Neutrophilic inflammation as a major determinant in the progression of cystic fibrosis

Drug News and Perspectives

Volumn 19, Issue 10, 2006, Pages 609-614

  Tirouvanziam, Rabindra ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; GLUTATHIONE; IBUPROFEN; LIPOXIN A; NORADRENALIN; STEROID; TRANSMEMBRANE CONDUCTANCE REGULATOR; ANTIINFLAMMATORY AGENT;

CELL DEATH; CYSTIC FIBROSIS; DISEASE COURSE; DRUG EFFECT; DRUG MEGADOSE; HUMAN; LUNG DISEASE; LUNG FLUID; NEUTROPHIL; NONHUMAN; PNEUMONIA; REVIEW; SHORT COURSE THERAPY; STRESS; UNSPECIFIED SIDE EFFECT; ANIMAL; CHRONIC DISEASE; GENETICS; GENOTYPE; IMMUNOLOGY; MICROBIOLOGY; NEUTROPHIL CHEMOTAXIS; PATHOPHYSIOLOGY; PHENOTYPE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CHRONIC DISEASE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DISEASE PROGRESSION; GENOTYPE; HUMANS; NEUTROPHIL INFILTRATION; NEUTROPHILS; PHENOTYPE; PNEUMONIA; STRESS;

EID: 34247161953     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2006.19.10.1068008     Document Type: Review

References (60)

1. Davis, P.B. Cystic fibrosis since 1938. Am J Respir Crit Care Med 2006, 173: 475-82.
2. Deeley, R.G., Westlake, C. and Cole, S.P. Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 2006, 86: 849-99.
3. Gibson, R.L., Burns, J.L. and Ramsey, B.W. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am J Respir Crit Care Med 2003, 168: 918-51.
4. Chmiel, J.F., Berger, M. and Konstan, M.W. The role of inflammation in the pathophysiology of CF lung disease. Clin Rev Allergy Immunol 2002, 23: 5-27.
5. Palomaki, G.E., FitzSimmons, S.C. and Haddow, J.E. Clinical sensitivity of prenatal screening for cystic fibrosis via CFTR carrier testing in a United States panethnic population. Genet Med 2004, 6: 405-14.
6. Schwiebert, E.M., Benos, D.J. and Fuller, CM. Cystic fibrosis: A multiple exocrinopathy caused by dysfunctions in a multifunctional transport protein. Am J Med 1998, 104: 576-90.
7. Bertrand, C.A. and Frizzell, R.A. The role of regulated CFTR trafficking in epithelial secretion. Am J Physiol Cell Physiol 2003, 285: C1-18.
8. Chow, C.W., Landau, L.I. and Taussig, L.M. Bronchial mucous glands in the newborn with cystic fibrosis. Eur J Pediatr 1982, 139: 240-3.
9. Meyer, K.C., Nunley, D.R., Dauber, J.H. et al. Neutrophils, unopposed neutrophil elastase, and alpha1-antiprotease defenses following human lung transplantation. Am J Respir Crit Care Med 2001, 164: 97-102.
10. Konstan, M.W. and Davis, P.B. Pharmacological approaches for the discovery and development of new anti-inflammatory agents for the treatment of cystic fibrosis. Adv Drug Deliv Rev 2002, 54: 1409-23.
11. Davies, J.C., Griesenbach, U. and Alton, E. Modifier genes in cystic fibrosis. Pediatr Pulmonol 2005, 39: 383-91.
12. Tirouvanziam, R. The neutrophil: New concepts on a powerful and versatile actor of immunity. In: Recent Advances in Immunology. S. Kundu-Raychaudhuri, Research Signpost, Trivandrum, India 2005, 1-22.
13. Nathan, C. Neutrophils and immunity: Challenges and opportunities. Nat Rev Immunol 2006, 6: 173-82.
14. Scapini, P., Lapinet-Vera, J.A., Gasperini, S., Calzetti, F., Bazzoni, F. and Cassatella, M.A. The neutrophil as a cellular source of chemokines. Immunol Rev 2000, 177: 195-203.
15. Borregaard, N. and Cowland, J.B. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 1997, 89: 3503-21.
16. Karlsson, A. and Dahlgren, C. Assembly and activation of the neutrophil NADPH oxidase in granule membranes. Antioxid Redox Signal 2002, 4: 49-60.
17. Wagner, C., Pioch, M., Meyer, C., Iking-Konert, C., Andrassy, K. and Hansch, G.M. Differentiation of polymorphonuclear neutrophils in patients with systemic infections and chronic inflammatory diseases: Evidence of prolonged life span and de novo synthesis of fibronectin. J Mol Med 2000, 78: 337-45.
18. Theilgaard-Monch, K., Porse, B.T. and Borregaard, N. Systems biology of neutrophil differentiation and immune response. Curr Opin Immunol 2006, 18: 54-60.
19. Oehler, L., Majdic, O., Pickl, W.F. et al. Neutrophil granulocyte-committed cells can be driven to acquire dendritic cell characteristics. J Exp Med 1998, 187: 1019-28.
20. Tacchini-Cottier, F., Zweifel, C., Belkaid, Y. et al. An immunomodulatory function for neutrophils during the induction of a CD4+ Th2 response in BALB/c mice infected with Leishmania major. J Immunol 2000, 165: 2628-36.
21. Brinkmann, V., Reichard, U., Goosmann, C. et al. Neutrophil extracellular traps kill bacteria. Science 2004, 303: 1532-5.
22. Armstrong, D.S., Grimwood, K., Carlin, J.B. et al. Lower airway inflammation in infants and young children with cystic fibrosis. Am J Respir Crit Care Med 1997, 156: 1197-204.
23. Khan, T.Z., Wagener, J.S., Bost, T., Martinez, J., Accurso, F.J. and Riches, D.W. Early pulmonary inflammation in infants with cystic fibrosis (see comments). Am J Respir Crit Care Med 1995, 151: 1075-82.
24. Tirouvanziam, R., de Bentzmann, S., Hubeau, C. et al. Inflammation and infection in naive human cystic fibrosis airway grafts. Am J Respir Cell Mol Biol 2000, 23: 121-7.
25. Tirouvanziam, R., Khazaal, I. and Peault, B. Primary inflammation in human cystic fibrosis small airways. Am J Physiol Lung Cell Mol Physiol 2002, 283: L445-51.
26. Sheils, C.A., Kas, J., Travassos, W. et al. Actin filaments mediate DNA fiber formation in chronic inflammatory airway disease. Am J Pathol 1996, 148: 919-27.
27. Kettle, A.J., Chan, T., Osberg, I. et al. Myeloperoxidase and protein oxidation in the airways of young children with cystic fibrosis. Am J Respir Crit Care Med 2004, 170: 1317-23.
28. Birrer, P. Proteases and antiproteases in cystic fibrosis: Pathogenetic considerations and therapeutic strategies. Respiration 1995, 62 Suppl 1: 25-8.
29. Muhlebach, M.S., Stewart, P.W., Leigh, M.W. and Noah, T.L. Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients. Am J Respir Crit Care Med 1999, 160: 186-91.
30. Shapiro, S.D. Neutrophil elastase: Path clearer, pathogen killer, or just pathologic? Am J Respir Cell Mol Biol 2002, 26: 266-8.
31. Zheng, S., De, B.P., Choudhary, S. et al. Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis. Immunity 2003, 18: 619-30.
32. Saiman, L. Microbiology of early CF lung disease. Paediatr Respir Rev 2004, 5 Suppl A: S367-9.
33. Rogers, G.B., Carroll, M.P., Serisier, D.J. et al. Bacterial activity in cystic fibrosis lung infections. Respir Res 2005, 6: 49.
34. Taylor, R.F., Hodson, M.E. and Pitt, T.L. Auxotrophy of Pseudomonas aeruginosa in cystic fibrosis. FEMS Microbiol Lett 1992, 71: 243-6.
35. Bjarnsholt, T., Jensen, P.O., Burmolle, M. et al. Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent. Microbiology 2005, 151: 373-83.
36. Whitchurch, C.B., Tolker-Nielsen, T., Ragas, P.C. and Mattick, J.S. Extracellular DNA required for bacterial biofilm formation. Science 2002, 295: 1487.
37. Kobayashi, H. Airway biofilms: Implications for pathogenesis and therapy of respiratory tract infections. Treat Respir Med 2005, 4: 241-53.
38. Moss, R.B. Pathophysiology and immunology of allergic bronchopulmonary aspergillosis. Med Mycol 2005, 43 Suppl 1: S203-6.
39. Witko-Sarsat, V., Allen, R.C., Paulais, M. et al. Disturbed myeloperoxidase-dependent activity of neutrophils in cystic fibrosis homozygotes and heterozygotes, and its correction by amiloride. J Immunol 1996, 157: 2728-35.
40. Taggart, C., Coakley, R.J., Greally, P., Canny, G., O'Neill, S.J. and McElvaney, N.G. Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-alpha and interleukin-8. Am J Physiol Lung Cell Mol Physiol 2000, 278: L33-41.
41. Coakley, R.J., Taggart, C., Canny, G., Greally, P., O'Neill, S.J. and McElvaney, N.G. Altered intracellular pH regulation in neutrophils from patients with cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 2000, 279: L66-74.
42. Bonfield, T.L., Panuska, J.R., Konstan, M.W. et al. Inflammatory cytokines in cystic fibrosis lungs. Am J Respir Crit Care Med 1995, 152: 2111-8.
43. Cantin, A.M. Potential for antioxidant therapy of cystic fibrosis. Curr Opin Pulm Med 2004, 10: 531-6.
44. Tirouvanziam, R., Conrad, C.K., Bottiglieri, T., Herzenberg, L.A., Moss, R.B. and Herzenberg, L.A. High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis. Proc Natl Acad Sci U S A 2006, 103: 4628-33.
45. Campbell, E.J., Campbell, M.A., Boukedes, S.S. and Owen, C.A. Quantum proteolysis by neutrophils: Implications for pulmonary emphysema in alpha 1-antitrypsin deficiency. J Clin Invest 1999, 104: 337-44.
46. Vandivier, R.W., Fadok, V.A., Hoffmann, P.R. et al. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest 2002, 109: 661-70.
47. Karp, C.L., Flick, L.M., Yang, R., Uddin, J. and Petasis, N.A. Cystic fibrosis and lipoxins. Prostaglandins Leukot Essent Fatty Acids 2005, 73: 263-70.
48. Fittschen, C. and Henson, P.M. Linkage of azurophil granule secretion in neutrophils to chloride ion transport and endosomal transcytosis. J Clin Invest 1994, 93: 247-55.
49. Segal, A.W. How neutrophils kill microbes. Annu Rev Immunol 2005, 23: 197-223.
50. Christensen, R.D. and Calhoun, D.A. Congenital neutropenia. Clin Perinatol 2004, 31: 29-38.
51. Mallory, G.B. Jr. Inflammation in lung transplantation for CF. Immunosuppression and modulation of inflammation. Clin Rev Allergy Immunol 2002, 23: 105-22.
52. Sterling, K.M. Jr., Shah, S., Kim, R.J., Johnston, N.I., Salikhova, A.Y. and Abraham, E.H. Cystic fibrosis transmem brane conductance regulator in human and mouse red blood cell membranes and its interaction with ecto-apyrase. J Cell Biochem 2004, 91: 1174-82.
53. Tousson, A., Van Tine, B.A., Naren, A.P., Shaw, G.M. and Schwiebert, L.M. Characterization of CFTR expression and chloride channel activity in human endothelia. Am J Physiol 1998, 275: C1555-64.
54. Yoshimura, K., Nakamura, H., Trapnell, B.C. et al. Expression of the cystic fibrosis transmembrane conductance regulator gene in cells of non-epithelial origin. Nucleic Acids Res 1991, 19: 5417-23.
55. Moss. R.B., Hsu, Y.P. and Olds, L. Cytokine dysregulation in activated cystic fibrosis (CF) peripheral lymphocytes. Clin Exp Immunol 2000, 120: 518-25.
56. Baudouin-Legros, M., Hinzpeter, A., Jaulmes, A. et al. Cell-specific posttranscriptional regulation of CFTR gene expression via influence of MAPK cascades on 3′UTR part of transcripts. Am J Physiol Cell Physiol 2005, 289: C1240-50.
57. Rabin, H.R., Butler, S.M., Wohl, M.E. et al. Pulmonary exacerbations in cystic fibrosis. Pediatr Pulmonol 2004, 37: 400-6.
58. VanDevanter, D.R. and Van Dalfsen, J.M. How much do Pseudomonas biofilms contribute to symptoms of pulmonary exacerbation in cystic fibrosis? Pediatr Pulmonol 2005, 39: 504-6.
59. Keatings, V.M. and Barnes, P.J. Granulocyte activation markers in induced sputum: Comparison between chronic obstructive pulmonary disease, asthma, and normal subjects. Am J Respir Crit Care Med 1997, 155: 449-53.
60. Fahy, J.V., Kim, K.W., Liu, J. and Boushey, H.A. Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol 1995, 95: 843-52.