Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis

Free Radical Biology and Medicine

Volumn 49, Issue 9, 2010, Pages 1354-1360

  Thomson, Eline ^a   Brennan, Siobhain ^b   Senthilmohan, Revathy ^a   Gangell, Catherine L ^b   Chapman, Anna L ^a   Sly, Peter D ^c   Kettle, Anthony J ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Cystic fibrosis; Free radicals; Hypochlorous acid; Myeloperoxidase; Neutrophils; Oxidative stress; Peroxidase

Indexed keywords

3 BROMOTYROSINE; 3 CHLOROTYROSINE; HYPOCHLOROUS ACID; MYELOPEROXIDASE; THIOCYANATE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BRONCHOSCOPY; CHILD; CLINICAL ASSESSMENT; CLINICAL ASSESSMENT TOOL; CLINICAL FEATURE; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HUMAN; INFANT; LUNG INFECTION; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; OXIDATIVE STRESS; PATHOGENICITY; PNEUMONIA; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PSEUDOMONAS AERUGINOSA;

BRONCHOALVEOLAR LAVAGE FLUID; CHILD; CHILD, PRESCHOOL; CYSTIC FIBROSIS; DISEASE PROGRESSION; FEMALE; HUMANS; INFANT; INFLAMMATION; MALE; NEUTROPHILS; OXIDATION-REDUCTION; PEROXIDASE; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT INFECTIONS; TYROSINE;

PSEUDOMONAS AERUGINOSA;

EID: 77957150688     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.07.010     Document Type: Article

References (39)

1. Ratjen F., Doring G. Cystic fibrosis. Lancet 2003, 361:681-689.
2. Linsdell P. Thiocyanate as a probe of the cystic fibrosis transmembrane conductance regulator chloride channel pore. Can. J. Physiol. Pharmacol. 2001, 79:573-579.
3. Khan T.Z., Wagener J.S., Bost T., Martinez J., Accurso F.J., Riches D.W. Early pulmonary inflammation in infants with cystic fibrosis. Am. J. Respir. Crit. Care Med. 1995, 151:1075-1082.
4. Sly P.D., Brennan S., Gangell C., de Klerk N., Murray C., Mott L., Stick S.M., Robinson P.J., Robertson C.F., Ranganathan S.C. Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening. Am. J. Respir. Crit. Care Med. 2009, 180:146-152.
5. Koller D.Y., Gotz M., Wojnarowski C., Eichler I. Relationship between disease severity and inflammatory markers in cystic fibrosis. Arch. Dis. Child. 1996, 75:498-501.
6. van der Vliet A., Nguyen M.N., Shigenaga M.K., Eiserich J.P., Marelich G.P., Cross C.E. Myeloperoxidase and protein oxidation in cystic fibrosis. Am. J. Physiol. 2000, 279:L537-L546.
7. Kettle A.J., Chan T., Osberg I., Senthilmohan R., Chapman A.L., Mocatta T.J., Wagener J.S. Myeloperoxidase and protein oxidation in the airways of young children with cystic fibrosis. Am. J. Respir. Crit. Care Med. 2004, 170:1317-1323.
8. Regelmann W.E., Siefferman C.M., Herron J.M., Elliot G.R., Clawson C.C., Gray B.H. Sputum peroxidase activity correlates with the severity of lung disease in cystic fibrosis. Pediatr. Pulmonol. 1995, 19:1-9.
9. Koller D.Y., Gotz M., Eichler I., Urbanek R. Eosinophilic activation in cystic fibrosis. Thorax 1994, 49:496-499.
10. Garner H.P., Phillips J.R., Herron J.G., Severson S.J., Milla C.E., Regelmann W.E. Peroxidase activity within circulating neutrophils correlates with pulmonary phenotype in cystic fibrosis. J. Lab. Clin. Med. 2004, 144:127-133.
11. Wijkstrom-Frei C., El-Chemaly S., Ali-Rachedi R., Gerson C., Cobas M.A., Forteza R., Salathe M., Conner G.E. Lactoperoxidase and human airway host defense. Am. J. Respir. Cell Mol. Biol. 2003, 29:206-212.
12. Kettle A.J., Winterbourn C.C. Myeloperoxidase: a key regulator of neutrophil oxidant production. Redox Rep. 1997, 3:3-15.
13. Saude E.J., Lacy P., Musat-Marcu S., Mayes D.C., Bagu J., Man S.F., Sykes B.D., Moqbel R. NMR analysis of neutrophil activation in sputum samples from patients with cystic fibrosis. Magn. Reson. Med. 2004, 52:807-814.
14. Conner G.E., Wijkstrom-Frei C., Randell S.H., Fernandez V.E., Salathe M. The lactoperoxidase system links anion transport to host defense in cystic fibrosis. FEBS Lett. 2007, 581:271-278.
15. van Dalen C.J., Whitehouse M.W., Winterbourn C.C., Kettle A.J. Thiocyanate and chloride as competing substrates for myeloperoxidase. Biochem. J. 1997, 327:487-492.
16. Furtmuller P.G., Burner U., Jantschko W., Regelsberger G., Obinger C. The reactivity of myeloperoxidase compound I formed with hypochlorous acid. Redox Rep. 2000, 5:173-178.
17. Xu Y., Szep S., Lu Z. The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:20515-20519.
18. Kanga J., Kuhn R., Craigmyle L., Haverstock D., Church D. Cystic fibrosis clinical score: a new scoring system to evaluate acute pulmonary exacerbation. Clin. Ther. 1999, 21:1343-1356.
19. Bozeman P.M., Learn D.B., Thomas E.L. Assay of the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase. J. Immunol. Methods 1990, 126:125-133.
20. 2 compound. Acta Chem. Scand. 1963, 17(Suppl. 1):S332-S338.
21. Mocatta T.J., Pilbrow A.P., Cameron V.A., Senthilmohan R., Frampton C.M., Richards A.M., Winterbourn C.C. Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction. J. Am. Coll. Cardiol. 2007, 49:1993-2000.
22. Maurer H.R. Disc Electrophoresis and Related Techniques of Poly-acrylamide Gel Electrophoresis 1971, de Gruyter, Berlin/New York.
23. Buss I.H., Chan T.P., Sluis K.B., Domigan N.M., Winterbourn C.C. Protein carbonyl measurement by a sensitive ELISA method. Free Radic. Biol. Med. 1997, 23:361-366.
24. de Blic J., Midulla F., Barbato A., Clement A., Dab I., Eber E., Green C., Grigg J., Kotecha S., Kurland G., Pohunek P., Ratjen F., Rossi G. Bronchoalveolar lavage in children: ERS Task Force on Bronchoalveolar Lavage in Children. Eur. Respir. J. 2000, 15:217-231.
25. Bozeman P.M., Learn D.B., Thomas E.L. Inhibition of the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase by dapsone. Biochem. Pharmacol. 1992, 44:553-563.
26. Thomas E.L., Jefferson M.M., Joyner R.E., Cook G.S., King C.C. Leukocyte myeloperoxidase and salivary lactoperoxidase: identification and quantitation in human mixed saliva. J. Dent. Res. 1994, 73:544-555.
27. Koller D.Y., Nilsson M., Enander I., Venge P., Eichler I. Serum eosinophil cationic protein, eosinophil protein X and eosinophil peroxidase in relation to pulmonary function in cystic fibrosis. Clin. Exp. Allergy 1998, 28:241-248.
28. Moskwa P., Lorentzen D., Excoffon K.J., Zabner J., McCray P.B., Nauseef W.M., Dupuy C., Banfi B. A novel host defense system of airways is defective in cystic fibrosis. Am. J. Respir. Crit. Care Med. 2007, 175:174-183.
29. Heinecke J.W. Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis. Atherosclerosis 1998, 141:1-15.
30. Pattison D.I., Davies M.J. Reactions of myeloperoxidase-derived oxidants with biological substrates: gaining chemical insight into human inflammatory diseases. Curr. Med. Chem. 2006, 13:3271-3290.
31. Wu W., Chen B.K., d'Avignon A., Hazen S.L. 3-Bromotyrosine and 3, 5-dibromotyrosine are major products of protein oxidation by eosinophil peroxidase: potential markers for eosinophil-dependent tissue injury in vivo. Biochemistry 1999, 38:3538-3548.
32. Henderson J.P., Byun J., Williams M.V., McCormick M.L., Parks W.C., Ridnour L.A., Heinecke J.W. Bromination of deoxycytidine by eosinophil peroxidase: a mechanism for mutagenesis by oxidative damage of nucleotide precursors. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:1631-1636.
33. Weiss S.J., Test S.T., Eckmann C.M., Roos D., Regiani S. Brominating oxidants generated by human eosinophils. Science 1986, 234:200-203.
34. Senthilmohan R., Kettle A.J. Bromination and chlorination reactions of myeloperoxidase at physiological concentrations of bromide and chloride. Arch. Biochem. Biophys. 2006, 445:235-244.
35. Chapman A.L., Skaff O., Senthilmohan R., Davies M.J., Kettle A.J. Hypobromous acid and bromamine production by neutrophils and their modulation by superoxide. Biochem. J. 2009, 417:773-781.
36. Gaut J.P., Yeh G.C., Tran H.D., Byun J., Henderson J.P., Richter G.M., Brennan M.L., Lusis A.J., Belaaouaj A., Hotchkiss R.S., Heinecke J.W. Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:11961-11966.
37. van der Vliet A., Eiserich J.P., Shigenaga M.K., Cross C.E. Reactive nitrogen species and tyrosine nitration in the respiratory tract: epiphenomena or a pathobiologic mechanism of disease?. Am. J. Respir. Crit. Care Med. 1999, 160:1-9.
38. Kohlhoff S.A., Kohler E., Sollich V. Serum myeloperoxidase in cystic fibrosis patients receiving systemic antibiotics. Scand. J. Infect. Dis. 2007, 39:163-166.
39. Sloane A.J., Lindner R.A., Prasad S.S., Sebastian L.T., Pedersen S.K., Robinson M., Bye P.T., Nielson D.W., Harry J.L. Proteomic analysis of sputum from adults and children with cystic fibrosis and from control subjects. Am. J. Respir. Crit. Care Med. 2005, 172:1416-1426.