Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice

Inflammation Research

Volumn 60, Issue 7, 2011, Pages 619-632

  Su, Xiao ^a   Looney, Mark R ^a,b   Su, Hang ^a   Lee, Jae Woo ^a,b   Song, Yuanlin ^b   Matthay, Michael A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bone marrow transplantation; Cystic fibrosis transmembrane conductance regulator; Cytokine; Lipopolysaccharide; Neutrophils

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1; TRANSMEMBRANE CONDUCTANCE REGULATOR; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INFLAMMATION; ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; BONE MARROW; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; GENE; GENE DOSAGE; GENE EXPRESSION; GENE MUTATION; INFLAMMATORY CELL; INTERFERON GAMMA GENE; INTERLEUKIN 13 GENE; INTERLEUKIN 1BETA GENE; LEUKOCYTE COUNT; LUNG BLOOD VESSEL; LUNG EXTRAVASCULAR FLUID; LUNG LAVAGE; MACROPHAGE INFLAMMATORY PROTEIN 2 GENE; MONOCYTE CHEMOTACTIC PROTEIN 1 GENE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NONHUMAN; PHARMACOLOGICAL BLOCKING; PNEUMONIA; TRANSFORMING GROWTH FACTOR BETA1 GENE; TRANSMEMBRANE CONDUCTANCE REGULATOR GENE; TUMOR NECROSIS FACTOR ALPHA GENE;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELLS, CULTURED; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; LIPOPOLYSACCHARIDES; LUNG; MICE; MICE, KNOCKOUT; NEUTROPHILS; NF-KAPPA B; PNEUMONIA;

EID: 80051663317     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-011-0313-x     Document Type: Article

References (45)

1. Nguyen M, Pace AJ, Koller BH. Mice lacking NKCC1 are protected from development of bacteremia and hypothermic sepsis secondary to bacterial pneumonia. J Exp Med. 2007;204:1383-93. (Pubitemid 46919876)
2. Matthay MA, Su X. Pulmonary barriers to pneumonia and sepsis. Nat Med. 2007;13:780-1. (Pubitemid 47038178)
3. Courtney JM, Ennis M, Elborn JS. Cytokines and inflammatory mediators in cystic fibrosis. J Cyst Fibros. 2004;3:223-31. (Pubitemid 40232976)
4. Terheggen-Lagro SW, Rijkers GT, van der Ent CK. The role of airway epithelium and blood neutrophils in the inflammatory response in cystic fibrosis. J Cyst Fibros. 2005;4(Suppl 2):15-23. (Pubitemid 41131324)
5. Venkatakrishnan A, Stecenko AA, King G, Blackwell TR, Brigham KL, Christman JW, et al. Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cells. Am J Respir Cell Mol Biol. 2000;23:396-403.
6. Blackwell TS, Stecenko AA, Christman JW. Dysregulated NFkappaB activation in cystic fibrosis: evidence for a primary inflammatory disorder. Am J Physiol Lung Cell Mol Physiol. 2001;281:L69-70. (Pubitemid 32927358)
7. Perez A, Issler AC, Cotton CU, Kelley TJ, Verkman AS, Davis PB. CFTR inhibition mimics the cystic fibrosis inflammatory profile. Am J Physiol Lung Cell Mol Physiol. 2007;292:L383-95.
8. Vij N, Mazur S, Zeitlin PL. CFTR is a negative regulator of NFkappaB mediated innate immune response. PLoS One. 2009;4:e4664.
9. Di A, Brown ME, Deriy LV, Li C, Szeto FL, Chen Y, et al. CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nat Cell Biol. 2006;8:933-44. (Pubitemid 44314724)
10. Painter RG, Valentine VG, Lanson NA Jr, Leidal K, Zhang Q, Lombard G, et al. CFTR expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis. Biochemistry. 2006;45:10260-9. (Pubitemid 44384801)
11. Thomas GR, Costelloe EA, Lunn DP, Stacey KJ, Delaney SJ, Passey R, et al. G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages. J Immunol. 2000;164:3870-7. (Pubitemid 30169846)
12. Bruscia EM, Zhang PX, Ferreira E, Caputo C, Emerson JW, Tuck D, et al. Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice. Am J Respir Cell Mol Biol. 2009;40:295-304.
13. Corvol H, Fitting C, Chadelat K, Jacquot J, Tabary O, Boule M, et al. Distinct cytokine production by lung and blood neutrophils from children with cystic fibrosis. Am J Physiol Lung Cell Mol Physiol. 2003;284:L997-1003. (Pubitemid 36687135)
14. Wine JJ. The genesis of cystic fibrosis lung disease. J Clin Invest. 1999;103:309-12. (Pubitemid 29069979)
15. Engelhardt JF, Zepeda M, Cohn JA, Yankaskas JR, Wilson JM. Expression of the cystic fibrosis gene in adult human lung. J Clin Invest. 1994;93:737-49. (Pubitemid 24072817)
16. Tirouvanziam R, Khazaal I, Peault B. Primary inflammation in human cystic fibrosis small airways. Am J Physiol Lung Cell Mol Physiol. 2002;283:L445-51. (Pubitemid 34804002)
17. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342:1334-49. (Pubitemid 30408719)
18. Su X, Matthay MA, Malik AB.Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. J Immunol. 2010;184:401-410
19. Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, et al. Thiazolidinone CFTR inhibitor identified by ighthroughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002;110:1651-8. (Pubitemid 35424243)
20. Sonawane ND, Hu J, Muanprasat C, Verkman AS. Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera. Faseb J. 2006;20: 130-2. (Pubitemid 43100490)
21. Song Y, Sonawane ND, Salinas D, Qian L, Pedemonte N, Galietta LJ, et al. Evidence against the rescue of defective DeltaF508- CFTR cellular processing by curcumin in cell culture and mouse models. J Biol Chem. 2004;279:40629-33. (Pubitemid 39287655)
22. Colledge WH, Abella BS, Southern KW, Ratcliff R, Jiang C, Cheng SH, et al. Generation and characterization of a delta F508 cystic fibrosis mouse model. Nat Genet. 1995;10:445-52.
23. Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA. Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol. 2005;175:2598-605. (Pubitemid 41113873)
24. Su X, Johansen M, Looney MR, Brown EJ, Matthay MA. CD47 deficiency protects mice from lipopolysaccharide-induced cute lung injury and Escherichia coli pneumonia. J Immunol. 2008;180:6947-53.
25. Lefort J, Singer M, Leduc D, Renesto P, Nahori MA, Huerre M, et al. Systemic administration of endotoxin induces bronchopulmonary hyperreactivity dissociated from TNF-alpha formation and neutrophil sequestration into the murine lungs. J Immunol. 1998;161:474-80. (Pubitemid 28285557)
26. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006;116:1615-23.
27. Mocsai A, Abram CL, Jakus Z, Hu Y, Lanier LL, Lowell CA. Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol. 2006;7:1326-33. (Pubitemid 46111254)
28. Armstrong DA, Major JA, Chudyk A, Hamilton TA. Neutrophil chemoattractant genes KC and MIP-2 are expressed in different cell populations at sites of surgical injury. J Leukoc Biol. 2004;75:641-8. (Pubitemid 38405655)
29. Matzer SP, Baumann T, Lukacs NW, Rollinghoff M, Beuscher HU. Constitutive expression of macrophage-inflammatory rotein 2 (MIP-2) mRNA in bone marrow gives rise to peripheral neutrophils with preformed MIP-2 protein. J Immunol. 2001;167: 4635-43. (Pubitemid 32954344)
30. Tsujimoto H, Ono S, Mochizuki H, Aosasa S, Majima T, Ueno C, et al. Role of macrophage inflammatory protein 2 in acute lung injury in murine peritonitis. J Surg Res. 2002;103:61-7. (Pubitemid 34953393)
31. Gupta S, Feng L, Yoshimura T, Redick J, Fu SM, Rose CE Jr. Intra-alveolar macrophage-inflammatory peptide 2 induces rapid neutrophil localization in the lung. Am J Respir Cell Mol Biol. 1996;15:656-63. (Pubitemid 126440605)
32. Goldblum SE, Hennig B, Jay M, Yoneda K, McClain CJ. Tumor necrosis factor alpha-induced pulmonary vascular endothelial injury. Infect Immun. 1989;57:1218-26. (Pubitemid 19087870)
33. Burdon PC, Martin C, Rankin SM. The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner. Blood. 2005;105:2543-8. (Pubitemid 40387057)
34. Spight D, Zhao B, Haas M, Wert S, Denenberg A, Shanley TP. Immunoregulatory effects of regulated, lung-targeted expression of IL-10 in vivo. Am J Physiol Lung Cell Mol Physiol. 2005;288:L251-65. (Pubitemid 40105364)
35. Tabary O, Zahm JM, Hinnrasky J, Couetil JP, Cornillet P, Guenounou M, et al. Selective up-regulation of chemokine IL-8 expression in cystic fibrosis bronchial gland cells in vivo and in vitro. Am J Pathol. 1998;153:921-30. (Pubitemid 28419044)
36. Legssyer R, Huaux F, Lebacq J, Delos M, Marbaix E, Lebecque P, et al. Azithromycin reduces spontaneous, induced nflammation in DeltaF508 cystic fibrosis mice. Respir Res. 2006;7:134.
37. Karp CL, Flick LM, Park KW, Softic S, Greer TM, Keledjian R, et al. Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway. Nat Immunol. 2004;5:388-92. (Pubitemid 38500087)
38. Doring G, Conway SP, Heijerman HG, Hodson ME, Hoiby N, Smyth A, et al. Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensus. Eur Respir J. 2000;16:749-67.
39. Scheid P, Kempster L, Griesenbach U, Davies JC, Dewar A, Weber PP, et al. Inflammation in cystic fibrosis airways: relationship to increased bacterial adherence. Eur Respir J. 2001;17:27-35. (Pubitemid 32600552)
40. Davidson DJ, Dorin JR, McLachlan G, Ranaldi V, Lamb D, Doherty C, et al. Lung disease in the cystic fibrosis mouse exposed to bacterial pathogens. Nat Genet. 1995;9:351-7.
41. McKeon DJ, Cadwallader KA, Idris S, Cowburn AS, Pasteur MC, Barker H, et al. Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation. Eur Respir J. 2010;35:1264-72.
42. Painter RG, Marrero L, Lombard GA, Valentine VG, Nauseef WM, Wang G. CFTR-mediated halide transport in phagosomes of human neutrophils. J Leukoc Biol. 2010;87:933-42.
43. Sonawane ND, Verkman AS. Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis. Bioorg Med Chem. 2008;16:8187-95.
44. Dechecchi MC, Nicolis E, Bezzerri V, Vella A, Colombatti M, Assael BM, et al. MPB-07 reduces the inflammatory response to Pseudomonas aeruginosa in cystic fibrosis bronchial cells. Am J Respir Cell Mol Biol. 2007;36:615-24. (Pubitemid 46676721)
45. Elizur A, Cannon CL, Ferkol TW. Airway inflammation in cystic fibrosis. Chest 2008;133:489-95. 632 (Pubitemid 351272410)