp. 2916-2924
    • Dacheux, D.1    Toussaint, B.2    Richard, M.3    Brochier, G.4    Croize, J.5    Attree, I.6
  • 189
    • 0031933986 scopus 로고    scopus 로고
    • Catalase, myeloperoxidase and hydrogen peroxide in cystic fibrosis
    • [Research Support, Non-U.S. Gov't]
    • Worlitzsch D., Herberth G., Ulrich M., Doring G. Catalase, myeloperoxidase and hydrogen peroxide in cystic fibrosis. Eur Respir J 1998, 11(2):377-383. [Research Support, Non-U.S. Gov't].
    • (1998) Eur Respir J , vol.11 , Issue.2 , pp. 377-383
    • Worlitzsch, D.1    Herberth, G.2    Ulrich, M.3    Doring, G.4
  • 190
    • 33645537729 scopus 로고    scopus 로고
    • Myeloperoxidase promoter polymorphism -463G is associated with more severe clinical expression of cystic fibrosis pulmonary disease
    • Reynolds W.F., Sermet-Gaudelus I., Gausson V., Feuillet M.N., Bonnefont J.P., Lenoir G., et al. Myeloperoxidase promoter polymorphism -463G is associated with more severe clinical expression of cystic fibrosis pulmonary disease. Mediators Inflamm 2006, 2006(2):36735.
    • (2006) Mediators Inflamm , vol.2006 , Issue.2 , pp. 36735
    • Reynolds, W.F.1    Sermet-Gaudelus, I.2    Gausson, V.3    Feuillet, M.N.4    Bonnefont, J.P.5    Lenoir, G.6
  • 191
    • 0030587191 scopus 로고    scopus 로고
    • Disturbed myeloperoxidase-dependent activity of neutrophils in cystic fibrosis homozygotes and heterozygotes, and its correction by amiloride
    • Witko-Sarsat V., Allen R.C., Paulais M., Nguyen A.T., Bessou G., Lenoir G., et al. Disturbed myeloperoxidase-dependent activity of neutrophils in cystic fibrosis homozygotes and heterozygotes, and its correction by amiloride. J Immunol 1996, 157(6):2728-2735.
    • (1996) J Immunol , vol.157 , Issue.6 , pp. 2728-2735
    • Witko-Sarsat, V.1    Allen, R.C.2    Paulais, M.3    Nguyen, A.T.4    Bessou, G.5    Lenoir, G.6
  • 192
    • 0033775768 scopus 로고    scopus 로고
    • Phagocyte oxidants and nitric oxide in cystic fibrosis: new therapeutic targets?
    • van der Vliet A., Cross C.E. Phagocyte oxidants and nitric oxide in cystic fibrosis: new therapeutic targets?. Curr Opin Pulm Med 2000, 6(6):533-539.
    • (2000) Curr Opin Pulm Med , vol.6 , Issue.6 , pp. 533-539
    • van der Vliet, A.1    Cross, C.E.2
  • 194
    • 34247161953 scopus 로고    scopus 로고
    • Neutrophilic inflammation as a major determinant in the progression of cystic fibrosis
    • Tirouvanziam R. Neutrophilic inflammation as a major determinant in the progression of cystic fibrosis. Drug News Perspect 2006, 19(10):609-614.
    • (2006) Drug News Perspect , vol.19 , Issue.10 , pp. 609-614
    • Tirouvanziam, R.1
  • 195
    • 79952535973 scopus 로고    scopus 로고
    • The Cystic Fibrosis Neutrophil: A Specialized Yet Potentially Defective Cell
    • Hayes E., Pohl K., McElvaney N.G., Reeves E.P. The Cystic Fibrosis Neutrophil: A Specialized Yet Potentially Defective Cell. Arch Immunol Ther Exp 2011, 59(2):97-112.
    • (2011) Arch Immunol Ther Exp , vol.59 , Issue.2 , pp. 97-112
    • Hayes, E.1    Pohl, K.2    McElvaney, N.G.3    Reeves, E.P.4
  • 196
    • 84866173145 scopus 로고    scopus 로고
    • Is There a Primary Neutrophil Defect in Cf?
    • Downey G.P. Is There a Primary Neutrophil Defect in Cf?. Pediatr Pulmonol 2011, 163-164.
    • (2011) Pediatr Pulmonol , pp. 163-164
    • Downey, G.P.1
  • 197
    • 77958025778 scopus 로고    scopus 로고
    • Novel Method to Process Cystic Fibrosis Sputum for Determination of Oxidative State
    • Hector A., Jonas F., Kappler M., Feilcke M., Hartl D., Griese M. Novel Method to Process Cystic Fibrosis Sputum for Determination of Oxidative State. Respiration 2010, 80(5):393-400.
    • (2010) Respiration , vol.80 , Issue.5 , pp. 393-400
    • Hector, A.1    Jonas, F.2    Kappler, M.3    Feilcke, M.4    Hartl, D.5    Griese, M.6
  • 198
    • 41949120305 scopus 로고    scopus 로고
    • Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways
    • Tirouvanziam R., Gernez Y., Conrad C.K., Moss R.B., Schrijver I., Dunn C.E., et al. Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways. Proc Natl Acad Sci U S A 2008, 105(11):4335-4339.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.11 , pp. 4335-4339
    • Tirouvanziam, R.1    Gernez, Y.2    Conrad, C.K.3    Moss, R.B.4    Schrijver, I.5    Dunn, C.E.6
  • 199
    • 65249151394 scopus 로고    scopus 로고
    • Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs
    • Makam M., Diaz D., Laval J., Gernez Y., Conrad C.K., Dunn C.E., et al. Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs. Proc Natl Acad Sci U S A 2009, 106(14):5779-5783.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.14 , pp. 5779-5783
    • Makam, M.1    Diaz, D.2    Laval, J.3    Gernez, Y.4    Conrad, C.K.5    Dunn, C.E.6
  • 200
    • 71849108112 scopus 로고    scopus 로고
    • Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases
    • Hartl D., Krauss-Etschmann S., Koller B., Hordijk P.L., Kuijpers T.W., Hoffmann F., et al. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol 2008, 181(11):8053-8067.
    • (2008) J Immunol , vol.181 , Issue.11 , pp. 8053-8067
    • Hartl, D.1    Krauss-Etschmann, S.2    Koller, B.3    Hordijk, P.L.4    Kuijpers, T.W.5    Hoffmann, F.6
  • 204
    • 70350029796 scopus 로고    scopus 로고
    • NETs: a new strategy for using old weapons
    • Papayannopoulos V., Zychlinsky A. NETs: a new strategy for using old weapons. Trends Immunol 2009, 30(11):513-521.
    • (2009) Trends Immunol , vol.30 , Issue.11 , pp. 513-521
    • Papayannopoulos, V.1    Zychlinsky, A.2
  • 205
    • 84858298737 scopus 로고    scopus 로고
    • Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy
    • Manzenreiter R., Kienberger F., Marcos V., Schilcher K., Krautgartner W.D., Obermayer A., et al. Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy. J Cyst Fibros 2012, 11(2):84-92.
    • (2012) J Cyst Fibros , vol.11 , Issue.2 , pp. 84-92
    • Manzenreiter, R.1    Kienberger, F.2    Marcos, V.3    Schilcher, K.4    Krautgartner, W.D.5    Obermayer, A.6
  • 206
    • 69849083858 scopus 로고    scopus 로고
    • Extracellular DNA and F-actin as targets in antibiofilm cystic fibrosis therapy
    • Tolker-Nielsen T., Hoiby N. Extracellular DNA and F-actin as targets in antibiofilm cystic fibrosis therapy. Future Microbiol 2009, 4(6):645-647.
    • (2009) Future Microbiol , vol.4 , Issue.6 , pp. 645-647
    • Tolker-Nielsen, T.1    Hoiby, N.2
  • 207
    • 10344264976 scopus 로고    scopus 로고
    • DNA concentrations in BAL fluid of cystic fibrosis patients with early lung disease: influence of treatment with dornase alpha
    • Ratjen F., Paul K., van Koningsbruggen S., Breitenstein S., Rietschel E., Nikolaizik W. DNA concentrations in BAL fluid of cystic fibrosis patients with early lung disease: influence of treatment with dornase alpha. Pediatr Pulmonol 2005, 39(1):1-4.
    • (2005) Pediatr Pulmonol , vol.39 , Issue.1 , pp. 1-4
    • Ratjen, F.1    Paul, K.2    van Koningsbruggen, S.3    Breitenstein, S.4    Rietschel, E.5    Nikolaizik, W.6
  • 208
    • 0033724757 scopus 로고    scopus 로고
    • DNA and actin bind and inhibit interleukin-8 function in cystic fibrosis sputa: in vitro effects of mucolytics
    • Perks B., Shute J.K. DNA and actin bind and inhibit interleukin-8 function in cystic fibrosis sputa: in vitro effects of mucolytics. Am J Respir Crit Care Med 2000, 162(5):1767-1772.
    • (2000) Am J Respir Crit Care Med , vol.162 , Issue.5 , pp. 1767-1772
    • Perks, B.1    Shute, J.K.2
  • 209
    • 0029799340 scopus 로고    scopus 로고
    • Increased DNA levels in bronchoalveolar lavage fluid obtained from infants with cystic fibrosis
    • Kirchner K.K., Wagener J.S., Khan T.Z., Copenhaver S.C., Accurso F.J. Increased DNA levels in bronchoalveolar lavage fluid obtained from infants with cystic fibrosis. Am J Respir Crit Care Med 1996, 154(5):1426-1429.
    • (1996) Am J Respir Crit Care Med , vol.154 , Issue.5 , pp. 1426-1429
    • Kirchner, K.K.1    Wagener, J.S.2    Khan, T.Z.3    Copenhaver, S.C.4    Accurso, F.J.5
  • 210
    • 84874427243 scopus 로고    scopus 로고
    • Effective Pseudomonas Aeruginosa-Induced Neutrophil Extracellular Trap Response by Normal & Cystic Fibrosis Neutrophils
    • Young R.L., Malcolm K.C., Kret J.E., Poch K.R., Nichols D., Saavedra M.T., et al. Effective Pseudomonas Aeruginosa-Induced Neutrophil Extracellular Trap Response by Normal & Cystic Fibrosis Neutrophils. Pediatr Pulmonol 2010, 281-282.
    • (2010) Pediatr Pulmonol , pp. 281-282
    • Young, R.L.1    Malcolm, K.C.2    Kret, J.E.3    Poch, K.R.4    Nichols, D.5    Saavedra, M.T.6
  • 211
    • 77958091269 scopus 로고    scopus 로고
    • NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus
    • McCormick A., Heesemann L., Wagener J., Marcos V., Hartl D., Loeffler J., et al. NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus. Microbes Infect 2010, 12(12-13):928-936.
    • (2010) Microbes Infect , vol.12 , Issue.12-13 , pp. 928-936
    • McCormick, A.1    Heesemann, L.2    Wagener, J.3    Marcos, V.4    Hartl, D.5    Loeffler, J.6
  • 213
    • 78049421626 scopus 로고    scopus 로고
    • Specific resistance to Pseudomonas aeruginosa infection in zebrafish is mediated by the cystic fibrosis transmembrane conductance regulator
    • Phennicie R.T., Sullivan M.J., Singer J.T., Yoder J.A., Kim C.H. Specific resistance to Pseudomonas aeruginosa infection in zebrafish is mediated by the cystic fibrosis transmembrane conductance regulator. Infect Immun 2010, 78(11):4542-4550.
    • (2010) Infect Immun , vol.78 , Issue.11 , pp. 4542-4550
    • Phennicie, R.T.1    Sullivan, M.J.2    Singer, J.T.3    Yoder, J.A.4    Kim, C.H.5
  • 214
    • 80051663317 scopus 로고    scopus 로고
    • Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice
    • Su X., Looney M.R., Su H.E., Lee J.W., Song Y., Matthay M.A. Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Inflamm Res 2011, 60(7):619-632.
    • (2011) Inflamm Res , vol.60 , Issue.7 , pp. 619-632
    • Su, X.1    Looney, M.R.2    Su, H.E.3    Lee, J.W.4    Song, Y.5    Matthay, M.A.6
  • 216
    • 33751177801 scopus 로고    scopus 로고
    • Azithromycin reduces spontaneous and induced inflammation in DeltaF508 cystic fibrosis mice
    • Legssyer R., Huaux F., Lebacq J., Delos M., Marbaix E., Lebecque P., et al. Azithromycin reduces spontaneous and induced inflammation in DeltaF508 cystic fibrosis mice. Respir Res 2006, 7:134.
    • (2006) Respir Res , vol.7 , pp. 134
    • Legssyer, R.1    Huaux, F.2    Lebacq, J.3    Delos, M.4    Marbaix, E.5    Lebecque, P.6
  • 217
    • 61549139061 scopus 로고    scopus 로고
    • Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice
    • Bruscia E.M., Zhang P.X., Ferreira E., Caputo C., Emerson J.W., Tuck D., et al. Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice. Am J Respir Cell Mol 2009, 40(3):295-304.
    • (2009) Am J Respir Cell Mol , vol.40 , Issue.3 , pp. 295-304
    • Bruscia, E.M.1    Zhang, P.X.2    Ferreira, E.3    Caputo, C.4    Emerson, J.W.5    Tuck, D.6
  • 218
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: balance, tolerance, and diversity
    • Mantovani A., Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 2010, 22(2):231-237.
    • (2010) Curr Opin Immunol , vol.22 , Issue.2 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 219
    • 77952395705 scopus 로고    scopus 로고
    • Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients
    • del Fresno C., Garcia-Rio F., Gomez-Pina V., Soares-Schanoski A., Fernandez-Ruiz I., Jurado T., et al. Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients. J Immunol 2009, 182(10):6494-6507.
    • (2009) J Immunol , vol.182 , Issue.10 , pp. 6494-6507
    • del Fresno, C.1    Garcia-Rio, F.2    Gomez-Pina, V.3    Soares-Schanoski, A.4    Fernandez-Ruiz, I.5    Jurado, T.6
  • 220
    • 77956898288 scopus 로고    scopus 로고
    • Characterization of macrophage activation states in patients with cystic fibrosis
    • Murphy B.S., Bush H.M., Sundareshan V., Davis C., Hagadone J., Cory T.J., et al. Characterization of macrophage activation states in patients with cystic fibrosis. J Cyst Fibros 2010, 9(5):314-322.
    • (2010) J Cyst Fibros , vol.9 , Issue.5 , pp. 314-322
    • Murphy, B.S.1    Bush, H.M.2    Sundareshan, V.3    Davis, C.4    Hagadone, J.5    Cory, T.J.6
  • 221
    • 77954126948 scopus 로고    scopus 로고
    • Comment on "potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients"
    • Krysko O., Van Zele T., Claeys S., Bachert C. Comment on "potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients". J Immunol 2009, 183(8):4831.
    • (2009) J Immunol , vol.183 , Issue.8 , pp. 4831
    • Krysko, O.1    Van Zele, T.2    Claeys, S.3    Bachert, C.4
  • 222
    • 70149123741 scopus 로고    scopus 로고
    • Azithromycin Reduces Exaggerated Cytokine Production by M1 Alveolar Macrophages in Cystic Fibrosis
    • Meyer M., Huaux F., Gavilanes X., van den Brule S., Lebecque P., Lo Re S., et al. Azithromycin Reduces Exaggerated Cytokine Production by M1 Alveolar Macrophages in Cystic Fibrosis. Am J Respir Cell Mol 2009, 41(5):590-602.
    • (2009) Am J Respir Cell Mol , vol.41 , Issue.5 , pp. 590-602
    • Meyer, M.1    Huaux, F.2    Gavilanes, X.3    van den Brule, S.4    Lebecque, P.5    Lo Re, S.6
  • 223
    • 80053367462 scopus 로고    scopus 로고
    • The epithelial cell contingency: myeloid cells and inflammation resolution
    • Bonfield T.L., Hodges C.A., Drumm M.L. The epithelial cell contingency: myeloid cells and inflammation resolution. Pediatr Pulmonol 2011, 33(33):272.
    • (2011) Pediatr Pulmonol , vol.33 , Issue.33 , pp. 272
    • Bonfield, T.L.1    Hodges, C.A.2    Drumm, M.L.3
  • 224
    • 0036565902 scopus 로고    scopus 로고
    • Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities
    • Oceandy D., McMorran B.J., Smith S.N., Schreiber R., Kunzelmann K., Alton E.W.F.W., et al. Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Hum Mol Genet 2002, 11(9):1059-1067.
    • (2002) Hum Mol Genet , vol.11 , Issue.9 , pp. 1059-1067
    • Oceandy, D.1    McMorran, B.J.2    Smith, S.N.3    Schreiber, R.4    Kunzelmann, K.5    Alton, E.W.F.W.6
  • 226
    • 80655134731 scopus 로고    scopus 로고
    • Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis
    • Abdulrahman B.A., Abu Khweek A., Akhter A., Caution K., Kotrange S., Abdelaziz D.H.A., et al. Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis. Autophagy 2011, 7(11):1359-1370.
    • (2011) Autophagy , vol.7 , Issue.11 , pp. 1359-1370
    • Abdulrahman, B.A.1    Abu Khweek, A.2    Akhter, A.3    Caution, K.4    Kotrange, S.5    Abdelaziz, D.H.A.6
  • 227
    • 72149093771 scopus 로고    scopus 로고
    • Disease-causing Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator Determine the Functional Responses of Alveolar Macrophages
    • Deriy L.V., Gomez E.A., Zhang G.P., Beacham D.W., Hopson J.A., Gallan A.J., et al. Disease-causing Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator Determine the Functional Responses of Alveolar Macrophages. J Biol Chem 2009, 284(51):35926-35938.
    • (2009) J Biol Chem , vol.284 , Issue.51 , pp. 35926-35938
    • Deriy, L.V.1    Gomez, E.A.2    Zhang, G.P.3    Beacham, D.W.4    Hopson, J.A.5    Gallan, A.J.6
  • 228
    • 33748146503 scopus 로고    scopus 로고
    • CFTR regulates phagosome acidification in macrophages and alters bactericidal activity
    • Di A., Brown M.E., Deriy L.V., Li C., Szeto F.L., Chen Y., et al. CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nat Cell Biol 2006, 8(9):933-944.
    • (2006) Nat Cell Biol , vol.8 , Issue.9 , pp. 933-944
    • Di, A.1    Brown, M.E.2    Deriy, L.V.3    Li, C.4    Szeto, F.L.5    Chen, Y.6
  • 229
    • 79952163545 scopus 로고    scopus 로고
    • Listeria monocytogenes exploits cystic fibrosis transmembrane conductance regulator (CFTR) to escape the phagosome
    • Radtke A.L., Anderson K.L., Davis M.J., DiMagno M.J., Swanson J.A., O'Riordan M.X. Listeria monocytogenes exploits cystic fibrosis transmembrane conductance regulator (CFTR) to escape the phagosome. Proc Natl Acad Sci U S A 2011, 108(4):1633-1638.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.4 , pp. 1633-1638
    • Radtke, A.L.1    Anderson, K.L.2    Davis, M.J.3    DiMagno, M.J.4    Swanson, J.A.5    O'Riordan, M.X.6
  • 230
    • 79956194922 scopus 로고    scopus 로고
    • Dysfunctional CFTR alters the bactericidal activity of human macrophages against Pseudomonas aeruginosa
    • Del Porto P., Cifani N., Guarnieri S., Di Domenico E.G., Mariggio M.A., Spadaro F., et al. Dysfunctional CFTR alters the bactericidal activity of human macrophages against Pseudomonas aeruginosa. PLoS One 2011, 6(5):19970-19978.
    • (2011) PLoS One , vol.6 , Issue.5 , pp. 19970-19978
    • Del Porto, P.1    Cifani, N.2    Guarnieri, S.3    Di Domenico, E.G.4    Mariggio, M.A.5    Spadaro, F.6
  • 231
    • 4644313798 scopus 로고    scopus 로고
    • Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered
    • Zaman M.M., Gelrud A., Junaidi O., Regan M.M., Warny M., Shea J.C., et al. Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered. Clin Diagn Lab Immunol 2004, 11(5):819-824.
    • (2004) Clin Diagn Lab Immunol , vol.11 , Issue.5 , pp. 819-824
    • Zaman, M.M.1    Gelrud, A.2    Junaidi, O.3    Regan, M.M.4    Warny, M.5    Shea, J.C.6
  • 232
    • 79959572825 scopus 로고    scopus 로고
    • Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis
    • Bruscia E.M., Zhang P.X., Satoh A., Caputo C., Medzhitov R., Shenoy A., et al. Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol 2011, 186(12):6990-6998.
    • (2011) J Immunol , vol.186 , Issue.12 , pp. 6990-6998
    • Bruscia, E.M.1    Zhang, P.X.2    Satoh, A.3    Caputo, C.4    Medzhitov, R.5    Shenoy, A.6
  • 233
    • 17344381330 scopus 로고    scopus 로고
    • G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages
    • Thomas G.R., Costelloe E.A., Lunn D.P., Stacey K.J., Delaney S.J., Passey R., et al. G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages. J Immunol 2000, 164(7):3870-3877.
    • (2000) J Immunol , vol.164 , Issue.7 , pp. 3870-3877
    • Thomas, G.R.1    Costelloe, E.A.2    Lunn, D.P.3    Stacey, K.J.4    Delaney, S.J.5    Passey, R.6
  • 234
    • 38049091190 scopus 로고    scopus 로고
    • Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages
    • Andersson C., Zaman M.M., Jones A.B., Freedman S.D. Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages. J Cyst Fibros 2008, 7(1):68-78.
    • (2008) J Cyst Fibros , vol.7 , Issue.1 , pp. 68-78
    • Andersson, C.1    Zaman, M.M.2    Jones, A.B.3    Freedman, S.D.4
  • 235
    • 0025949558 scopus 로고
    • Expression of the Cystic-Fibrosis Transmembrane Conductance Regulator Gene in Cells of Nonepithelial Origin
    • Yoshimura K., Nakamura H., Trapnell B.C., Chu C.S., Dalemans W., Pavirani A., et al. Expression of the Cystic-Fibrosis Transmembrane Conductance Regulator Gene in Cells of Nonepithelial Origin. Nucleic Acids Res 1991, 19(19):5417-5423.
    • (1991) Nucleic Acids Res , vol.19 , Issue.19 , pp. 5417-5423
    • Yoshimura, K.1    Nakamura, H.2    Trapnell, B.C.3    Chu, C.S.4    Dalemans, W.5    Pavirani, A.6
  • 236
    • 79960641412 scopus 로고    scopus 로고
    • Defective CFTR Expression and Function Are Detectable in Blood Monocytes: Development of a New Blood Test for Cystic Fibrosis
    • Sorio C., Buffelli M., Angiari C., Ettorre M., Johansson J., Vezzalini M., et al. Defective CFTR Expression and Function Are Detectable in Blood Monocytes: Development of a New Blood Test for Cystic Fibrosis. PLoS One 2011, 6(7).
    • (2011) PLoS One , vol.6 , Issue.7
    • Sorio, C.1    Buffelli, M.2    Angiari, C.3    Ettorre, M.4    Johansson, J.5    Vezzalini, M.6
  • 237
    • 35748973573 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages
    • Haggie P.M., Verkman A.S. Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages. J Biol Chem 2007, 282(43):31422-31428.
    • (2007) J Biol Chem , vol.282 , Issue.43 , pp. 31422-31428
    • Haggie, P.M.1    Verkman, A.S.2
  • 238
    • 70349778629 scopus 로고    scopus 로고
    • Does the Ph of Intracellular Organelles Differ in Cf Cells?
    • Haggie P.M. Does the Ph of Intracellular Organelles Differ in Cf Cells?. Pediatr Pulmonol 2009, 117-118.
    • (2009) Pediatr Pulmonol , pp. 117-118
    • Haggie, P.M.1
  • 239
    • 84874399411 scopus 로고    scopus 로고
    • Revisiting the Role of Cftr and Counterion Permeability in the Ph Regulation of Endolysosomes and Phagosomes
    • Barriere H., Bagdany M., Bossard F., Okiyoneda T., Wojewodka G., Gruenert D., et al. Revisiting the Role of Cftr and Counterion Permeability in the Ph Regulation of Endolysosomes and Phagosomes. Pediatr Pulmonol 2009, 221-222.
    • (2009) Pediatr Pulmonol , pp. 221-222
    • Barriere, H.1    Bagdany, M.2    Bossard, F.3    Okiyoneda, T.4    Wojewodka, G.5    Gruenert, D.6
  • 240
    • 84555191356 scopus 로고    scopus 로고
    • Translocated LPS might cause endotoxin tolerance in circulating monocytes of Cystic Fibrosis patients
    • del Campo R., Martinez E., del Fresno C., Alenda R., Gomez-Pina V., Fernandez-Ruiz I., et al. Translocated LPS might cause endotoxin tolerance in circulating monocytes of Cystic Fibrosis patients. PLoS One 2011, 6(12):29577-29587.
    • (2011) PLoS One , vol.6 , Issue.12 , pp. 29577-29587
    • del Campo, R.1    Martinez, E.2    del Fresno, C.3    Alenda, R.4    Gomez-Pina, V.5    Fernandez-Ruiz, I.6
  • 241
    • 50549102070 scopus 로고    scopus 로고
    • Monocytes from cystic fibrosis patients are locked in an LPS tolerance state: down-regulation of TREM-1 as putative underlying mechanism
    • del Fresno C., Gomez-Pina V., Lores V., Soares-Schanoski A., Fernandez-Ruiz I., Rojo B., et al. Monocytes from cystic fibrosis patients are locked in an LPS tolerance state: down-regulation of TREM-1 as putative underlying mechanism. PLoS One 2008, 3(7):2667-2675.
    • (2008) PLoS One , vol.3 , Issue.7 , pp. 2667-2675
    • del Fresno, C.1    Gomez-Pina, V.2    Lores, V.3    Soares-Schanoski, A.4    Fernandez-Ruiz, I.5    Rojo, B.6
  • 242
    • 22544455326 scopus 로고    scopus 로고
    • The inflammatory versus constitutive trafficking of mononuclear phagocytes into the alveolar space of mice is associated with drastic changes in their gene expression profiles
    • Srivastava M., Jung S., Wilhelm J., Fink L., Buhling F., Welte T., et al. The inflammatory versus constitutive trafficking of mononuclear phagocytes into the alveolar space of mice is associated with drastic changes in their gene expression profiles. J Immunol 2005, 175(3):1884-1893.
    • (2005) J Immunol , vol.175 , Issue.3 , pp. 1884-1893
    • Srivastava, M.1    Jung, S.2    Wilhelm, J.3    Fink, L.4    Buhling, F.5    Welte, T.6
  • 243
    • 33745121896 scopus 로고    scopus 로고
    • Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease
    • Vandivier R.W., Henson P.M., Douglas I.S. Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. Chest 2006, 129(6):1673-1682.
    • (2006) Chest , vol.129 , Issue.6 , pp. 1673-1682
    • Vandivier, R.W.1    Henson, P.M.2    Douglas, I.S.3
  • 244
    • 23744490412 scopus 로고    scopus 로고
    • Neutrophil cell death, activation and bacterial infection in cystic fibrosis
    • Watt A.P., Courtney J., Moore J., Ennis M., Elborn J.S. Neutrophil cell death, activation and bacterial infection in cystic fibrosis. Thorax 2005, 60(8):659-664.
    • (2005) Thorax , vol.60 , Issue.8 , pp. 659-664
    • Watt, A.P.1    Courtney, J.2    Moore, J.3    Ennis, M.4    Elborn, J.S.5
  • 245
    • 70349759567 scopus 로고    scopus 로고
    • Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences
    • Vandivier R.W., Richens T.R., Horstmann S.A., deCathelineau A.M., Ghosh M., Reynolds S.D., et al. Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. Am J Physiol Lung Cell Mol Physiol 2009, 297(4):L677-L686.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297 , Issue.4
    • Vandivier, R.W.1    Richens, T.R.2    Horstmann, S.A.3    deCathelineau, A.M.4    Ghosh, M.5    Reynolds, S.D.6
  • 247
    • 0036195343 scopus 로고    scopus 로고
    • Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis
    • Vandivier R.W., Fadok V.A., Hoffmann P.R., Bratton D.L., Penvari C., Brown K.K., et al. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest 2002, 109(5):661-670.
    • (2002) J Clin Invest , vol.109 , Issue.5 , pp. 661-670
    • Vandivier, R.W.1    Fadok, V.A.2    Hoffmann, P.R.3    Bratton, D.L.4    Penvari, C.5    Brown, K.K.6
  • 248
    • 68949135137 scopus 로고    scopus 로고
    • Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells
    • Xu Y.Q., Tertilt C., Krause A., Quadri L.E.N., Crystal R.G., Worgall S. Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells. Respir Res 2009, 3:10.
    • (2009) Respir Res , vol.3 , pp. 10
    • Xu, Y.Q.1    Tertilt, C.2    Krause, A.3    Quadri, L.E.N.4    Crystal, R.G.5    Worgall, S.6
  • 249
    • 84866145737 scopus 로고    scopus 로고
    • Characterization of Pulmonary Dendritic Cells in the Lungs of Cystic Fibrosis Mice Following Pseudomonas Aeruginosa Infection
    • Xu Y., Krause A., Wu W., Joh J., Limberis M.P., Stefan W. Characterization of Pulmonary Dendritic Cells in the Lungs of Cystic Fibrosis Mice Following Pseudomonas Aeruginosa Infection. Pediatr Pulmonol 2009, 255-256.
    • (2009) Pediatr Pulmonol , pp. 255-256
    • Xu, Y.1    Krause, A.2    Wu, W.3    Joh, J.4    Limberis, M.P.5    Stefan, W.6
  • 250
    • 33845543471 scopus 로고    scopus 로고
    • Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase
    • Roghanian A., Drost E.M., MacNee W., Howie S.E.M., Sallenave J.M. Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase. Am J Respir Crit Care Med 2006, 174(11):1189-1198.
    • (2006) Am J Respir Crit Care Med , vol.174 , Issue.11 , pp. 1189-1198
    • Roghanian, A.1    Drost, E.M.2    MacNee, W.3    Howie, S.E.M.4    Sallenave, J.M.5
  • 251
    • 84863359416 scopus 로고    scopus 로고
    • Distinct patterns of inflammation in the airway lumen and bronchial mucosa of children with cystic fibrosis
    • Thorax Feb
    • Regamey N, Tsartsali L, Hilliard TN, Fuchs O, Tan HL, Zhu J, et al. Distinct patterns of inflammation in the airway lumen and bronchial mucosa of children with cystic fibrosis. Thorax Feb;67(2):164-170.
    • , vol.67 , Issue.2 , pp. 164-170
    • Regamey, N.1    Tsartsali, L.2    Hilliard, T.N.3    Fuchs, O.4    Tan, H.L.5    Zhu, J.6
  • 252
    • 0034107637 scopus 로고    scopus 로고
    • Lymphocytes migrate from the blood into the bronchoalveolar lavage and lung parenchyma in the asthma model of the brown Norway rat
    • Schuster M., Tschernig T., Krug N., Pabst R. Lymphocytes migrate from the blood into the bronchoalveolar lavage and lung parenchyma in the asthma model of the brown Norway rat. Am J Respir Crit Care Med 2000, 161(2):558-566.
    • (2000) Am J Respir Crit Care Med , vol.161 , Issue.2 , pp. 558-566
    • Schuster, M.1    Tschernig, T.2    Krug, N.3    Pabst, R.4
  • 254
    • 0029090598 scopus 로고
    • Lymphocytes in the Lung - an Often Neglected Cell - Numbers, Characterization and Compartmentalization
    • Pabst R., Tschernig T. Lymphocytes in the Lung - an Often Neglected Cell - Numbers, Characterization and Compartmentalization. Anat Embryol 1995, 192(4):293-299.
    • (1995) Anat Embryol , vol.192 , Issue.4 , pp. 293-299
    • Pabst, R.1    Tschernig, T.2
  • 255
    • 67349234068 scopus 로고    scopus 로고
    • IL-17 and Th17 cells in human inflammatory diseases
    • Miossec P. IL-17 and Th17 cells in human inflammatory diseases. Microbes Infect 2009, 11(5):625-630.
    • (2009) Microbes Infect , vol.11 , Issue.5 , pp. 625-630
    • Miossec, P.1
  • 256
    • 37149048081 scopus 로고    scopus 로고
    • Interleukin-17 in pulmonary host defense
    • Aujla S.J., Dubin P.J., Kolls J.K. Interleukin-17 in pulmonary host defense. Exp Lung Res 2007, 33(10):507-518.
    • (2007) Exp Lung Res , vol.33 , Issue.10 , pp. 507-518
    • Aujla, S.J.1    Dubin, P.J.2    Kolls, J.K.3
  • 257
    • 84874416309 scopus 로고    scopus 로고
    • Interplay between pathogenic effector Th17 and regulatory T cells in autoimmunity and tissue inflammation
    • Kuchroo V., Korn T., Bettelli E., Carrier Y., Gao W., Strom T., et al. Interplay between pathogenic effector Th17 and regulatory T cells in autoimmunity and tissue inflammation. Clin Exp Rheumatol 2008, 26(4):7145.
    • (2008) Clin Exp Rheumatol , vol.26 , Issue.4 , pp. 7145
    • Kuchroo, V.1    Korn, T.2    Bettelli, E.3    Carrier, Y.4    Gao, W.5    Strom, T.6
  • 258
    • 32244442562 scopus 로고    scopus 로고
    • TGF beta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., Stockinger B. TGF beta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006, 24(2):179-189.
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 260
    • 40049098958 scopus 로고    scopus 로고
    • IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
    • Aujla S.J., Chan Y.R., Zheng M.Q., Fei M.J., Askew D.J., Pociask D.A., et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 2008, 14(3):275-281.
    • (2008) Nat Med , vol.14 , Issue.3 , pp. 275-281
    • Aujla, S.J.1    Chan, Y.R.2    Zheng, M.Q.3    Fei, M.J.4    Askew, D.J.5    Pociask, D.A.6
  • 261
    • 67349275024 scopus 로고    scopus 로고
    • IL-22: A critical mediator in mucosal host defense
    • Aujla S.J., Kolls J.K. IL-22: A critical mediator in mucosal host defense. J Mol Med Immunol 2009, 87(5):451-454.
    • (2009) J Mol Med Immunol , vol.87 , Issue.5 , pp. 451-454
    • Aujla, S.J.1    Kolls, J.K.2
  • 262
    • 80051565623 scopus 로고    scopus 로고
    • IL-17 in Cystic Fibrosis: More Than Just Th17 Cells
    • Dubin P.J., Kolls J.K. IL-17 in Cystic Fibrosis: More Than Just Th17 Cells. Am J Respir Crit Care Med 2011, 184(2):155-157.
    • (2011) Am J Respir Crit Care Med , vol.184 , Issue.2 , pp. 155-157
    • Dubin, P.J.1    Kolls, J.K.2
  • 263
    • 34347396792 scopus 로고    scopus 로고
    • Is cystic fibrosis a TH17 disease?
    • Dubin P.J., McAllister F., Kolls J.K. Is cystic fibrosis a TH17 disease?. Inflamm Res 2007, 56(6):221-227.
    • (2007) Inflamm Res , vol.56 , Issue.6 , pp. 221-227
    • Dubin, P.J.1    McAllister, F.2    Kolls, J.K.3
  • 264
    • 33847043963 scopus 로고    scopus 로고
    • IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in mice
    • Dubin P.J., Kolls J.K. IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in mice. Am J Physiol Lung Cell Mol Physiol 2007, 292(2):L519-L528.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , Issue.2
    • Dubin, P.J.1    Kolls, J.K.2
  • 265
    • 84857091052 scopus 로고    scopus 로고
    • Interleukin-23-Mediated Inflammation in Pseudomonas aeruginosa Pulmonary Infection
    • Dubin P.J., Martz A., Eisenstatt J.R., Fox M.D., Logar A., Kolls J.K. Interleukin-23-Mediated Inflammation in Pseudomonas aeruginosa Pulmonary Infection. Infect Immun 2012, 80(1):398-409.
    • (2012) Infect Immun , vol.80 , Issue.1 , pp. 398-409
    • Dubin, P.J.1    Martz, A.2    Eisenstatt, J.R.3    Fox, M.D.4    Logar, A.5    Kolls, J.K.6
  • 266
    • 81555195667 scopus 로고    scopus 로고
    • Can cells other than Th17 lymphocytes be important sources of IL-17 in the lungs?
    • Brodlie M., Lordan J., Ward C. Can cells other than Th17 lymphocytes be important sources of IL-17 in the lungs?. Thorax 2011, 66(12):1096-1097.
    • (2011) Thorax , vol.66 , Issue.12 , pp. 1096-1097
    • Brodlie, M.1    Lordan, J.2    Ward, C.3
  • 267
    • 79957981191 scopus 로고    scopus 로고
    • Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease
    • Brodlie M., McKean M.C., Johnson G.E., Anderson A.E., Hilkens C.M.U., Fisher A.J., et al. Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease. Eur Respir J 2011, 37(6):1378-1385.
    • (2011) Eur Respir J , vol.37 , Issue.6 , pp. 1378-1385
    • Brodlie, M.1    McKean, M.C.2    Johnson, G.E.3    Anderson, A.E.4    Hilkens, C.M.U.5    Fisher, A.J.6
  • 268
    • 84866150723 scopus 로고    scopus 로고
    • Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable Cystic Fibrosis patients
    • Decraene A., Willems-Widyastuti A., Kasran A., De Boeck K., Bullens D.M., Dupont L.J. Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable Cystic Fibrosis patients. Respir Res 2010, 10:11.
    • (2010) Respir Res , vol.10 , pp. 11
    • Decraene, A.1    Willems-Widyastuti, A.2    Kasran, A.3    De Boeck, K.4    Bullens, D.M.5    Dupont, L.J.6
  • 270
    • 1542269619 scopus 로고    scopus 로고
    • Lymphocytes in cystic fibrosis lung disease: a tale of two immunities
    • Moss R.B. Lymphocytes in cystic fibrosis lung disease: a tale of two immunities. Clin Exp Immunol 2004, 135(3):358-360.
    • (2004) Clin Exp Immunol , vol.135 , Issue.3 , pp. 358-360
    • Moss, R.B.1
  • 271
    • 0034046253 scopus 로고    scopus 로고
    • Cytokine dysregulation in activated cystic fibrosis (CF) peripheral lymphocytes
    • Moss R.B., Hsu Y.P., Olds L. Cytokine dysregulation in activated cystic fibrosis (CF) peripheral lymphocytes. Clin Exp Immunol 2000, 120(3):518-525.
    • (2000) Clin Exp Immunol , vol.120 , Issue.3 , pp. 518-525
    • Moss, R.B.1    Hsu, Y.P.2    Olds, L.3
  • 272
    • 79953006218 scopus 로고    scopus 로고
    • Cystic fibrosis and the innate immune system: therapeutic implications
    • Conese M. Cystic fibrosis and the innate immune system: therapeutic implications. Endocr Metab Immune Disord Drug Targets 2011, 11(1):8-22.
    • (2011) Endocr Metab Immune Disord Drug Targets , vol.11 , Issue.1 , pp. 8-22
    • Conese, M.1
  • 274
    • 8644255090 scopus 로고    scopus 로고
    • Impaired pulmonary status in cystic fibrosis adults with two mutated MBL-2 alleles
    • Davies J.C., Turner M.W., Klein N., Grp L.M.C.S. Impaired pulmonary status in cystic fibrosis adults with two mutated MBL-2 alleles. Eur Respir J 2004, 24(5):798-804.
    • (2004) Eur Respir J , vol.24 , Issue.5 , pp. 798-804
    • Davies, J.C.1    Turner, M.W.2    Klein, N.3    Grp, L.M.C.S.4
  • 275
    • 77952668529 scopus 로고    scopus 로고
    • Use of a modeling framework to evaluate the effect of a modifier gene (MBL2) on variation in cystic fibrosis
    • McDougal K.E., Green D.M., Vanscoy L.L., Fallin M.D., Grow M., Cheng S., et al. Use of a modeling framework to evaluate the effect of a modifier gene (MBL2) on variation in cystic fibrosis. Eur J Hum Genet 2010, 18(6):680-684.
    • (2010) Eur J Hum Genet , vol.18 , Issue.6 , pp. 680-684
    • McDougal, K.E.1    Green, D.M.2    Vanscoy, L.L.3    Fallin, M.D.4    Grow, M.5    Cheng, S.6
  • 276
    • 84874422215 scopus 로고    scopus 로고
    • The effect of MBL2 gene variants on the age of first infection in Cystic Fibrosis (CF) patients is modified by TGF beta 1 gene variants
    • Taylor C., Huang B., Dorfman R., Zielenski J., Sandford A., Pare P., et al. The effect of MBL2 gene variants on the age of first infection in Cystic Fibrosis (CF) patients is modified by TGF beta 1 gene variants. Genet Epidemiol 2007, 31(6):646-647.
    • (2007) Genet Epidemiol , vol.31 , Issue.6 , pp. 646-647
    • Taylor, C.1    Huang, B.2    Dorfman, R.3    Zielenski, J.4    Sandford, A.5    Pare, P.6
  • 278
    • 84866158636 scopus 로고    scopus 로고
    • Analysis of mannose binding lectin (MBL) haplotyes in a large cohort of cystic fibrosis patients
    • Zielenski J.S., Pereira L., Culpi L., Raskin S., Tsui L.C. Analysis of mannose binding lectin (MBL) haplotyes in a large cohort of cystic fibrosis patients. Am J Hum Genet 2001, 69(4):650-651.
    • (2001) Am J Hum Genet , vol.69 , Issue.4 , pp. 650-651
    • Zielenski, J.S.1    Pereira, L.2    Culpi, L.3    Raskin, S.4    Tsui, L.C.5
  • 280
    • 67649540913 scopus 로고    scopus 로고
    • Association of MBL2, TGF-beta 1 and CD14 gene polymorphisms with lung disease severity in cystic fibrosis
    • de Faria E.J., de Faria I.C.J., Ribeiro J.D., Ribeiro A.F., Liessel G., Bertuzzo C.S. Association of MBL2, TGF-beta 1 and CD14 gene polymorphisms with lung disease severity in cystic fibrosis. J Bras Pneumol 2009, 35(4):334-342.
    • (2009) J Bras Pneumol , vol.35 , Issue.4 , pp. 334-342
    • de Faria, E.J.1    de Faria, I.C.J.2    Ribeiro, J.D.3    Ribeiro, A.F.4    Liessel, G.5    Bertuzzo, C.S.6
  • 281
    • 67349211438 scopus 로고    scopus 로고
    • Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease
    • Gu Y., Harley I.T., Henderson L.B., Aronow B.J., Vietor I., Huber L.A., et al. Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature 2009, 458(7241):1039-1042.
    • (2009) Nature , vol.458 , Issue.7241 , pp. 1039-1042
    • Gu, Y.1    Harley, I.T.2    Henderson, L.B.3    Aronow, B.J.4    Vietor, I.5    Huber, L.A.6
  • 282
    • 0035721749 scopus 로고    scopus 로고
    • Modifier genes and variation in cystic fibrosis
    • Drumm M.L. Modifier genes and variation in cystic fibrosis. Respir Res 2001, 2(3):125-128.
    • (2001) Respir Res , vol.2 , Issue.3 , pp. 125-128
    • Drumm, M.L.1
  • 283
    • 79957588506 scopus 로고    scopus 로고
    • Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2
    • Wright F.A., Strug L.J., Doshi V.K., Commander C.W., Blackman S.M., Sun L., et al. Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2. Nat Genet 2011, 43(6):539-546.
    • (2011) Nat Genet , vol.43 , Issue.6 , pp. 539-546
    • Wright, F.A.1    Strug, L.J.2    Doshi, V.K.3    Commander, C.W.4    Blackman, S.M.5    Sun, L.6
  • 284
  • 285
    • 66849089934 scopus 로고    scopus 로고
    • Cystic fibrosis: pathogenesis and future treatment strategies
    • Ratjen F.A. Cystic fibrosis: pathogenesis and future treatment strategies. Respir Care 2009, 54(5):595-605.
    • (2009) Respir Care , vol.54 , Issue.5 , pp. 595-605
    • Ratjen, F.A.1


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