Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis

European Respiratory Journal

Volumn 34, Issue 3, 2009, Pages 655-661

  Brennan, S ^a,b   Sly, P D ^a,b,c   Gangell, C L ^a,b   Sturges, N ^a,b   Winfield, K ^a,b   Wikstrom, M ^a,b   Gard, S ^a,b   Upham, J W ^a,b,d  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

CC chemokines; Children; Cystic fibrosis; Macrophages

Indexed keywords

BETA CHEMOKINE; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES;

ARTICLE; CELL COUNT; CHILD; CONTROLLED STUDY; CYSTIC FIBROSIS; FEMALE; HUMAN; HUMAN CELL; LUNG ALVEOLUS MACROPHAGE; LUNG INFECTION; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL COUNT; PRESCHOOL CHILD; PRIORITY JOURNAL; SYMPTOMATOLOGY;

BRONCHOALVEOLAR LAVAGE; CASE-CONTROL STUDIES; CELL COUNT; CHEMOKINE CCL2; CHEMOKINE CCL5; CHILD, PRESCHOOL; CYSTIC FIBROSIS; FEMALE; HUMANS; INFANT; LUNG; MACROPHAGE INFLAMMATORY PROTEINS; MACROPHAGES, ALVEOLAR; MALE; RESPIRATORY TRACT INFECTIONS;

EID: 70349095833     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00178508     Document Type: Article

References (33)

1. Armstrong D, Grimwood K, Carzino R, et al. Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis. BMJ 1995; 310: 1571-1572.
2. Balough K, McCubbin M, Weinberger M, et al. The relationship between infection and inflammation in the early stages of lung disease from cystic fibrosis. Pediatr Pulmonol 1995; 20: 63-70.
3. Brennan S, Hall GL, Horak F, et al. Correlation of forced oscillation technique in preschool children with cystic fibrosis with pulmonary inflammation. Thorax 2005; 60: 159-163. (Pubitemid 40222900)
4. Khan TZ, Wagener JS, Bost T, et al. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 1995; 151: 1075-1082.
5. Kerby GS, Cottin V, Accurso FJ, et al. Impairment of macrophage survival by NaCl: implications for early pulmonary inflammation in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 2002; 283: L188-L197.
6. Knight RA, Kollnberger S, Madden B, et al. Defective antigen presentation by lavage cells from terminal patients with cystic fibrosis. Clin Exp Immunol 1997; 107: 542-547. (Pubitemid 27102144)
7. Roghanian A, Drost EM, MacNee W, et al. Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase. Am J Respir Crit Care Med 2006; 174: 1189-1198. (Pubitemid 44924819)
8. Vandivier RW, Fadok VA, Hoffmann PR, et al. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest 2002; 109: 661-670.
9. Vandivier RW, Fadok VA, Ogden CA, et al. Impaired clearance of apoptotic cells from cystic fibrosis airways. Chest 2002; 121: Suppl. 3, 89S.
10. Hubeau C, Puchelle E, Gaillard D. Distict patterns of immune cell populations in the lung of human fetuses with cystic fibrosis. J Allergy Clin Immunol 2001; 108: 524-529. (Pubitemid 32978021)
11. -/- mice. Am J Respir Cell Mol Biol 2009; 40: 295-304.
12. Starner T, Barker C, Jia H, et al. CCL20 is an inducible product of human airway epithelia with innate immune properties. Am J Respir Cell Mol Biol 2003; 29: 627-633. (Pubitemid 37357715)
13. Augarten A, Paret G, Avneri I, et al. Systemic inflammatory mediators and cystic fibrosis genotype. Clin Exp Med 2004; 4: 99-102. (Pubitemid 39506601)
14. Koller DY, Nething I, Otto J, et al. Cytokine concentrations in sputum from patients with cystic fibrosis and their relation to eosinophil activity. Am J Respir Crit Care Med 1997; 155: 1050-1054. (Pubitemid 27133422)
15. Wyatt HA, Sampson AP, Balfour-Lynn IM, et al. Production of the potent neutrophil chemokine, growth-related protein a (GRO-a), is not elevated in cystic fibrosis children. Respir Med 2000; 94: 106-111.
16. Gibson LE, Cooke RE. A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis. Pediatrics 1959; 23: 545.
17. de Blic J, Midulla F, Badbato A, et al. Bronchoalveolar lavage in children. Eur Respir J 2000; 15: 217-231.
18. Franklin P, Hall G, Moeller A, et al. Exhaled nitric oxide is not reduced in infants with cystic fibrosis. Eur Respir J 2006; 27: 350-353. (Pubitemid 43180913)
19. Moeller A, Horak F, Lane C, et al. Expression of inducible nitric oxide synthase gene in airway epithelial cells in young children with cystic fibrosis. Thorax 2006; 61: 514-520. (Pubitemid 43901522)
20. Delacourt C, Herigault S, Delclaux C, et al. Protection against acute lung injury by intravenous or intratracheal pretreatment with EPIHNE-4, a new potent neutrophil elastase inhibitor. Am J Respir Cell Mol Biol 2002; 26: 290-297. (Pubitemid 34170055)
21. Lambrecht B. Alveolar macrophage in the driver's seat. Immunity 2006; 24: 366-368.
22. Hartl D, Buckland K, Hogaboam C. Chemokines in allergic aspergillosis - from animal models to human lung diseases. Inflamm Allergy Drug Targets 2006; 5: 219-228. (Pubitemid 44941932)
23. Rao S, Wright AK, Montiero W, et al. Monocyte chemoattractant chemokines in cystic fibrosis. J Cyst Fibros 2009; 8: 97-103.
24. Hartl D, Latzin P, Zissel G, et al. Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. Am J Respir Crit Care Med 2006; 173: 1370-1376. (Pubitemid 43900712)
25. Hartl D, Griese M, Kappler M, et al. Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis. J Allergy Clin Immunol 2006; 117: 204-211. (Pubitemid 43017162)
26. Mrugacz M, Zelazowska B, Bakunowicz-Lazarczyk A, et al. Elevated tear fluid levels of MIP-1a in patients with cystic fibrosis. J Interferon Cytokine Res 2007; 27: 491-495. (Pubitemid 46986596)
27. Amano H, Morimoto K, Senba M, et al. Essential contribution of monocyte chemoattractant protein-1/C-C chemokine ligand-2 to resolution and repair processes in acute bacterial pneumonia. J Immunol 2004; 172: 398-409. (Pubitemid 38020494)
28. Ariel A, Fredman G, Sun YP, et al. Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat Immunol 2006; 7: 1209-1216. (Pubitemid 44594317)
29. Marriott HM, Hellewell PG, Cross SS, et al. Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia. J Immunol 2006; 177: 6480-6488.
30. Rao S, Grigg J. New insights into pulmonary inflammation in cystic fibrosis. Arch Dis Child 2006; 91: 786-788. (Pubitemid 44351184)
31. Gordon S. The macrophage: past, present and future. Eur J Immunol 2007; 37: S9-S17.
32. Di A, Brown ME, Deriy LV, et al. CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nat Cell Biol 2006; 8: 933-944.
33. Kettle AJ, Chan T, Osberg I, et al. Myeloperoxidase and protein oxidation in the airways of young children with cystic fibrosis. Am J Respir Crit Care Med 2004; 170: 1317-1323. (Pubitemid 39657196)