Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages

Journal of Cystic Fibrosis

Volumn 7, Issue 1, 2008, Pages 68-78

  Andersson, Charlotte ^a   Zaman, Munir M ^a   Jones, Amanda B ^a   Freedman, Steven D ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Cystic fibrosis mice; Cytokines; Docosahexaenoic acid; Inflammation; Macrophages; Nuclear receptors

Indexed keywords

ABC TRANSPORTER A1; CELL NUCLEUS RECEPTOR; CYTOKINE; DOCOSAHEXAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LIVER X RECEPTOR; LIVER X RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOKINE RELEASE; DRUG ACTIVITY; GEL MOBILITY SHIFT ASSAY; IMMUNE RESPONSE; IN VIVO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILD TYPE;

ANIMALS; CYSTIC FIBROSIS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DOCOSAHEXAENOIC ACIDS; IMMUNITY, NATURAL; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION;

EID: 38049091190     PISSN: 15691993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcf.2007.05.004     Document Type: Article

References (58)

1. Vandivier R.W., Henson P.M., and Douglas I.S. Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. Chest 129 (2006) 1673-1682
2. Tirouvanziam R., de Bentzmann S., Hubeau C., Hinnrasky J., Jacquot J., Peault B., et al. Inflammation and infection in naive human cystic fibrosis airway grafts. Am J Respir Cell Mol Biol 23 (2000) 121-127
3. Zahm J.M., Gaillard D., Dupuit F., Hinnrasky J., Porteous D., Dorin J.R., et al. Early alterations in airway mucociliary clearance and inflammation of the lamina propria in CF mice. Am J Physiol 272 (1997) C853-C859
4. Xu Y., Clark J.C., Aronow B.J., Dey C.R., Liu C., Wooldridge J.L., et al. Transcriptional adaptation to cystic fibrosis transmembrane conductance regulator deficiency. J Biol Chem 278 (2003) 7674-7682
5. Bonfield T.L., Panuska J.R., Konstan M.W., Hilliard K.A., Hilliard J.B., Ghnaim H., et al. Inflammatory cytokines in cystic fibrosis lungs. Am J Respir Crit Care Med 152 (1995) 2111-2118
6. Moss R.B. Lymphocytes in cystic fibrosis lung disease: a tale of two immunities. Clin Exp Immunol 135 (2004) 358-360
7. Zaman M.M., Gelrud A., Junaidi O., Regan M.M., Warny M., Shea J.C., et al. Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered. Clin Diagn Lab Immunol 11 (2004) 819-824
8. Thomas G.R., Costelloe E.A., Lunn D.P., Stacey K.J., Delaney S.J., Passey R., et al. G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages. J Immunol 164 (2000) 3870-3877
9. -/- mice and the effect of docosahexaenoic acid. J Appl Physiol 92 (2002) 2169-2176
10. Heeckeren A., Walenga R., Konstan M.W., Bonfield T., Davis P.B., and Ferkol T. Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa. J Clin Invest 100 (1997) 2810-2815
11. -/-) mice. Proc Natl Acad Sci U S A 96 (1999) 13995-14000
12. Freedman S.D., Blanco P.G., Zaman M.M., Shea J.C., Ollero M., Hopper I.K., et al. Association of cystic fibrosis with abnormalities in fatty acid metabolism. N Engl J Med 350 (2004) 560-569
13. -/- mice results in bile duct injury. Am J Physiol Gastrointest Liver Physiol 287 (2004) G491-G496
14. Glass C.K., and Ogawa S. Combinatorial roles of nuclear receptors in inflammation and immunity. Nat Rev Immunol 6 (2006) 44-55
15. Cuzzocrea S., Mazzon E., Di Paola R., Peli A., Bonato A., Britti D., et al. The role of the peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in the regulation of acute inflammation. J Leukoc Biol 79 (2006) 999-1010
16. Jiang C., Ting A.T., and Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391 (1998) 82-86
17. Wang A.C., Dai X., Luu B., and Conrad D.J. Peroxisome proliferator-activated receptor-gamma regulates airway epithelial cell activation. Am J Respir Cell Mol Biol 24 (2001) 688-693
18. Joseph S.B., Castrillo A., Laffitte B.A., Mangelsdorf D.J., and Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 9 (2003) 213-219
19. Cunard R., Ricote M., DiCampli D., Archer D.C., Kahn D.A., Glass C.K., et al. Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors. J Immunol 168 (2002) 2795-2802
20. Chinetti G., Griglio S., Antonucci M., Torra I.P., Delerive P., Majd Z., et al. Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages. J Biol Chem 273 (1998) 25573-25580
21. Padilla J., Leung E., and Phipps R.P. Human B lymphocytes and B lymphomas express PPAR-gamma and are killed by PPAR-gamma agonists. Clin Immunol 103 (2002) 22-33
22. Ricote M., Li A.C., Willson T.M., Kelly C.J., and Glass C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391 (1998) 79-82
23. Woerly G., Honda K., Loyens M., Papin J.P., Auwerx J., Staels B., et al. Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation. J Exp Med 198 (2003) 411-421
24. Asada K., Sasaki S., Suda T., Chida K., and Nakamura H. Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages. Am J Respir Crit Care Med 169 (2004) 195-200
25. Joseph S.B., Bradley M.N., Castrillo A., Bruhn K.W., Mak P.A., Pei L., et al. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell 119 (2004) 299-309
26. Devchand P.R., Keller H., Peters J.M., Vazquez M., Gonzalez F.J., and Wahli W. The PPARalpha-leukotriene B4 pathway to inflammation control. Nature 384 (1996) 39-43
27. Auboeuf D., Rieusset J., Fajas L., Vallier P., Frering V., Riou J.P., et al. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 46 (1997) 1319-1327
28. Svensson P.A., Hagg D.A., Jernas M., Englund M.C., Hulten L.M., Ohlsson B.G., et al. Identification of genes predominantly expressed in human macrophages. Atherosclerosis 177 (2004) 287-290
29. Repa J.J., and Mangelsdorf D.J. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol 16 (2000) 459-481
30. Zhang Y., Beyer T.P., Bramlett K.S., Yao S., Burris T.P., Schmidt R.J., et al. Liver X receptor and retinoic X receptor mediated ABCA1 regulation and cholesterol efflux in macrophage cells-messenger RNA measured by branched DNA technology. Mol Genet Metab 77 (2002) 150-158
31. Janowski B.A., Willy P.J., Devi T.R., Falck J.R., and Mangelsdorf D.J. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 383 (1996) 728-731
32. Lehmann J.M., Kliewer S.A., Moore L.B., Smith-Oliver T.A., Oliver B.B., Su J.L., et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem 272 (1997) 3137-3140
33. Yoshikawa T., Shimano H., Yahagi N., Ide T., Amemiya-Kudo M., Matsuzaka T., et al. Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements. J Biol Chem 277 (2002) 1705-1711
34. Tobin K.A., Steineger H.H., Alberti S., Spydevold O., Auwerx J., Gustafsson J.A., et al. Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha. Mol Endocrinol 14 (2000) 741-752
35. Barish G.D., Downes M., Alaynick W.A., Yu R.T., Ocampo C.B., Bookout A.L., et al. A nuclear receptor atlas: macrophage activation. Mol Endocrinol 19 (2005) 2466-2477
36. Kehrer J.P., Biswal S.S., La E., Thuillier P., Datta K., Fischer S.M., et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J 356 (2001) 899-906
37. Pfeffer K.D., Huecksteadt T.P., and Hoidal J.R. Expression and regulation of tumor necrosis factor in macrophages from cystic fibrosis patients. Am J Respir Cell Mol Biol 9 (1993) 511-519
38. Yoshimura K., Nakamura H., Trapnell B.C., Chu C.S., Dalemans W., Pavirani A., et al. Expression of the cystic fibrosis transmembrane conductance regulator gene in cells of non-epithelial origin. Nucleic Acids Res 19 (1991) 5417-5423
39. Muller J.M., Ziegler-Heitbrock H.W., and Baeuerle P.A. Nuclear factor kappa B, a mediator of lipopolysaccharide effects. Immunobiology 187 (1993) 233-256
40. Urban M.B., Schreck R., and Baeuerle P.A. NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit. EMBO J 10 (1991) 1817-1825
41. Liu H., Sidiropoulos P., Song G., Pagliari L.J., Birrer M.J., Stein B., et al. TNF-alpha gene expression in macrophages: regulation by NF-kappa B is independent of c-Jun or C/EBP beta. J Immunol 164 (2000) 4277-4285
42. Chen B.C., Liao C.C., Hsu M.J., Liao Y.T., Lin C.C., Sheu J.R., et al. Peptidoglycan-induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-kappa B. J Immunol 177 (2006) 681-693
43. Joseph T., Look D., and Ferkol T. NF-kappaB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol 288 (2005) L471-L479
44. Novak T.E., Babcock T.A., Jho D.H., Helton W.S., and Espat N.J. NF-kappa B inhibition by omega-3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcription. Am J Physiol Lung Cell Mol Physiol 284 (2003) L84-L89
45. Weldon S.M., Mullen A.C., Loscher C.E., Hurley L.A., and Roche H.M. Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid. J Nutr Biochem 18 (2007) 250-258
46. Zhao G., Etherton T.D., Martin K.R., Vanden Heuvel J.P., Gillies P.J., West S.G., et al. Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. Biochem Biophys Res Commun 336 (2005) 909-917
47. -/-mice. J Cell Physiol 200 (2004) 235-244
48. Kostadinova R., Wahli W., and Michalik L. PPARs in diseases: control mechanisms of inflammation. Curr Med Chem 12 (2005) 2995-3009
49. Ding G., Cheng L., Qin Q., Frontin S., and Yang Q. PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes. J Mol Cell Cardiol (2006)
50. Hsu M.H., Savas U., Griffin K.J., and Johnson E.F. Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells. J Biol Chem 276 (2001) 27950-27958
51. Varanasi U., Chu R., Huang Q., Castellon R., Yeldandi A.V., and Reddy J.K. Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene. J Biol Chem 271 (1996) 2147-2155
52. Tontonoz P., Nagy L., Alvarez J.G., Thomazy V.A., and Evans R.M. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93 (1998) 241-252
53. Munteanu A., Taddei M., Tamburini I., Bergamini E., Azzi A., and Zingg J.M. Antagonistic effects of oxidized low density lipoprotein and alpha-tocopherol on CD36 scavenger receptor expression in monocytes: involvement of protein kinase B and peroxisome proliferator-activated receptor-gamma. J Biol Chem 281 (2006) 6489-6497
54. Hong G., Davis B., Khatoon N., Baker S.F., and Brown J. PPAR gamma-dependent anti-inflammatory action of rosiglitazone in human monocytes: suppression of TNF alpha secretion is not mediated by PTEN regulation. Biochem Biophys Res Commun 303 (2003) 782-787
55. Hong S., Gronert K., Devchand P.R., Moussignac R.L., and Serhan C.N. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 278 (2003) 14677-14687
56. Marcheselli V.L., Hong S., Lukiw W.J., Tian X.H., Gronert K., Musto A., et al. Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem 278 (2003) 43807-43817
57. Serhan C.N. Novel omega-3-derived local mediators in anti-inflammation and resolution. Pharmacol Ther 105 (2005) 7-21
58. Serhan C.N., Hong S., Gronert K., Colgan S.P., Devchand P.R., and Mirick G. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med 196 (2002) 1025-1037