메뉴 건너뛰기




Volumn 180, Issue 11, 2008, Pages 7764-7773

Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; NEUTRALIZING ANTIBODY; TOLL LIKE RECEPTOR 5; FLAGELLIN;

EID: 47249131603     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.11.7764     Document Type: Article
Times cited : (79)

References (51)
  • 1
    • 0037460729 scopus 로고    scopus 로고
    • Cystic fibrosis
    • Raljen, F., and G. Doling. 2003. Cystic fibrosis. Lancet 361: 681-689.
    • (2003) Lancet , vol.361 , pp. 681-689
    • Raljen, F.1    Doling, G.2
  • 2
    • 34247464737 scopus 로고    scopus 로고
    • Inflammation and anti-inflammatory therapies for cystic fibrosis
    • Chmiel, J. F., and M. W. Konstan. 2007. Inflammation and anti-inflammatory therapies for cystic fibrosis. Clin. Chest Med. 28: 331-346.
    • (2007) Clin. Chest Med , vol.28 , pp. 331-346
    • Chmiel, J.F.1    Konstan, M.W.2
  • 3
    • 0021970474 scopus 로고
    • Alternate-day prednisone reduces morbidity and improves pulmonary function in cystic fibrosis
    • Aucrbach, H. S., M. Williams, J. A. Kirkpatrick, and H. R. Colten. 1985. Alternate-day prednisone reduces morbidity and improves pulmonary function in cystic fibrosis. Lancet 2: 686-688.
    • (1985) Lancet , vol.2 , pp. 686-688
    • Aucrbach, H.S.1    Williams, M.2    Kirkpatrick, J.A.3    Colten, H.R.4
  • 4
    • 0028914667 scopus 로고
    • Effect of high-dose ibuprofen in patients with cystic fibrosis
    • Konstan, M. W., P. J. Byard, C. L. Hoppel, and P. B. Davis. 1995. Effect of high-dose ibuprofen in patients with cystic fibrosis. N. Engl. J. Med. 332: 848-854.
    • (1995) N. Engl. J. Med , vol.332 , pp. 848-854
    • Konstan, M.W.1    Byard, P.J.2    Hoppel, C.L.3    Davis, P.B.4
  • 5
    • 33745191871 scopus 로고    scopus 로고
    • What's new in CF airway inflammation: An update
    • Ratjen, F. 2006. What's new in CF airway inflammation: an update. Paediatr. Respir. Rev. 7: S70-S72.
    • (2006) Paediatr. Respir. Rev , vol.7
    • Ratjen, F.1
  • 6
    • 33746583563 scopus 로고    scopus 로고
    • Innate immune response in CF airway epithelia: Hyperin-flammatory?
    • Machen, T. E. 2006. Innate immune response in CF airway epithelia: hyperin-flammatory? Am. J. Physiol. 291: C218-C230.
    • (2006) Am. J. Physiol , vol.291
    • Machen, T.E.1
  • 11
    • 0031035884 scopus 로고    scopus 로고
    • Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis
    • Noah, T. L., H. R. Black, P. W. Cheng, R. E. Wood, and M. W. Leigh. 1997. Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis. J. Infect. Dis. 175: 638-647.
    • (1997) J. Infect. Dis , vol.175 , pp. 638-647
    • Noah, T.L.1    Black, H.R.2    Cheng, P.W.3    Wood, R.E.4    Leigh, M.W.5
  • 12
    • 4344618967 scopus 로고    scopus 로고
    • Lipopoly-saccharides of Bacleroides fragilis, Chlamydia trachomatis, and Pseudomonas aeruginosa signal via Toll-like receptor 2
    • Erridge, C, A. Pridmore, A. Eley, J. Stewart, and I. R. Poxton. 2004. Lipopoly-saccharides of Bacleroides fragilis, Chlamydia trachomatis, and Pseudomonas aeruginosa signal via Toll-like receptor 2. J. Med. Microbiol. 53: 735-740.
    • (2004) J. Med. Microbiol , vol.53 , pp. 735-740
    • Erridge, C.1    Pridmore, A.2    Eley, A.3    Stewart, J.4    Poxton, I.R.5
  • 14
    • 2342535902 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM 1 and Toll-like receptor 2 as well as Toll-like receptor 5
    • Adamo, R., S. Sokol, G. Soong, M. I. Gomez, and A. Prince. 2004. Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM 1 and Toll-like receptor 2 as well as Toll-like receptor 5. Am. J. Respir. Cell Mol. Biol. 30: 627-634.
    • (2004) Am. J. Respir. Cell Mol. Biol , vol.30 , pp. 627-634
    • Adamo, R.1    Sokol, S.2    Soong, G.3    Gomez, M.I.4    Prince, A.5
  • 15
    • 0027412209 scopus 로고
    • Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter
    • Flotte, T. R., S. A. Afione, R. Solow, M. L. Drumm, D. Markakis, W. B. Guggino, P. L. Zeitlin, and B. J. Carter. 1993. Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter. J. Biol. Chem. 268: 3781-3790.
    • (1993) J. Biol. Chem , vol.268 , pp. 3781-3790
    • Flotte, T.R.1    Afione, S.A.2    Solow, R.3    Drumm, M.L.4    Markakis, D.5    Guggino, W.B.6    Zeitlin, P.L.7    Carter, B.J.8
  • 17
    • 0028172499 scopus 로고
    • Construction of improved Escherichia-Pseudomonas shuttle vectors derived from pUC18/19 and sequence of the region required for their replication in Pseudomonas aeruginosa
    • West, S. E., H. P. Schweizer, C. Dall, A. K. Sample, and L. J. Runyen-Janecky. 1994. Construction of improved Escherichia-Pseudomonas shuttle vectors derived from pUC18/19 and sequence of the region required for their replication in Pseudomonas aeruginosa. Gene 148: 81-86.
    • (1994) Gene , vol.148 , pp. 81-86
    • West, S.E.1    Schweizer, H.P.2    Dall, C.3    Sample, A.K.4    Runyen-Janecky, L.J.5
  • 18
  • 19
    • 0028012203 scopus 로고
    • Nonmotility and phagocytic resistance of Pseudomonas aeruginosa isolates from chronically colonized patients with cystic fibrosis
    • Mahenthiralingam, E., M. E. Campbell, and D. P. Speert. 1994. Nonmotility and phagocytic resistance of Pseudomonas aeruginosa isolates from chronically colonized patients with cystic fibrosis. Infect. Immun. 62: 596-605.
    • (1994) Infect. Immun , vol.62 , pp. 596-605
    • Mahenthiralingam, E.1    Campbell, M.E.2    Speert, D.P.3
  • 20
    • 0024565912 scopus 로고
    • A cAMP-regulated chloride channel in lymphocytes that is affected in-cystic fibrosis
    • Chen, J. H., H. Schulman, and P. Gardner. 1989. A cAMP-regulated chloride channel in lymphocytes that is affected in-cystic fibrosis. Science 243: 657-660.
    • (1989) Science , vol.243 , pp. 657-660
    • Chen, J.H.1    Schulman, H.2    Gardner, P.3
  • 22
    • 4043059295 scopus 로고    scopus 로고
    • Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1
    • Gomez, M. I., A. Lee, B. Reddy, A. Muir, G. Soong, A. Pitt, A. Cheung, and A. Prince. 2004. Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1. Nat. Med. 10: 842-848.
    • (2004) Nat. Med , vol.10 , pp. 842-848
    • Gomez, M.I.1    Lee, A.2    Reddy, B.3    Muir, A.4    Soong, G.5    Pitt, A.6    Cheung, A.7    Prince, A.8
  • 23
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Homung, V., S. Rothenfusser, S. Britsch, A. Krug, B. Jahrsdorfer, T. Giese, S. Endres, and G. Hartmann. 2002. Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168: 4531-4537.
    • (2002) J. Immunol , vol.168 , pp. 4531-4537
    • Homung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 24
    • 34548679608 scopus 로고    scopus 로고
    • TLRS and Ipaf: Dual sensors of bacterial flagellin in the innate immune system
    • Miao, E. A., E. Andersen-Nissen, S. E. Warren, and A. Aderem. 2007. TLRS and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin. Immunopathol. 29: 275-288.
    • (2007) Semin. Immunopathol , vol.29 , pp. 275-288
    • Miao, E.A.1    Andersen-Nissen, E.2    Warren, S.E.3    Aderem, A.4
  • 25
    • 38549168320 scopus 로고    scopus 로고
    • CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells
    • Vij, N., M. O. Amoako, S. Mazur, and P. L. Zeitlin. 2008. CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 38: 176-184.
    • (2008) Am. J. Respir. Cell Mol. Biol , vol.38 , pp. 176-184
    • Vij, N.1    Amoako, M.O.2    Mazur, S.3    Zeitlin, P.L.4
  • 26
    • 34247891494 scopus 로고    scopus 로고
    • Induction of IL-6 gene expression in a CF bronchial epithelial cell line by Pseudomonas aeruginosa is dependent on transcription factors belonging to the Spl superfamily
    • Borgatti, M., V. Bezzerri, I. Mahcini, E. Nicolis, M. C. Dechecchi, I. Lampronti, P. Rizzotti, G. Cabrini, and R. Gambari. 2007. Induction of IL-6 gene expression in a CF bronchial epithelial cell line by Pseudomonas aeruginosa is dependent on transcription factors belonging to the Spl superfamily. Biochem. Biophys. Res. Commun. 357: 977-983.
    • (2007) Biochem. Biophys. Res. Commun , vol.357 , pp. 977-983
    • Borgatti, M.1    Bezzerri, V.2    Mahcini, I.3    Nicolis, E.4    Dechecchi, M.C.5    Lampronti, I.6    Rizzotti, P.7    Cabrini, G.8    Gambari, R.9
  • 27
    • 34247106830 scopus 로고    scopus 로고
    • Enhanced IL-lβ-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-κB signaling
    • Muselet-Charlier, C, T. Roque, E. Boncoeur, K. Chadelat, A. Clement, J. Jacquot, and O. Tabary. 2007. Enhanced IL-lβ-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-κB signaling. Biochem. Biophys. Res. Commun. 357: 402-407.
    • (2007) Biochem. Biophys. Res. Commun , vol.357 , pp. 402-407
    • Muselet-Charlier, C.1    Roque, T.2    Boncoeur, E.3    Chadelat, K.4    Clement, A.5    Jacquot, J.6    Tabary, O.7
  • 28
    • 10344254339 scopus 로고    scopus 로고
    • The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice
    • Power, M. R., Y. Peng, E. Maydanski, J. S. Marshall, and T. J. Lin. 2004. The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice. J. Biol. Chem. 279: 49315-49322.
    • (2004) J. Biol. Chem , vol.279 , pp. 49315-49322
    • Power, M.R.1    Peng, Y.2    Maydanski, E.3    Marshall, J.S.4    Lin, T.J.5
  • 29
    • 33645454457 scopus 로고    scopus 로고
    • Innate immune responses of human tracheal epithelium to Pseudomonas aeruginosa flagellin, TNF-α, and IL-1β
    • Tseng, J., J. Do, J. H. Widdicombe, and T. E. Machen. 2006. Innate immune responses of human tracheal epithelium to Pseudomonas aeruginosa flagellin, TNF-α, and IL-1β. Am. J. Physiol. 290: C678-C690.
    • (2006) Am. J. Physiol , vol.290
    • Tseng, J.1    Do, J.2    Widdicombe, J.H.3    Machen, T.E.4
  • 31
    • 0034703072 scopus 로고    scopus 로고
    • CD14-dependent lipopolysaccharide-induced β-defensin-2 expression in human tra-cheobronchial epithelium
    • Becker, M. N., G. Diamond, M. W. Verghese, and S. H. Randell. 2000. CD14-dependent lipopolysaccharide-induced β-defensin-2 expression in human tra-cheobronchial epithelium. J. Biol. Chem. 275: 29731-29736.
    • (2000) J. Biol. Chem , vol.275 , pp. 29731-29736
    • Becker, M.N.1    Diamond, G.2    Verghese, M.W.3    Randell, S.H.4
  • 32
    • 24744455884 scopus 로고    scopus 로고
    • TLRs 2 and 4 are not involved in hypersusceptibility to acute Pseudomonas aeruginosa lung infections
    • Ramphal, R., V. Balloy, M. Huerre, M. Si-Tahar, and M. Chignard. 2005. TLRs 2 and 4 are not involved in hypersusceptibility to acute Pseudomonas aeruginosa lung infections. J. Immunol. 175: 3927-3934.
    • (2005) J. Immunol , vol.175 , pp. 3927-3934
    • Ramphal, R.1    Balloy, V.2    Huerre, M.3    Si-Tahar, M.4    Chignard, M.5
  • 34
    • 34147215995 scopus 로고    scopus 로고
    • Exacerbations in cystic fibrosis. 1: Epidemiology and pathogenesis
    • Goss, C. H., and J. L. Burns. 2007. Exacerbations in cystic fibrosis. 1: Epidemiology and pathogenesis. Thorax 62: 360-367.
    • (2007) Thorax , vol.62 , pp. 360-367
    • Goss, C.H.1    Burns, J.L.2
  • 36
    • 1642473047 scopus 로고    scopus 로고
    • Cystic fibrosis airway epithelial cell polarity and bacterial flagellin determine host response to Pseudomonas aeruginosa
    • Hybiske, K., J. K. Ichikawa, V. Huang, S. J. Lory, and T. E. Machen. 2004. Cystic fibrosis airway epithelial cell polarity and bacterial flagellin determine host response to Pseudomonas aeruginosa. Cell. Microbiol. 6: 49-63.
    • (2004) Cell. Microbiol , vol.6 , pp. 49-63
    • Hybiske, K.1    Ichikawa, J.K.2    Huang, V.3    Lory, S.J.4    Machen, T.E.5
  • 37
    • 33846220724 scopus 로고    scopus 로고
    • Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa
    • Skerrett, S. J., C. B. Wilson, H. D. Liggitt, and A. M. Hajjar. 2007. Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa. Am. J. Physiol. 292: L312-L322.
    • (2007) Am. J. Physiol , vol.292
    • Skerrett, S.J.1    Wilson, C.B.2    Liggitt, H.D.3    Hajjar, A.M.4
  • 38
    • 27744459408 scopus 로고    scopus 로고
    • Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5
    • Zhang, Z., J. P. Louboutin. D. J. Weiner, J. B. Goldberg, and J. M. Wilson. 2005. Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5. Infect. Immun. 73: 7151-7160.
    • (2005) Infect. Immun , vol.73 , pp. 7151-7160
    • Zhang, Z.1    Louboutin, J.P.2    Weiner, D.J.3    Goldberg, J.B.4    Wilson, J.M.5
  • 39
    • 10744226016 scopus 로고    scopus 로고
    • A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to Legionnaires' disease
    • Hawn, T. R., A. Verbon, K. D. Lettinga, L. P. Zhao, S. S. Li, R. J. Laws, S. J. Skerrett, B. Beutler, L. Schroeder, A. Nachman, et al. 2003. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to Legionnaires' disease. J. Exp. Med. 198: 1563-1572.
    • (2003) J. Exp. Med , vol.198 , pp. 1563-1572
    • Hawn, T.R.1    Verbon, A.2    Lettinga, K.D.3    Zhao, L.P.4    Li, S.S.5    Laws, R.J.6    Skerrett, S.J.7    Beutler, B.8    Schroeder, L.9    Nachman, A.10
  • 40
    • 20144366015 scopus 로고    scopus 로고
    • Host susceptibility and clinical outcomes in Toll-like receptor 5-deficient patients with typhoid fever in Vietnam
    • Dunstan, S. J., T. R. Hawn, N. T. Hue, C. P. Parry, V. A. Ho, H. Vinh, T. S. Diep, D. House, J. Wain, A. Aderem, et al. 2005. Host susceptibility and clinical outcomes in Toll-like receptor 5-deficient patients with typhoid fever in Vietnam. J. Infect. Dis. 191: 1068-1071.
    • (2005) J. Infect. Dis , vol.191 , pp. 1068-1071
    • Dunstan, S.J.1    Hawn, T.R.2    Hue, N.T.3    Parry, C.P.4    Ho, V.A.5    Vinh, H.6    Diep, T.S.7    House, D.8    Wain, J.9    Aderem, A.10
  • 41
    • 34447257103 scopus 로고    scopus 로고
    • The role of flagellin versus motility in acute lung disease caused by Pseudomonas aeruginosa
    • Balloy, V., A. Verma, S. Kuravi, M. Si-Tahar, M. Chignard, and R. Ramphal. 2007. The role of flagellin versus motility in acute lung disease caused by Pseudomonas aeruginosa. J. Infect. Dis. 196: 289-296.
    • (2007) J. Infect. Dis , vol.196 , pp. 289-296
    • Balloy, V.1    Verma, A.2    Kuravi, S.3    Si-Tahar, M.4    Chignard, M.5    Ramphal, R.6
  • 42
    • 2342630062 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients
    • Wolfgang, M. C., J. Jyot, A. L. Goodman, R. Ramphal, and S. Lory. 2004. Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients. Proc. Natl. Acad. Sci. USA 101: 6664-6668.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 6664-6668
    • Wolfgang, M.C.1    Jyot, J.2    Goodman, A.L.3    Ramphal, R.4    Lory, S.5
  • 43
    • 21544481151 scopus 로고    scopus 로고
    • Role of motility and flagellin glycosylation in the pathogenesis of Pseudomonas aeruginosa bum wound infections
    • Arora, S. K., A. N. Neely, B. Blair, S. Lory, and R. Ramphal. 2005. Role of motility and flagellin glycosylation in the pathogenesis of Pseudomonas aeruginosa bum wound infections. Infect. Immun. 73: 4395-4398.
    • (2005) Infect. Immun , vol.73 , pp. 4395-4398
    • Arora, S.K.1    Neely, A.N.2    Blair, B.3    Lory, S.4    Ramphal, R.5
  • 45
    • 33845481599 scopus 로고    scopus 로고
    • Neutrophil elastase, an innate immunity effector molecule, represses flagellin transcription in Pseudomonas aeruginosa
    • Sonawane, A., J. Jyot, R. During, and R. Ramphal. 2006. Neutrophil elastase, an innate immunity effector molecule, represses flagellin transcription in Pseudomonas aeruginosa. Infect. Immun. 74: 6682-6689.
    • (2006) Infect. Immun , vol.74 , pp. 6682-6689
    • Sonawane, A.1    Jyot, J.2    During, R.3    Ramphal, R.4
  • 46
    • 33846604168 scopus 로고    scopus 로고
    • Genetic mechanisms involved in the repression of flagellar assembly by Pseudomonas aeruginosa in human mucus
    • Jyot, J., A. Sonawane, W. Wu, and R. Ramphal. 2007. Genetic mechanisms involved in the repression of flagellar assembly by Pseudomonas aeruginosa in human mucus. Mol. Microbiol. 63: 1026-1038.
    • (2007) Mol. Microbiol , vol.63 , pp. 1026-1038
    • Jyot, J.1    Sonawane, A.2    Wu, W.3    Ramphal, R.4
  • 47
    • 0026709740 scopus 로고
    • Genetic analysis of Pseudomonas aeruginosa adherence: Distinct genetic loci control attachment to epithelial cells and mucins
    • Simpson, D. A., R. Ramphal, and S. Lory. 1992. Genetic analysis of Pseudomonas aeruginosa adherence: distinct genetic loci control attachment to epithelial cells and mucins. Infect. Immun. 60: 3771-3779.
    • (1992) Infect. Immun , vol.60 , pp. 3771-3779
    • Simpson, D.A.1    Ramphal, R.2    Lory, S.3
  • 48
    • 0018613990 scopus 로고
    • Outer membrane of Pseudomonas aeruginosa: Heat-2-mercaptoethanol-modifiable proteins
    • Hancock, R. E., and A. M. Carey. 1979. Outer membrane of Pseudomonas aeruginosa: heat-2-mercaptoethanol-modifiable proteins. J. Bacteriol. 140: 902-910.
    • (1979) J. Bacteriol , vol.140 , pp. 902-910
    • Hancock, R.E.1    Carey, A.M.2
  • 49
    • 0018407710 scopus 로고
    • The extraction and analysis of lipopolysaccharides from Pseudomonas aeruginosa strain PAO, and three rough mutants
    • Kropinski, A. M., L. C. Chan, and F. H. Milazzo. 1979. The extraction and analysis of lipopolysaccharides from Pseudomonas aeruginosa strain PAO, and three rough mutants. Can. J. Microbiol. 25: 390-398.
    • (1979) Can. J. Microbiol , vol.25 , pp. 390-398
    • Kropinski, A.M.1    Chan, L.C.2    Milazzo, F.H.3
  • 50
    • 0019457159 scopus 로고
    • Isolation and characterization of a bacteriophage specific for the Iipopolysaccharide of rough derivatives of Pseudomonas aeruginosa strain PAO
    • Jarrell, K. F., and A. M. Kropinski. 1981. Isolation and characterization of a bacteriophage specific for the Iipopolysaccharide of rough derivatives of Pseudomonas aeruginosa strain PAO. J. Virol. 38: 529-538.
    • (1981) J. Virol , vol.38 , pp. 529-538
    • Jarrell, K.F.1    Kropinski, A.M.2
  • 51
    • 17844382115 scopus 로고    scopus 로고
    • Construction of a mini-Tn5-luxCD-ABE mutant library in Pseudomonas aeruginosa PAO1: A tool for identifying differentially regulated genes
    • Lewenza, S., R. K. Falsafi, G. Winsor, W. J. Gooderham, J. B. McPhee, F. S. Brinkman,.and R. E. Hancock. 2005. Construction of a mini-Tn5-luxCD-ABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes. Genome Res. 15: 583-589.
    • (2005) Genome Res , vol.15 , pp. 583-589
    • Lewenza, S.1    Falsafi, R.K.2    Winsor, G.3    Gooderham, W.J.4    McPhee, J.B.5    Brinkman, F.S.6    Hancock, R.E.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.